A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21287 results · page 292 of 710
Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
Mousavi SS, Karimi S, Hassannia MS et al. · 2025 · Preprint
Objective Electrocardiography and blood pressure (BP) measurement are two widely used tools for diagnosis and monitoring cardiovascular diseases. While the electrocardiogram (ECG) and BP have been considered complementary modalities, there…
Rosiles T, Nguyen M, Calin-Jageman RJ et al. · 2026 · eNeuro
Forming a long-term memory requires changes in neuronal transcription. What happens, though, as the memory is forgotten? And how does the transcriptional state relate to the maintenance and recall of the long-term memory? To answer these…
Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports
Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…
Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…
Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases
Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…
Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases
Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…
Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms
In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…
AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint
Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…
Witkin JM, Pandey KP, Smith JL · 2022 · Pharmacology, biochemistry, and behavior
Pharmacological modulation of glutamate has long been considered to be of immense therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for safely altering glutamate-driven excitation. Data support the…
Abdelmalek MF, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethylene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine
Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…
Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology
Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…
Hiester A, Che Y, Lusch A et al. · 2023 · European urology
Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…
Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association
Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…
Ahogni I, Avanon H, Hueha C et al. · 2026 · Malaria journal
Background Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs, concerns…
Bulut C, Arslan Z, Aydoğdu M et al. · 2026 · Forensic science international
Rising global alcohol consumption is a major public health and safety concern. Over the last decade, undeclared alcohol consumption has increasingly come into focus due to high inflation that has led many individuals to resort to unhealthy…
Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases
Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…
Watanabe T, Hirano T · 2026 · Clinical medicine insights. Pediatrics
Objective The importance and effectiveness of Newborn hearing screening (NHS) have been widely recognized. However, there are a few cases of false-negative NHS results. Hearing loss in children causes various disorders. Therefore,…
Mangiaterra T, Chabay P, Bellan C et al. · 2026 · Frontiers in immunology
Epstein-Barr virus (EBV) infects more than 90% of the global population and is etiologically linked to a wide spectrum of lymphoid and epithelial malignancies. Although its role as an oncogenic virus is well established, the mechanisms…
Wang X, Albayda J, Paik JJ et al. · 2025 · Rheumatology (Oxford, England)
Objective This study aims to evaluate the diagnostic accuracy of CA-125 and PET/CT in detecting cancer among adult patients with idiopathic inflammatory myopathy (IIM). Methods We conducted a retrospective study of a single-centre cohort…
Mann L, Samp P, Schäefer JH et al. · 2025 · Preprint
Background: / Objectives; After negative results of the SAMMPRIS-trial the indication for endovascular treatment of atherosclerotic intracranial artery stenosis (ICAS) was widely restricted. It was the aim of our study to report whether…
Kimura K, Kuwata T, Hiraoka Y et al. · 2026 · Journal of human genetics
Multigene panel testing (MGPT) is increasingly used for diagnosing hereditary cancers; however, its application in cascade testing remains limited, and the psychological impact on unaffected relatives is not well understood. This…
Blasich NP, Adelekan AM · 2026 · Health science reports
Background Point-of-care rapid diagnostic testing plays a critical role in HIV detection and timely linkage to care, particularly in decentralized healthcare settings. To support testing reliability, the National Health Laboratory Service…
Uyanık G, Yüksel M, Abay M et al. · 2026 · Veterinary journal (London, England : 1997)
The present study aimed to determine the diagnostic accuracy of the commercial Alertys OnFarm Pregnancy Test (AOPT) based on pregnancy-associated glycoprotein (PAG) for early pregnancy diagnosis in ewes. A total of 100 multiparous Awassi…
Zhang J, Hu Y, Dong P et al. · 2025 · Diagnostics (Basel, Switzerland)
Sarcoidosis is a rare multisystem inflammatory disease characterized by non-necrotizing granulomas, typically affecting the lungs, lymph nodes, skin, and bones. Due to its extreme clinical heterogeneity, diagnosis remains challenging.…
Pandey P, Bir R, Chatterjee K et al. · 2026 · Iranian journal of microbiology
Background and objectives Sepsis is a life threatening condition caused by a dysregulated host response to infection and is associated with high morbidity and mortality worldwide. Early bacterial detection and therapy with antibiotics…
Samkange A, Chitanga S, Mbiri P et al. · 2025 · The Onderstepoort journal of veterinary research
Neosporosis is a leading cause of bovine abortions worldwide, with a substantial economic impact because of reproductive losses, costing the cattle industry billions of dollars annually. Despite the global significance of Neospora caninum,…
Lis K · 2025 · Life (Basel, Switzerland)
Vitamin B1 (thiamine) is a water-soluble B vitamin. As a cofactor of many enzymes, it is essential for the proper functioning of many body systems and organs, including metabolic and energy metabolism. In extreme cases, vitamin B1…