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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 287 of 724

Negative / Null Result ReportMedicine

Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes.

Scalamera R, Covani M, Andreaggi S et al. · 2026 · European heart journal. Cardiovascular Imaging

Aims Cardiovascular risk factors predict adverse clinical outcomes, including acute coronary syndromes (ACS). A recent study showed a close correlation between the number of modifiable risk factors and plaque vulnerability. However, the…

View details →DOI: 10.1093/ehjci/jeag023
Negative / Null Result ReportMedicine

Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepióra F, Ciach M · 2025 · Forest Ecology and Management.

Although species with ecosystem engineering capabilities like woodpeckers, ungulates or saproxylic insects may initiate the formation of Tree-related Microhabitats (TreMs), their overall impact on TreM assemblages remains unexplored. Bark…

Negative / Null Result ReportMedicine

Heat-Killed <i>Enterococcus faecalis</i> EF-2001 Promotes Systemic Th1-Skewed Immune Activation Without Detectable Reduction of Influenza Viral Load in Mice.

Ohashi T, Hagihara M, Asai N et al. · 2026 · Microorganisms

Heat-killed Enterococcus faecalis EF-2001 (EF-2001) is a postbiotic preparation reported to modulate host immunity. However, its specific impact on host immune responses and virological outcomes during the early phase of influenza…

View details →DOI: 10.3390/microorganisms14020316
Negative / Null Result Report

Assessment of Heavy Metals in Organic and Non-Organic Vegetables Post Severe Tropical Cyclone Gabrielle: A cross-sectional comparative analysis.

Dearing C, Ye Z, Robertshaw G · 2025 · Preprint

Abstract* Background Heavy metals such as cadmium, lead, and mercury are ubiquitous in the environment, accumulating in plants, animals, water and human food. Human exposure through the consumption of vegetable crops is a global concern…

View details →DOI: 10.12688/f1000research.175538.1
Negative / Null Result ReportMedicine

Impact of neoadjuvant immunotherapy on postoperative cardiac adverse events in NSCLC: insights from a bidirectional cohort.

Yan C, Zhang X, Hu S et al. · 2026 · International journal of surgery (London, England)

The impact of neoadjuvant chemo-immunotherapy (nCIT) on perioperative cardiac safety in patients undergoing lung cancer resection remains unclear. This study aimed to evaluate the incidence and risk factors of postoperative cardiac adverse…

View details →DOI: 10.1097/js9.0000000000004846
Negative / Null Result ReportMedicine

Effect of acute intraperitoneal injection of methylglyoxal on organ injury and oxidative stress in chicks (Gallus gallus domestics).

Okino M, Makino R, Aoki M et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Methylglyoxal (MGO) is an α-dicarbonyl compound and produced from several metabolic pathways, including glucose metabolism. This compound induces oxidative stress and organ damage in mammals and is associated with various diseases,…

View details →DOI: 10.1016/j.cbpa.2026.111975
Negative / Null Result Report

Glucose coating tunes the catalytic reactivity of FeO@Fe 3 O 4 for biomedical applications: safety assessment using a 3D hepatic in vitro model

Ovalle MAM, Rozman I, Winkler EL et al. · 2026 · Preprint

Abstract Iron-oxide magnetic nanoparticles (MNPs) have been extensively investigated as magnetically actuable nanocatalysts for diagnostic and therapeutic applications. However, because wüstite/magnetite/maghemite phases can interconvert,…

View details →DOI: 10.21203/rs.3.rs-8474662/v1
Negative / Null Result Report

The Safety of Low-Molecular-Weight Heparin Bridging Therapy in Patients Receiving Preoperative Oral Antithrombotic Drugs During Spinal Fusion Surgery

Yan W, Che Z, Deng H et al. · 2026 · Preprint

Abstract 【Purpose】 To evaluate whether preoperative oral antithrombotic drugs increase perioperative bleeding risk in spinal fusion patients receiving low-molecular-weight-heparin (LMWH) bridging therapy, and compare bleeding risk with…

View details →DOI: 10.21203/rs.3.rs-8344022/v1
Negative / Null Result ReportMedicine

Shortening the perioperative prophylactic antimicrobial duration in pediatric ventriculoperitoneal (VP) shunt insertion.

Tada A, Ihara S, Suwa J et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Background Perioperative antimicrobial therapy is important to prevent central nervous system (CNS) infections following cerebrospinal fluid (CSF) shunt insertion, but the optimal duration remains unclear. This study aimed to evaluate the…

View details →DOI: 10.1111/ped.70372
Negative / Null Result ReportOpen accessMedicine

Impact of offset polyethylene liners on acetabular component loosening : an Australian Orthopaedic Association National Joint Replacement Registry-based analysis.

Shafiei SH, Latorre MR, Shimmin A · 2026 · Bone & joint open

Aims Restoring native hip biomechanics is essential for the long-term success of total hip arthroplasty (THA). Lateralized (offset) acetabular liners were developed to increase global offset and improve soft-tissue tension, but their…

View details →DOI: 10.1302/2633-1462.76.bjo-2026-0033.r1
Negative / Null Result ReportMedicine

Effectiveness of a Remote Physical Activity Intervention in Individuals with Alzheimer's Disease and their Caregivers: Results from a Randomized Trial.

Ptomey LT, Helsel BC, Montgomery RN et al. · 2026 · Medicine and science in sports and exercise

Purpose Individuals with Alzheimer's disease and related dementias (ADRD) and their caregivers often experience reduced physical activity (PA), diminished functional fitness, and heightened health risks. Remotely delivered PA interventions…

View details →DOI: 10.1249/mss.0000000000003974
Negative / Null Result ReportMedicine

Atherosclerotic Cardiovascular Risk in Patients with Chronic Hepatitis B: Tenofovir Disoproxil Fumarate Vs. Tenofovir Alafenamide: A Korean Nationwide Study.

Yang J, Lim J, Kim YJ et al. · 2026 · Journal of medical virology

Tenofovir alafenamide (TAF) exhibits antiviral efficacy comparable to tenofovir disoproxil fumarate (TDF). Nonetheless, concerns persist regarding TAF's impact on the lipid profile and potential atherosclerotic cardiovascular disease…

View details →DOI: 10.1002/jmv.70829
Negative / Null Result ReportMedicine

The Effect of High-Intensity Interval Training on Neuroplasticity-Related Proteins in the Cerebrum of Postnatally Growth-Restricted Mice.

Kim SH, Quinn MA, Ananyev J et al. · 2026 · Medicine and science in sports and exercise

Introduction Childhood growth restriction can lead to lasting developmental changes, increasing susceptibility to chronic diseases and neurodegenerative conditions in adulthood. High-intensity interval training (HIIT) elevates…

View details →DOI: 10.1249/mss.0000000000003964
Negative / Null Result ReportMedicine

A randomized trial of I-SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions.

Sunderrajan A, Cursio J, Mason N et al. · 2026 · Journal of hospital medicine

Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in…

View details →DOI: 10.1002/jhm.70273
Negative / Null Result ReportOpen accessMedicine

Effect of ruminally protected lysine on growth and nitrogen balance of grain-finished beef cattle fed diets of decreasing protein concentration.

Herzog DS, Jo J, Nakajima D et al. · 2026 · Translational animal science

Two experiments were conducted to determine the effect of ruminally protected lysine (AjiPro-L) supplementation on performance and nitrogen (N) balance of feedlot cattle fed decreasing concentrations of dietary protein. Diets contained (DM…

View details →DOI: 10.1093/tas/txag076
Negative / Null Result ReportMedicine

Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.

Medina Muñoz M, Gallego Campillo S, Martín Peinador Y et al. · 2026 · Indian pediatrics

Objective Lower respiratory tract infections (LRTIs) are a common cause of primary care visits in infants. This study was done to evaluate the course of LRTIs before-and-after the introduction of nirsevimab and to identify the associated…

View details →DOI: 10.1007/s13312-026-00385-6
Negative / Null Result ReportMedicine

The association between skin-suturing technique, prolonged healing and recurrence after Bascom's Cleft lift surgery.

Larsen MB, Faurschou IK, Haas S · 2026 · Techniques in coloproctology

Background The optimal treatment for complex Pilonidal Sinus Disease (PSD) is still debated. Despite great advances with the introduction of off-midline closure techniques, healing problems and recurrence remain challenges. We aimed to…

View details →DOI: 10.1007/s10151-026-03377-7
Negative / Null Result ReportMedicine

Impacts of temporal discrepancies between basal sap flow and canopy transpiration on estimating canopy ozone uptake in a warm temperate coniferous forest.

Tanaka R, Tokai S, Oi N et al. · 2026 · The Science of the total environment

Sap flow measured at basal trunk (Fd_base) has been used to estimate canopy transpiration and ozone uptake in forests. Although diurnal patterns of Fd_base do not always correspond to those of canopy transpiration, little is known about…

View details →DOI: 10.1016/j.scitotenv.2026.181975
Negative / Null Result ReportMedicine

The effect of Sebia's CZE IFCC-converted results on carbohydrate-deficient transferrin (CDT) interpretation in driver's license assessments.

Debunne N, De Letter K, Delanghe J et al. · 2026 · Clinical chemistry and laboratory medicine

Objectives Carbohydrate-deficient transferrin (CDT) is a specific biomarker for chronic excessive alcohol consumption. The IFCC Working Group on CDT Standardization recommends 2-sialo-transferrin (2-sialo-Tf) as the sole measurand, with a…

View details →DOI: 10.1515/cclm-2026-0346
Negative / Null Result ReportOpen accessMedicine

No significant increase in thrombotic risk following the widespread adoption of TPO-RAs in ITP: A comparative study.

Wang Y, Li H, Chen Y et al. · 2026 · Global medical genetics

In patients with primary immune thrombocytopenia (ITP), the risk of thrombosis associated with thrombopoietin receptor agonists (TPO-RAs) remains debated. This study compared the thrombosis occurrence in ITP patients before and after the…

View details →DOI: 10.1016/j.gmg.2026.100107
Negative / Null Result ReportMedicine

Outcomes of Patients With Mitral Stenosis With Prior Percutaneous Mitral Commissurotomy Undergoing Mitral Valve Surgery.

Ruangsubvilai N, Au-Yeung K, Wongbuddha C et al. · 2026 · The American journal of cardiology

Limited data exist on outcomes for patients with mitral stenosis (MS) who have previously undergone percutaneous mitral commissurotomy (PMC) and later require surgical mitral valve replacement (MVR). This study evaluates the impact of…

View details →DOI: 10.1016/j.amjcard.2025.12.023
Negative / Null Result ReportMedicine

Good enough assessment: A comparison of brief screener and detailed interview assessments of borderline personality disorder symptoms in a clinical research setting.

Furtado Fernandes L, Davis MT, Luo W et al. · 2026 · Personality disorders

Structured clinical interviews are the gold standard for identifying borderline personality disorder (BPD) in research. No self-report instrument has been validated as a replacement tool for BPD diagnosis. However, clinical interviews can…

View details →DOI: 10.1037/per0000771
Negative / Null Result ReportMedicine

Does Resident Involvement Affect Clinical Outcomes and Postoperative Complication Rates in Orthopaedic Sports Medicine Surgery?

Stokes DJ, Cram TR, Pasic N et al. · 2026 · The American journal of sports medicine

Background The "July effect" suggests increased patient morbidity and mortality during the early academic year due to new resident involvement. Evidence specific to orthopaedic sports medicine is limited. Purpose To evaluate the effect of…

View details →DOI: 10.1177/03635465261423216
Negative / Null Result ReportMedicine

Patiromer for Patients With Heart Failure at Risk of Hyperkalemia: CARE-HK in HF Registry.

Cantu-Martinez O, Greene SJ, Chinnakondepalli KM et al. · 2026 · Journal of cardiac failure

Background For patients with heart failure (HF), hyperkalemia (HK) may prevent optimal renin-angiotensin system inhibitor (RASi) use. Randomized trials show that patiromer, a contemporary potassium binder, reduces serum potassium (sK + )…

View details →DOI: 10.1016/j.cardfail.2026.03.025
Negative / Null Result ReportMedicine

Effect of clarithromycin versus placebo on risk of atrial fibrillation.

Jensen GB, Olsen MH, Jensen MT et al. · 2026 · Danish medical journal

Introduction The CLARICOR randomised trial of clarithromycin versus placebo in patients with stable ischaemic heart disease found increased all-cause and cardiovascular mortality after a brief clarithromycin regimen, suggesting a possible…

View details →DOI: 10.61409/a08250630
Negative / Null Result ReportMedicine

Effect of grape ripeness, alcohol content, and maceration duration on phenolic content and composition of cabernet sauvignon wines.

Pazos J, Fox DJ, Devi A et al. · 2026 · Food chemistry

Cabernet Sauvignon grapes were harvested at three different maturities (unripe, ripe, overripe, represented by Harvest 1, 2 and 3) and used for winemaking, adjusting total soluble solids of each harvest to three concentrations (∼11 %, 14…

View details →DOI: 10.1016/j.foodchem.2025.147714