Replication FailureMedicine
Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society
Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…
View details →DOI: 10.1002/mds.30187 Replication Failure
Wang Q, Kimura Y, Oba J et al. · 2025 · Preprint
Background: Kawasaki disease (KD) is an acute, pediatric vasculitis associated with coronary artery abnormality (CAA) development. Echocardiography at month 1 post-diagnosis remains the standard for CAA surveillance despite limitations,…
View details →DOI: 10.1101/2025.08.11.25333461 Negative / Null Result ReportMedicine
de Freitas ALS, Guth G, Araújo ALD et al. · 2026 · Archives of oral biology
Objective To investigate the temporal evolution and predictive value of individual histopathological features of oral epithelial dysplasia (OED) during carcinogenesis, and to evaluate the diagnostic utility of optical fluorescence imaging…
View details →DOI: 10.1016/j.archoralbio.2025.106444 Negative / Null Result ReportOpen accessMedicine
Barham E, Khan M, Del-Cristo M et al. · 2026 · Cureus
Chylothorax, a rare complication of hepatic cirrhosis, is often under-recognized in the absence of ascites or other classical signs of portal hypertension. The diagnosis can be challenging due to its infrequent presentation, which…
View details →DOI: 10.7759/cureus.100938 Negative / Null Result ReportOpen accessMedicine
Lee KK, Lin YN · 2026 · Cureus
Non-purulent skin and soft tissue infections (NP-SSTIs) are commonly managed with antibiotic therapy; however, a subset of patients demonstrate inadequate clinical response and develop refractory disease. At present, no standardized…
View details →DOI: 10.7759/cureus.102335 Negative / Null Result ReportMedicine
Dirisala A, Uchida S, Toh K et al. · 2025 · Journal of Controlled Release
Polycation-based mRNA delivery systems have an issue with mRNA integrity in the physiological milieu, particularly in blood compartments, despite their vast potential in mRNA therapeutics. Without comprehensive mechanistic analyses, design…
Negative / Null Result ReportMedicine
Pouplard C, Charuel N, Archer E et al. · 2026 · International journal of laboratory hematology
Background Immunoassays detecting anti-PF4/H antibodies must be sensitive to exclude heparin-induced thrombocytopenia (HIT), and optical density (OD) values are useful for confirming HIT, but no calibration is currently available.…
View details →DOI: 10.1111/ijlh.14547 Negative / Null Result Report
Biswas B, van Bergen E, Vaello T et al. · 2025 · Preprint
Plants and herbivorous insects are engaged in long-term coevolutionary arms races, where gains in novel plant defences and corresponding adaptations in herbivores may drive evolutionary change. One such recent innovation is the gain of…
View details →DOI: 10.1101/2025.07.04.663117 Negative / Null Result ReportOpen accessMedicine
Kaur J, Yogesvaran R, Mohd Khialdin S et al. · 2025 · Cureus
A 72-year-old male patient with multiple comorbidities was under our follow-up for bilateral advanced pseudoexfoliative glaucoma with uncontrolled intraocular pressure (IOP) despite maximum medical therapy. He had previously received…
View details →DOI: 10.7759/cureus.99396 Negative / Null Result ReportOpen accessMedicine
Benamou A, El Moudane A, Barki A · 2026 · Cureus
Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the standard adjuvant treatment for non-muscle-invasive bladder cancer. Although highly effective, BCG therapy may be associated with rare but potentially severe systemic…
View details →DOI: 10.7759/cureus.109252 Methods Dead-EndMedicine
Grant RC, He JC, Liu N et al. · 2025 · JAMA oncology
Importance Cisplatin is a widely used treatment for cancer that can permanently damage the kidneys. Treatment modifications and other strategies may prevent chronic kidney disease (CKD) in patients at risk; however, the incidence and…
View details →DOI: 10.1001/jamaoncol.2025.2590 Negative / Null Result ReportOpen accessMedicine
Hackett GI · 2025 · The world journal of men's health
TRAVERSE (TheRapy for Assessment of long-term Vascular events and Efficacy ResponSE in hypogonadal men) is multicentre randomized, double-blind, placebo-controlled, noninferiority trial of testosterone therapy, enrolling 5,246 men 45 to 80…
View details →DOI: 10.5534/wjmh.240081 Failed Experiment ReportOpen accessMedicine
Ciuro M, Sangiorgio M, Cantone G et al. · 2025 · Biology
Spinal cord injury leads to permanent neurological deficits, and aging further diminishes the plasticity and regenerative responses required for recovery. Activation of the Sonic hedgehog (Shh) pathway through the receptor Smoothened (Smo)…
View details →DOI: 10.3390/biology14111595 Negative / Null Result ReportMedicine
El Housheimi A, Tato Varela S, Kuhn WC · 2026 · Oncology research and treatment
Background Ovarian cancer (OC) accounts for the most cancer deaths in women worldwide, despite it being the 8th most common one. Almost two-thirds or OC cases present in advanced stages (III/IV) and will require maintenance therapy lasting…
View details →DOI: 10.1159/000547282 Negative / Null Result ReportOpen accessMedicine
Mano T · 2025 · Clinical medicine insights. Case reports
Cervical traction therapy is commonly used for cervical spondylosis; however, complications, such as subdural hematomas can occur. Possible mechanisms include cerebrospinal fluid (CSF) leakage and bridging vein damage. A 51-year-old…
View details →DOI: 10.1177/11795476251376464 Negative / Null Result ReportOpen accessMedicine
Serour MH, Mohammad H, Aziza O et al. · 2026 · Journal of surgical case reports
Chronic diabetic foot ulcers remain a major clinical challenge, particularly when complicated by tendon exposure and failure to respond to standard care. We report a 47-year-old male with Type II diabetes mellitus with a history of smoking…
View details →DOI: 10.1093/jscr/rjag109 Replication FailureMedicine
Gootjes EC, Bakkerus L, Adhin AA et al. · 2026 · JAMA
Importance Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking.…
View details →DOI: 10.1001/jama.2026.1929 Replication FailureOpen accessMedicine
Yano K, Ishida T, Yokosuka K et al. · 2026 · Internal medicine (Tokyo, Japan)
Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for…
View details →DOI: 10.2169/internalmedicine.5586-25 Negative / Null Result ReportMedicine
Kankotia S, Park S, Thomas J · 2025 · Current opinion in oncology
Purpose of review Relapsed or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a deadly disease that historically was treated with palliative chemotherapy-based regimens. Since 2019, immunotherapy-based regimens have become…
View details →DOI: 10.1097/cco.0000000000001127 Negative / Null Result ReportOpen accessMedicine
Glauser G, Kvint S, Ramayya AG et al. · 2025 · Neurosurgery practice
Background and objectives The purpose of the present work was to review our series of patients with far lateral disk herniations treated by the intertransverse approach. Methods Patients undergoing intertransverse approach to treat…
View details →DOI: 10.1227/neuprac.0000000000000165 Failed Experiment ReportMedicine
Tian F, Hu C, Liu W et al. · 2025 · The American journal of cardiology
Myocardial work (MW) by noninvasive pressure-strain loop (PSL) is a novel echocardiographic tool that provides a more precise estimation of right ventricular (RV) performance by accounting for the RV loading conditions. The study sought to…
View details →DOI: 10.1016/j.amjcard.2025.05.024 Negative / Null Result Report
Childs H, Zhou P, Donald BR · 2025 · Preprint
Due to their favorable therapeutic properties, including improved stability, bioavailability, and membrane permeability, D-peptides that bind biological L-proteins represent an important class of systems in computational drug design. A…
View details →DOI: 10.1101/2025.03.14.643307 Negative / Null Result ReportMedicine
Simeonova L, Leseva M, Stoyanov K et al. · 2025 · Biochimica et biophysica acta. Molecular basis of disease
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator…
View details →DOI: 10.1016/j.bbadis.2025.167915 Negative / Null Result ReportMedicine
Jackson CB, Xue W, Gupta AA et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose To evaluate local failure (LF) rates for patients with intermediate-risk rhabdomyosarcoma treated on the Children's Oncology Group ARST1431 clinical trial, the first and largest international, phase 3 randomized study to use FOXO1…
View details →DOI: 10.1016/j.ijrobp.2025.03.038 Negative / Null Result ReportOpen accessMedicine
Chow WD, Spinner RJ, Amrami KK et al. · 2026 · Journal of neurosurgery. Case lessons
Background Bertolotti syndrome is an underrecognized cause of chronic low back pain. Back pain generated from Bertolotti syndrome is believed to result from altered weight dissipation mechanics and/or instability of the pseudoarticulation,…
View details →DOI: 10.3171/case25948 Negative / Null Result Report
Boda A, Bandey IN, Chowdhury S et al. · 2025 · Preprint
Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported…
View details →DOI: 10.1101/2025.02.23.639774 Negative / Null Result ReportMedicine
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary anaesthesia and analgesia
Objective To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. Study design A crossover,…
View details →DOI: 10.1016/j.vaa.2025.06.007 Negative / Null Result ReportMedicine
Jacob A, He J, Peck A et al. · 2025 · Heliyon
Sjögren's (SS) involves salivary and lacrimal gland dysfunction. These studies examined metabolic profiles in the B6. Il14α transgene mouse model of SS and a cohort of human SS patients at different stages of disease. In B6. Il14α mice,…
Replication FailureOpen accessMedicine
Döhner H, Späth D, Saadati M et al. · 2026 · Blood
Abstract Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT. We report results from the randomized, open-label, phase 3 trial of intensive chemotherapy with or without…
View details →DOI: 10.1182/blood.2025030722 Negative / Null Result Report
Pae Y, Park H, Lee H et al. · 2024 · Preprint
Abstract Background Hyperhidrosis is the secretion of excess sweat beyond what the body needs for homeostatic regulation. Secondary hyperhidrosis is usually related to an underlying cause, mostly a medical condition, or extrinsic factors…
View details →DOI: 10.21203/rs.3.rs-5279798/v1 