Failed Experiment ReportOpen accessMedicine
García MA, Aceituno A, Díaz NB et al. · 2025 · Pharmaceutics
Background/Objectives: The static in vitro permeability assay based on cell monolayers has been widely used in the pharmaceutical industry and recognized by regulatory agencies as a surrogate method for BCS classification. However, the…
View details →DOI: 10.3390/pharmaceutics17091110 Failed Experiment ReportOpen accessMedicine
Miskelly MG, Lindqvist A, Jujić A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Statin use is associated with increased risk of type 2 diabetes (T2D) and mild hyperglycemia. The underlying mechanisms are not well studied, and the effect of statin treatment on glucagon-like peptide 1 (GLP-1) secretion or…
View details →DOI: 10.1210/clinem/dgaf608 Negative / Null Result ReportOpen accessMedicine
Alam KA, Martí-Solans J, Schall D et al. · 2026 · ACS chemical neuroscience
Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current ( I Ks ) that is…
View details →DOI: 10.1021/acschemneuro.6c00197 Negative / Null Result ReportOpen accessMedicine
Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice
Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…
View details →DOI: 10.1136/ejhpharm-2024-004392 Negative / Null Result ReportOpen accessMedicine
Uysal Yeler G, Sivaslıoğlu A, Gülsün T et al. · 2025 · International journal of molecular sciences
Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in the differentiation and maturation of preadipocytes. PPARγ promotes adipogenesis by inducing the expression of fatty acid-binding protein 4 (FABP4). Uncoupling…
View details →DOI: 10.3390/ijms27010139 Negative / Null Result ReportOpen accessMedicine
Crucitta S, Cinacchi P, Bargagna I et al. · 2026 · Therapeutic advances in drug safety
Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…
View details →DOI: 10.1177/20420986251414591 Negative / Null Result ReportOpen accessMedicine
Shah V, Pankratz VS, Cardona M et al. · 2024
Background Given the existence of firmly entrenched and rapidly increasing health disparities, novel approaches are needed to improve the health of socioeconomically disadvantaged groups, including American Indian communities. In a prior…
Negative / Null Result ReportOpen accessMedicine
van Oosterwijk JG, Richer L, Beimfohr-Griffing LK et al. · 2026 · Parasites & vectors
Background The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease…
View details →DOI: 10.1186/s13071-026-07380-7 Negative / Null Result ReportOpen accessMedicine
Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology
Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…
View details →DOI: 10.5152/pcp.2025.24981 Negative / Null Result ReportOpen accessMedicine
Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research
We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…
View details →DOI: 10.1111/pcmr.70025 Negative / Null Result ReportOpen accessMedicine
Tseng M, Middleton SJ, Farah A et al. · 2025 · Pain reports
Introduction Hyperexcitability, particularly of DRG neurons, is a key driver of persistent pain states including neuropathic pain. Contactin-associated protein-like 2 (CASPR2) is transmembrane protein known to interact and regulate the…
View details →DOI: 10.1097/pr9.0000000000001309 Negative / Null Result ReportOpen accessMedicine
Poljo A, Reichl JJ, Bürgi S et al. · 2025 · Obesity surgery
Background Obesity, a chronic disease with serious associated medical problems, remains a global health challenge. While metabolic bariatric surgery (MBS) is the most effective treatment for weight loss, GLP-1 receptor agonists (RAs) are…
View details →DOI: 10.1007/s11695-025-08136-5 Negative / Null Result ReportMedicine
Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity
Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…
View details →DOI: 10.1016/j.bbi.2024.04.027 Negative / Null Result ReportOpen accessMedicine
Ragamin A, Schappin R, Pasmans SGMA et al. · 2023 · Skin health and disease
National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of therapeutic clothing in atopic dermatitis. Therapeutic clothing is most frequently prescribed by dermatologists in a hospital…
View details →DOI: 10.1002/ski2.303 Negative / Null Result ReportOpen accessMedicine
Merlo JK, da Silva AV, Casonatto J et al. · 2024 · Healthcare (Basel, Switzerland)
Objective To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods Thirty-eight adults with CNLBP were randomly assigned to two…
View details →DOI: 10.3390/healthcare12141416 Negative / Null Result ReportMedicine
Stroemel-Scheder C, Lautenbacher S · 2023 · The journal of pain
Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the…
View details →DOI: 10.1016/j.jpain.2022.10.009 Negative / Null Result ReportOpen accessMedicine
Moretti L, Richelmi L, Cosentini D et al. · 2024 · Breast (Edinburgh, Scotland)
The efficacy of adjuvant denosumab in combination with hormonotherapy in breast cancer patients was investigated in two randomized trials, ABCSG-18 and D-Care, but the results were mixed with respect to the impact of this drug on…
View details →DOI: 10.1016/j.breast.2024.103826 Negative / Null Result ReportOpen accessMedicine
Góis KS, Braga M, Souza VH et al. · 2026 · Einstein (Sao Paulo, Brazil)
Objective This study aimed to analyze the possible association between rs2814778, rs12075 ( ACKR1 gene), and rs4073 ( CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods This cross-sectional study included 319 COVID-19…
View details →DOI: 10.31744/einstein_journal/2026ao1543 Negative / Null Result ReportMedicine
Hosier H, Lipkind HS, Rasheed H et al. · 2023 · Hypertension (Dallas, Tex. : 1979)
Background Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has been associated with preeclampsia in observational studies. We use Mendelian randomization analyses to estimate the association between lipid levels,…
View details →DOI: 10.1161/hypertensionaha.122.20426 Negative / Null Result ReportOpen accessMedicine
Richardson KE, Suo C, Albertella L et al. · 2025 · JAMA psychiatry
Importance Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training…
View details →DOI: 10.1001/jamapsychiatry.2025.2319 Negative / Null Result ReportOpen accessMedicine
da Silva NIS, de Araújo TLAC, Firmino SS et al. · 2026 · Tropical animal health and production
This study aimed to evaluate the effects of supplementing high-concentrate diets for sheep with green propolis extract (PRO) from Mimosa tenuiflora or with salinomycin (SAL) on feed intake, apparent digestibility, nitrogen balance, and…
View details →DOI: 10.1007/s11250-026-05012-x Negative / Null Result ReportOpen accessMedicine
Luzuriaga AL, Madrigal-González J, de la Cruz M et al. · 2026 · Ecology
The relationship between taxonomic and phylogenetic diversities remains underexplored. Our goal was to determine whether a causal link exists between species richness and phylogenetic diversity and to determine the direction of this…
View details →DOI: 10.1002/ecy.70361 Failed Experiment ReportOpen accessMedicine
Khasanov TA, Maleeva EE, Koshelev SG et al. · 2024 · Marine drugs
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic…
View details →DOI: 10.3390/md22090382 Negative / Null Result ReportOpen accessMedicine
Lo Verso L, Lessard M, Lauzon K et al. · 2026 · Journal of animal science
This study aimed to determine the effects of deoxynivalenol (DON) and zearalenone (ZEA) co-contamination on systemic immune responses and intestinal mucosal immunity in weaned piglets and to evaluate the mitigating ability of antioxidant…
View details →DOI: 10.1093/jas/skag080 Negative / Null Result ReportMedicine
Platzer HP, Köck A, Schobersberger W et al. · 2026 · Journal of strength and conditioning research
Abstract Platzer, H-P, Köck, A, Schobersberger, W, and Dünnwald, T. Ischemic preconditioning does not improve climbing specific performance in elite athletes. J Strength Cond Res 40(1): e69-e75, 2026-The aim of the present investigation…
View details →DOI: 10.1519/jsc.0000000000005271 Negative / Null Result ReportMedicine
Mosneag IE, Rubio M, Lemarchand E et al. · 2026 · Stroke
Background Inflammation contributes significantly to neuronal damage in ischemic stroke, with IL (interleukin)-1 being a key mediator. IL-1Ra (IL-1 receptor antagonist) inhibits IL-1 signaling, successfully reducing inflammation in…
View details →DOI: 10.1161/strokeaha.125.054941 Negative / Null Result ReportMedicine
Li S, De Vivo I, Davinelli S et al. · 2026 · GeroScience
Although mechanistic studies support a beneficial effect of several dietary flavonoids on telomere length (TL), to our knowledge no studies have examined associations between habitual flavonoid intakes and TL in population-based studies.…
View details →DOI: 10.1007/s11357-026-02126-w Negative / Null Result ReportMedicine
Alves Pereira D, Silva Bonatto M, Souza Santos S et al. · 2025 · Lasers in medical science
The aim of this study was to evaluate the effects of dual-wavelength photobiomodulation (PBMT) compared with antibiotic therapy with amoxicillin on postoperatory healing and symptoms after third molar extraction. Sixty patients were…
View details →DOI: 10.1007/s10103-025-04445-4 Negative / Null Result Report
Nikouli E, Vasilaki A, Nengas I et al. · 2026 · Preprint
The aim of this study was to evaluate the impact of two sustainable dietary protein sources on the structure and composition of the gut microbiota in European sea bass (Dicentrarchus labrax) juveniles. These protein sources were…
View details →DOI: 10.64898/2026.06.26.733563 Negative / Null Result ReportMedicine
Aloud A, Alzahrani H, Arzoo S et al. · 2026 · Acta pharmaceutica (Zagreb, Croatia)
This study examined the effects of omega-3 fatty acids supplementation on gut barrier integrity, systemic inflammation, neurotrans-mission and oxidative stress, in an aged rat model of propionic acid (PPA)-induced neurotoxicity.…
View details →DOI: 10.2478/acph-2026-0008 