A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21287 results · page 288 of 710
Yaqub M, Bonde N, Maity T et al. · 2026 · Preprint
Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections, particularly ventilator-associated pneumonia, for which therapeutic options are increasingly limited. Colistin, a polymyxin antibiotic, is a drug of…
Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer
Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…
Bonilla AM, Garrido G, Consolini AE et al. · 2025 · Preprint
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties re-main unexplored. The behavioral effects, underlying mechanisms,…
Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…
Effinger D, Hirschberger S, Arntjen T et al. · 2026 · Nutrients
Background/Objectives : The ketogenic diet (KD) has been shown to exert beneficial effects on human immunity by enhancing cytotoxic T lymphocyte function through metabolic reprogramming. However, strict dietary restrictions limit adherence…
Kobayashi A, Kawashima S, Kimura T et al. · 2026 · The journal of medical investigation : JMI
Whether the difference in video laryngoscope view affects the success of endotracheal intubation in beginners is unknown. In the current study, we aimed to investigate whether the revision of the monitor program in a Macintosh-type video…
Gálvez-García G, Romero-Arias T, Barramuño-Medina M et al. · 2026 · Behavioural brain research
This study examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on inhibitory control during motor tasks of varying complexity. Motor task complexity was manipulated in a Simon task using two approaches: (1)…
Al-Othman S, Wu Y, Fontanaud P et al. · 2026 · Preprint
SUMMARY Resident cardiac macrophages are understood to facilitate atrioventricular (AV) node conduction because they purportedly couple to AV node myocytes via connexin43 (Cx43) containing gap junctions. We tested this mechanism using…
Vieira Y, Sobral M, Mateus V et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Transcranial direct current stimulation (tDCS) has emerged as a promising tool to investigate and modulate emotional and social processes, including compassion. By targeting cortical regions implicated in empathy and prosocial behaviour…
Jin Z, Li J, Thackray AE et al. · 2026 · Appetite
Oxyntomodulin (OXM) is a gut-derived peptide hormone with anorexigenic properties that reduce food intake and increase energy expenditure. This study investigated the effect of a single bout of moderate-intensity running on OXM…
Harris MB, Milsom WK · 2025 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
During hibernation, golden-mantled ground squirrels (Spermophilus lateralis) breathe in distinct multi-breath episodes separated by prolonged periods of apnea. We hypothesized that vagal afferent feedback from pulmonary stretch receptors,…
Liu Y, Sun J, Hu Y et al. · 2026 · Clinical and experimental reproductive medicine
Objective Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-thawed embryo transfers (FET), potentially due to the supraphysiologic serum estradiol…
Flensted-Jensen M, Kleis-Olsen AS, Weinreich CM et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Advanced glycation end-products (AGEs) accumulate with age and may contribute to skeletal muscle decline, yet their distribution within muscle compartments is unknown. Resistance training (RT) and high-intensity interval training (HIIT)…
Park JK, Lee JE, Kim JS et al. · 2026 · Journal of hazardous materials
Microplastics (MPs) are emerging contaminants that disrupt development, physiology, and redox homeostasis in aquatic organisms. However, their detailed impacts on amphibians and the potential for antioxidant-based mitigation remain poorly…
Bahabri M, Figueiredo JN, Kara Y et al. · 2026 · Nanotechnology
In this study, the growth of vertical graphene (VG) nanosheets on copper (Cu) substrates in a direct-current plasma-enhanced chemical vapor deposition (PECVD) system was studied. The plasma process during the VG growth was characterized…
Lake J, Mariniello M, Schiano G et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Lipocalin-2 upregulation paralleled intracellular uromodulin aggregates in mouse and cellular models of autosomal dominant tubulointerstitial kidney disease because of pathogenic uromodulin. The induction of lipocalin-2 was…
Spry ER, Travis KB, Ragland KJ et al. · 2025 · Molecular and cellular endocrinology
Aims Semaglutide (SEMA) is a glucagon-like peptide-1 receptor agonist (GLP-1RA) that has recently emerged as a popular pharmacological treatment for type 2 diabetes and insulin resistance due to its weight loss properties. Previous studies…
Bos MD, Ho CSL, Meyer NH et al. · 2026 · The Journal of surgical research
Introduction Epidemiological studies indicate that physical activity reduces cancer risk and mortality, while sedentary behavior exerts opposite effects. However, their impact on tumor metastasis remains unclear. This study investigated…
Sogawa K, Funada M · 2026 · Toxicology letters
Cannabidiol (CBD) is a non-psychoactive cannabinoid with increasing global use, yet safety data during pregnancy remain limited. Preclinical studies suggest possible developmental neurotoxicity. Here, we examined the effects of CBD…
Takata M, Nishikawa M, Hayashi H et al. · 2025 · Cureus
Background It remains unclear whether omecamtiv mecarbil, a cardiac myosin direct activator, enhances vascular smooth muscle myosin function at clinical and supra-clinical doses. Aims The current study evaluated the effect of omecamtiv…
Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics
Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…
Hancock G, Batterby E, Dovers E et al. · 2026 · Emergency medicine Australasia : EMA
Background Point-of-care ultrasound (POCUS) is widely used in emergency departments (ED) and has potential value during cardiac arrest for identifying reversible causes (e.g., pericardial effusion, pneumothorax and pulmonary embolism) and…
Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…
Messanh KV, Muhie Ddine M, Ambrosini V et al. · 2026 · Journal of photochemistry and photobiology. B, Biology
Botrytis cinerea (B. cinerea) is a fungus with a high mutation rate and infects more than 200 plant species, causing significant yield losses. Therefore, new strategies to fight against this ubiquitous phytopathogen are highly sought…
Palner M, Kolesnik E, Baun C et al. · 2026 · Neuropharmacology
Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serotonin (5-HT). We tested the joint hypotheses that endogenous DMT would accumulate in rat…
Navez M, Gilbo N, Vandermeulen M et al. · 2026 · Preprint
Abstract Background Kidney transplantation from donation after circulatory death (DCD) donors is increasingly used but remains associated with warm ischemic injury. Normothermic machine perfusion (NMP) enables functional assessment and…
Baltin ME, Shulman AA, Nikulina MI et al. · 2025 · Preprint
Immersive virtual reality (VR) technologies are being increasingly applied in clinical settings, physiotherapy, and neurorehabilitation due to their potential to modulate neurophysiological functions. However, the mechanistic basis of VR’s…
Stub M, Ramhøj L, Axelstad M et al. · 2026 · Reproductive toxicology (Elmsford, N.Y.)
Perfluorooctane sulfonate (PFOS) and tetrabromobisphenol A (TBBPA) are environmental pollutants with known endocrine disrupting potential. Both substances display various thyroid hormone (TH) system disrupting effects, both in vitro and in…
Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal
Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…
Barbosa APO, Santos LM, Catelli AM et al. · 2026 · Preprint
Abstract Background Patients with chronic kidney failure (CKF) present changes in physical capacity and low exercise tolerance. Photobiomodulation therapy (PBMT) has shown an ergogenic effect on exercise in studies with different…