A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19743 results in Negative / Null Result Report · page 28 of 659
Gang Wang, Christo Wilson, Xiaohan Zhao et al. · 2012
Popular Internet services in recent years have shown that remarkable things can be achieved by harnessing the power of the masses using crowd-sourcing systems. However, crowd-sourcing systems can also pose a real challenge to existing…
Terry Judd, Gregor Kennedy, Simon J. Cropper · 2010 · Australasian Journal of Educational Technology
<span>Wikis are widely promoted as collaborative writing tools and are gaining in popularity in educational settings. However, while wikis include features that are designed to facilitate collaboration, it does not necessarily follow…
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt et al. · 2017 · European Heart Journal - Cardiovascular Imaging
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size:…
Brian W. Jacobs, Vinod R. Singhal · 2017 · Journal of Operations Management
Abstract Supply chain and reputational risks are often assumed to motivate firms to source production in developed, high‐cost countries rather than developing, low‐cost countries. To examine this assumption, we provide evidence from the…
R. Grace Walton, Cory M. Dungan, Douglas E. Long et al. · 2019 · Aging Cell
Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double-blind trial, participants received 1,700 mg/day metformin (N = 46) or placebo (N = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although respo
Elizabeth A. Archie, Jeanne Altmann, Susan C. Alberts · 2012 · Proceedings of the National Academy of Sciences
Social status can have striking effects on health in humans and other animals, but the causes often are unknown. In male vertebrates, status-related differences in health may be influenced by correlates of male social status that suppress…
Isaac Mbiti, Karthik Muralidharan, Mauricio Romero et al. · 2019 · The Quarterly Journal of Economics
Abstract We present results from a large-scale randomized experiment across 350 schools in Tanzania that studied the impact of providing schools with (i) unconditional grants, (ii) teacher incentives based on student performance, and (iii)…
Frédéric Satgé, Dimitri Defrance, Benjamin Sultan et al. · 2019 · Journal of Hydrology
This study aims reporting on 23 gridded precipitation datasets (P-datasets) reliability across West Africa through direct comparisons with rain gauges measurement at the daily and monthly time scales over a 4 years period (2000–2003). All…
Steven R. H. Beach, Gene H. Brody, Alexandre A. Todorov et al. · 2010 · Psychosomatic Medicine
OBJECTIVE: To examine epigenetic processes linking childhood sex abuse to symptoms of antisocial personality disorder (ASPD) in adulthood and to investigate the possibility that the link between childhood sex abuse and deoxyribonucleic…
Elizabeth C. Mormino, Reisa A. Sperling, Avram J. Holmes et al. · 2016 · Neurology
OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic…
Fengyu Song, Tengbin Xiong, Sheetal Parekh‐Bhurke et al. · 2011 · BMJ
OBJECTIVE: To investigate the agreement between direct and indirect comparisons of competing healthcare interventions. DESIGN: Meta-epidemiological study based on sample of meta-analyses of randomised controlled trials. Data sources…
Steven M. Opal, R. Phillip Dellinger, Jean‐Louis Vincent et al. · 2014 · Critical Care Medicine
OBJECTIVE: The developmental pipeline for novel therapeutics to treat sepsis has diminished to a trickle compared to previous years of sepsis research. While enormous strides have been made in understanding the basic molecular mechanisms…
Yasmine T. Asi, Julie E. Simpson, Paul R. Heath et al. · 2014 · Glia
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alterations in regional and cellular SNCA mRNA expression in MSA as a possible substrate for GCI formation. Quantitative reverse transcription polymerase chain reaction (qPCR) was performed on postmortem br
Liselotte van Asten, Cees van den Wijngaard, Wilfrid van Pelt et al. · 2012 · The Journal of Infectious Diseases
BACKGROUND: Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance…
Gil Rilov · 2016 · Scientific Reports
Even during the current biodiversity crisis, reports on population collapses of highly abundant, non-harvested marine species were rare until very recently. This is starting to change, especially at the warm edge of species' distributions where populations are more vulnerable to stress. The Levant basin is the southeastern edge of distribution of most Mediterranean species. Coastal water conditions are naturally extreme, and are fast warming, making it a potential hotspot for species collapses. Using multiple data sources, I found strong evidence for major, sustained, population collapses of t
Chris G. Sibley, Joseph Bulbulia · 2012 · PLoS ONE
On 22 February 2011, Christchurch New Zealand (population 367,700) experienced a devastating earthquake, causing extensive damage and killing one hundred and eighty-five people. The earthquake and aftershocks occurred between the 2009 and 2011 waves of a longitudinal probability sample conducted in New Zealand, enabling us to examine how a natural disaster of this magnitude affected deeply held commitments and global ratings of personal health, depending on earthquake exposure. We first investigated whether the earthquake-affected were more likely to believe in God. Consistent with the Religio
US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005,…
Ryan A. Decker, John Haltiwanger, Ron S. Jarmin et al. · 2020 · American Economic Review
The pace of job reallocation has declined in the United States in recent decades. We draw insight from canonical models of business dynamics in which reallocation can decline due to (i ) lower dis persion of idiosyncratic shocks faced by…
Sally E. Koerner, Scott L. Collins · 2014 · Ecology
Grazing, fire, and climate shape mesic grassland communities. With global change altering all three factors, understanding how grasslands respond to changes in these combined drivers may aid in projecting future changes in grassland…
Abhijit Banerjee, Esther Duflo, Gilles Postel‐Vinay et al. · 2010 · The Review of Economics and Statistics
Between 1863 and 1890, phylloxera destroyed 40% of French vineyards. Using the regional variation in the timing of this shock, we identify and examine the effects on adult height, health, and life expectancy of children born in the years…
Pan Zhang, Cristopher Moore · 2014 · Proceedings of the National Academy of Sciences
Modularity is a popular measure of community structure. However, maximizing the modularity can lead to many competing partitions, with almost the same modularity, that are poorly correlated with each other. It can also produce illusory…
Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon et al. · 2015 · Arthritis & Rheumatology
OBJECTIVE: To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. METHODS: We studied 355…
Long Sha, James V. Haxby, Hervé Abdi et al. · 2014 · Journal of Cognitive Neuroscience
Major theories for explaining the organization of semantic memory in the human brain are premised on the often-observed dichotomous dissociation between living and nonliving objects. Evidence from neuroimaging has been interpreted to…
Martín D. Ezcurra, Federico L. Agnolín · 2011 · Systematic Biology
Late Mesozoic palaeobiogeography has been characterized by a distinction between the northern territories of Laurasia and the southern landmasses of Gondwana. The repeated discovery of Gondwanan lineages in Laurasia has led to the proposal…
John R. Robinson, Yanfeng Xue, Yong Yu · 2011 · The Accounting Review
ABSTRACT We investigate the economic forces that influence noncompliance with mandatory compensation disclosures and the effect of a subsequent focused enforcement action. We utilize SEC evaluations of compensation disclosures mandated by…
Alejandro P. Gutiérrez, José M. Yáñez, Steve Fukui et al. · 2015 · PLoS ONE
Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼ 480 individuals from the Cermaq Canada broodstock pr
Ala Al‐Fuqaha, Abdallah Khreishah, Mohsen Guizani et al. · 2015 · IEEE Communications Magazine
Several divergent application protocols have been proposed for Internet of Things (IoT) solutions including CoAP, REST, XMPP, AMQP, MQTT, DDS, and others. Each protocol focuses on a specific aspect of IoT communications. The lack of a…
Meeta Prasad Kerlin, Dylan S. Small, Elizabeth Cooney et al. · 2013 · New England Journal of Medicine
BACKGROUND: Increasing numbers of intensive care units (ICUs) are adopting the practice of nighttime intensivist staffing despite the lack of experimental evidence of its effectiveness. METHODS: We conducted a 1-year randomized trial in an…
Emma Parry · 2011 · The International Journal of Human Resource Management
This article examines the potential use of e-human resource management (e-HRM) as a means to increase the value of the human resources (HR) function, within the framework of the resource-based view. Past research has suggested that e-HRM…
Brandon J. Farley, Michael C. Quirk, James Doherty et al. · 2010 · Journal of Neuroscience
The significance of the mismatch negativity (MMN), an event-related potential measured in humans which indexes novelty in the auditory environment, has motivated a search for a cellular correlate of this process. A leading candidate is…