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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 279 of 724

Negative / Null Result ReportMedicine

The renin angiotensin system in cognitive flexibility: Effects of single-dose losartan on task-switching in healthy volunteers.

Prasad D, Feltham G, De Giorgi R et al. · 2026 · Journal of psychopharmacology (Oxford, England)

Introduction Cognitive flexibility, defined as the ability to shift mental strategies when environmental demands change, may influence psychological well-being and psychiatric treatment outcomes. Research increasingly implicates the renin…

View details →DOI: 10.1177/02698811261456198
Negative / Null Result ReportMedicine

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation.

Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition

Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…

View details →DOI: 10.1002/bdd.70034
Negative / Null Result ReportMedicine

Multitasking Across Physical and Virtual Displays: The Effect of Spatial Discontinuity and Task Load.

Zhang P, Iskandarani ME, Riggs S · 2026 · IEEE transactions on visualization and computer graphics

Optical see-through head-mounted displays (OST-HMDs) allow users to interact with both physical and virtual displays overlaid in the real world within augmented reality (AR) environments. When arranging these displays in space, spatial…

View details →DOI: 10.1109/tvcg.2026.3679118
Negative / Null Result Report

Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice

Liu W, Tang Y, Ding W et al. · 2026 · Preprint

Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…

View details →DOI: 10.64898/2026.06.23.734114
Negative / Null Result ReportMedicine

Short-term intraocular pressure changes following intravitreal aflibercept 8 mg versus 2 mg in diabetic macular edema: a prospective observational study.

Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports

This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…

View details →DOI: 10.1038/s41598-026-55363-6
Negative / Null Result ReportMedicine

The impact of the vaginal birth after cesarean as a new delivery mode on quality of life, sexual function, sleep quality and urinary incontinence during the postpartum period and comparison with the results of vaginal birth and cesarean delivery.

Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…

View details →DOI: 10.1002/ijgo.71150
Negative / Null Result ReportMedicine

Postural threat influences reactive stepping characteristics at the single-step threshold, but not when a step is necessary.

Avalos MA, Shah S, Rosenblatt NJ · 2026 · Experimental brain research

Following a loss of balance, proper reactive responses are needed to avoid a fall. Efforts have focused on how physiological factors affect these responses, but few have addressed psychological states. One psychological factor of…

View details →DOI: 10.1007/s00221-026-07328-4
Negative / Null Result ReportMedicine

Comprehensive assessment of hyperoside: cytotoxic, anti-cancer, genoprotective, radical scavenging and computational toxicity properties through <i>in vitro</i> and <i>in silico</i> approaches.

Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods

Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…

View details →DOI: 10.1080/15376516.2026.2691542
Negative / Null Result ReportMedicine

Mitigation of antibiotic resistance risk in aerobic sludge by zero-valent iron: From pathogen reduction to conjugation inhibition and network weakening.

Wu Y, Zhu L, Lin G et al. · 2026 · Bioresource technology

Antibiotic resistance genes (ARGs) are an increasing environmental and public health concern in wastewater treatment systems due to their persistence, mobility, and links to human bacterial pathogens (HBPs). In this study, aerobic…

View details →DOI: 10.1016/j.biortech.2026.135253
Negative / Null Result ReportMedicine

<i>SLC28A3 </i>expression and fludarabine-emergent autoimmune hemolytic anemia in chronic lymphocytic leukemia: A new player in an old equation.

Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine

Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…

View details →DOI: 10.17305/bb.2026.14208
Negative / Null Result ReportMedicine

A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain.

Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology

Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…

View details →DOI: 10.1152/ajpgi.00394.2025
Negative / Null Result ReportMedicine

Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.

Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…

View details →DOI: 10.1016/j.ymthe.2026.06.027
Negative / Null Result ReportMedicine

Initial static, pseudo-static, dynamic, and cognitive fit evaluation of three passive shoulder exoskeletons while performing simulated manufacturing tasks.

Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics

Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…

View details →DOI: 10.1016/j.apergo.2026.104809
Negative / Null Result ReportMedicine

Outcomes of transmediastinal esophagectomy for patients with esophagogastric junction cancers.

Sugawara K, Yagi K, Yajima S et al. · 2026 · International journal of clinical oncology

Purpose We aimed to evaluate the outcomes of transmediastinal esophagectomy (TME) for esophagogastric junction cancer (EGJC) patients. Methods We retrospectively reviewed patients who underwent TME for EGJC (Siewert Type II) between 2018…

View details →DOI: 10.1007/s10147-026-03068-1
Negative / Null Result ReportMedicine

Does asthma treatment influence COVID-19 severity? A comparative cohort study of SMART vs. Traditional therapy.

Li Y, Chen W, Hill R et al. · 2026 · European clinical respiratory journal

Asthma is a chronic respiratory condition that can be managed using Single Maintenance and Reliever Therapy (SMART) or traditional therapy with inhaled corticosteroid (ICS)-long-acting beta-agonist (LABA) for maintenance and short-acting…

View details →DOI: 10.1080/20018525.2026.2683007
Negative / Null Result ReportMedicine

Chasing the Present: Cognitive Distortions, Time Perspective, and Alcohol use in Adolescent Gambling.

Cosenza M, Fabbri M, Pizzini B et al. · 2026 · Journal of gambling studies

Adolescence represents a critical developmental period for the emergence of maladaptive gambling behaviors, including loss chasing, a key marker of gambling-related harm. The present study provides the first behavioral examination of the…

View details →DOI: 10.1007/s10899-026-10516-0
Negative / Null Result ReportMedicine

Impact of an educational video on the quality of bowel preparation prior to colonoscopy: a randomized controlled study.

Vidon M, Wang X, Costes L et al. · 2026 · Clinics and research in hepatology and gastroenterology

Background and study aims Educational interventions have been proposed to improve adherence to bowel preparation instructions. We evaluated whether adding a short instructional video to standard written and oral information improves bowel…

View details →DOI: 10.1016/j.clinre.2026.102860
Negative / Null Result ReportMedicine

Broiler response to partial replacement of groundnut cake with soaked chickpea (Cicer arietinum L.) and enzyme supplementation.

Ahmed ME, Mahjoub SMAH, Adam SIY · 2026 · Tropical animal health and production

This study evaluated the effects of partially replacing groundnut cake with soaked chickpea (Cicer arietinum L.) seeds, with or without enzyme supplementation, on growth performance, carcass traits, serum biochemical indices, and…

View details →DOI: 10.1007/s11250-026-05146-y
Negative / Null Result Report

Effects of Substituting Dietary Ryegrass with Licorice Residue on Growth Performance, Meat Quality, Serum Biochemistry and Cecal Microbiota of Rabbits

Ren X, Wu Q, Zhao M et al. · 2026 · Preprint

This research aimed to determine the effects of replacing ryegrass (Lolium perenne L.) with licorice residue (LR) on growth performance, slaughtering performance, meat quality, serum biochemistry and cecal flora. Five pelleted rations were…

View details →DOI: 10.20944/preprints202605.1776.v1
Negative / Null Result Report

Investigation of the Effect of Different Glide Path Files on Canal Transportation and Centering in Curved Root Canals – A Micro-Computed Tomography Study

Uğurlu T, Sağlam BC, Koçak S et al. · 2026 · Preprint

Abstract Background The aim of this in vitro study was to examine the effects of different glide path files on root canal transportation and centering in curved root canals. Methods In this study, 33 mandibular first molars with a 10 mm…

View details →DOI: 10.21203/rs.3.rs-9516903/v1
Negative / Null Result ReportMedicine

Mechanisms Linking Bonding and Bridging Social Capital and Self-Rated Health Among U.S. Refugees: A Structural Equation Modeling Approach.

Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities

Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…

View details →DOI: 10.1007/s40615-026-03052-5
Negative / Null Result ReportMedicine

Diagnostic value of 18F-FDG PET/CT and MRI in patients suspected of cancer of unknown primary in the head and neck.

Mathiesen KK, Rasmussen JH, Channir H et al. · 2026 · Acta oto-laryngologica

Background Cancer of unknown primary (CUP) is diagnostically challenging. Diagnostic strategy remains controversial. Aim The aim of this retrospective study was to evaluate the diagnostic value of FDG-PET/CT and MRI in detecting primary…

View details →DOI: 10.1080/00016489.2025.2612018