A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21287 results · page 279 of 710
Liu, Zheng, Ding et al. · 2026 · Lupus science & medicine
To identify the predictors of renal relapse in patients with lupus nephritis (LN) and develop a predictive model. The patients with LN who received renal biopsies from 2005 to 2024 in Xijing Hospital were enrolled. This study was designed…
Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…
Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy
Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…
Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology
Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…
Mello, Horliana, Bezerra et al. · 2026 · Journal of dentistry
Postoperative pain, swelling, and functional limitations are common after mandibular third molar surgery, affecting recovery and quality of life. This randomized, double-blind clinical trial evaluated the effects of preemptive…
Nathani, Swaminathan, Kasmirski et al. · 2026 · The Journal of surgical research
In patients undergoing surgery for hyperparathyroidism (HPT), ectopic parathyroid glands can often make the operation challenging. Understanding the most common locations of ectopic parathyroids may provide guidance if an abnormal gland…
Lamarca, Palmer, Wasan et al. · 2026 · ESMO open
The ABC-06 trial established FOLFOX as the reference second-line regimen for patients diagnosed with advanced biliary tract cancer (ABC). Here we analysed the prognostic role of tumour markers carbohydrate antigen 19-9 (CA19-9),…
Leruste, Ley, Gottrand et al. · 2026 · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
Although recommendations for structured transition programs in adolescents with Inflammatory Bowel Diseases (IBD) have been published, few studies have addressed the implementation of transition in real-life settings at a national level.…
Hernandez, Walia, Coady et al. · 2026 · The journal of sexual medicine
Peyronie's disease (PD) is an acquired connective tissue disorder characterized by fibrous plaque formation within the penile tunica albuginea that may be influenced by androgen status. To evaluate whether baseline testosterone levels and…
Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research
Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…
Zhang, Xie, Zhang et al. · 2026 · Shock (Augusta, Ga.)
Sepsis-associated encephalopathy (SAE) is a diffuse neurological injury that results from severe sepsis, and its underlying pathophysiological mechanisms remain largely unknown. This study aimed to elucidate the pathological basis of SAE…
Eitzel, Ulle, Meyer et al. · 2026 · PloS one
Measuring human interactions with protected areas is a key need in conservation social science, both to assess the potential for continuing negative impacts on sensitive resources and to support positive relationships with important…
Benson, Cohen, Peskin et al. · 2026 · Digestive diseases (Basel, Switzerland)
Introduction Familial Dysautonomia (FD) is characterized by abnormal function of autonomic and sensory nervous systems. Gastrointestinal (GI) symptoms are extremely prevalent in FD patients, but the impact of FD on the pancreas is less…
Çakıcı, Akkoç · 2026 · Caries research
Caries risk assessment (CRA) is essential for individualized caries management in early childhood, but existing tools are difficult to standardize in routine practice. The ability of large language model (LLM)-based artificial intelligence…
Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology
While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…
Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…
Curtis, McCrary, Daud et al. · 2026 · Cardiovascular journal of Africa
Epstein-Barr virus (EBV) affects greater than 95% of the global population, and when acquired at an early age, results in poor control of viral replication and increased risk to subsequent chronic illnesses. To analye the association…
Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery
Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…
Şibar, Biçici, Şibar et al. · 2026 · Orthopedics
Periprosthetic joint infection (PJI) is one of the most serious complications following total knee arthroplasty (TKA). Vancomycin powder has been proposed as a low-cost adjunct to reduce infection by providing high local antibiotic…
Fussey, Manzie, Nanayakkara et al. · 2026 · ANZ journal of surgery
It is unknown whether the method of application of povidone iodine solution for skin antisepsis affects its efficacy. The primary aim of this study was to compare the efficacy of spray-on aqueous povidone iodine solution in preventing…
Sakamoto · 2026 · Traffic injury prevention
While previous research suggests that e-scooter riders and pedestrians may exhibit similar injury patterns due to a shared standing posture, direct comparisons using unified datasets are lacking. This study aims to identify the distinctive…
Wang, Wang, Zhang et al. · 2026 · Journal of agricultural and food chemistry
Reactive carbonyl species (RCS) are highly reactive molecules linked to chronic diseases. Dihydromyricetin (DMY), a high-activity RCS scavenger, exhibited MGO- and ACR-scavenging rates of 70.1% (0.5 h) and 70.3% (2 h) at 37 °C,…
Yu, Zhao, Duan et al. · 2026 · Cancer medicine
The adoption of robotic partial nephrectomy has grown significantly over the past decade, prompting a debate on the merits of transperitoneal versus retroperitoneal surgical access. This study evaluated the association between surgical…
Yin, Bae, Ni · 2026 · Journal of anthropological sciences = Rivista di antropologia : JASS
Since its appearance at the terminal Pleistocene, intentional cranial modification ("ICM") and its implications have generated considerable scientific debate regarding how or why such a tradition arose. Here, we report on newly discovered…
Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology
Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…
Eldabe, Adel-Khattab, Beshay et al. · 2026 · BMC oral health
This clinical trial was conducted to compare the four types of static fully guided surgical guides (bilateral tooth-supported guides, unilateral tooth-supported guides, mucosa-supported complete arch guides, and stackable bony-supported…
Aprina, Rahayu, Prihartono et al. · 2026 · Korean journal of ophthalmology : KJO
To investigate the effect of higher cylindrical power and axis misalignment of toric SCL in mild and moderate astigmatism on visual acuity, contrast sensitivity, visual satisfaction, and vision acceptability. 20 astigmatic participants…
Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology
Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…
El-Tallawy, Pergolizzi, Alsubaie et al. · 2026 · Cureus
Background  Postoperative pain management in children remains a significant challenge due to developmental differences in pain perception, reporting, and communication. However, limited evidence exists regarding age-specific…
Sykes, Brindle, Kazmi et al. · 2026 · ERJ open research
Azithromycin is beneficial in a multitude of respiratory diseases; however, its effects on both subjective and objective measures of cough have been less extensively studied. Traditional 24-h cough counting assessments are highly variable,…