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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21287 results · page 278 of 710

Negative / Null Result ReportMedicine

Effects of yoga on pain, sleep quality, and aerobic endurance in young women with primary dysmenorrhea: A randomized controlled trial.

Bicici Ulusahin S, Celik C, Abut CZ et al. · 2026 · Health care for women international

Primary dysmenorrhea (PD) is a prevalent condition in young women, characterized by menstrual pain, sleep disturbances, and reduced physical activity. Yoga has been suggested as a non-pharmacological intervention. We examined the effects…

View details →DOI: 10.1080/07399332.2026.2682319
Negative / Null Result ReportMedicine

Patterns of household behavior around a family member's disability onset.

Kim J, Han E · 2026 · Disability and health journal

Background Households including a member with disabilities carry greater caregiving burdens than those without, increasing the likelihood of economic and emotional imbalances. Objectives Using Korea Welfare Panel Study (KOWEPS) waves 1-19,…

View details →DOI: 10.1016/j.dhjo.2026.102110
Negative / Null Result ReportMedicine

Can Psychological Capital Enhance Innovation? A three-wave intervention and the role of consideration of future consequences.

Blasco-Giner C, Salanova M, Meneghel I · 2026 · The Journal of general psychology

This study draws on the Conservation of Resources Theory to examine two objectives: (1) whether consideration of future consequences (CFC) moderates the relationship between psychological capital (PsyCap) and innovative work behavior…

View details →DOI: 10.1080/00221309.2026.2667811
Negative / Null Result ReportMedicine

The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial.

Jurgelewicz M, D'Adamo CR, Malaya CA · 2026 · Integrative medicine (Encinitas, Calif.)

Background Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production.…

Negative / Null Result ReportMedicine

Barriers, facilitators and promising interventions for reducing sedentary behaviour during and after stroke rehabilitation - A scoping review.

Te Lindert L, van Meijeren-Pont W, Meesters J et al. · 2026 · Disability and rehabilitation

Purpose Reducing sedentary behaviour (SB) in stroke rehabilitation is essential, yet effects of most interventions remain limited. This review used the Behaviour Change Wheel to identify: (1) barriers and facilitators for reducing SB of…

View details →DOI: 10.1080/09638288.2026.2686317
Negative / Null Result ReportMedicine

SlROP4 negatively regulates drought tolerance in tomato.

Cheng C, Li M, Sun B et al. · 2026 · Plant science : an international journal of experimental plant biology

Rho-like GTPases of plants (ROPs) regulate diverse cellular processes, but their roles in tomato drought responses are largely unknown. In this study, nine ROP genes were identified in tomato (Solanum lycopersicum). Among them, SlROP4, the…

View details →DOI: 10.1016/j.plantsci.2026.113273
Negative / Null Result ReportOpen accessMedicine

Effects of Phenolic-Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP-Sarc Project.

Besora-Moreno M, Jiménez-Ten Hoevel C, Queral J et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic-rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB)…

View details →DOI: 10.1002/jcsm.70247
Negative / Null Result Report

Toxicological evaluation of seed-derived alkaloids from Smyrnium olusatrum L. following acute and repeated intraperitoneal administration in mice

Sekkout Z, Boudaia O, Radallah D et al. · 2026 · Preprint

Abstract Smyrnium olusatrum L., traditionally used for its medicinal properties, contains alkaloids with various pharmacological activities. Despite its historical use, comprehensive toxicological data remain scarce, limiting its safe…

View details →DOI: 10.21203/rs.3.rs-9867368/v1
Negative / Null Result Report

Geriatric dentistry in brazilian dental education

Moimaz SAS, Dias GZT, Martins RJ et al. · 2026 · Preprint

Abstract Introduction: The increase in life expectancy in Brazil has led to significant changes in the population pyramid. Considering the different stages of life and the specific oral health conditions associated with older adults,…

View details →DOI: 10.1590/scielopreprints.16466
Negative / Null Result ReportOpen accessMedicine

Lumbar Plexus Block

Yao PY, Hendrix JM · 2026

The concept of a regional anesthesia technique that provides neural blockade of the entire lumbar plexus, a lumbar plexus block, dates back nearly 50 years. The first description of such a block by Winnie et al in 1973 was an “inguinal…

Negative / Null Result ReportOpen accessMedicine

Features and trends of marine heat waves and marine cold spells along the Western Iberian Coast from four decades of satellite data.

Biguino B, Haigh ID, Dias JM et al. · 2025 · Scientific reports

Marine Heat Waves (MHWs) have been the focus of numerous studies due to the dramatic consequences they can have on coastal systems. However, Marine Cold Spells (MCSs) can also have harmful effects on the environment while play an important…

View details →DOI: 10.1038/s41598-025-31504-1
Negative / Null Result ReportMedicine

Assessing the impact of residual coarctation of the aorta on renal perfusion.

Cesna S, Bielinis A, Zvirblis T et al. · 2026 · Cardiology in the young

Objectives Despite the effectiveness of the surgical or percutaneous treatment of coarctation of the aorta, the presence of hypertension in these patients remains a common and concerning issue. This study was undertaken to explore the…

View details →DOI: 10.1017/s1047951126113663
Negative / Null Result ReportMedicine

Inclusion of high-pressure-treated grape pomace to modulate barbecued Frankfurter sausages: insights into oxidation and PAH generation during barbecuing.

Andrés AI, Martín-Mateos MJ, D'Arrigo M et al. · 2026 · Food chemistry

This study evaluated the effects of high hydrostatic pressure (HHP)-treated white (WGP) and red grape pomace (RGP) on oxidative stability, volatile compounds, and polycyclic aromatic hydrocarbons (PAHs) in barbecued Frankfurter sausages.…

View details →DOI: 10.1016/j.foodchem.2026.150132
Negative / Null Result ReportOpen accessMedicine

Investigating cycle-to-cycle variation and the impact of endometrial injury through differential gene expression analysis.

Teh WT, Chung J, Donoghue JF et al. · 2026 · Human reproduction (Oxford, England)

Study question Does endometrial gene expression change across consecutive cycles and after endometrial injury? Summary answer Although paired endometrial samples collected from the same woman across two consecutive cycles show greater…

View details →DOI: 10.1093/humrep/deag025
Negative / Null Result ReportMedicine

Metabolic impact of exercise timing: Myonectin dynamics in overweight and obese postmenopausal women following high-intensity interval training.

Jafari A, Amani Beni S · 2026 · Maturitas

Background Myonectin is a myokine that regulates lipid metabolism, and levels are often reduced in obesity and insulin resistance. This study examined whether the timing of exercise influences myonectin and metabolic responses to…

View details →DOI: 10.1016/j.maturitas.2026.109027
Negative / Null Result ReportMedicine

Influence of Cryptosporidium parvum and Giardia duodenalis on glucose transport mechanisms and tight junctions in co-infected enterocytes.

Delling C, Kirchner M, May K et al. · 2026 · Parasites & vectors

Background Cryptosporidium parvum and Giardia duodenalis (assemblages A and B) are ubiquitously occurring protozoan parasites infecting a broad range of hosts. Co-infection with both parasites in suitable hosts have been reported, but…

View details →DOI: 10.1186/s13071-026-07537-4
Negative / Null Result ReportMedicine

Effect of Tai Chi vs. Strength Training on Body Composition, Physical Performance, and Well-Being in Community-Dwelling Older Mexican Women.

Flores-Bello C, Correa-Muñoz E, Sánchez-Rodríguez MA et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Tai Chi (TC) practice has been shown to positively affect the physical, psychological, and cognitive health of older adults. However, discrepancies persist regarding its effectiveness compared to strength training…

View details →DOI: 10.3390/healthcare14050663
Negative / Null Result Report

Effects of Glutamate Delta 1 Receptor (GluD1) Deletion on the Ultrastructural Features of Corticostriatal and Thalamostriatal Synapses in Mice

Yue L, Dalal K, Dravid SM et al. · 2026 · Preprint

The glutamate delta 1 receptor (GluD1) represents a unique subtype of ionotropic glutamate receptors that is strongly expressed in the mammalian striatum. Disruptions of the GRID1 gene, which encodes GluD1, have been associated with…

View details →DOI: 10.64898/2026.05.26.727726
Negative / Null Result ReportOpen accessMedicine

The effect of smartphone texting on cervical spine sagittal alignment in healthy young adults.

Trior Simonovich I, Haddad E, Vider S et al. · 2025 · Journal of spine surgery (Hong Kong)

Background Never before has technology been so universally accepted as the modern-era cell phone, the smartphone. Spine surgeons have noticed a rise in patients in their offices complaining of neck and upper back pain. Many patients are of…

View details →DOI: 10.21037/jss-24-19
Negative / Null Result ReportMedicine

Pharmacokinetics, pharmacodynamics, and radiomitigative efficacy of IEPA in a non-human primate model of acute radiation syndrome.

Wesolowski R, Asang C, Eibl M et al. · 2026 · International journal of radiation biology

Purpose The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally…

View details →DOI: 10.1080/09553002.2026.2672477
Negative / Null Result ReportMedicine

[Translated article] Is one year follow-up sufficient to assess functional outcomes after rotator cuff repair?

Pasqualini I, Lucero Viviani N, Turan O et al. · 2026 · Revista espanola de cirugia ortopedica y traumatologia

Background Arthroscopic rotator cuff repair (ARCR) traditionally requires a 2-year follow-up to report results. However, most of the recovery occurs within the first year. The aim of this study was to determine if there are clinically…

View details →DOI: 10.1016/j.recot.2026.06.012
Negative / Null Result Report

Acceptability, Implementation Fidelity, and Preliminary Psychological Outcomes of a DBT- Informed Emotional Skills Program in a Secondary School: A Pre–Post Study Among Adolescents in Chile

Gaete J, Romo V, Contreras C et al. · 2026 · Preprint

Abstract Background School-based interventions grounded in evidence-based psychological approaches are increasingly used to promote adolescent mental health. Dialectical Behavior Therapy (DBT) skills training has shown promise; however,…

View details →DOI: 10.21203/rs.3.rs-9571403/v1
Negative / Null Result ReportOpen accessMedicine

IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression.

Pérez-González A, Alonso-Domínguez J, Martínez-Barros I et al. · 2026 · Frontiers in immunology

Introduction Modern antiretroviral treatment allowed a significant improvement in the life expectancy of people with HIV (PWH), exhibiting robust and sustained efficacy with scarce toxicities, both in two-drug regimens (2DRs) and…

View details →DOI: 10.3389/fimmu.2026.1784890
Negative / Null Result ReportMedicine

Condylar Positional Changes Following Manual Proximal Segment Positioning During Bilateral Sagittal Split Ramus Osteotomy: A Cephalometric Study.

Tanrısever NC, Gökalp H · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Maintenance of condylar position during bilateral sagittal split ramus osteotomy (BSSRO) is important for preserving temporomandibular joint biomechanics and skeletal stability. During surgery, loss of muscle…

View details →DOI: 10.3390/medicina62061154
Negative / Null Result ReportMedicine

Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial.

Quezada-Bascuñán C, Ferri-Morales A, Martínez-Vizcaíno V et al. · 2026 · Menopause (New York, N.Y.)

Objective To evaluate the efficacy of nonablative capacitive-resistive monopolar radiofrequency on sexual function and vaginal health in postmenopausal women with genitourinary syndrome of menopause. Methods This was a single-blind,…

View details →DOI: 10.1097/gme.0000000000002743