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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 267 of 710

Negative / Null Result ReportMedicine

A combined Ames and in vivo genotoxicity assessment of dimyricetin-yl-diselenide, a structurally defined organoselenium flavonoid.

Zhang L, Liu X, Zhang C et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Dimyricetin-yl-diselenide (DMS; 3,5,7-trihydroxy-8-[[3,5,7-trihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chromen-8-yl]diselanyl]-2-(3,4,5-trihydroxyphenyl)chromen-4-one) is a structurally defined organoselenium flavonoid dimer in which two…

View details →DOI: 10.1016/j.fct.2026.116172
Negative / Null Result ReportMedicine

Adding Self-directed Psychological Support to Usual Rehabilitation Following Anterior Cruciate Ligament Reconstruction Did Not Increase Return-to-Sport Rates at 12 Months. Results From the BAck iN the Game (BANG) Randomized Controlled Trial.

Fältström A, Hedevik H, Ardern CL et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To evaluate the efficacy of internet-delivered psychological support-the BAck iN the Game (BANG) intervention-after anterior cruciate ligament reconstruction (ACLR) for improving return to sport (RTS). DESIGN: Randomized…

View details →DOI: 10.2519/jospt.2026.13749
Negative / Null Result ReportMedicine

Increasing meniscal repair rates during ACL reconstruction did not increase reoperation risk: An analysis of surgical trends from 2015 to 2023.

Kekki C, Essen CV, Cristiani R et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To evaluate surgical trends over time in meniscal procedures during anterior cruciate ligament reconstruction (ACLR) and compare meniscal reoperation rates and subjective outcomes between 2015-2019 and 2020-2023. Methods This study…

View details →DOI: 10.1002/ksa.70388
Failed Experiment ReportMedicine

Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post hoc analysis of the CANVAS and CREDENCE trials.

Doi Y, Hamano T, Fukuda-Doi M et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis Despite established cardiorenal benefits, concerns about urinary tract infection (UTI) risk may limit SGLT2 inhibitor use, especially in high-risk patients. We hypothesized that urine leukocyte esterase (LE) and…

View details →DOI: 10.1093/ndt/gfag062
Negative / Null Result ReportMedicine

Luspatercept and thrombotic events in patients with myelodysplastic syndrome: a target trial emulation framework using TriNetX database.

Vojjala N, Nassar M, Nanjareddy S et al. · 2026 · Leukemia & lymphoma

Myelodysplastic syndrome (MDS) is an identified risk for both venous and arterial thromboembolism (ATE). The thrombotic risk of drugs used in MDS, such as Luspatercept and Erythropoietin-stimulating agents (ESAs), has yielded conflicting…

View details →DOI: 10.1080/10428194.2026.2684311
Negative / Null Result ReportMedicine

A pilot study of a sexual health workshop for oncology staff: feasibility, impact, and gaps in addressing young adult breast cancer survivorship needs.

Rick TJ, Girard A, Topalian A et al. · 2026 · Journal of cancer survivorship : research and practice

Purpose Sexual health concerns are highly prevalent and distressing among adolescent and young adult (AYA) breast cancer survivors, yet are rarely addressed in routine oncology care. Lack of provider training remains a key barrier to…

View details →DOI: 10.1007/s11764-026-01985-8
Negative / Null Result ReportMedicine

Osteoarticular Infections in MIMIC-IV, A Clinical and Microbiological Analysis.

Azarpira M, Gascoin JC · 2026 · Studies in health technology and informatics

Osteoarticular infections (OAIs) remain challenging, particularly in the context of rising antimicrobial resistance. Using the MIMIC-IV database, this study applies a structured informatics workflow to characterize inflammatory marker (IM)…

View details →DOI: 10.3233/shti260147
Negative / Null Result ReportMedicine

Exploring unconventional antimicrobial stewardship models: options beyond traditional prospective audit and feedback.

Christensen AB, Cochran GL, Avedissian SN et al. · 2026 · Infection control and hospital epidemiology

Background Prospective audit and feedback (PAF) is a core antimicrobial stewardship strategy. Discontinuing PAF in favor of alternative interventions has not been previously evaluated. Methods This descriptive study assessed changes in…

View details →DOI: 10.1017/ice.2026.10500
Negative / Null Result ReportMedicine

Cytotoxic and Genotoxic Stress Transiently Increase the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production.

Meng Y, Ren X, Li R et al. · 2026 · Experimental hematology

Platelets are produced via a canonical pathway emanating from multilineage hematopoietic stem cells (ML-HSCs) and a faster, direct pathway used by platelet-biased (P-) HSCs where the latter circumvents progenitors intermediate between HSCs…

View details →DOI: 10.1016/j.exphem.2026.105456
Negative / Null Result Report

ADHD is not a risk factor for service-related PTSD in Israeli military conscripts: Evidence from a population-based cohort study of 1.4 million recruits

Porat DB, Abuhasira S, Ekka-Zohar A · 2026 · Preprint

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been hypothesized to increase vulnerability to post-traumatic stress disorder (PTSD) due to emotional dysregulation, impulsivity, and executive function deficits. Most…

View details →DOI: 10.21203/rs.3.rs-9741341/v1
Negative / Null Result ReportMedicine

Understanding Repression Under Secretion Stress in <i>Trichoderma reesei</i> During Cellulase Expression.

Jadhav R, Demirbas Uzel G, Charest J et al. · 2026 · Microorganisms

The filamentous fungus Trichoderma reesei is one of the most important workhorses for industrial enzyme production, but the cellular mechanisms that balance protein folding stress with secretion, such as the unfolded protein response (UPR)…

View details →DOI: 10.3390/microorganisms14061371
Negative / Null Result ReportMedicine

Donning gloves before patient contact, with or without prior hand hygiene.

Bayhan GI, Aydın Altuntaş C, Cevahir N · 2026 · Journal of infection in developing countries

Objective Hand hygiene (HH) is a fundamental infection prevention measure in healthcare settings, playing a crucial role in reducing healthcare-associated infections (HAIs). Despite its importance, HH compliance remains suboptimal…

View details →DOI: 10.3855/jidc.22190
Failed Experiment ReportMedicine

The risk of cerebrospinal fluid rhinorrhea from early resumption of positive pressure ventilation after transsphenoidal surgery with autologous fat graft repair.

Kim LJ, Rennert RC, Couldwell WT · 2026 · Journal of neurosurgery

Objective Multiple closure techniques may prevent CSF leak after transsphenoidal surgery for sellar lesions. In patients with obstructive sleep apnea requiring positive pressure ventilation (PPV), the optimal closure technique remains…

View details →DOI: 10.3171/2026.1.jns251476
Negative / Null Result ReportOpen accessMedicine

Changes in THC Positivity Rates in Adolescents Corresponding to Legalization of Recreational Marijuana in Illinois.

Gassé E, Brill A · 2026 · The western journal of emergency medicine

Introduction As public access to tetrahydrocannabinol (THC) products expands under state legalization, there is concern for increased use in adolescents under 18 years of age and its subsequent effects. Adverse effects of THC use have been…

View details →DOI: 10.5811/westjem.62946
Negative / Null Result ReportMedicine

Differential Expression of Dopamine-Related Genes Across Developmental and Parental Stages in the Burying Beetles, Nicrophorus orbicollis.

Panaitof SC, Kermagi MM · 2026 · Archives of insect biochemistry and physiology

Dopamine has diverse roles in the regulation of reproduction and social behaviors in insects. In the burying beetle, Nicrophorus orbicollis, a species with extended care, our previous work has shown that brain dopamine levels increase…

View details →DOI: 10.1002/arch.70177
Negative / Null Result ReportMedicine

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Majoe M, Stolarek N, Vizueta J et al. · 2026 · Journal of evolutionary biology

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers…

View details →DOI: 10.1093/jeb/voag043
Negative / Null Result ReportOpen accessMedicine

Effects of an orexin receptor 2-selective agonist on salivary secretion in rats.

Ichishima J, Nakakariya M, Kimura H · 2026 · Scientific reports

Narcolepsy type 1 (NT1) is caused by a significant loss of orexin-producing neurons. In clinical trials, multiple orexin receptor 2 (OX2R)-selective agonists (e.g., danavorexton, TAK-994, and oveporexton) improved wakefulness and decreased…

View details →DOI: 10.1038/s41598-026-44080-9
Replication FailureMedicine

Comparison Between Eccentric-Concentric and Eccentric-Only Dumbbell Arm Curl Exercise for the Number of Repetitions to Failure Over Five Sets.

Shibata K, Yamaguchi T, Takizawa K et al. · 2026 · Journal of strength and conditioning research

Abstract Shibata, K, Yamaguchi, T, Takizawa, K, and Nosaka, K. Comparison between eccentric-concentric and eccentric-only (ECC-only) dumbbell arm curl exercise for the number of repetitions to failure over five sets. J Strength Cond Res…

View details →DOI: 10.1519/jsc.0000000000005432