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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 266 of 710

Negative / Null Result ReportMedicine

Dissolved oxygen effects on human growth hormone stability during freeze-thaw and metal-catalyzed oxidation.

Miyahara Y, Nagel R, Frieß W · 2026 · Journal of pharmaceutical sciences

Dissolved oxygen (DO) has been proposed to influence protein stability during freeze-thaw (F/T) processing, yet its direct impact remains unclear. This study evaluated whether DO levels or vacuum degassing affect the stability of human…

View details →DOI: 10.1016/j.xphs.2026.104316
Negative / Null Result ReportMedicine

Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer.

Rawal R, Thyagarajan A, Sahu RP · 2026 · Medical sciences (Basel, Switzerland)

Background/objectives Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality, driven by invasive behavior and frequent resistance to systemic therapies. Epidermal growth factor receptor tyrosine kinase inhibitors…

View details →DOI: 10.3390/medsci14020301
Negative / Null Result ReportMedicine

Effects of Dietary Composite Postbiotic Preparation on Growth Performance, Immune Function, and Gut Microbiota in Nubian Black Goats.

Yin Y, Li C, Feng Y et al. · 2026 · Veterinary sciences

This study investigated the effects of composite postbiotic preparation on the growth performance, immune function, and microbiota composition of Nubian black goats. Thirty healthy Nubian black goats with similar body weights were randomly…

View details →DOI: 10.3390/vetsci13060599
Negative / Null Result ReportMedicine

Randomized Trial of Intensive Nurse-Led Follow‑Up Versus Standard Care in Inflammatory Bowel Disease.

Barkan R, Goren I, Fischman M et al. · 2026 · Digestive diseases and sciences

Background Nurses play a key role in inflammatory bowel disease (IBD) management. This randomized controlled trial evaluated intensive nurse-led program in patients with IBD starting advanced therapy. Methods Patients were randomized (1:1)…

View details →DOI: 10.1007/s10620-026-10015-7
Negative / Null Result ReportMedicine

MR Imaging-Based Biomarkers for Strength Prediction: A Statistical Shape and Architecture Modeling of Quadriceps Muscles.

Bin Ghouth S, Cigdem O, Mazzoli V · 2026 · Journal of magnetic resonance imaging : JMRI

Background Muscle mass decline, associated with strength decline, is a hallmark of aging. Yet, strength decline greatly exceeds mass decline. This indicates that aspects of muscle quality and architecture-not reflected by mass-also…

View details →DOI: 10.1002/jmri.70377
Negative / Null Result ReportMedicine

Effect of choice of instruction language on anatomy learning outcomes.

Alghamdi MA, Almasaad JM, Ahmed ME et al. · 2026 · Anatomical sciences education

The choice of instructional language in medical education continues to be debated across non-English-speaking nations. In Saudi Arabia, medical schools use English as the medium of instruction, which may challenge students who previously…

View details →DOI: 10.1002/ase.70246
Negative / Null Result ReportMedicine

A vest-based sling provides greater hip flexion and abduction than a traditional Ehmer sling, with limited tolerability in healthy dogs.

Huber AL, Picavet PP, Hamon M et al. · 2026 · American journal of veterinary research

Objective To measure hip flexion, abduction, and internal rotation in a static standing position with the limb maintained with a traditional Ehmer sling (TES), compare these with a commercially available vest-based sling (VBS), and…

View details →DOI: 10.2460/ajvr.26.02.0067
Replication FailureOpen accessMedicine

Is a combined proximal femoral osteotomy necessary when performing open reduction and Dega acetabuloplasty in walking-age children with developmental dysplasia of the hip.

Yu J, Li L, Shi L et al. · 2026 · SICOT-J

Purpose To determine the necessity of simultaneous proximal femoral osteotomy (PFO) during open reduction (OR) and Dega acetabuloplasty (DA) in patients with developmental dysplasia of the hip (DDH) by comparing the clinical and…

View details →DOI: 10.1051/sicotj/2026031
Negative / Null Result ReportMedicine

Effect of acupuncture on postoperative nausea and vomiting in lumbar disc herniation surgery.

Erdem G, Kavak Akelma F, Nalbant B et al. · 2026 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective Nausea, vomiting and pain are common postoperative complications. The aim of this study was to evaluate the effects of ondansetron combined with acupuncture at bilateral PC6 during the intraoperative period on the incidence of…

View details →DOI: 10.1177/09645284261441885
Replication FailureMedicine

Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.

Stepanovic Z, Ristic B, Matic A et al. · 2026 · Journal of clinical medicine

Background : The optimal route of tranexamic acid (TXA) administration remains one of the most debated topics in total knee arthroplasty. This study aimed to compare the effects of intravenous (IV), intra-articular (IA), and combined TXA…

View details →DOI: 10.3390/jcm15124776
Negative / Null Result ReportMedicine

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.

Østergaard AM, Rosenbæk JB, Ejlersen JA et al. · 2026 · Physiological reports

Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests…

View details →DOI: 10.14814/phy2.70919
Negative / Null Result ReportMedicine

Assessing the impact of an integrated health-system specialty pharmacy model on clinical disease activity index scores in patients with rheumatoid arthritis.

Phan T, Datt P, Zhao L et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune joint disorder necessitating the use of complex, specialty medications. Health-system specialty pharmacies (HSSPs) operate under closed-loop models that have been shown to minimize…

View details →DOI: 10.1093/ajhp/zxaf351
Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Energy Metabolism and Aerobic Capacity in Physically Active Young Adults.

Júnior FC, Santos WRD, Cordeiro Feitosa R et al. · 2026 · Research quarterly for exercise and sport

Taurine (TAU) is a conditionally essential amino acid whose consumption has recently increased, particularly among young people, through supplements and energy drinks. It has potential beneficial effects on physical performance; however,…

View details →DOI: 10.1080/02701367.2026.2671781
Negative / Null Result ReportMedicine

Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial.

Haskic A, Hadziabdic N, Miron RJ · 2026 · International journal of oral and maxillofacial surgery

Postoperative sequelae such as pain, swelling, and trismus are common following mandibular third molar surgery. This single-blind controlled trial was performed to evaluate the effects of two newer platelet-rich fibrin (PRF) formulations,…

View details →DOI: 10.1016/j.ijom.2026.04.011
Negative / Null Result ReportMedicine

Ensuring continuous buprenorphine access: A multi-component quality improvement initiative in a university-affiliated clinic and outpatient pharmacy.

Choo LY, Zheng W, Wen S et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use. Objectives The purpose of this quality improvement (QI)…

View details →DOI: 10.1016/j.japh.2026.103469
Negative / Null Result ReportMedicine

Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka.

DiBona ER, Elliott J, Labeille RO et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with immunotoxic potential, yet impacts on immune development remain poorly defined. We examined effects of developmental PFAS exposure on host resistance and…

View details →DOI: 10.1016/j.aquatox.2026.107902
Negative / Null Result ReportMedicine

Superinfection risk in critically ill patients with severe COVID-19: a retrospective analysis of pulse steroid therapy with and without tocilizumab.

Gok A, Kavakli AS, Sugur T et al. · 2026 · Expert review of anti-infective therapy

Background This study aimed to assess culture positivity rates and the microbiological profile of intensive care unit (ICU)-acquired superinfections in patients with severe COVID-19 pneumonia treated with pulse-dose methylprednisolone,…

View details →DOI: 10.1080/14787210.2026.2682316
Negative / Null Result ReportMedicine

Does the methane-mitigating feed additive 3-nitrooxypropanol affect additive genetic variance and ranking of methane and yield traits in Holstein dairy cows?

Stephansen RB, Lassen J, Lund MS et al. · 2026 · Journal of dairy science

This study aimed to quantify the effect of the methane-mitigating feed additive 3-NOP on genetic parameters and potential genotype-by-environment (G × E) interaction for gas emission traits, i.e., methane (CH 4 ) and, carbon dioxide (CO 2…

View details →DOI: 10.3168/jds.2026-28686
Negative / Null Result ReportMedicine

Effects of cabin thermal conditions and road type on driver workload and performance: A driving simulator study.

Lu B, Liu X, Zhang P et al. · 2026 · Traffic injury prevention

Objective Driver workload is a safety-relevant factor that may contribute to impaired driving performance and an increased risk of traffic injury. Cabin temperature is a modifiable in-vehicle environmental condition, but its influence on…

View details →DOI: 10.1080/15389588.2026.2682437
Negative / Null Result ReportMedicine

Effect of polymerization mode on dentin bond strength of universal adhesives: influence of aging and application strategy.

Yazici Akbiyik S, Yikici Col C, Bakir E · 2026 · Quintessence international (Berlin, Germany : 1985)

Objectives This study evaluated the effect of polymerization mode on dentin bond strength of universal adhesives applied using etch-and-rinse (ER) and self-etch (SE) strategies, before and after thermocycling. Method and materials A total…

View details →DOI: 10.3290/j.qi.b6982835
Negative / Null Result ReportMedicine

Leader behaviors to improve teamwork during interprofessional rounds in the NICU.

Traylor AM, Bell EA, Lewis NCM et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective We investigated the impact of leaders' interprofessional teamwork behaviors on NICU staff perceptions of teamwork processes, trust, psychological safety, and voice behavior. Study design To develop a measure of leaders'…

View details →DOI: 10.1038/s41372-026-02689-8
Negative / Null Result ReportMedicine

Is Seeing Believing and Hearing Trusting? Exploring the Role of Visual and Vocal Cues in Shaping User Trust in VR News Anchors.

Gao Y, Guo Z, Liang HN · 2026 · IEEE transactions on visualization and computer graphics

Amid the global decline in news credibility, immersive journalism in virtual reality (VR) offers opportunities to enhance trust and engagement through presence and interactivity. As the communicators of news, virtual news anchors play a…

View details →DOI: 10.1109/tvcg.2026.3680672
Negative / Null Result ReportMedicine

Mode of delivery among breech presentations with and without External Cephalic Version: A retrospective observational study.

Athiel Y, Goffinet F, Le Ray C et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Objective To compare the mode of delivery among women with singleton breech presentation at 36 weeks who attempted external cephalic version (ECV) with those who declined the procedure, in a tertiary center characterized by a low ECV…

View details →DOI: 10.1016/j.jogoh.2026.103217
Negative / Null Result ReportMedicine

Antibacterial activity and multi-target mechanism of naringenin against Alicyclobacillus acidoterrestris and its application in apple juice.

Zhang Y, Zhao N, Hu B et al. · 2026 · International journal of food microbiology

Alicyclobacillus acidoterrestris (A. acidoterrestris) poses a major spoilage risk in pasteurized fruit juices, owing to its thermophilicity and acidophilicity. Naringenin, a natural flavonoid, has been investigated for its potential…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111897
Negative / Null Result ReportMedicine

Neuroticism, perceived stress, psychological resilience, and pre-dive state anxiety in professional divers: a cross-sectional study.

Zhao H, Wang L, Zhang S et al. · 2026 · BMC psychology

Background Professional divers work in safety-critical environments that require sustained attention, rapid judgment, and stable emotional control. Neuroticism is a vulnerability trait related to negative affectivity, perceived stress…

View details →DOI: 10.1186/s40359-026-05029-9