A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21277 results · page 248 of 710
Grewe I, Hennigs A, Olearo F et al. · 2025 · IDCases
Burkholderia pseudomallei can cause severe systemic infection with involvement of multiple organs and abscess formation. Carbapenems are considered superior to ceftazidime in severe cases. We here report a case of Melioidosis in a…
Peters S, Tan DSW, Gerber DE et al. · 2026 · Nature cancer
Over 50% of persons with unresectable stage III non-small cell lung cancer (NSCLC) treated with standard-of-care concurrent chemoradiotherapy (CCRT) and durvalumab consolidation progress or die within 18 months. Here adults with untreated,…
Schulz JV, Doerflinger JT, Behm C et al. · 2026 · Health psychology : official journal of the Division of Health Psychology, American Psychological Association
Objective This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating…
Yang Y, He Y, Lin B et al. · 2026 · Health care science
Background The aim of this study was to investigate the clinical value of combined detection of preoperative serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) for diagnosing medullary thyroid carcinoma (MTC), as well as predicting…
Drago E, Lavarello C, Alongi A et al. · 2026 · Clinical and experimental rheumatology
Objectives Development and psychometric evaluation of a disease-specific, paediatric-targeted multidimensional questionnaire for the assessment of juvenile fibromyalgia syndrome (JFS) in routine clinical practice. Methods The Juvenile…
Genuth G, Stavrou P, Brown C et al. · 2026 · Foot & ankle international
Background Acute lateral ankle sprains are among the most common musculoskeletal injuries, accounting for up to 20% of all sports-related injuries and a leading cause of time lost from athletic participation. Although most cases respond to…
Hebisch J, Van Puyenbroeck P, Schwabe L et al. · 2025 · Preprint
A bstract Brainstem arousal systems including the locus coeruleus noradrenaline system, respond transiently to behaviorally relevant events. Locus coeruleus activity also drives dilations of the pupil, which are often observed during…
Dertsiz Kozan B, Utlu B · 2026 · International ophthalmology
Purpose To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora. Material and methods Demographic characteristics, follow-up period,…
Shi Z, Chen X, Chun Y et al. · 2026 · Preprint
Abstract Objective To evaluate the efficacy, safety, and prognostic factors of chimeric antigen receptor-T cell (CAR-T) therapy in patients with relapsed/refractory ileocecal lymphoma and provide evidence for salvage therapy. Methods This…
Pérez-Fernández N, Arbizu L · 2026 · Journal of clinical medicine
Background : Differentiating Ménière's disease (MD) from vestibular migraine (VM) remains difficult because current diagnostic frameworks are predominantly clinical and incorporate pure-tone thresholds, risking incorporation bias. We asked…
Cekic SG, Unal C, Benlioglu C et al. · 2026 · Preprint
Abstract Background The purpose of the study is to evaluate whether the change in cervical length (ΔCx) between the first and second trimesters can predict spontaneous preterm birth (sPTB) in women with a normal mid-trimester cervical…
Al Saeedi M, Abdurakhimova DA, Arabi T et al. · 2026 · Radiology
Background Renal artery stenosis (RAS) can trigger the development of renal damage and poststenotic dilatation (PSD). However, the clinical relevance and mechanisms are ill-characterized. Purpose To characterize the mechanisms underlying…
Hwang S, Kim PH, Kim H et al. · 2026 · Journal of neuro-oncology
Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic pathway…
Vuaran E, Trunfio M, Russo M et al. · 2026 · Journal of neurovirology
INTRODUCTION: Blood biomarkers would be the ideal tool in routine practice in early identifying People With HIV (PWH) with low cognitive performance (LNP). We aimed to assess the diagnostic performance of neurodegeneration and brain injury…
Le Thi TG, Geist M, Novosad Y et al. · 2026 · European journal of preventive cardiology
Aims This overview of systematic reviews (SRs) summarizes evidence on effectiveness and safety of treatment for paediatric heterozygous familial hypercholesterolaemia (heFH) and multifactorial dyslipidaemia (MFD). Methods and results…
Heidari Z, Gharibi G, Alaeen H et al. · 2026 · Journal of pineal research
This study aimed to evaluate the effects of melatonin supplementation on disease severity, sleep quality, and quality of life in adult patients with atopic dermatitis (AD). This study was designed as a randomized, double-blind,…
Das T, Belenje A, Joseph J et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis. Methods Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical…
Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy
Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…
Redman N, Brumbaugh K, Farquharson K · 2025 · Seminars in speech and language
This investigation compared the effectiveness of the Cycles Approach with and without auditory stimulation. Using an alternating treatment design (AATD), three preschool-aged children with severe phonological disorders received a modified…
Li X, Yan M, Li T et al. · 2025 · Preprint
Abstract Background Perineural invasion (PNI), though reported with varying incidence in rectal cancer, is a recognized marker of adverse prognosis. While postoperative adjuvant radiotherapy is a cornerstone of multidisciplinary management…
Minkley M, Ravasia K, Nghiem T et al. · 2026 · Virchows Archiv : an international journal of pathology
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an aggressive and molecularly heterogenous cancer with poorly defined treatment strategies. We aimed to (i) assess whether RB1 immunohistochemistry alone can prognostically stratify…
Kakihara S, Busza AM, Duffy BV et al. · 2026 · American journal of ophthalmology
Objective To determine whether foveal avascular zone (FAZ) enlargement and geometric perfusion deficits in the deep capillary plexus (GPDd) are independently associated with retinal nonperfusion in different regions of ultrawidefield…
Bansaghi S, Klein J · 2026 · Preprint
Background Cruise ships are relatively small, crowded spaces where many people travel in a new environment, making infection control especially important. Proper hand hygiene is the first line of defense against the spread of infection.…
Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine
Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…
Silva LEV, Balcarcel D, Ko TS et al. · 2026 · Resuscitation
Aims Heart rate variability (HRV), a non-invasive measure of autonomic function, may offer prognostic value after pediatric cardiac arrest. We used machine learning models to determine whether HRV features within the first 24 h after…
Miao Y, Zhang H, Wu J et al. · 2026 · Journal of clinical anesthesia
Background Clinical evidence on obturator nerve involvement after supra-inguinal fascia iliaca compartment block (SFICB) is limited. This study aimed to investigate whether a 40-mL SFICB reliably anesthetizes the obturator nerve and…
Aitken D, Cai G, Hill CL et al. · 2026 · JAMA internal medicine
Importance Knee osteoarthritis (OA) is disabling, with few effective treatments. Anti-inflammatory treatments may be effective for patients with an inflammatory phenotype. Objectives To evaluate the efficacy of the interleukin-1β blocker…
Bori-Bru B, Salvador JP, Crehuet R · 2025 · Preprint
Generative models have advanced profusely in recent years, generating great impact in computational modelling and structural bioinformatics. A part of computational protein design focuses on antibody and nanobody engineering, targeting…
Najjar-Debbiny R, Cohen R, Arbel A et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
BACKGROUND: Mycobacterium simiae is an emerging cause of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the Middle East, yet treatment outcomes remain unclear. We aimed to evaluate clinical and microbiologic outcomes of M.…
Rhyu KH, Cho YJ, Chun YS et al. · 2026 · Clinical orthopaedics and related research
Background Cementing a new liner into a well-fixed acetabular cup with a deficient locking mechanism has been reported as a viable option, but concerns remain regarding complications such as dislocation and late loosening.…