A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Morales AA, Camarena V, Peart L et al. · 2025 · Preprint
Abstract Geleophysic dysplasia (GD) is a rare genetic disorder characterized by short stature, joint contractures, and cardiopulmonary complications, with early mortality, and linked to mutations in ADAMTSL2 (GD1), FBN1 (GD2), or LTBP3…
Fatima H, Schaffert J, Carlew AR et al. · 2025 · The Clinical neuropsychologist
Objective Cognitive dispersion (CD) or neuropsychological test score variability has been associated with more rapid cognitive decline, and the development of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The predictive…
Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology
Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…
Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation
Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…
Kwon Y, Park J, Kim D et al. · 2026 · Obesity surgery
Background While bariatric surgery (BS) is an effective treatment for gout in patients with morbid obesity, little is known about how BS influences subsequent use of gout medications. We investigated the impact of BS on gout medication…
Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics
Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…
Sınır B, Ortan P, Sayin SS et al. · 2026 · Respiratory medicine
Purpose Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and sleep fragmentation, which may alter gut microbiota composition. We primarily aimed to compare intestinal Desulfovibrio detection/abundance between patients…
Kumar A, Sinha RRK, Sahu SP et al. · 2026 · Preprint
Abstract The present experiment was conducted to compare three housing systems Individual cages, Colony cages and Deep litter on welfare, behaviour, and physiological traits in Rhode Island Red laying hens under tropical conditions. A…
Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…
Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…
Sabharwal P, Kaur N, Kaur R et al. · 2026 · Journal of ultrasound
Objectives To determine the incremental diagnostic value of multiparametric quantitative ultrasound-integrating B-mode, Color Doppler, Strain, and Shear Wave Elastography (SWE)-in differentiating benign and malignant breast lesions, using…
Wang L, Pulgrossi RC, Anderson J et al. · 2026 · The journal of applied laboratory medicine
Background Acute graft-versus-host disease (aGVHD) is a common complication of allogenic hematopoietic cell transplantation (HCT). The aGVHD presymptomatic algorithm is comprised of 2 serum biomarkers, suppression of tumorigenicity 2 and…
Delaye-Martínez MA, Aguilar-Rodea BP, Cardona-Ortiz AF et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Nebulized colistin has shown promise in treating ventilator-associated pneumonia (VAP) due to carbapenem-resistant strains; evidence in burn patients is limited. This study evaluated the efficacy of nebulized colistin as an adjunct…
Rusa AM, Schmidlin PR, Sarkar P et al. · 2026 · Swiss dental journal
Large language models (LLMs) are increasingly used in clinical and educational settings. However, there is a paucity of data on LLMs' performance in specialized dental domains. This study assessed the performance of four LLMs, including…
Zou Q, Huang Q, Li J et al. · 2026 · International urology and nephrology
Background The optimal treatment strategy for androgen receptor pathway inhibitor (ARPI)-pretreated and chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) remains unclear. Chemotherapy has limited efficacy as a…
Oscorbin IP, Smertina MA, Kunova MS et al. · 2025 · Preprint
The metal-binding periplasmic protein CusF has been proposed as a bifunctional tag enhancing solubility of recombinant proteins and enabling purification using Cu affinity chromatography. However, evidence for its performance remains…
van Boven M, Bennis F, Onland W et al. · 2025 · IEEE journal of biomedical and health informatics
Machine learning models predicting neurodevelopmental outcome in preterm infants have great potential, but have often relied on inaccessible brain magnetic resonance imaging measurements. This study aimed to build models using readily…
Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care
Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…
Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia
Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…
Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation
Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…
Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology
Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…
Kang Y, Workneh F, Yibeltal K et al. · 2026 · The Journal of nutrition
Background Suboptimal gestational weight gain (GWG) is associated with adverse pregnancy outcomes; however, evidence on the impact of nutritional interventions on GWG in low-income settings remains limited. Objectives This study aims to…
Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open
Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…
Orozco MPV, Seefluth D, Ciston AB et al. · 2025 · Preprint
Focusing on external movement outcomes rather than the movements themselves has been reported to enhance motor performance, although the mechanisms for this attentional focus effect remain unclear. We examined whether the effectiveness of…
Nyström L, Granhag A, Neofotistos E et al. · 2026 · Preprint
Introduction. The Shift-of-Strategy (SoS) approach aims to obtain concealed information from semi-cooperative suspects by prompting them to shift toward more forthcoming counter-interrogation strategies. While previous studies on the…
Khan A, Islam I, Mannakkara N et al. · 2026 · Future cardiology
Background Echocardiography after myocardial infarction (MI) provides clinically useful information through assessment of regional wall motion abnormalities, but interpretation requires expertise and remains subject to observer…
Ystrøm IK, Jensen SK, Andersen IT et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Background and hypothesis IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences vary substantially across countries. This study assessed the epidemiology of IgAN including…
van de Bovenkamp AA, Nassiri S, de Man FS et al. · 2026 · European journal of heart failure
Aims Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementation on cardiovascular function and…
Yi Y, Yano K · 2025 · Physiologia Plantarum.
Elevated CO₂ (eCO₂) can enhance plant growth, but it may also accelerate senescence, which could offset the growth benefits. Phosphorus (P) supply can enhance the photosynthetic rate under eCO₂ conditions and promote biomass accumulation.…
Sponholtz MR, Ma D, Byrne PO et al. · 2026 · Preprint
ABSTRACT Herpes simplex virus type 2 (HSV-2) causes genital herpes through latent infection and periodic reactivation. Although antivirals alleviate symptoms, no prophylactic or therapeutic vaccines have been licensed. Glycoprotein B (gB)…