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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 233 of 724

Replication FailureOpen accessMedicine

Liposomal Bupivacaine versus Ropivacaine with Dexamethasone in Rectus Sheath Block for Laparoscopic Gastrectomy: A Randomized Controlled Trial.

Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy

Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…

View details →DOI: 10.2147/dddt.s574724
Negative / Null Result ReportOpen access

A realist approach to implementation fidelity in a mixed-method evaluation of electronic decision support systems to improve the quality of antenatal care in Nepal

Radovich E, Karki S, Das S et al. · 2024 · Preprint

Background Understanding implementation fidelity, or adherence to the intervention-as-intended, is essential to interpreting the results of evaluations. In this paper, we propose a longitudinal, explanatory approach to implementation…

View details →DOI: 10.1101/2024.05.07.24306757
Negative / Null Result ReportOpen accessMedicine

Time-varying trends from Arctic ozonesonde time series in the years 1994-2022.

Nilsen K, Kivi R, Laine M et al. · 2024 · Scientific reports

Although evidence of recovery in Antarctic stratospheric ozone has been found, evidence of recovery in Arctic ozone is still elusive, even though 25 years have passed since the peak in ozone depleting substances. Here we have used a…

View details →DOI: 10.1038/s41598-024-75364-7
Negative / Null Result ReportOpen accessMedicine

Independent associations of physical activity and depression with open-angle glaucoma in a population-based analysis.

Lee SY, Shin SJ, Lee J et al. · 2025 · Scientific reports

Patients with open-angle glaucoma (OAG), a chronic visual impairment, are at elevated risk of developing depression. Physical activity (PA) has been associated with benefits for mental health, but evidence is limited regarding its impact…

View details →DOI: 10.1038/s41598-025-28364-0
Negative / Null Result ReportMedicine

Does additional education affect memory consistently? An analysis of compulsory schooling reforms across Europe and U.S.

Perez-Arce F, Knapp D, Lobo R et al. · 2026 · Social science & medicine (1982)

Background A growing literature suggests that education positively influences cognitive function in later life. However, the magnitude and consistency of this effect across study designs and populations remain open questions. Methods This…

View details →DOI: 10.1016/j.socscimed.2026.119377
Negative / Null Result ReportOpen accessMedicine

Preschoolers' Early Sentence Comprehension: Comparing Bilingual and Monolingual Children and the Role of Executive Function and Vocabulary Development.

Rodenhurst N, Messenger K · 2026 · Developmental science

Previous research into children's comprehension of syntactic structures has investigated early awareness of transitive and intransitive structures amongst monolingual children but research into bilingual children's understanding of the…

View details →DOI: 10.1111/desc.70232
Negative / Null Result ReportOpen accessMedicine

Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making.

Robins PL, Gilbert JR, Luber B et al. · 2026 · Human brain mapping

A core function of episodic memory is to distinguish between overlapping experiences by converting similar inputs into distinct, non-overlapping representations, a process termed pattern separation. While anatomical models emphasize the…

View details →DOI: 10.1002/hbm.70529
Negative / Null Result Report

The Evaluation of Devaluation: Deficient outcome devaluation leads to wrongly considering goal-directed actions as habits

Vázquez-Millán A, Martínez-López P, Romero MR et al. · 2026 · Preprint

Habits are stimulus-driven responses that are produced independently of the current outcome value. They enable efficient actions in familiar contexts while freeing up cognitive resources. Habits are expected to influence behavior after…

View details →DOI: 10.31234/osf.io/zh39t_v5
Negative / Null Result Report

Association of educational attainment with incident orientation impairment among Chinese older adults with and without stroke: evidence from a longitudinal study with external validation

Shi C, Wu L, Yang Q et al. · 2026 · Preprint

Abstract Background Orientation impairment is an early and clinically meaningful marker of cognitive vulnerability in older adults and is associated with subsequent functional decline, dementia, and mortality. Although stroke is a…

View details →DOI: 10.21203/rs.3.rs-9092847/v1
Negative / Null Result ReportMedicine

Do Anti-immigration Rhetoric and Policy Impact Reporting of Intimate Partner Violence To Police Among Latina/e Survivors in the United States? A Comparative Interrupted Time Series Study.

Bevilacqua K, Gemmill A, Jackson D et al. · 2026 · Journal of immigrant and minority health

Latina/e women in the United States (US) experience intimate partner violence (IPV) at similar or lower rates than other women but worse IPV-related health outcomes, perhaps due to barriers to help-seeking. IPV reporting to police is one…

View details →DOI: 10.1007/s10903-026-01877-0
Negative / Null Result ReportMedicine

Genetic Susceptibility to <i>Helicobacter pylori</i> Infection and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomisation Study.

Yang NY, Ke TM, Huang Y et al. · 2026 · Life (Basel, Switzerland)

Background/Objectives : Pancreatic cancer is one of the most lethal malignancies, with poor survival and few established modifiable risk factors. While Helicobacter pylori ( H. pylori ) infection is a known cause of gastric cancer, its…

View details →DOI: 10.3390/life16020284
Negative / Null Result Report

Ischemic stroke after bivalent mRNA COVID-19 vaccination and influenza vaccination during the 2022-2023 season: a multi-site self-controlled case series study

Xu S, Sy LS, Hong V et al. · 2026 · Preprint

Background The Vaccine Safety Datalink (VSD) detected a statistical signal for ischemic events (ischemic stroke or transient ischemic attack) following bivalent mRNA COVID-19 vaccination through prospective surveillance during 2022-2023.…

View details →DOI: 10.64898/2026.05.20.26353716
Negative / Null Result ReportOpen accessMedicine

Interferon-γ +874T/A polymorphism, <i>Toxoplasma gondii</i> serostatus, and risk of paranoid schizophrenia in males: a case-control study.

Braun D, Olmer A · 2026 · Frontiers in psychiatry

Background and hypothesis Toxoplasma gondii (TG) exposure and host immunogenetic variation have been implicated in psychosis. Interferon-gamma (IFN-γ) is central to TG control; the IFN-γ +874T/A polymorphism has been linked to variability…

View details →DOI: 10.3389/fpsyt.2026.1771815
Negative / Null Result ReportOpen accessMedicine

No Evidence That Women's Sociosexuality or Self-Perceived Mate Value Predict Their Preferences for Men's Face-Shape Masculinity.

Lee P, Li J, Jones BC et al. · 2025 · Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior

Researchers have suggested that men with more masculine facial characteristics have stronger immune systems but are perceived to be less likely to invest resources in partners and offspring. How women resolve this putative trade-off…

View details →DOI: 10.1177/14747049251376924
Negative / Null Result Report

The individual and combined impacts of school-based water, sanitation, and hygiene (WASH) education and infrastructure operation and maintenance (O&M): A factorial cluster-randomized controlled trial in Uttar Pradesh, India

Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint

ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…

View details →DOI: 10.1101/2025.10.23.25338677
Negative / Null Result ReportMedicine

Replicating the use of motivational interviewing and facilitated contraceptive access to reduce repeat adolescent pregnancy: A randomized trial.

Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception

Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…

View details →DOI: 10.1016/j.contraception.2025.111200
Negative / Null Result ReportMedicine

Independent effects of sex and ear-canal size on auditory brainstem response amplitudes in young adults.

Guest H, Plack CJ, Munro KJ et al. · 2026 · International journal of audiology

Objective Adult auditory brainstem response (ABR) amplitudes are employed by both researchers and clinicians, but exhibit substantial between-subject variability, reducing their sensitivity as measures of underlying auditory health. One…

View details →DOI: 10.1080/14992027.2025.2530713
Negative / Null Result ReportOpen accessMedicine

Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell.

Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology

This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…

View details →DOI: 10.1111/bcpt.70035