Negative / Null Result ReportMedicine
Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…
View details →DOI: 10.1007/s00395-026-01194-5 Negative / Null Result Report
Urashima AS, Coraini N, Teixeira O et al. · 2026 · Preprint
Abstract Sugarcane sett is the primary inoculum source of ratoon stunt (RSD). RSD-free setts and thermotherapy are measures to control it, but they are not disseminated in Brazil due to little information on the importance of RSD on modern…
View details →DOI: 10.21203/rs.3.rs-8855239/v1 Negative / Null Result ReportMedicine
Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology
Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…
View details →DOI: 10.1016/j.tjog.2025.07.033 Negative / Null Result ReportMedicine
Oldham L, Arnott G, Briffa M et al. · 2026 · Biology letters
Skill is the ability to do a challenging behaviour well. We examined how contest skill influences contest success, costs and whether skilful behaviour enhances welfare. We measured skill across three domains: accuracy, appropriateness…
View details →DOI: 10.1098/rsbl.2025.0563 Negative / Null Result ReportMedicine
Mangold MH, Kazmierczak J, Gerigk M et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
INTRODUCTION: Patients undergoing radical cystectomy (RC) face a heightened risk of infectious complications around the time of ureteral stent removal. This study aimed to determine whether a culture-guided antimicrobial strategy reduces…
View details →DOI: 10.1007/s10096-026-05514-4 Negative / Null Result ReportMedicine
Kim DH, Beathe J, Wetmore DS et al. · 2026 · Regional anesthesia and pain medicine
Background The adductor canal block (ACB), known for its motor-sparing properties, has gained popularity as part of the multimodal analgesic regimen in total knee arthroplasty (TKA) patients. However, the duration of single-injection…
View details →DOI: 10.1136/rapm-2026-107719 Negative / Null Result Report
Kalkonde Y, Jadhao S, Bhusari V et al. · 2026 · Preprint
Background: Stroke is the second leading cause of death globally. We tested whether it was feasible to deliver a community-based intervention package for prevention of stroke and, whether such an intervention would reduce stroke mortality…
View details →DOI: 10.12688/wellcomeopenres.26002.1 Negative / Null Result ReportOpen accessMedicine
Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research
Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…
View details →DOI: 10.1186/s12931-025-03457-6 Negative / Null Result ReportMedicine
Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma
The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…
View details →DOI: 10.1177/08977151261451145 Negative / Null Result ReportMedicine
Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology
Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…
View details →DOI: 10.2340/sju.v61.45711 Negative / Null Result ReportMedicine
Mauter F, Anton M, van Engen R et al. · 2026 · Physics in medicine and biology
Objective. Digital mammography (DM) and dual-energy contrast-enhanced mammography (CEM) use the same anti-scatter grid, despite their differences in x-ray spectra. This study investigated grid performance under clinically relevant…
View details →DOI: 10.1088/1361-6560/ae2c39 Negative / Null Result ReportMedicine
Szarpak L, Al-Jeabory M, Pecold J et al. · 2026 · The aging male : the official journal of the International Society for the Study of the Aging Male
Introduction Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. Objectives To synthesise current…
View details →DOI: 10.1080/13685538.2026.2655544 Replication FailureMedicine
Takeda Y, Nakai T, Okamoto T et al. · 2026 · The Journal of arthroplasty
Background Mirogabalin, a selective α2δ-1 ligand, has been proposed to exhibit potent analgesic effects with fewer central nervous system (CNS) side effects than prior gabapentinoids. Its effectiveness for acute postoperative pain after…
View details →DOI: 10.1016/j.arth.2026.03.095 Negative / Null Result ReportMedicine
Carnevali A, Chisari D, Mancini A et al. · 2026 · Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Introduction Inferior retinal detachment (I-RD) complicated by proliferative vitreoretinopathy (PVR) is challenging to treat and prone to recurrence (retinal detachment recurrence [RDR]). Heavy silicone oil (HSO) tamponades such as…
View details →DOI: 10.1159/000551398 Negative / Null Result ReportMedicine
Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics
Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…
View details →DOI: 10.1007/s00431-026-06904-8 Replication FailureMedicine
Magno Serrano P, Barros P, Dores M et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
Introduction Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of…
View details →DOI: 10.4081/aiua.2026.14883 Replication FailureMedicine
Oreskovic NM, Erwin AE, Allon ZA et al. · 2026 · The American journal of managed care
Objectives Office-based care coordination programs are increasingly utilizing social work-trained care coordinators to manage high-cost, high-need (HCHN) patients with increased psychosocial risk, including patients covered by Medicaid.…
View details →DOI: 10.37765/ajmc.2026.89922 Replication FailureMedicine
Mølhave M, Olsen ZL, Svanesøe S et al. · 2025 · Acta oto-laryngologica
Background Tracheostomy is widely used in critically ill patients, yet limited clinical data exist from Danish ENT departments. Aims/objectives To describe clinical outcomes and perioperative care in patients undergoing tracheostomy at a…
View details →DOI: 10.1080/00016489.2025.2561917 Replication FailureMedicine
Bhardwaj A, Jain A, Jain N et al. · 2026 · Indian pediatrics
Objective To evaluate whether epinephrine nebulization, when used in addition to standard care, reduces extubation failure (EF) in term and preterm neonates. Methods A parallel, randomized controlled superiority trial was conducted in a…
View details →DOI: 10.1007/s13312-026-00306-7 Negative / Null Result ReportMedicine
Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)
Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…
View details →DOI: 10.1097/gme.0000000000002808 Negative / Null Result ReportMedicine
Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine
Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…
View details →DOI: 10.1136/rapm-2024-106247 Negative / Null Result ReportMedicine
Yang M, Chen Y, Yang L et al. · 2026 · International journal of biological macromolecules
Plants face significant threats from pathogens while chemical pesticides remain the primary method for disease control. However, excessive use of chemical pesticides has led to increased pathogen resistance and environmental hazards,…
View details →DOI: 10.1016/j.ijbiomac.2026.152953 Negative / Null Result Report
Lima VHA, Reis EFd, Devilla IA et al. · 2026 · Preprint
Most studies in the field of application technology have focused on the interaction between adjuvants and agrochemicals, highlighting the need for further research to evaluate the behavior of adjuvants in association with other classes of…
View details →DOI: 10.20944/preprints202604.0247.v1 Negative / Null Result ReportMedicine
Benade F, Jülke S, Schwelm A et al. · 2026 · Journal of experimental botany
The clubroot pathogen Plasmodiophora brassicae has an effector protein that can methylate the plant defense compound salicylic acid (SA), and the protein sequence is highly conserved in different isolates worldwide. Sequencing the…
View details →DOI: 10.1093/jxb/eraf548 Negative / Null Result Report
Richardson M, Masurkar RA, Tyson L et al. · 2026 · Preprint
Intrusive memories are a central feature of posttraumatic stress disorder (PTSD) and are thought to emerge through associative learning processes during trauma. Cognitive models propose that conditioned stimuli (CSs) occurring in close…
View details →DOI: 10.31234/osf.io/26zry_v1 Negative / Null Result ReportMedicine
Lam AD, Foreman SR, Davidson SJ et al. · 2026 · The Journal of arthroplasty
Background The growing expansion of outpatient total knee arthroplasty (TKA) and emphasis on multimodal pain control to reduce opioid consumption are essential in optimizing perioperative care. This study aimed to assess postoperative…
View details →DOI: 10.1016/j.arth.2026.03.033 Negative / Null Result ReportMedicine
Mans-Gallart N, Carlhäll S, Hildebrand E et al. · 2026 · American journal of obstetrics and gynecology
Background Preeclampsia is a substantial cause of maternal and perinatal morbimortality, with complications becoming more severe the earlier it manifests during pregnancy. The Fetal Medicine Foundation has developed a method that combines…
View details →DOI: 10.1016/j.ajog.2025.10.028 Negative / Null Result ReportMedicine
Biddlestone M, Green R, Toribio-Flórez D et al. · 2025 · British journal of psychology (London, England : 1953)
Prebunking can be used to pre-emptively refute conspiracy narratives. We developed a new approach to prebunking - fighting fire with fire - which introduces a plausible 'meta-conspiracy' suggesting that conspiracy theories are deliberately…
View details →DOI: 10.1111/bjop.70023 Negative / Null Result Report
Snape D, Wainwright B, Parsons IT et al. · 2026 · Preprint
Short-term heat acclimation (HA) induces cardiovascular and fluid-regulatory adaptations, but it’s impact on markers of renal tubular injury and acute kidney injury risk (AKI) during exercise-heat stress remains unclear. Fourteen healthy…
View details →DOI: 10.64898/2026.03.06.710014 Negative / Null Result ReportMedicine
Jourquin S, Lowie T, Clinquart J et al. · 2026 · Journal of dairy science
This randomized clinical trial evaluated the effect of upon-arrival intranasal vaccination against bovine coronavirus (BCoV) on pneumonia risk in a beef-on-dairy veal production system. Secondary objectives were to assess the effect…
View details →DOI: 10.3168/jds.2026-28339 