Negative / Null Result ReportOpen accessSurgery
Taner İyigun, Mugisha Kyaruzi, Barış Timur et al. · 2019 · Turkish Journal of Vascular Surgery
Objectives: This study aims to compare midterm results of patch angioplasty with primary closure techniques in patients undergoing carotid endarterectomy (CEA) in terms of restenosis. Patients and methods: This prospective, single-center, randomized study included a total of 137 patients (42 females, 95 males; mean age 64.4±8.8 years; range 36 to 86 years) who underwent CEA between January 2010 and October 2015. The patients were divided into two groups: the patch angioplasty group (n=70) and the primary closure group (n=67). The mean follow-up was 2-7 years. Carotid computed tomography angiog
Negative / Null Result ReportOpen accessMedical technology
Simon Marchant, Shona Michael, Laura Milner et al. · 2019 · Journal of Rehabilitation and Assistive Technologies Engineering
Introduction Functional electrical stimulation uses clinician-set parameters to modify stimulation. This study aimed to investigate whether timing parameters in the ODFS Pace functional electrical stimulation device have an effect on the gait of the general population of functional electrical stimulation users who have a foot drop. Methods Twelve functional electrical stimulation users with foot drop resulting from upper motor neurone disorders were recruited from the functional electrical stimulation Service in Leeds, UK. A crossover trial design was used, comparing adjusted values of rising
View details →DOI: 10.1177/2055668319859142 Negative / Null Result ReportOpen accessEducation
ولاء أحمد عباس مرسى · 2018 · تکنولوجیا التعلیم: سلسلة دراسات و بحوث
هدف البحث إلى تحديد انسب نمط لبيئة التعلم المقلوب (تدريس الأقران مقابل الاستقصائي) في إطار تفاعله مع استراتيجية التنظيم الذاتي للتعلم (البحث عن المساعدة مقابل البحث عن المعلومات)، ودراسة مدى تأثيرها في تنمية التحصيل الفوري والمرجأ، ودافعية الإنجاز، والرضا عن بيئة التعلم لدى طلاب تکنولوجيا التعليم. وقد استخدم في هذا البحث التصميم التجريبي ذي المجموعات التجريبية الأربعة، وهو امتداد للتصميم التجريبي ذي المجموعة الواحدة، واشتمل البحث على متغير مستقل وله مستويان: بيئة التعلم المقلوب (تدريس الأقران مقابل الاستقصائي)، مع استراتيجية التنظيم الذاتي للتعلم (البحث عن المساعدة مقابل البحث عن المعلومات)، و
View details →DOI: 10.21608/tesr.2018.124659 Negative / Null Result ReportOpen accessSurgery
Amber M. Parker, MD, Nicholas Genovese, MD, Alexy Ilchuk, BS et al. · 2026 · Journal of Hand Surgery Global Online
Purpose: To assess and compare the associative value of comorbidity fracture-specific index (CFI) versus the Charlson comorbidity index (CCI) in identifying patients at risk for early complications after open reduction and internal fixation (ORIF) of distal radius fractures (DRFs). Methods: We performed a single-center retrospective cohort study including patients ≥40 years who underwent ORIF for closed DRF using a volar locking plate with a minimum of 1 year follow-up. CCI and CFI scores were calculated based on comorbidities over the prior 15 years. The primary outcome was 90-day postoperati
View details →DOI: 10.1016/j.jhsg.2026.100959 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Grisel J. Lopez, Jens Lichtenberg, Nahid Tayebi et al. · 2022 · Frontiers in Neurology
ObjectiveBiallelic mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase, cause the lysosomal storage disorder Gaucher disease (GD). In addition, mutations in GBA1 are the most common genetic risk factor for future development of Parkinson's disease (PD). However, most mutation carriers will never develop parkinsonism. Olfactory dysfunction is often a prodromal symptom in patients with PD, appearing many years prior to motor dysfunction. The purpose of this study was to assess olfactory function longitudinally in individuals with and without parkinsonism who carry at least o
View details →DOI: 10.3389/fneur.2022.1039214 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Xingwang Li, Xingwang Li, Shaoqing Guo et al. · 2025 · Frontiers in Oncology
ObjectivesThe field of view through transanal endoscopic provides new treatment approaches for solving complex clinical problems. TAMIS belongs to single-port endoscopic surgery, and the operation is complex. Analyzing the learning curve of TAMIS aims to facilitate its better clinical promotion.MethodsA retrospective cohort study analyzed the clinical data of 58 patients who underwent TAMIS by the same surgeon from January 2018 to October 2024. The learning curve of TAMIS was obtained using the cumulative sum (CUSUM) analysis, and the optimal number of surgeries was determined based on the pea
View details →DOI: 10.3389/fonc.2025.1545589 Negative / Null Result ReportOpen accessOrthopedic surgery
A.N. Toro-Ibarguen, E. Sánchez Benito, J.M. Cortés Villar · 2026 · Revista Española de Cirugía Ortopédica y Traumatología
Background and objective: The primary objective is to evaluate the clinical and functional outcomes of tape reinforcement in anterior cruciate ligament (ACL) reconstructions, recording complications, as well as the rate of reinterventions and graft failure. Materials and methods: Retrospective analysis of ACL reconstructions with hamstring (HS) autograft that were reinforced with high-strength tape. We included patients in whom we obtained a graft of HS <8 mm or ≥8 mm of poor quality. Age, sex, body mass index (BMI), and previous activity were recorded. Clinical and functional evaluation were
View details →DOI: 10.1016/j.recot.2025.11.004 Negative / Null Result ReportOpen accessMedicine (General)
Sacide Karakas, Ayfer Metin Tellioglu, Mehmet Bilgin et al. · 2019 · Eurasian Journal of Medicine
Abstract Objective: Thalassemias major are the most common autosomal recessive disorders; they are characterized by anomalies in the synthesis of the beta chains of hemoglobin and are often associated with varying degrees of craniofacial anomalies. The purpose of this study was to evaluate the craniofacial dimensions of β-thalassemia patients and to identify differences by comparing them to those of a control group. Materials and Methods: The study comprised 43 thalassemia major patients and 26 age- and sex- matched healthy control subjects. Anthropometric measurements were performed in six di
View details →DOI: 10.5152/eurasianjmed.2016.150013 Negative / Null Result ReportOpen accessScience
Michelle E. Cameron, Susan Pfeiffer · 2014 · South African Journal of Science
Diaphyseal cross-sectional geometry can be used to infer activity patterns in archaeological populations. We examined the cross-sectional geometric (CSG) properties of adult Later Stone Age (LSA) herder–forager long bones from the inland lower Orange River Valley of South Africa (n=5 m, 13 f). We then compared their CSG properties to LSA forager adults from the coastal fynbos (n=23 m, 14 f) and forest (n=17 m, 19 f) regions, building on a previous report (Stock and Pfeiffer, 2004). The periosteal mould method was used to quantify total subperiosteal area, torsional strength, bilateral asymmetr
View details →DOI: 10.1590/sajs.2014/20130369 Negative / Null Result ReportOpen accessMedicine
Priscila Lima de Luna FREIRE, Priscila Hernández CAMPOS, Fabíola Galbiatti CARVALHO et al. · Revista de Odontologia da UNESP
Abstract Introduction Methods of decontamination or sanitization of toothbrushes have been questioned. Objective This study assessed the effectiveness of pomegranate peels infusion as a disinfectant of toothbrushes against Streptococcus mutans. Material and method A sample of 16 schoolchildren aged between 7 and 9 years performed brushing 5 days/week, with a careful brushing once a day. After each day of brushing, the toothbrushes were washed and sprayed with one disinfectant solution. This procedure was repeated for 4 weeks using one of the different solutions per week: distilled water (G1; n
View details →DOI: 10.1590/1807-2577.01416 Methods Dead-EndOpen accessFinance
Manuel Rosinus, Jan Lansky · 2025 · International Journal of Financial Studies
As investors increasingly use Environmental, Social, and Governance (ESG) criteria, a key challenge remains: ESG data is typically reported annually, while financial markets move much faster. This study investigates whether incorporating annual ESG scores can improve monthly stock return forecasts for German DAX-listed firms. We employ a multivariate long short-term memory (LSTM) network, a machine learning model ideal for time series data, to test this hypothesis over two periods: an 8-year analysis with a full set of ESG scores and a 16-year analysis with a single disclosure score. The evalu
View details →DOI: 10.3390/ijfs13030167 Failed Experiment ReportOpen accessDentistry
Alper Yuzbasioglu, Cennet Neslihan Eroglu · 2024 · BMC Oral Health
Abstract Background Alveolar osteitis is a type of small-scale osteomyelitis of the alveolar bone that occurs after tooth extraction, the etiology of which remains unknown, and alternative methods are being investigated for its treatment. The aim of this study was to compare the effectiveness of advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), and Alveogyl (butamben, idoform, eugenol), which have shown success in the treatment of alveolar osteitis, with that of pentoxifylline (PTX) to determine whether PTX could be an alternative treatment for alveolar osteitis. Methods This st
View details →DOI: 10.1186/s12903-024-05372-6 Failed Experiment ReportOpen accessMedicine
Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →DOI: 10.1371/journal.pone.0266901 Negative / Null Result ReportOpen accessGeriatrics
Michael S. Kain, David Saper, Kyle Lybrand et al. · 2020 · Geriatrics
In current clinical practice, orthopedic surgeons often delay the surgery intervention on geriatric hip fracture patients to optimize the international normalized ratio (INR), in order to decrease the risk of postoperative hematological complications. However, some evidence suggests that full reversal protocols may not be necessary, especially for patients with prior thromboembolic history. Our study aims to compare the surgical outcomes of patients with normal versus elevated INR values. We conducted a retrospective chart review on 217 patients who underwent surgeries on hip fractures at two
View details →DOI: 10.3390/geriatrics5030043 Negative / Null Result ReportOpen accessAnimal culture
Í.R.R. Castro, G.B.C. Leite, I.F. Carrari et al. · 2025 · Animal
Available literature on the effect of various physical forms of starter feed (PFSF) on calf performance is conflicting. Thus, this study aimed to investigate the effect of the PFSF on feed intake, growth performance, blood metabolites, and the health of dairy calves. Twenty-four female Holstein calves (5-d-old; 40.4 ± 3.86 kg BW; mean ± SD) were used in a completely randomized block design. Calves were individually housed and randomly assigned to the treatments (n = 12 calves/treatment): (1) textured starter feed (TSF, a mix of pelleted ingredients and whole-kernel corn) and (2) pelleted start
View details →DOI: 10.1016/j.animal.2024.101400 Negative / Null Result ReportOpen accessMedicine
Sarah M. Alghamdi, Paul N. Schofield, Robert Hoehndorf · 2022 · Disease Models & Mechanisms
Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past decade, cross-species phenotype comparisons have proven valuble, and several ontologies have been developed for this purpose. The relative contribution of different model organisms to computational identification of disease-associated genes is not fully explored. We used phenotype ontologies to semantically relate phenotypes resulting from loss-of-function mu
View details →DOI: 10.1242/dmm.049441 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Maria Antonietta Gambacorta, Antonino De Paoli, Marco Lupattelli et al. · 2018 · Clinical and Translational Radiation Oncology
Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6–8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned. Adjuvant chemotherapy was administrated in ypN1-2 pts. After a median f/u of
View details →DOI: 10.1016/j.ctro.2018.02.003 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Rathi N. Pillai, MD, Suresh S. Ramalingam, MD, Meena Thayu, MD et al. · 2021 · JTO Clinical and Research Reports
Introduction: The programmed death-ligand 1 inhibitor atezolizumab improves progression-free survival (PFS) and overall survival (OS) for patients with previously treated advanced NSCLC. Preclinical studies indicate that targeting CD38-positive cells with daratumumab may synergistically enhance atezolizumab’s antitumor activity by increasing the effector T-cell activity. Methods: This phase 1b-2 study included a safety run-in (one cycle of daratumumab plus atezolizumab) and randomized phases (daratumumab plus atezolizumab versus atezolizumab alone). The primary objective of the randomized phas
View details →DOI: 10.1016/j.jtocrr.2020.100104 Negative / Null Result ReportOpen accessVeterinary medicine
E. Milena Vazquez, Beatriz Romero, Raquel Diez et al. · 2026 · Frontiers in Veterinary Science
Optimizing the use of the existing anthelmintics has become a priority, as resistance is a growing concern worldwide and the development of novel antiparasitic drugs slow. The paper describes the pharmacokinetic interaction between the antiparasitic albendazole (ABZ) and the choleretic drug menbutone (MEN) in calves, when ABZ was administered orally (7.5 mg/kg) alone or with intramuscular MEN (10 mg/kg) (1 or 2 doses 24 h apart) to 12 animals. Blood samples were collected at 14 sampling points over 72 h, and plasma concentrations of ABZ, albendazole sulfoxide (ABZSO, active metabolite), and al
View details →DOI: 10.3389/fvets.2026.1834486 Negative / Null Result ReportOpen accessVeterinary medicine
Andrew S. Hanzlicek, Kate S. KuKanich, Audrey K. Cook et al. · 2023 · Journal of Veterinary Internal Medicine
Abstract Background Culture can be used for diagnosis and antifungal susceptibility testing in animals with fungal infections. Limited information is available regarding the diagnostic performance of culture and the susceptibility patterns of Histoplasma spp. isolates. Hypothesis/Objectives Describe the clinical utility of culture and the susceptibility patterns of Histoplasma spp. isolates causing histoplasmosis in cats and dogs. Animals Seventy‐one client‐owned animals, including 33 cats and 19 dogs with proven or probable histoplasmosis. Methods Culture was attempted from tissue or fluid sa
View details →DOI: 10.1111/jvim.16725 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Katrin Abram, Silvia Bohne, Peter Bublak et al. · 2016 · Dementia and Geriatric Cognitive Disorders Extra
Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in al
View details →DOI: 10.1159/000450602 Negative / Null Result ReportOpen accessMedicine
Christopher B Estopinal, Janneke H van Dijk, Stanley Sitali et al. · 2012 · PLoS ONE
Background We assessed the impact of home-based care (HBC) for HIV+ patients, comparing outcomes between two groups of Zambians receiving antiretroviral therapy (ART) who lived in villages with and without HBC teams. Methods We conducted a retrospective cohort study using medical charts from Macha Mission Hospital, a hospital providing HIV care in Zambia's rural Southern Province. Date of birth, date of ART initiation, place of residence, sex, body mass index (BMI), CD4+ cell count, and hemoglobin (Hgb) were abstracted. Logistic regression was used to test our hypothesis that HBC was associate
View details →DOI: 10.1371/journal.pone.0049564 Negative / Null Result ReportOpen accessMedicine
Simson Tarigan, Gita Sekarmila, Apas et al. · 2024 · PLoS ONE
Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a
View details →DOI: 10.1371/journal.pone.0306153 Negative / Null Result ReportMedicine
Blow KE, Quigley D, Sosso GC · 2026 · The Journal of chemical physics
Molecular dynamics is routinely used to investigate crystal nucleation rates via computer simulations. According to classical nucleation theory, the size of the largest cluster should be the best approximation of the reaction coordinate.…
View details →DOI: 10.1063/5.0318093 Negative / Null Result Report
Wu H, Liang Y, Li J et al. · 2025 · Preprint
Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to…
View details →DOI: 10.21203/rs.3.rs-404499/v2 Failed Experiment ReportMedicine
Day M, Kearney S · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To explore methods of evaluating success of optical myopia control interventions, and to apply these methods retrospectively to a clinical population. Methods A retrospective cohort study was conducted on pediatric patients…
View details →DOI: 10.1002/ovs2.70075 Failed Experiment Report
Tibenderana JR, Kessy SA, Kimaro LJ et al. · 2026 · Preprint
Abstract Background Universal Health Coverage (UHC) aims to ensure that all individuals have access to essential healthcare services without financial hardship, including institutional childbirth which is key component for reducing…
View details →DOI: 10.21203/rs.3.rs-9518942/v1 Negative / Null Result ReportMedicine
Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy
Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…
View details →DOI: 10.1007/s40258-026-01051-5 Negative / Null Result ReportMedicine
Guevara-Freire D, Escudero RM, Calvo L et al. · 2026 · Meat Science.
This study evaluated the effect of dietary linoleic acid (C18:2) inclusion on fat deposition and fatty acid composition in barrows and gilts. A total of 960 Danbred pigs (half barrows, half gilts) were assigned to two dietary treatments…
Negative / Null Result ReportOpen accessMedicine
Amırlı H, Gurbanli E · 2026 · BMC psychology
The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…
View details →DOI: 10.1186/s40359-026-04520-7 