A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21707 results · page 227 of 724
Djordjevic N, Todorovic A, Sazdanovic P et al. · 2025 · Biomedicines
Objectives : Chlamydia trachomatis (CT) infection affects female fertility. The purpose of our study was to assess the association between serological and follicular fluid markers of CT infection and in vitro fertilization (IVF) success.…
Kyriakidis I, Pelagiadis I, Martimianaki G et al. · 2026 · Cureus
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children, but the inherited factors influencing susceptibility are not fully understood. Given the link between defective microRNA biogenesis and aggressive NB,…
Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics
Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…
Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology
Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…
Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…
Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica
Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…
Zhang X, Goldberg SB, Baldwin SA et al. · 2025 · Journal of consulting and clinical psychology
Objective This study applied a machine-learning-based skill assessment system to investigate the association between supportive counseling skills (empathy, open questions, and reflections) and treatment outcomes. We hypothesized that…
Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care
Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…
Ellenardóttir V, Coronel R, Folke F et al. · 2024 · Open heart
Aim Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the…
Nacar MC, Yigit S · 2023 · Nucleosides, nucleotides & nucleic acids
Background Osteoporosis (OP) is a common systemic, metabolic bone disease that affects 40% of postmenopausal women. Oxidative stress (OS) ìs caused by reactive oxygen species (ROS), inhibits osteoblast differentiation and causes apoptosis…
Sato K, Arasaki N, Agena S et al. · 2025 · JMA journal
Introduction Increased muscle mass may positively influence the recovery of balance function. In this study, we aimed to investigate the relationship between changes in muscle mass and improved balance in patients with cerebral infarction.…
Lozano-Meca JA, Gacto-Sánchez M, Montilla-Herrador J · 2024 · European journal of pain (London, England)
Introduction Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR).…
Daniel S, Hou R, Galea I et al. · 2025 · Brain, behavior, & immunity - health
Background Subarachnoid haemorrhage (SAH) is a severe type of intracranial bleed that causes significant morbidity. One of the most overlooked yet commonly reported symptom is persistent fatigue. Fatigue in the general population has been…
Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports
This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…
Tian Y, Kim H, Ratcliffe PJ et al. · 2026 · Preprint
Oxidative post-translational modifications on the sulfhydryl group of cysteines can occur spontaneously or enzymatically. The dioxygenation of N-terminal cysteines has emerged as a new oxygen sensing paradigm, catalysed by…
Franco Vega I · 2026 · Journal of sex research
This study assessed the effects of condom types and brands on use in a free condom distribution intervention in hostales (love hotels). New policies are needed to overcome the low levels of contraceptive use in Perú. Hostales could serve…
Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals
Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…
Sundarakrishnan A, Siek B, Clarke PBS · 2026 · Behavioural brain research
The sucrose preference test is the primary measure of anhedonia in rat models of depression, but it does not specifically assess anticipatory anhedonia, a deficit commonly observed in patients. Anticipatory 50-kHz ultrasonic vocalizations…
Getman-Pickering Z, Thaler J, Davis J et al. · 2026 · Preprint
During domestication, selection has typically decreased plant resistance to herbivores and reduced beneficial relationships with microbial mutualists such as mycorrhizae. These two processes raise the question of whether reductions in…
S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology
This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…
Gonotkov MA, Safiulina VF · 2026 · Preprint
Whole-cell patch-clamp studies often fail to observe the expected effect of melatonin on the IK1 current in cardiomyocytes, which may be due to cytoplasmic dialysis and the loss of key components of the intracellular signaling system. The…
Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…
Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…
Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…
Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…
Alshuweishi Y, Binzomah Alghamdi F, Patrick K et al. · 2025 · Cells
AMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane. In contrast, we have previously reported…
Kishinevsky M, Ferrer-Suay M, Ives AR · 2024 · Preprint
The enemy release hypothesis, that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range, can be an important explanation for successful invasions. Testing this…
Almutairi NM, Hayes J, Hampson KM et al. · 2025 · Vision research
Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate…
Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells
Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…
Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…