Negative / Null Result ReportOpen accessMedicine
Ghalib A Akinlabi, Paul L Kaufman, Julie A Kiland · 2021 · PLoS ONE
Purpose In earlier experiments in Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model. The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates. Methods Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3). The monkeys were sedated with 5-10 mg/kg ketamine HCl IM. PT was administered to the right eye and BSS to the left eye. Baseline IOP was measured just prior to beginning treatment, and on day
View details →DOI: 10.1371/journal.pone.0256422 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →DOI: 10.20996/1819-6446-2025-3241 Negative / Null Result ReportOpen accessMedicine
Shurong Huang, Zhe Su, Huiping Su et al. · 2022 · Scientific Reports
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
View details →DOI: 10.1038/s41598-022-19470-4 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Edvan de Queiroz Crusoe, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha et al. · 2014 · Revista Brasileira de Hematologia e Hemoterapia
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone. Methods: The records of 152 patients who underwent autologous transplantation at this institution
View details →DOI: 10.5581/1516-8484.20140008 Negative / Null Result ReportOpen accessSpecial aspects of education
Élida de Fátima Diniz Souza, Ana Paula Ramos Machado, José Danúzio Leite de Oliveira et al. · 2025 · BMC Medical Education
Abstract Background In Brazil, residency programmes in Family and Community Medicine (FCM) and Multiprofessional Residency in Family Health (MRFH) are two-year specialisation courses, funded by the federal government, which aim to train professionals to work in Primary Health Care (PHC). The aim of this study was to draw up an inventory of the assessed competences of the residency programmes in the state of Paraíba, Brazil. Our study’s hypothesis is that self-assessment of competences can be a useful tool for monitoring the development of competences in the training of health professionals, co
View details →DOI: 10.1186/s12909-025-07521-z Negative / Null Result ReportOpen accessMedicine
Christine B. French, Sharon L. McDonnell, Reinhold Vieth · 2019 · Journal of Medical Case Reports
Abstract Background Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw. Case presentation The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from
View details →DOI: 10.1186/s13256-018-1948-9 Negative / Null Result ReportOpen accessSpecial aspects of education
Wei Han Hong, Jamunarani Vadivelu, Esther Gnanamalar Sarojini Daniel et al. · 2015 · Medical Education Online
Background: Studies have shown the importance of metacognition in medical education. Metacognitive skills consist of two dimensions: knowledge of metacognition and regulation of metacognition. Aim: This study hypothesizes that the knowledge and regulation of metacognition is significantly different at the beginning and end of the academic year, and a correlation exists between the two dimensions of metacognitive skills with academic performance. Methods: The Metacognitive Skills Inventory comprising 52 Likert-scale items was administered to 159 first-year medical students at the University of
View details →DOI: 10.3402/meo.v20.27561 Negative / Null Result ReportOpen accessGynecology and obstetrics
Bingqian Zhang, Lianbao Cao, Lingling Ding et al. · 2017 · Gynecology and Minimally Invasive Therapy
Objective: To evaluate the effects of different treatment methods for previous ectopic pregnancies (EP) on cryopreserved embryo transfer (CET) outcomes. Materials and Methods: This was a retrospective cohort study. Patients with EP histories were divided into four groups based on their previous EP treatments: Group 1—unilateral tubal removal; Group 2—bilateral tubal removal or unilateral tubal removal with contralateral tubal ligation; Group 3—conservative surgery group; and Group 4—conservative medication group. A total of 1333 women with previous histories of being admitted to the hospital f
View details →DOI: 10.1016/j.gmit.2017.01.001 Negative / Null Result ReportOpen accessMedicine (General)
Rui Ping Peng, Zi Qian Zhu, Hong Yi Shen et al. · 2022 · Frontiers in Medicine
ObjectiveThis study aimed to observe vascular and neuroretinal alterations in people with prediabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)] and normal glucose metabolism.MethodsA total of 21 patients with prediabetes (42 eyes) and 20 healthy controls (40 eyes) participated in our study. All patients underwent a complete eye examination [including fundus fluorescein angiography (FFA) and optical coherence tomography (OCT)] and a related general examination (complete biochemical analysis, routine blood tests, and glycosylated hemoglobin).ResultsOn FFA, no patients
View details →DOI: 10.3389/fmed.2022.777646 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Alexandra Skovran, Mason Hinke, Shelly N. B. Sloan et al. · 2022 · Emergency and Critical Care Medicine
Abstract. Background. Sepsis is the leading cause of death in hospitalized patients and significant effort has been made to facilitate early diagnosis and management. However, aggressive treatment can have negative effects, especially in patients with unstable volume status, such as those with congestive heart failure. Methods. We used electronic medical records to perform a retrospective study looking at hospital outcomes in patients from Southwest Missouri who were admitted with sepsis and had a comorbid diagnosis of hypertensive heart failure. Our primary outcome was in-hospital mortality.
View details →DOI: 10.1097/ec9.0000000000000033 Negative / Null Result ReportOpen accessDentistry
Utku Böcüoğlu, Esra Ateş Yıldırım, Selma Erdoğan Düzcü et al. · 2026 · BMC Oral Health
Abstract Objectives This in vitro study aimed to evaluate the effect of laser photobiomodulation on the structural integrity and degradation resistance of two types of platelet-rich fibrin membranes: Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Titanium-Prepared Platelet-Rich Fibrin (T-PRF). Structural changes in the fibrin network were assessed using Scanning Electron Microscopy (SEM) and light microscopy. Materials and methods Our study was performed on 15 systemically healthy individuals and four L-PRF and four T-PRF membranes obtained from each individual, totaling 120 samples. L-PRF wa
View details →DOI: 10.1186/s12903-026-07974-8 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Zhu Guo-Pei, Lu Jiade, Xiong Xiao-Peng et al. · 2011 · Radiation Oncology
Abstract Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were rando
View details →DOI: 10.1186/1748-717x-6-4 Negative / Null Result ReportOpen accessSurgery
Eiji Nomura, Takatoshi Seki, Kentaro Yatabe et al. · 2024 · World Journal of Surgical Oncology
Abstract Background Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary. Methods A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative condit
View details →DOI: 10.1186/s12957-024-03488-1 Negative / Null Result ReportOpen accessMedicine
Falcão MG, Suarez MA, Ferreira ACOP et al. · 2026 · Acta ortopedica brasileira
Objective To analyze the outcomes related to partial and total hip arthroplasties in elderly patients with femoral neck fractures at a hospital in the city of São Paulo. Material and methods We reviewed the medical records of patients…
View details →DOI: 10.1590/1413-785220263403e299827 Negative / Null Result ReportOpen accessDentistry
Muhammad Zubair Ahmad · 2024 · International Journal of Dentistry
Objectives. Rotary single-file endodontic systems are commonly used for root canal treatment. However, very few studies have evaluated the apical extrusion of debris generated by these systems during canal preparation at normal body temperature in laboratory conditions. The aim of this study was to evaluate the amount of apically extruded debris caused by seven different single-file endodontic instrumentation systems at body temperature in mandibular molar teeth with curved root canals. Methods. One hundred forty mandibular first permanent molars were randomly divided into seven groups (n = 20
View details →DOI: 10.1155/2024/8367693 Negative / Null Result ReportOpen accessBiotechnology
Cai Wang, Cai Wang, Dongyuan Xin et al. · 2023 · Frontiers in Bioengineering and Biotechnology
Introduction: Interleukin-6 (IL-6) is a multifunctional polypeptide cytokine composed of two glycoprotein chains, which plays an important role in many cellular reactions, pathological processes, diagnosis and treatment of diseases and so on. The detection of IL-6 plays a promising role in the cognition of clinical diseases.Methods: 4-mercaptobenzoic acid (4-MBA) was immobilized on the gold nanoparticles modified platinum carbon (PC) electrode with the linker IL-6 antibody, and finally formed an electrochemical sensor that specifically recognized IL-6. Through the highly specific antigen-antib
View details →DOI: 10.3389/fbioe.2023.1128934 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia et al. · 2025 · Therapeutic Advances in Gastroenterology
Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients’ outcomes. Design: A single-c
View details →DOI: 10.1177/17562848251323529 Negative / Null Result ReportOpen accessMedicine
Qina Ye, Shaodan Sun, Jian Deng et al. · 2023 · Scientific Reports
Abstract To investigate the gut microbiota distribution and its functions in children with avoidant/restrictive food intake disorder (ARFID). A total of 135 children were enrolled in the study, including 102 children with ARFID and 33 healthy children. Fecal samples were analyzed to explore differences in gut microbiota composition and diversity and functional differences between the ARFID and healthy control (HC) groups via 16S rDNA and metagenomic sequencing. The gut microbiota composition and diversity in children with ARFID were different from those in heathy children, but there is no diff
View details →DOI: 10.1038/s41598-023-47760-y Negative / Null Result ReportOpen accessAnimal culture
R. Shi, D. Liu, J. Sun et al. · 2015 · Czech Journal of Animal Science
Iron (Fe) is an essential mineral for animal development and function. The present study was carried out to evaluate the effect of replacing FeSO4 with iron glycine chelate (Fe-Gly) in the equal Fe level in diets on broiler chickens. The broilers were randomly allotted to 6 dietary treatments with 5 replicate pens and 10 birds per pen. The treatments consisted of: Control group (100 mg Fe from FeSO4/kg diet), Experimental group 1 (80 mg Fe from FeSO4 + 20 mg Fe from Fe-Gly/kg diet), Experimental group 2 (60 mg Fe from FeSO4 + 40 mg Fe from Fe-Gly/kg diet), Experimental group 3 (40 mg Fe from F
View details →DOI: 10.17221/8173-cjas Negative / Null Result ReportOpen accessBanking
Suripto, Arif Sugiono, Havid Dasuki · 2023 · Banks and Bank Systems
This study aims to analyze the comparison of the resilience of Islamic and conventional banking in the Association of Southeast Asian Nations (ASEAN) during the COVID-19 pandemic. Comparison of banking resilience was proxied by the Capital Adequacy Ratio (CAR) and Loan-to-Deposit Ratio (LDR) factors, Return on Assets (ROA) and Non-Performing Loans (NPL) with the Multiple Discriminant Analysis test. In this case, the emphasis is placed on the patterns by which Islamic and conventional banking in ASEAN weathered the recent financial crisis during the COVID-19 pandemic. The explanatory and quanti
View details →DOI: 10.21511/bbs.18(3).2023.16 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Davies Isabel R, Gavrilovic Jelena, Baugh Mark D et al. · 2003 · Cardiovascular Diabetology
Abstract Background Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte – macrophages. As MMP expression can be promoted by the modified lipoproteins, oxidative stress and hyperglycaemia that characterises Type 2 diabetes, we hypothesised that peripheral monocytes in these patients, exposed to these factors in vivo, would demonstrate increased MMP production compared to controls. Methods We examined peripheral venous monocyte expression of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 18
View details →DOI: 10.1186/1475-2840-2-3 Negative / Null Result ReportOpen accessMedicine
Sabah Jalal Sherif, Baderkhan Saeed Ahmed, Botan Abdul Kadir Ali · 2023 · Advanced Medical Journal
Background and objective: Acute appendicitis is one of the most common surgical emergency con-ditions. This study was done to clarify the effect of antibiotics in reducing post appendectomy com- plications after open and laparoscopic appendectomy in patients with non-perforated appendicitis. Methods:This is a randomized controlled trial. Three hundred and twenty one patients, who underwent appendectomy for non-perforated appendicitis and fulfilled the selection criteria, were randomly divided into two groups. The patients in group A received double dose of pre-operative and postoperative antib
View details →DOI: 10.56056/amj.2016.09 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Guozhong Wang, Quanming Zhao, Qing Cheng et al. · 2019 · BMC Cardiovascular Disorders
Abstract Background The rational length of stay following non-complicated percutaneous coronary intervention (PCI) for Non-ST elevation myocardial infarction (NSTEMI) patients remains controversial. Few studies have examined the impact of early discharge on short-term outcomes in NSTEMI patients, but short-time discharge is not uncommon in real world practice. This study examined the impact of short time discharge following non-complicated PCI on 30-day net adverse clinical events in NSTEMI patients. Methods This retrospective study enrolled 1424 consecutive patients with NSTEMI diagnoses who
View details →DOI: 10.1186/s12872-019-1096-1 Negative / Null Result ReportOpen accessPlant culture
Qing Zhou, Qing Zhou, Qing Zhou et al. · 2020 · Frontiers in Plant Science
Triploid breeding is a central way to improve growth traits, timber quality, and stress resistance in Populus. In the present study, the morphology and viability of colchicine-induced 2n pollen, triploid production by crossing induced 2n pollen, and identification of genetic constitution of colchicine-induced 2n pollen were conducted in Populus canescens based on optimizing technology for inducing chromosome doubling in pollen. We found that the meiotic stage, injection time, and the interaction between the meiotic stage and injection time had highly significant effects on the 2n pollen produc
View details →DOI: 10.3389/fpls.2020.00295 Negative / Null Result ReportOpen accessDentistry
Azam Valian, Zahra Jaber Ansari, Mohammad Moien Rezaie et al. · 2021 · BMC Oral Health
Abstract Background Esthetic dental restorations have gained increasing popularity. The surface of restorations should be smooth enough to achieve maximum esthetics and prevent the adhesion of microorganisms and food particles. This study aimed to assess the surface roughness and color change of composite specimens following airflow usage. Methods In this in vitro, experimental study, 30 Tokuyama composite discs were fabricated and randomly divided into three groups (n = 10) for the use of airflow with calcium carbonate/bicarbonate powder and conventional polishing with FlexiDisc. The surface
View details →DOI: 10.1186/s12903-021-01745-3 Negative / Null Result ReportOpen accessMedicine
Mustafa Umut Somuncu, Huseyin Karakurt · 2019 · Türk Kardiyoloji Derneği Arşivi
Objective: Primary prevention of sudden cardiac death in ST-elevation myocardial infarction (STEMI) is a complicated issue due to the highly heterogeneous population. The effect of T-wave alternans (TWA) on cardiac mortality has been examined in various populations, most often in patients with a high risk of fatal arrhythmia, such as patients with a low left ventricular ejection fraction (LVEF). The aim of the present study was to investigate the prevalence of TWA and its relationship to cardiac mortality in young STEMI patients with preserved LVEF. Methods: A total of 108 STEMI patients with
View details →DOI: 10.5543/tkda.2019.47905 Negative / Null Result ReportOpen accessMedicine (General)
Xu Xiaofeng, Zhan Linsen, Lu Huarong et al. · 2024 · Vojnosanitetski Pregled
Background/Aim. Since finding a safe and efficient strategy of multimodal postoperative analgesia and sedation is particularly critical, it is important that dexmedetomidine (DM) combined with opioid anesthetics can enhance that through a synergistic action. The aim of the study was to assess the effect of butorphanol tartrate (BT) combined with DM on postoperative analgesia. Methods. A total of 100 elderly patients undergoing general anesthesia surgery from January 2019 to June 2022 were selected. The patients were divided into two equal groups – research group (RG) and control group (CG), us
View details →DOI: 10.2298/vsp230606003x Negative / Null Result ReportOpen accessDentistry
Mohamed Abo-El-Saad, Sherif Ayad, Lydia Melek et al. · 2023 · Alexandria Dental Journal
Background: After extracting teeth, both remarkable resorption in the alveolar bone and an obvious reduction have occurred in the labial bone plate as a consequence of the blood supply deficiency that happens especially when the periodontal ligaments are lost. Therefore, to keep the periodontal ligaments preserved, a socket shield technique with autogenous dentine was introduced.Aim of this study: Radiographic evaluation of a combined technique using autogenous dentin graft with socket shield for pre-implant socket preservationPatient and method: Eight patients received socket preservation usi
View details →DOI: 10.21608/adjalexu.2022.146114.1290 Negative / Null Result ReportOpen accessOphthalmology
Jehan Fauzi Rakhmandani, Indra Tri Mahayana, Felicia Widyaputri et al. · 2023 · Taiwan Journal of Ophthalmology
PURPOSE: To assess the change of interleukin-6 (IL-6) levels in tears and ocular clinical parameters in corneal ulcer patients with moderate-to-severe infection after adjunctive therapy with platelet-rich fibrin (PRF) lysate-eyedrops compared with autologous serum eyedrops. MATERIALS AND METHODS: This study was a randomized double-blind controlled trial, which compared two groups of patients at Dr. Sardjito Hospital, Yogyakarta. A total of 42 patients (42 eyes) were divided into the control group (21 patients) and the intervention group (21 patients). All patients received antibacterial/antifu
View details →DOI: 10.4103/tjo.tjo-d-23-00023 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Reza Azizkhani, Mehrdad Esmailian, Azadeh shojaei et al. · 2015 · Emergency
Introduction: Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. Therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular injection of hydrochloride ketamine in pediatric patients need laceration repair. Methods: The presented study is a single-blinded clinical trial performed through 2013 to 2014 in Ayatollah Kashani and Alzahr
