A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
84 results in Abandoned Hypothesis · page 2 of 3
M. Jůzl, A. Saláková, M. Müllerová et al. · 2018
Higher salt content in foods brings health risks associated with hypertension and leads to an increased risk of strokes and fatal vascular diseases. For this study, a frankfurter was chosen as a frequently consumed meat product. In…
A. Saiiari, M. Kashef, M. Adel et al. · 2017
Background: In the majority of cardiovascular diseases, cardiovascular structure changes in line with the type of disease. One of the goals of cardiac rehabilitation is the improvement of cardiac performance and reversibility of…
Kathleen F Brookfield, Michael C Cheung, Relin Yang et al. · 2009 · PLoS ONE
OBJECTIVE: Patient chances for cure and palliation for a variety of malignancies may be greatly affected by the care provided by a treating hospital. We sought to determine the effect of volume and teaching status on patient outcomes for five gynecologic malignancies: endometrial, cervical, ovarian and vulvar carcinoma and uterine sarcoma. METHODS: The Florida Cancer Data System dataset was queried for all patients undergoing treatment for gynecologic cancers from 1990-2000. RESULTS: Overall, 48,981 patients with gynecologic malignancies were identified. Endometrial tumors were the most common
Jalan R, Patel VC, Shoaie S · 2026 · The lancet. Gastroenterology & hepatology
This Viewpoint examines the evolving role of rifaximin in cirrhosis, arguing that therapeutic drift has outpaced evidence and antimicrobial stewardship. While rifaximin is effective for secondary prevention of recurrent overt hepatic…
Derakhshan A, Zia MJ, Tavakkol Afshari J et al. · 2026 · Medical hypothesis, discovery & innovation ophthalmology journal
Background Primary open-angle glaucoma (POAG) is characterized by increased resistance to aqueous humor outflow. Transforming growth factor beta-1 (TGF-beta1) contributes to this resistance by promoting synthesis and remodeling of the…
Sommer K, Russell S, Paynter J · 2026 · Preprint
This pre-registered study examined whether autistic preschool children could learn novel words from a social robot during a shared eBook reading session, how their engagement with the robot relates to word learning, and whether their…
Nunthakunatip K, Borhan S · 2026 · Emergency medicine journal : EMJ
A focused literature review assessed whether starting therapeutic anticoagulation (AC) during or soon after hospitalisation for sepsis-induced new-onset atrial fibrillation (AF) affects stroke or bleeding risk. Four observational studies…
Chang TP, Kuo YH, Bery AK · 2026 · Frontiers in neurology
Background Dizziness is common in older adults, and often presents a diagnostic challenge. Vestibular function declines with age, but the prevalence and diagnostic explanatory value of mild vestibular loss in isolation (i.e., the clinical…
Smurzynska Z, Lerolland E, Siedlecki KL · 2026 · Memory (Hove, England)
Previous research examining the directive function in autobiographical memory in college-aged participants found that recalling autobiographical memories related to physical activity was associated with an increase in subsequent physical…
Potapova S, Zugan E, Isakov Y et al. · 2026 · International journal of molecular sciences
Fetal hypoxia and maternal stress during pregnancy are major risk factors for neurological disorders. The effects of maternal hypoxia may be transmitted to the next generation through persistent alterations in maternal endocrine and…
Yu M, Mao E, Xu Y et al. · 2026 · Journal of clinical medicine
Background : The prognostic significance of early triglyceride (TG) reduction in hyper-triglyceridemic acute pancreatitis (HTG-AP) remains controversial. This study aimed to investigate the association between admission TG levels, early TG…
Sun YM, Wang YJ, Wang HF et al. · 2026 · Zhonghua er ke za zhi = Chinese journal of pediatrics
Objective: To analyze the clinical and genetic characteristics of infantile-onset Pompe disease (IOPD) and evaluate the long-term efficacy of enzyme replacement therapy (ERT). Methods: A retrospective cohort study was conducted on 24 IOPD…
Holmqvist Larsson K, Falkenström F, Andersson G et al. · 2026 · Child and adolescent psychiatry and mental health
Background Emotion dysregulation is a transdiagnostic construct associated with psychiatric symptomatology. Improving strategies to regulate emotions is an important focus in several psychological treatments. In the current study we…
Gerogianni A, Sørensen G, Hoel TN et al. · 2026 · International journal of molecular sciences
Left ventricular assist device (LVAD) implantation is a life-saving therapy for end-stage heart failure but may compromise immune integrity. Mechanical shear stress and surface-induced innate immune activation can trigger bleeding and…
Sporns PB, Almohammad M, Minnerup J et al. · 2025 · Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
BackgroundWhile endovascular thrombectomy (EVT) is firmly established for large vessel occlusion stroke, recent enthusiasm for extending EVT to distal medium vessel occlusions (DMVOs) has been tempered by the neutral results of three major…
Xu X, Qin F, Li L et al. · 2025 · BMC pregnancy and childbirth
Objective To present 2 cases of placental rupture at delivery after fetoscopic SOLOMON technique for twin-twin transfusion syndrome. Methods 2 cases diagnosed with TTTS in the second trimester. Fetoscopic SOLOMON procedure was performed…
Jones GA · 2025 · Critical criminology
Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…
Al Essa A, Schmidt HG, Mamede S et al. · 2026 · Medical education
Objective The purpose of the study reported in this article was to shed light on the cognitive mechanism mediating between biasing information and diagnostic error. The literature suggests at least two different hypotheses: premature…
McNamara ME, Becker MS, Nota JA et al. · 2026 · Journal of anxiety disorders
While rumination has been recognized in clinical settings as prevalent and problematic for individuals with obsessive compulsive disorder (OCD), its relationship to OCD symptom trajectories has been understudied. In a large sample of N =…
Bybee SG, Clayton JL, Aruscavage N et al. · 2025 · The Gerontologist
Background and objectives Persons living with dementia often rely upon a care partner as their surrogate medical decision maker, yet little is known about how dementia care dyads achieve advance care planning (ACP) concordance: when a care…
Reynolds GP · 2024 · Journal of psychopharmacology (Oxford, England)
A major effort of the pharmaceutical industry has been to identify and market drug treatments that are effective in ameliorating the symptoms of psychotic illness but without the limitations of the current treatments acting at dopamine D2…
McCutcheon RA, Jauhar S, Pillinger T · 2026 · The British journal of psychiatry : the journal of mental science
Half a century of neuroimaging has transformed our understanding of psychiatric disorders but not our clinical practice. This piece examines why that promise remains unfulfilled and argues that the future lies not in ever newer tools but…
Kwon SB, Megjhani M, Nametz D et al. · 2023 · Resuscitation plus
Background Despite significant progress in cardiopulmonary resuscitation and post-cardiac arrest care, favorable outcome in out-of hospital sudden cardiac arrest patients remains low. One of the main reasons for mortality in these patients…
Trinh AT, McMurray JC, Pittman LM et al. · 2025 · JACC. Case reports
Background IgE-mediated anaphylaxis to iodinated contrast media (ICM) is rare but potentially life threatening. Unlike non-IgE-mediated reactions, cases are often resistant to corticosteroid and antihistamine premedication. Case summary A…
Fauny M, Fresse A, Loeuille D et al. · 2026 · Journal of medical case reports
Background Intra-articular corticosteroid injections represent a therapeutic option for the management of various pain conditions; however, they are not devoid of the potential for adverse drug reactions. In this study, we present a rare…
Wen CP, Tsai MK, Wen C et al. · 2026 · Gut and liver
Background/aims Colorectal cancer (CRC) risk is approximately 0.1% according to registry data, and fecal immunochemical tests (FITs) identify approximately 5% of screened individuals as positive. We evaluated whether a negative FIT result…
Feng W, Ye Q, Wang Q et al. · 2026 · Journal of surgical case reports
Hemorrhagic rupture of a simple liver cyst is a rare clinical occurrence. Whether external physical forces can trigger such rupture remains unclear. A 47-year-old woman presented with acute abdominal pain 72 h following an electrical…
Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA
Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…
Bruno MT, Pagana A, Aiello T et al. · 2026 · BMC cancer
Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…
Das Gupta S, Kamishita K, Kondo M et al. · 2026 · Journal of functional morphology and kinesiology
Objectives : Treadmill walking is often employed for tightly controlled gait and energetics research, but growing evidence suggests that treadmill-based metabolic and biomechanical measurements may not directly reflect the ecologically…