A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Martín Cowie, Holger Woehrle, Karl Wegscheider et al. · 2015 · New England Journal of Medicine
BACKGROUND: Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering…
Mark R. Gilbert, Meihua Wang, Kenneth Aldape et al. · 2013 · Journal of Clinical Oncology
PURPOSE: Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of…
Mark S. George, Sarah H. Lisanby, David Avery et al. · 2010 · Archives of General Psychiatry
CONTEXT: Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions. OBJECTIVE: To…
Nicholas J. Robert, Véronique Dièras, John A. Glaspy et al. · 2011 · Journal of Clinical Oncology
PURPOSE: This phase III study compared the efficacy and safety of bevacizumab (BV) when combined with several standard chemotherapy regimens versus those regimens alone for first-line treatment of patients with human epidermal growth…
Lawrence S. Honig, Bruno Vellas, Mark Woodward et al. · 2018 · New England Journal of Medicine
BACKGROUND: Alzheimer's disease is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to increase the clearance from the brain of soluble Aβ, peptides that may…
Carlos A. Morillo, José Antônio Marin‐Neto, Álvaro Avezum et al. · 2015 · New England Journal of Medicine
BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who…
Richard Klein, Michelangelo Vianello, Fred Hasselman et al. · 2018 · Advances in Methods and Practices in Psychological Science
We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was…
Andreas Wieland, Carl Marcus Wallenburg · 2013 · International Journal of Physical Distribution & Logistics Management
Purpose – The purpose of this research is to explore the resilience domain, which is important in the field of supply chain management; it investigates the effects relational competencies have for resilience and the effect resilience, in…
Usha Satish, Mark J. Mendell, Krishnamurthy Shekhar et al. · 2012 · Environmental Health Perspectives
BACKGROUND: Associations of higher indoor carbon dioxide (CO2) concentrations with impaired work performance, increased health symptoms, and poorer perceived air quality have been attributed to correlation of indoor CO2 with concentrations of other indoor air pollutants that are also influenced by rates of outdoor-air ventilation. OBJECTIVES: We assessed direct effects of increased CO2, within the range of indoor concentrations, on decision making. METHODS: Twenty-two participants were exposed to CO2 at 600, 1,000, and 2,500 ppm in an office-like chamber, in six groups. Each group was exposed
Vivek Y. Reddy, Shephal K. Doshi, Saibal Kar et al. · 2017 · Journal of the American College of Cardiology
BACKGROUND: The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, St.…
Broido, Anna D, Clauset, Aaron · 2019 · CU Scholar (University of Colorado Boulder)
Real-world networks are often claimed to be scale free, meaning that the fraction of nodes with degree k follows a power law k-α, a pattern with broad implications for the structure and dynamics of complex systems. However, the universality of scale-free networks remains controversial. Here, we organize different definitions of scale-free networks and construct a severe test of their empirical prevalence using state-of-the-art statistical tools applied to nearly 1000 social, biological, technological, transportation, and information networks. Across these networks, we find robust evidence that
Ventura Simonovich, Leandro Daniel Burgos Pratx, Paula Scibona et al. · 2020 · New England Journal of Medicine
BACKGROUND: Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered…
Robert Gottlieb, Ajay Nirula, Peter Chen et al. · 2021 · JAMA
Importance: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19. Objective: To determine the effect of bamlanivimab monotherapy and combination therapy…
P.J. Devereaux, Marko Mrkobrada, Daniel I. Sessler et al. · 2014 · New England Journal of Medicine
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a…
The ORIGIN Trial Investigators · 2012 · New England Journal of Medicine
BACKGROUND: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown. METHODS: In this…
Paulina Salminen, Mika Helmiö, Jari Ovaska et al. · 2018 · JAMA
Importance: Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass. Objective: To determine whether laparoscopic…
Anna D. Broido, Aaron Clauset · 2019 · Nature Communications
, a pattern with broad implications for the structure and dynamics of complex systems. However, the universality of scale-free networks remains controversial. Here, we organize different definitions of scale-free networks and construct a severe test of their empirical prevalence using state-of-the-art statistical tools applied to nearly 1000 social, biological, technological, transportation, and information networks. Across these networks, we find robust evidence that strongly scale-free structure is empirically rare, while for most networks, log-normal distributions fit the data as well or be
Victor Shih, Christopher Adolph, Mingxing Liu · 2012 · American Political Science Review
Spectacular economic growth in China suggests the ruling Chinese Communist Party (CCP) has somehow gotten it right. A key hypothesis in both economics and political science is that the CCP's cadre evaluation system, combined with China's…
Hedy L. Kindler, Donna Niedzwiecki, Donna Hollis et al. · 2010 · Journal of Clinical Oncology
PURPOSE: The combination of gemcitabine plus bevacizumab produced a 21% response rate and a median survival of 8.8 months in a multicenter phase II trial in patients with metastatic pancreatic cancer. These encouraging data led Cancer and…
The CDMS II Collaboration · 2010 · Science
Astrophysical observations indicate that dark matter constitutes most of the mass in our universe, but its nature remains unknown. Over the past decade, the Cryogenic Dark Matter Search (CDMS II) experiment has provided world-leading…
Antoni Ribas, Richard Kefford, Margaret Marshall et al. · 2013 · Journal of Clinical Oncology
PURPOSE: In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall…
Mark R. Thursz, Paul Richardson, Michael Allison et al. · 2015 · New England Journal of Medicine
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease…
Anis Eliyana, Syamsul Maarif, Muzakki Muzakki · 2019 · European Research on Management and Business Economics
This research focuses on the discussion regarding antecedent variable of transformational leadership with its effect to work performance of the middle-level leaders at the organization of Pelabuhan Indonesia III Inc. The samples used in…
Katrina L. Salazar, Haijun Zhou, Jiaqiong Xu et al. · 2015 · Acta Cytologica
OBJECTIVE: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to…
Michael Young, Stephen T. Slota, Andrew B. Cutter et al. · 2012 · Review of Educational Research
Do video games show demonstrable relationships to academic achievement gains when used to support the K-12 curriculum? In a review of literature, we identified 300+ articles whose descriptions related to video games and academic…
Friedrich Koehler, Sebastian Winkler, Michael Schieber et al. · 2011 · Circulation
BACKGROUND: This study was designed to determine whether physician-led remote telemedical management (RTM) compared with usual care would result in reduced mortality in ambulatory patients with chronic heart failure (HF). METHODS AND…
Thomas G. Brott, George Howard, Gary S. Roubin et al. · 2016 · New England Journal of Medicine
BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke,…
Philipp Stiefel, Sabrina Schmidt-Emrich, Katharina Maniura‐Weber et al. · 2015 · BMC Microbiology
BACKGROUND: Viability staining with SYTO9 and propidium iodide (PI) is a frequently used tool in microbiological studies. However, data generated by such routinely used method are often not critically evaluated for their accuracy. In this study we aim to investigate the critical aspects of this staining method using Staphylococcus aureus and Pseudomonas aeruginosa as the model microorganisms for high throughput studies in microtiter plates. SYTO9 or PI was added alone or consecutively together to cells and the fluorescence intensities were measured using microplate reader and confocal laser sc
Russell Fulmer, Angela Joerin, Breanna Gentile et al. · 2018 · JMIR Mental Health
BACKGROUND: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Integrative psychological artificial intelligence (AI) offers a scalable solution as the demand for affor
Marco Valgimigli, Gianluca Campo, Monia Monti et al. · 2012 · Circulation
BACKGROUND: The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of…