Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease
Lawrence S. Honig; Bruno Vellas; Mark Woodward; Merçé Boada; Roger Bullock; Michael Borrie; Klaus Häger; Niels Andreasen · 2018 · New England Journal of Medicine
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
BACKGROUND: Alzheimer's disease is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to increase the clearance from the brain of soluble Aβ, peptides that may…
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WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1056/nejmoa1705971