A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 19 of 658
Le Han, Takashi Okiji · 2013 · International Endodontic Journal
AIM: To compare white ProRoot MTA (WMTA), EndoSequence BC sealer (BC sealer) and Biodentine with regard to their ability to produce apatites and cause Ca and Si incorporation in adjacent human root canal dentine after immersion in…
Alba A. Brandes, Alain Carpentier, Santosh Kesari et al. · 2016 · Neuro-Oncology
BACKGROUND: The combination of galunisertib, a transforming growth factor (TGF)-β receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in murine models of glioblastoma. METHODS: Galunisertib (300 mg/day) was…
James H. Love, Stephen Roper, Ying Zhou · 2015 · International Business Review
We consider the determinants of SME exporting performance using a survey of internationally engaged UK SMEs. We first develop a model incorporating organisational and prior managerial learning effects. Our empirical analysis then allows us to identify separately the positive effects on exporting from the international experience of the firm and the negative effects of firm age. Positive exporting effects also result from grafted knowledge – acquired by the recruitment of management with prior international experience. Innovation also has positive exporting effects with more radical new-to-the-
A. David M. Latham, M. Cecilia Latham, Mark S. Boyce et al. · 2011 · Ecological Applications
Woodland caribou (Rangifer tarandus caribou) populations are declining across most of their range. Predation by wolves (Canis lupus) is believed to be the main proximate cause of these declines. However, it has been hypothesized that…
James D. A. Parker, Graeme J. Taylor, Michael Bagby · 2010 · Psychotherapy and Psychosomatics
Slides of photographs depicting posed facial expressions of nine different emotions were presented to 131 females and 85 males who were asked to identify the emotion(s) being experienced by the person in each photograph. Subjects were then…
Christian Conrad, Anessa Custovic, Éric Ghysels · 2018 · Journal of risk and financial management
We use the GARCH-MIDAS model to extract the long- and short-term volatility components of cryptocurrencies. As potential drivers of Bitcoin volatility, we consider measures of volatility and risk in the US stock market as well as a measure of global economic activity. We find that S&P 500 realized volatility has a negative and highly significant effect on long-term Bitcoin volatility. The finding is atypical for volatility co-movements across financial markets. Moreover, we find that the S&P 500 volatility risk premium has a significantly positive effect on long-term Bitcoin volatility
K. Wyat Appel, George Pouliot, Heather Simon et al. · 2013 · Geoscientific model development
Abstract. The Community Multiscale Air Quality (CMAQ) model is a state-of-the-science air quality model that simulates the emission, transformation, transport, and fate of the many different air pollutant species that comprise particulate matter (PM), including dust (or soil). The CMAQ model version 5.0 (CMAQv5.0) has several enhancements over the previous version of the model for estimating the emission and transport of dust, including the ability to track the specific elemental constituents of dust and have the model-derived concentrations of those elements participate in chemistry. The late
Stefan Lohmander, Scarlett Hellot, Don Dreher et al. · 2014 · Arthritis & Rheumatology
OBJECTIVE: To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). METHODS: The study was a randomized, double-blind,…
Marco Gui, Gianluca Argentin · 2011 · New Media & Society
This article outlines the main results and methodological challenges of a large-scale survey on actual digital skills. A test covering three main dimensions of digital literacy (theoretical, operational and evaluation skills) was…
Ji Chen, Lars Elsgaard, Kees Jan van Groenigen et al. · 2020 · Global Change Biology
concentrations. However, the mechanisms underlying changes in soil C storage are not well understood, hampering long-term predictions of climate C-feedbacks. The activity of the extracellular enzymes ligninase and cellulase can be used to…
Steven T. Lanier, Eric D. Wang, John J. Chen et al. · 2010 · Annals of Plastic Surgery
Tissue expander/implant breast reconstructions by 5 surgeons at a single institution from 2005 to 2008 were retrospectively identified and divided into 2 cohorts: use of acellular dermal matrix (ADM, n = 75) versus standard submuscular…
Kaitlin B. Casaletto, Anya Umlauf, Jennifer L. Beaumont et al. · 2015 · Journal of the International Neuropsychological Society
Demographic factors impact neuropsychological test performances and accounting for them may help to better elucidate current brain functioning. The NIH Toolbox Cognition Battery (NIHTB-CB) is a novel neuropsychological tool, yet the…
Geoffrey Gorisse, Olivier Christmann, Étienne Armand Amato et al. · 2017 · Frontiers in Robotics and AI
Current design of virtual reality (VR) applications relies essentially on the transposition of users' viewpoint in first-person perspective (1PP). Within this context, our research aims to compare the impact and the potentialities enabled via the integration of the third-person perspective (3PP) in immersive virtual environments (IVE). Our empirical study is conducted in order to assess the sense of presence, the sense of embodiment and performance of users confronted with a series of tasks presenting a case of potential use for the video game industry. Our results do not reveal significant di
Taofeek K. Owonikoko, Keunchil Park, Ramaswamy Govindan et al. · 2021 · Journal of Clinical Oncology
PURPOSE: In extensive-disease small-cell lung cancer (ED-SCLC), response rates to first-line platinum-based chemotherapy are robust, but responses lack durability. CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus…
Atthaphorn Trakarnsanga, Mithat Gönen, Jinru Shia et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Tumor regression grade (TRG) is a measure of histopathological response of rectal cancer to neoadjuvant chemoradiation and is associated with outcomes. Several TRG systems are used: Mandard (5,3-tier), Dowrak/Rödel (5,3-tier),…
Gus A. Baker, Rebecca Bromley, Maria Briggs et al. · 2014 · Neurology
OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and…
Jason Brown, Mark Duggan, Ilyana Kuziemko et al. · 2014 · American Economic Review
To combat adverse selection, governments increasingly base payments to health plans and providers on enrollees’ scores from risk-adjustment formulae. In 2004, Medicare began to risk-adjust capitation payments to private Medicare Advantage…
Ayden I. Scheim, Greta R. Bauer · 2019 · Social Science & Medicine
BACKGROUND AND OBJECTIVE: Although intersectional approaches have gained traction in population health research, quantitative discrimination and health studies have tended to focus on a single axis of discrimination (e.g., racism, homophobia). As few discrimination measures function across multiple social identities or positions, we developed the Intersectional Discrimination Index (InDI) for intercategorical intersectionality research, including measures of Anticipated (InDI-A), Day-to-Day (InDI-D), and Major (InDI-M) discrimination that do not require attribution to particular grounds. METHO
Felix Duecker, Alexander T. Sack · 2015 · Frontiers in Psychology
Sham transcranial magnetic stimulation (TMS) approaches are widely used in basic and clinical research to ensure that observed effects are due to the intended neural manipulation instead of being caused by various possible side effects. We here critically discuss several methodological aspects of sham TMS. Importantly, we propose to carefully distinguish between the placebo versus sensory side effects of TMS. In line with this conceptual distinction, we describe current limitations of sham TMS approaches in the context of placebo effects and blinding success, followed by a short review of our
Marianna Fontana, Steve K White, Sanjay M Banypersad et al. · 2012 · Journal of Cardiovascular Magnetic Resonance
BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using
Martin Schneider, Mihai Păunescu · 2012 · Socio-Economic Review
In this paper, the varieties of capitalism (VoC) approach by Hall and Soskice (2001) is tested with longitudinal data and with measures covering all four institutional spheres differentiated in this approach. Among 26 OECD countries, we…
Paul A. Dirmeyer, Gianpaolo Balsamo, Eleanor Blyth et al. · 2021 · AGU Advances
Abstract The 2018 drought and heatwave over northern Europe were exceptional, with unprecedented forest fires in Sweden, searing heat in Germany and water restrictions in England. Monthly, daily, and hourly data from ERA5, verified with in situ soil water content and surface flux measurements, are examined to investigate the subseasonal‐to‐seasonal progression of the event and the diurnal evolution of tropospheric profiles over Britain to quantify the anomalous land surface contribution to heat and drought. Data suggest the region entered an unprecedented condition of becoming a “hot spot” for
Kenneth F. Scheve, David Stasavage · 2012 · American Political Science Review
In this article we use an original data set to provide the first empirical analysis of the political economy of inherited wealth taxation that covers a significant number of countries and a long time frame (1816–2000). Our goal is to…
Didier Keh, Evelyn Trips, Gernot Marx et al. · 2016 · JAMA
Importance: Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with severe sepsis without shock remains controversial. Objective: To…
David Cutler, Winnie Fung, Michael Kremer et al. · 2010 · American Economic Journal Applied Economics
We examine the effects of exposure to malaria in early childhood on educational attainment and economic status in adulthood by exploiting geographic variation in malaria prevalence in India prior to a nationwide eradication program in the 1950s. We find that the program led to modest increases in household per capita consumption for prime age men, and the effects for men are larger than those for women in most specifications. We find no evidence of increased educational attainment for men and mixed evidence for women. (JEL I12, I18, I21, 015, 018)
Conrad Wasko, Ashish Sharma · 2017 · Scientific Reports
There is overwhelming consensus that the intensity of heavy precipitation events is increasing in a warming world. It is generally expected such increases will translate to a corresponding increase in flooding. Here, using global data sets for non-urban catchments, we investigate the sensitivity of extreme daily precipitation and streamflow to changes in daily temperature. We find little evidence to suggest that increases in heavy rainfall events at higher temperatures result in similar increases in streamflow, with most regions throughout the world showing decreased streamflow with higher tem
Susan M. Sheridan, Lisa L. Knoche, Carolyn Pope Edwards et al. · 2010 · Early Education and Development
RESEARCH FINDINGS: Parental engagement with children has been linked to a number of adaptive characteristics in preschool children, and relationships between families and professionals are an important contributor to school readiness.…
Toni I. Gossmann, Bao‐Hua Song, Aaron J. Windsor et al. · 2010 · Molecular Biology and Evolution
The relative contribution of advantageous and neutral mutations to the evolutionary process is a central problem in evolutionary biology. Current estimates suggest that whereas Drosophila, mice, and bacteria have undergone extensive…
Deanna D. Caputo, Shari Lawrence Pfleeger, Jesse D. Freeman et al. · 2013 · IEEE Security & Privacy
To explore the effectiveness of embedded training, researchers conducted a large-scale experiment that tracked workers' reactions to a series of carefully crafted spear phishing emails and a variety of immediate training and awareness…
Fabian Staubach, John F. Baines, Sven Künzel et al. · 2013 · PLoS ONE
The fruit fly Drosophila is a classic model organism to study adaptation as well as the relationship between genetic variation and phenotypes. Although associated bacterial communities might be important for many aspects of Drosophila biology, knowledge about their diversity, composition, and factors shaping them is limited. We used 454-based sequencing of a variable region of the bacterial 16S ribosomal RNA gene to characterize the bacterial communities associated with wild and laboratory Drosophila isolates. In order to specifically investigate effects of food source and host species on bact