A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
Alba A. Brandes; Alain Carpentier; Santosh Kesari; Juan Manuel Sepúlveda-Sánchez; Helen Wheeler; Olivier Chinot; Lawrence Cher; Joachim P. Steinbach · 2016 · Neuro-Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: The combination of galunisertib, a transforming growth factor (TGF)-β receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in murine models of glioblastoma. METHODS: Galunisertib (300 mg/day) was…
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Metadata source: OpenAlex · DOI 10.1093/neuonc/now009