A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 186 of 724
Ronnie LaMastro, Noel Vera-Gonzalez, Kayla Campbell et al. · 2021 · Access Microbiology
Candida albicans infections can be challenging to treat, as current antifungal drugs exhibit poor water solubility and host toxicity. To overcome these issues, new methods of drug delivery are needed. Liposomes have been shown to be an…
Iván Sánchez-Iglesias, Celia Martín-Aguilar · 2023 · Journal of Clinical Medicine
Clinical trials are the backbone of medical scientific research. However, this experimental strategy has some drawbacks. We focused on two issues: (a) The internal validity ensured by clinical trial procedures does not necessarily allow…
Anna Ness, Ali Zarei‐Baygi, Dave Macnevin · 2023 · Opflow
Available, effective methods of virus detection adequately address the risks in treating water for potable reuse.
Nathan Cofnas · 2022 · Academic Questions
Seven years ago, under the leadership of Jonathan Haidt, Heterodox Academy set out to organize a meaningful resistance to the reigning social justice orthodoxy on campus. “Seven years later,” writes Nathan Cofnas, “you can count HxA’s…
Caroline R. Toth, Brian J. Schutte · 2024 · Weed Science
Abstract Barley ( Hordeum vulgare L.) and brown mustard [ Brassica juncea (L.) Czern.] are winter cover crops known to produce allelochemicals that suppress plant growth. Incorporating barley or brown mustard residues into the soil before…
Jing Wu · 2022 · Wireless Communications and Mobile Computing
Chinese A‐shares were officially included in the Morgan Stanley Capital International (MSCI) Emerging Markets Index from June 2018. The inclusion of the A‐share market into the MSCI Index is one of the most influential events in the…
E. Ergüder, C. Verkade, C. Ersak et al. · 2025 · Colorectal Disease
Abstract Aim To assess the outcomes of transanal advancement flap repair (TAFR) following failed ligation of intersphincteric fistula tract (LIFT) treatment for cryptoglandular anal fistulas, with a focus on healing and functional results.…
Jacqueline Lubin, null null, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day
Research has shown there is a positive correlation between self-determination skills and quality of life of college students with autism spectrum disorder (ASD). The purpose of this literature review is to highlight research on…
Arash Farhadian, Mayce Arreem Issa, Karl Kingsley et al. · 2024 · Pediatric Reports
Recent evidence suggests that an ever-growing number of pediatric patients require invasive treatments such as root canal therapy (RCT) in their permanent dentition, albeit with little information about risk factors such as prior invasive…
Vidhu Anand, Christopher G. Scott, Khaled Ali et al. · 2025 · Journal of the American Heart Association
Background Tricuspid valve surgery is recommended for severe isolated tricuspid regurgitation (TR) if symptoms persist despite optimal medical therapy. The definition of optimal therapy for TR is unclear beyond managing underlying…
James A. Kelhoffer · 2018 · Early Christianity
Eine sprachliche Analyse der stilistischen und theologischen Eigenheiten von 2Clem 19,1–20,5 im Vergleich zu 2Clem 1–18 macht einige Unterschiede deutlich, die für die letzten beiden Kapitel sehr wahrscheinlich auf einen späteren Autor…
Jian-Yong Wang, Lei Cui, Hong-Yi Shi et al. · 2023 · Frontiers in Genetics
Background: DNA methylation plays an important role in Parkinson’s disease (PD) pathogenesis. DNA methyltransferase 1 (DNMT1) is critical for maintaining DNA methylation in mammals. The link between DNMT1 polymorphisms and PD remains…
Zack J. Quirk, Selena Y. Smith, R. Paul Acosta et al. · 2024 · American Journal of Botany
Abstract Premise The ecological conditions that constrain plants to an environmental niche are assumed to be constant through time. While the fossil record has been used previously to test for niche conservatism of woody flowering plants,…
Marie Kostelanska, Karel Holada · 2022 · Molecules
Prion disorders, or transmissible spongiform encephalophaties (TSE), are fatal neurodegenerative diseases affecting mammals. Prion-infectious particles comprise of misfolded pathological prion proteins (PrPTSE). Different TSEs are…
Edy Wibowo, Naily Ulya, Mamat Rokhmat · 2025 · Physics Education
Abstract Here, we present an inquiry-based, low-cost rolling motion experiment as an alternative to traditional ‘confirm g ‘activities, integrating both confirmatory and inquiry-based elements. Using seven everyday objects—modeled as…
Shaojun Nong, Yangbo Guan, Zhiwei Wang et al. · 2019 · Oncology and Translational Medicine
Abstract Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4 (OCT4) and interleukin-18 (IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene…
Ruilin Xiong, Wei Wang, Xianwen Shang et al. · 2023 · Therapeutic Advances in Ophthalmology
Background: Diabetic retinopathy, a common microvascular complication of diabetes mellitus, is one of the leading causes of vision loss worldwide. Although some oral drugs have been suggested to affect the risk of diabetic retinopathy,…
Ana Gabriela Pérez-Castillo, Weynner Giraldo-Sanclemente, Mayela Monge-Muñoz et al. · 2024 · Frontiers in Agronomy
Urea is widely used as nitrogen (N) source for rice fertilization in Costa Rica, despite its low efficiency linked to ammonia losses. To assess urea management alternatives, two field experiments were conducted in the Central Pacific…
H Kim, H-C Shin, CK Yom et al. · 2010 · Cancer Research
Abstract Purpose: CYP2D6 variant alleles have been suspected to influence on the clinical efficacy of tamoxifen because CYP2D6 is an enzyme which metabolizes tamoxifen into its active forms, endoxifen and 4-hydroxytomoxifen. This study was…
Alexandra Lenhard, Marie-Pierre Minten, Wolfgang Lenhard · 2023 · Frontiers in Psychology
Introduction In this study, we investigated the impact of age on mate selection preferences in males and females, and explored how the formation and duration of committed relationships depend on the sex of the person making the selection.…
Emiliya Vacheva, Borislav Naumov · 2024 · Historia naturalis bulgarica
The eastern green lizard (Lacerta viridis) is a mostly insectivorous species, based on multiple studies from across its range. However, for Bulgaria the published data of such kind are limited to five publications. We investigated faecal…
Tom Love · 2025 · Research Notes of the AAS
Abstract A recent study found pulsation frequencies in the RR Lyrae star HH Puppis that were identified as gravity modes, and argued that this phenomenon could explain the Blazhko effect in which pulsations of RR Lyrae stars undergo long…
Sehoon Park, Yisak Kim, Chung Hee Baek et al. · 2025 · Kidney Research and Clinical Practice
Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using…
Antonella Tammaro, Francesca Magri, Chiara Iacovino et al. · 2019 · Journal of Cosmetic Dermatology
Summary Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory skin disease of unknown etiology. It mainly affects the anogenital area, while the extragenital involvement is uncommon. It manifests as pale, ivory‐colored lesions and…
Benjamin K. Kogutt, Jeanne S. Sheffield · 2020 · Obstetrics & Gynecology
INTRODUCTION: Pregnancy is an ideal opportunity for women to focus on physical health; however, exercise recommendations are rarely met. At-home fitness is more accessible than ever due to technology-based interventions, and with the…
Nataliia Vyspinska · 2019 · Revista Romaneasca pentru Educatie Multidimensionala
Numerous possibilities, that have arisen in the result of globalization and cultural integration, require modern specialists, and musicians in particular, to speak English language fluently. Thus, methods of teaching professionally…
Alexander Esibov, Tyson G Taylor, Sharon B Melnick et al. · 2015 · Circulation
Introduction: Ischemic post-conditioning (IPC) has shown promise in mitigating ischemia-reperfusion injury. Controlled pauses during CPR (CP-CPR) following cardiac arrest (CA) and prolonged downtime may help invoke IPC mechanisms and have…
Hideyuki Yamamoto, Shotaro Hagiwara, Yuki Kojima et al. · 2011 · Blood
Abstract Abstract 1629 Background: With the widespread use of highly active antiretroviral therapy (HAART), the prognosis of HIV infected subjects has been improved, even if with AIDS-related lymphoma. Burkitt lymphoma progresses very…
Eugene Yeung, Nadia Sant, Ewa Sucha et al. · 2024 · Journal of the Association of Medical Microbiology and Infectious Disease Canada
Background: Knowledge of time to positivity (TTP) for blood cultures is useful to assess timing of discontinuation of empiric antimicrobials for suspected bacteremia with no focus. Methods: An audit of positive blood cultures from the…
Dario Nicolì, Silvio Gualdi, Panos J Athanasiadis · 2025 · Environmental Research Letters
Abstract The Mediterranean region is highly sensitive to climate change, having experienced an intense warming and drying trend in recent decades. In the context of decision-making processes, there is growing interest in understanding the…