Negative / Null Result ReportSocial Sciences
Aqeel Ahmed Soomro, Robert J. Breitenecker, Syed Afzal Shah · 2018 · South Asian Journal of Business Studies
Purpose People in both the developing and developed worlds now face issues like work-to-family and family-to-work conflicts. Accordingly, the purpose of this paper is to explore the relationships between work-life balance, work-family…
View details →DOI: 10.1108/sajbs-02-2017-0018Cited by 289 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Manjit Mehat, Venki Sundaram, Caterina Ripamonti et al. · 2018 · Ophthalmology
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analysis of retinal structure and function in the treated area. DESIGN: Phase 1/2 open-label dose-escalation trial to evaluate safety and potential efficacy (clinicaltrials.gov identifier, NCT01469832). PARTICIPANTS: Twelve participants with advanced Stargardt disease (STGD1), the most common cause of macular degeneration in children and young adults. M
View details →DOI: 10.1016/j.ophtha.2018.04.037Cited by 288 Negative / Null Result ReportOpen accessNeuroscience
Jan Gläscher, David Rudrauf, Roberto Colom et al. · 2010 · Proceedings of the National Academy of Sciences
General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or…
View details →DOI: 10.1073/pnas.0910397107Cited by 288 Negative / Null Result ReportOpen accessMedicine
Matthew J. Reilley, Patricia McCoon, Carl Cook et al. · 2018 · Journal for ImmunoTherapy of Cancer
BACKGROUND: The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune responses. In diffuse large B-cell lymphoma (DLBCL), the transcription factor STAT3 has been associated with aggressive disease phenotype and worse overall survival. While multiple therapies inhibit upstream signaling, there has been limited success in selectively targeting STAT3 in patients. Antisense oligonucleotides (ASOs) represent a comp
View details →DOI: 10.1186/s40425-018-0436-5Cited by 288 Negative / Null Result ReportOpen accessMedicine
Navneet Singh, Stephen J. Hopkins, Sharon Hulme et al. · 2014 · Journal of Neuroinflammation
BACKGROUND: Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. METHODS: A small phase II, double-blind, randomised controlled study was carried out across two UK neurosurgical centres
View details →DOI: 10.1186/1742-2094-11-1Cited by 288 Negative / Null Result ReportOpen accessMedicine
Maria Justine, Azliyana Azizan, Vally Hassan et al. · 2013 · Singapore Medical Journal
INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to…
View details →DOI: 10.11622/smedj.2013203Cited by 288 Negative / Null Result ReportOpen accessNeuroscience
Gilles Dutilh, Joachim Vandekerckhove, Birte U. Forstmann et al. · 2011 · Attention Perception & Psychophysics
People tend to slow down after they make an error. This phenomenon, generally referred to as post-error slowing, has been hypothesized to reflect perceptual distraction, time wasted on irrelevant processes, an a priori bias against the…
View details →DOI: 10.3758/s13414-011-0243-2Cited by 287 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthias Fleckenstein, Francis A. Longstaff, Hanno Lustig · 2013 · The Journal of Finance
ABSTRACT We show that the price of a Treasury bond and an inflation‐swapped Treasury Inflation‐Protected Securities (TIPS) issue exactly replicating the cash flows of the Treasury bond can differ by more than $20 per $100 notional.…
View details →DOI: 10.1111/jofi.12032Cited by 287 Negative / Null Result ReportOpen accessPsychology
Jeroen Borghuis, Jaap J. A. Denissen, Daniel L. Oberski et al. · 2017 · Journal of Personality and Social Psychology
Using data from 2 large and overlapping cohorts of Dutch adolescents, containing up to 7 waves of longitudinal data each (N = 2,230), the present study examined Big Five personality trait stability, change, and codevelopment in friendship…
View details →DOI: 10.1037/pspp0000138Cited by 286 Negative / Null Result ReportOpen accessImmunology and Microbiology
Joris D. Veltman, Margaretha Lambers, Menno van Nimwegen et al. · 2010 · BMC Cancer
BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased expression of arginase I and production of reactive oxygen species (ROS) and nitric oxide (NO). Immune suppression by MDSC was found to be one of the main factors for immunotherapy insufficiency. Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by in
View details →DOI: 10.1186/1471-2407-10-464Cited by 285 Negative / Null Result ReportOpen accessPhysics and Astronomy
Timothy D. Brandt · 2021 · The Astrophysical Journal Supplement Series
Abstract We present a cross-calibration of Hipparcos and Gaia EDR3 intended to identify astrometrically accelerating stars and to fit orbits to stars with faint, massive companions. The resulting catalog, the EDR3 edition of the…
View details →DOI: 10.3847/1538-4365/abf93cCited by 285 Negative / Null Result ReportPsychology
Andrew T. Jebb, Mike Morrison, Louis Tay et al. · 2020 · Psychological Science
Using representative cross-sections from 166 nations (more than 1.7 million respondents), we examined differences in three measures of subjective well-being over the life span. Globally, and in the individual regions of the world, we found…
View details →DOI: 10.1177/0956797619898826Cited by 285 Negative / Null Result ReportOpen accessEnvironmental Science
Gabriella Andreotti, Stella Koutros, Jonathan N Hofmann et al. · 2017 · JNCI Journal of the National Cancer Institute
Background: Glyphosate is the most commonly used herbicide worldwide, with both residential and agricultural uses. In 2015, the International Agency for Research on Cancer classified glyphosate as "probably carcinogenic to humans," noting…
View details →DOI: 10.1093/jnci/djx233Cited by 285 Negative / Null Result ReportOpen accessImmunology and Microbiology
Peter Aaby, Cesário Martins, M.‐L. Garly et al. · 2010 · BMJ
OBJECTIVE: To examine in a randomised trial whether a 25% difference in mortality exists between 4.5 months and 3 years of age for children given two standard doses of Edmonston-Zagreb measles vaccines at 4.5 and 9 months of age compared…
View details →DOI: 10.1136/bmj.c6495Cited by 284 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Colter Mitchell, John Hobcraft, Sara McLanahan et al. · 2014 · Proceedings of the National Academy of Sciences
Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety…
View details →DOI: 10.1073/pnas.1404293111Cited by 284 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Thorsten Beck, Asli Demirgüç‐Kunt, María Soledad Martínez Pería · 2010 · Journal of Financial Services Research
Using data for 91 large banks from 45 countries, this paper finds that foreign, domestic private, and government-owned banks use different lending technologies and organizational structures for SME financing. The extent, type, and pricing…
View details →DOI: 10.1007/s10693-010-0085-4Cited by 284 Negative / Null Result ReportOpen accessMedicine
Gaurav Aggarwal, Giuseppe Lippi, Brandon Michael Henry · 2020 · International Journal of Stroke
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.…
View details →DOI: 10.1177/1747493020921664Cited by 284 Negative / Null Result ReportOpen accessMedicine
Huijuan Wu, Christopher P. Larsen, Cesar F. Hernandez-Arroyo et al. · 2020 · Journal of the American Society of Nephrology
Significance Statement Kidney involvement may occur in coronavirus disease 2019 (COVID-19), and can be severe among Black individuals. In this study of collapsing glomerulopathy in six Black patients with COVID-19, the authors found that…
View details →DOI: 10.1681/asn.2020050558Cited by 284 Negative / Null Result ReportOpen accessPhysics and Astronomy
Drake Deming, Heather A. Knutson, Joshua A. Kammer et al. · 2015 · The Astrophysical Journal
HAT-P-20b is a giant metal-rich exoplanet orbiting a metal-rich star. We analyze two secondary eclipses of the planet in each of the 3.6 and 4.5 m bands of Warm Spitzer. We have developed a simple, powerful, and radically different method…
View details →DOI: 10.1088/0004-637x/805/2/132Cited by 283 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Feargal J. Ryan, Anna M. Ahern, Rachel S. Fitzgerald et al. · 2020 · Nature Communications
Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn's disease (CD); 80 ulcerative colitis (UC); 31 controls]. Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe interactions, and show only marginal microbiota associations with habitual diet. Epi
View details →DOI: 10.1038/s41467-020-15342-5Cited by 283 Negative / Null Result ReportPsychology
Trevor J. Egli, Helen W. Bland, Bridget F. Melton et al. · 2011 · Journal of American College Health
OBJECTIVE: The authors examined differences in exercise motivation between age, sex, and race for college students. PARTICIPANTS: Students from 156 sections of physical activity classes at a midsize university were recruited (n = 2,199;…
View details →DOI: 10.1080/07448481.2010.513074Cited by 283 Negative / Null Result ReportOpen accessMedicine
Felipe Lobelo, Isabel Garcia de Quevedo · 2014 · American Journal of Lifestyle Medicine
Physical inactivity constitutes the fourth leading cause of death worldwide. Health care providers (HCPs) should play a key role in counseling and appropriately referring their patients to adopt physical activity (PA). Previous reports…
View details →DOI: 10.1177/1559827613520120Cited by 283 Negative / Null Result ReportSocial Sciences
Maxim Pinkovskiy, Xavier Sala-i-Martín · 2016 · The Quarterly Journal of Economics
Abstract GDP per capita and household survey means present conflicting pictures of the rate of economic development in emerging countries. One of the areas in which the national accounts–household surveys debate is key is the measurement…
View details →DOI: 10.1093/qje/qjw003Cited by 283 Negative / Null Result ReportOpen accessMedicine
Chris Eijsbouts, Tenghao Zheng, Nicholas A. Kennedy et al. · 2021 · Nature Genetics
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1 ,
View details →DOI: 10.1038/s41588-021-00950-8Cited by 282 Failed Experiment ReportNeuroscience
C. Warren Olanow, Raymond T. Bartus, Tiffany Baumann et al. · 2015 · Annals of Neurology
OBJECTIVE: A 12-month double-blind sham-surgery-controlled trial assessing adeno-associated virus type 2 (AAV2)-neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for the…
View details →DOI: 10.1002/ana.24436Cited by 282 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Ali Alqerban, Reinhilde Jacobs, Steffen Fieuws et al. · 2011 · European Journal of Orthodontics
The diagnostic accuracy for the localization of impacted canines and the detection of canine-induced root resorption of maxillary incisors were compared between conventional radiographic procedures using one two-dimensional (2D) panoramic…
View details →DOI: 10.1093/ejo/cjq034Cited by 282 Negative / Null Result ReportOpen accessSocial Sciences
James Druckman, ERIK PETERSON, RUNE SLOTHUUS · 2013 · American Political Science Review
Competition is a defining element of democracy. One of the most noteworthy events over the last quarter-century in U.S. politics is the change in the nature of elite party competition: The parties have become increasingly polarized.…
View details →DOI: 10.1017/s0003055412000500Cited by 282 Negative / Null Result ReportOpen accessNeuroscience
Kyle S. Honegger, Robert A. A. Campbell, Glenn Turner · 2011 · Journal of Neuroscience
Sensory stimuli are represented in the brain by the activity of populations of neurons. In most biological systems, studying population coding is challenging since only a tiny proportion of cells can be recorded simultaneously. Here we…
View details →DOI: 10.1523/jneurosci.1099-11.2011Cited by 281 Negative / Null Result ReportMedicine
Mats Brittberg, David P. Recker, John Ilgenfritz et al. · 2018 · The American Journal of Sports Medicine
Background: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…
View details →DOI: 10.1177/0363546518756976Cited by 281 Negative / Null Result ReportOpen accessEnvironmental Science
Matthew C. Yates, Dylan J. Fraser, Alison M. Derry · 2019 · Environmental DNA
Abstract The use of eDNA to detect the presence/absence of rare or invasive species is well documented and its use in biodiversity monitoring is expanding. Preliminary laboratory research has also shown a positive correlation between the concentration of species‐specific eDNA particles and the density/biomass of a species in a given environment. However, the extent to which these results can be extended to natural environments has yet to be formally quantified. We collated data from experiments that examined the correlation between eDNA and two metrics of abundance (biomass and density) and, u
View details →DOI: 10.1002/edn3.7Cited by 281 