Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration
Manjit Mehat; Venki Sundaram; Caterina Ripamonti; Anthony G. Robson; Alexander J. Smith; Shyamanga Borooah; Martha R. Robinson; Adam N. Rosenthal · 2018 · Ophthalmology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analysis of retinal structure and function in the treated area. DESIGN: Phase 1/2 open-label dose-escalation trial to evaluate safety and potential efficacy (clinicaltrials.gov identifier, NCT01469832). PARTICIPANTS: Twelve participants with advanced Stargardt disease (STGD1), the most common cause of macular degeneration in children and young adults. M
Abstract by Manjit Mehat; Venki Sundaram; Caterina Ripamonti; Anthony G. Robson; Alexander J. Smith; Shyamanga Borooah; Martha R. Robinson; Adam N. Rosenthal, Ophthalmology (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.ophtha.2018.04.037