Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
Feargal J. Ryan; Anna M. Ahern; Rachel S. Fitzgerald; Emilio J. Laserna‐Mendieta; E. M. Power; Adam G. Clooney; KEITH O'DONOGHUE; Paul J. McMurdie · 2020 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe interactions, and show only marginal microbiota associations with habitual diet.”
Abstract
Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn's disease (CD); 80 ulcerative colitis (UC); 31 controls]. Changes in community-wide and within-patient microbiota are linked with inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe interactions, and show only marginal microbiota associations with habitual diet. Epi
Abstract by Feargal J. Ryan; Anna M. Ahern; Rachel S. Fitzgerald; Emilio J. Laserna‐Mendieta; E. M. Power; Adam G. Clooney; KEITH O'DONOGHUE; Paul J. McMurdie, Nature Communications (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-020-15342-5