COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
Joris D. Veltman; Margaretha Lambers; Menno van Nimwegen; Rudi W. Hendriks; Henk C. Hoogsteden; Joachim G.J.V. Aerts; Joost P. Hegmans · 2010 · BMC Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased expression of arginase I and production of reactive oxygen species (ROS) and nitric oxide (NO). Immune suppression by MDSC was found to be one of the main factors for immunotherapy insufficiency. Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by in
Abstract by Joris D. Veltman; Margaretha Lambers; Menno van Nimwegen; Rudi W. Hendriks; Henk C. Hoogsteden; Joachim G.J.V. Aerts; Joost P. Hegmans, BMC Cancer (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1471-2407-10-464