Negative / Null Result ReportOpen accessEnvironmental Science
Wolfgang Wüster · 2025 · Vertebrate Zoology
The advent of molecular methods has revolutionised the field of species delimitation and description, one of the key tasks of systematic biology. In animal taxonomy, one marker, the mitochondrial DNA (mtDNA) molecule, has acquired and retained disproportionate influence. This is despite its uniparental, clonal mode of inheritance, as a result of which the entire molecule acts as a single locus, and that precludes its use as a test for admixture between putative lineages, a key consideration in species delimitation. To establish the extent to which the limitations of mtDNA affect present-day ta
View details →DOI: 10.3897/vz.75.e161536Cited by 9 Negative / Null Result ReportOpen accessMedicine
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →DOI: 10.1021/mp500460gCited by 9 Negative / Null Result ReportOpen accessChemistry
Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →DOI: 10.3390/microorganisms9040701Cited by 9 Negative / Null Result ReportOpen accessEngineering
E. Maartensson, N. Welch, M. Scarpari et al. · 2026 · Nuclear Fusion
Abstract ST-E1 is Tokamak Energy’s commercially competitive fusion power plant design featuring a lifetime high-temperature superconducting (HTS) magnet cage, which has completed its pre-concept design stage. A central challenge at the pre-concept stage is the need to iteratively and consistently integrate the development of the magnet cage, core plasma physics, and power-exhaust systems, while avoiding serial design loops and late discovery of infeasible operating scenarios. Accurate representation of inductive current drive is particularly critical, as it tightly couples magnetic equilibria,
View details →DOI: 10.1088/1741-4326/ae773bCited by 9 Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →DOI: 10.1172/jci189570Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →DOI: 10.1126/sciadv.adv3758Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Davide Faccialà, M. Bonanomi, Bruno Nunes Cabral Tenorio et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide We report a study of the electronic and nuclear relaxation dynamics of the photoexcited RNA base uracil in the gas phase using time-resolved core-level photoelectron spectroscopy together with high-level calculations. The dynamics was investigated by trajectory surface hopping calculations, and the core ionization energies were calculated for geometries sampled from these. The molecule was excited by a UV laser and dynamics probed on the oxygen, nitrogen, and carbon sites by core electron spectroscopy. We find that the main de-excitation chann
View details →DOI: 10.1021/jacs.5c04874Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Jonas Schmidinger, Viacheslav Barkov, Sebastian Vogel et al. · 2025 · Computers and Electronics in Agriculture
Machine learning and geostatistics are two fundamentally different frameworks for the prediction and spatial mapping of soil properties. Geostatistics leverages the spatial structure of soil properties, whereas machine learning models capture the relationship between available environmental features and soil properties. We propose a hybrid framework that augments machine learning with spatial context through the engineering of ‘spatial lag’ features derived from ordinary kriging. We call this approach ‘kriging prior regression’ (KpR), as it reverses the logic of regression kriging by incorpera
View details →DOI: 10.1016/j.compag.2025.111352Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Sabine Willems, Vasily Morozov, Julian A. Marschner et al. · 2025 · Journal of Medicinal Chemistry
The ligand-activated transcription factors of the NR4A family are implicated as promising drug targets with neuroprotective and anticancer potential and attract strong attention in drug discovery. Several NR4A modulators have been…
View details →DOI: 10.1021/acs.jmedchem.5c00459Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →DOI: 10.1093/mnras/staf2023Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Eliza Neights, Eric Burns, Chris L. Fryer et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Gamma-ray bursts are the most luminous electromagnetic events in the Universe. Their prompt gamma-ray emission has typical durations between a fraction of a second and several minutes. A rare subset of these events have durations in excess of a thousand seconds, referred to as ultra-long gamma-ray bursts. Here, we report the discovery of the longest gamma-ray burst ever seen with a $\sim$25 000 s gamma-ray duration, GRB 250702B, and characterize this event using data from four instruments in the InterPlanetary Network and the Monitor of All-sky X-ray Image. We find a hard spectrum, su
View details →DOI: 10.1093/mnras/staf2019Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Lambodhar Damodaran, Anna S. Jaeger, Louise H. Moncla · 2025 · Nature
Abstract Since late 2021, a panzootic of highly pathogenic H5N1 has devastated wild birds, agriculture and mammals. Here an analysis of 1,818 haemagglutinin sequences from wild birds, domestic birds and mammals reveals that the North American panzootic was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild, migratory birds. Transmission was primarily driven by Anseriformes, while non-canonical species acted as dead-end hosts. In contrast to the epizootic of 2015 (refs. 1,2 ), outbreaks in domestic birds were driven by around
View details →DOI: 10.1038/s41586-025-09737-xCited by 9 Negative / Null Result ReportOpen accessEngineering
Hanxu Ma, Shunda Qiao, Ying He et al. · 2026 · Reports on Progress in Physics
Abstract This paper proposed an optical detection mechanism that utilized orthogonal phase modulation (OPM) and Lissajous mode decoupling within a light-induced thermoelastic spectroscopy (LITES) sensor for the first time, enabling…
View details →DOI: 10.1088/1361-6633/ae79a3Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhenghao Sun, Qian Gong, Zi-lai Wang et al. · 2026 · International Journal of Biological Sciences
The gut microbiota, as a source of profound genetic and metabolic capacity, affects every aspect of human biology including health, development and aging, as well as disease. Studies have demonstrated the crosstalk between the gut…
View details →DOI: 10.7150/ijbs.124499Cited by 9 Negative / Null Result ReportOpen accessPsychology
Lujain Ibrahim, Franziska Sofia Hafner, Luc Rocher · 2026 · Nature
. Here we show how this can create a significant trade-off: optimizing language models for warmth can undermine their performance, especially when users express vulnerability. We conducted controlled experiments on five different language models, training them to produce warmer responses, then evaluating them on consequential tasks. Warm models showed substantially higher error rates (+10 to +30 percentage points) than their original counterparts, promoting conspiracy theories, providing inaccurate factual information and offering incorrect medical advice. They were also significantly more lik
View details →DOI: 10.1038/s41586-026-10410-0Cited by 9 Negative / Null Result ReportOpen accessEngineering
Mohamed Abdellatief, Mohamed Mortagi · 2026 · Scientific Reports
Accurate prediction of the unconfined compressive strength (UCS) of geopolymer-stabilized clayey soil is critical for geotechnical engineering. Conventional regression algorithms and even advanced machine learning approaches such as artificial neural networks often struggle to fully capture the highly non-linear interactions among soil properties and geopolymer mix parameters while maintaining computational efficiency and interpretability on limited datasets. To address these challenges, this investigation proposes a novel hybrid predictive framework based on a sector fruit fly optimization al
View details →DOI: 10.1038/s41598-026-47208-zCited by 9 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
View details →DOI: 10.1208/s12249-026-03374-xCited by 9 Negative / Null Result Report
Chanaka Bulathsinghalage, Lu Liu · 2020 · BMC Bioinformatics
Abstract Background Chromosome conformation capture-based methods, especially Hi-C, enable scientists to detect genome-wide chromatin interactions and study the spatial organization of chromatin, which plays important roles in gene…
View details →DOI: 10.1186/s12859-020-03689-xCited by 8 Negative / Null Result Report
Marlene Grillon, Andy Wai Kan Yeung · 2022 · Applied Sciences
No prior study has evaluated the content of YouTube videos that demonstrated how to take periapical radiographs, one of the commonest radiographic examinations in dentistry. This study provided a content analysis on these YouTube videos.…
View details →DOI: 10.3390/app12199602Cited by 8 Negative / Null Result Report
Nam-Hee Kim, Se-Hwan Jung, Ichiro Kawachi · 2021 · International Journal of Environmental Research and Public Health
The Korean National Health Insurance extended its coverage to reduce the economic burden of receiving dentures and implants for older adults in 2012 and 2014, respectively. We examined whether the new policy resulted in reduced…
View details →DOI: 10.3390/ijerph18063003Cited by 8 Negative / Null Result Report
Harrison Preusse, Rebecca Skulsky, Marlena R. Fraune et al. · 2021 · Frontiers in Robotics and AI
As robots are becoming more prevalent and entering hospitality settings, understanding how different configurations of individuals and groups interact with them becomes increasingly important for catering to various people. This is…
View details →DOI: 10.3389/frobt.2021.730399Cited by 8 Negative / Null Result Report
Kelvin K. F. Tsoi, Nicholas B. Chan, Felix C. H. Chan et al. · 2018 · npj Digital Medicine
Abstract Twitter is a social media platform for online message sharing. The aim of this study is to evaluate the effectiveness of using Twitter to search for people who got lost due to dementia. The online messages on Twitter, i.e.,…
View details →DOI: 10.1038/s41746-018-0017-5Cited by 8 Negative / Null Result Report
Trent Cross, Lynne Bartlett, Chrispen Mushaya et al. · 2012 · International Surgery
Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with…
View details →DOI: 10.9738/cc92.1Cited by 8 Negative / Null Result Report
Yao Luo, Hui Shi, Weiqiang Wang · 2021 · Aquatic Ecosystem Health & Management
Abstract The frequency of extreme wave events is increasing with climate change. The temporal and spatial variations of extreme wave height affect both human livelihood and the usage of ocean resources. The South China Sea and northern…
View details →DOI: 10.14321/aehm.024.03.12Cited by 8 Negative / Null Result Report
Raluca B. Dumitru, Lesley‐Anne Bissell, Bara Erhayiem et al. · 2023 · ACR Open Rheumatology
Objective Subclinical systemic sclerosis (SSc) primary heart involvement is commonly described. Whether these findings progress over time is not clear. The study aimed to investigate cardiovascular magnetic resonance (CMR) interval change…
View details →DOI: 10.1002/acr2.11515Cited by 8 Negative / Null Result Report
Mohammad Ehsanul Karim · 2024 · BMC Medical Research Methodology
Abstract Purpose Propensity score matching is vital in epidemiological studies using observational data, yet its estimates relies on correct model-specification. This study assesses supervised deep learning models and unsupervised…
View details →DOI: 10.1186/s12874-024-02284-5Cited by 8 Negative / Null Result Report
Shalane K. Sadri, Peter M. McEvoy, Sarah J. Egan et al. · 2017 · Behavioural and Cognitive Psychotherapy
Background: The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is…
View details →DOI: 10.1017/s1352465817000194Cited by 8 Negative / Null Result Report
Samta Jain, Smita Kashiramka, P.K. Jain · 2020 · Review of International Business and Strategy
Purpose The purpose of this paper is to examine the impact of cross-border acquisitions (CBAs) on the financial and operating performance of acquiring firms from emerging economies in the long-term; the acquiring firms have been segregated…
View details →DOI: 10.1108/ribs-12-2019-0160Cited by 8 Negative / Null Result Report
Christine F. Schubert, Ulrike Schmidt, Hannah Comtesse et al. · 2019 · Stress and Health
Abstract Posttraumatic growth (PTG) may play a role in the treatment of posttraumatic stress disorder (PTSD) as it is supposed to have either beneficial or dysfunctional effects on treatment‐related PTS symptom (PTSS) changes. This study…
View details →DOI: 10.1002/smi.2894Cited by 8 Negative / Null Result Report
Chun Wang, David J. Weiss · 2017 · Applied Psychological Measurement
The measurement of individual change has been an important topic in both education and psychology. For instance, teachers are interested in whether students have significantly improved (e.g., learned) from instruction, and counselors are…
View details →DOI: 10.1177/0146621617726787Cited by 8 