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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21252 results · page 158 of 709

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Accurate prediction of quantitative traits with failed SNP calls in canola and maize

Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science

In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al

View details →DOI: 10.3389/fpls.2023.1221750Cited by 9
Negative / Null Result Report

Flow Cytometry Method Analysis of Apoptosis

Xiao-yan Xu, Xiao-cui Nie, Hai-ying Ma et al. · 2014 · Technology in Cancer Research & Treatment

Flow cytometry method (FCM) is a generally accepted tool to analyze apoptosis. Although apoptosis assay kit was applied by many companies, the manufacturers were not consistent with whether using Trypsin with EDTA to collect the adherent…

View details →DOI: 10.7785/tcrt.2012.500406Cited by 9
Negative / Null Result ReportOpen accessMedicine

“Chronic urticaria and obstructive sleep apnea: Is there a significant association?”

Iván Chérrez-Ojeda, Marcus Maurer, Miguel Félix et al. · 2021 · World Allergy Organization Journal

BackgroundFew studies have explored the association between obstructive sleep apnea (OSA) and chronic urticaria (CU). Our study aims to fill this gap by determining the frequency of the risk categories for OSA and how they might correlate…

View details →DOI: 10.1016/j.waojou.2021.100577Cited by 9
Negative / Null Result Report

Statistical models for assessing agreement for quantitative data with heterogeneous random raters and replicate measurements

Claus Thorn Ekstrøm, Bendix Carstensen · 2024 · The International Journal of Biostatistics

Abstract Agreement between methods for quantitative measurements are typically assessed by computing limits of agreement between pairs of methods and/or by illustration through Bland–Altman plots. We consider the situation where the…

View details →DOI: 10.1515/ijb-2023-0037Cited by 9
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Use of Beauveria bassiana to control northern fowl mites (Ornithonyssus sylviarum) on roosters in an agricultural research facility.

Matthew S W Rassette, Elizabeth I. Pierpont, Tina Wahl et al. · 2011 · PubMed

Treatment of Northern fowl mite (Ornithonyssus sylviarum) infestation on poultry in research facilities can be challenging. The mite has a rapid reproductive cycle (egg to adult in 5 to 7 d), and chemical treatments can be toxic to birds,…

Negative / Null Result ReportOpen accessNeuroscience

Decoding of Attentional State Using High-Frequency Local Field Potential Is As Accurate As Using Spikes

Surya Prakash, Aritra Das, Sidrat Tasawoor Kanth et al. · 2021 · Cerebral Cortex

Local field potentials (LFPs) in visual cortex are reliably modulated when the subject's focus of attention is cued into versus out of the receptive field of the recorded sites, similar to modulation of spikes. However, human psychophysics…

View details →DOI: 10.1093/cercor/bhab088Cited by 9
Negative / Null Result Report

Where Do Women With Urinary Incontinence Find Information About Absorbent Products and How Useful Do They Find It?

Nicholas Smith, Kathleen F. Hunter, Saima Rajabali et al. · 2019 · Journal of Wound, Ostomy & Continence Nursing

PURPOSE: This study aimed to determine from what sources women with urinary and dual urinary and fecal incontinence sought and received information about incontinence and absorbent products. We also evaluated source utility. DESIGN:…

View details →DOI: 10.1097/won.0000000000000494Cited by 9
Negative / Null Result Report

The magic bullet as cancer therapeutic—has nanotechnology failed to find its mark?

Gordon Minru Xiong, Kailash Venkatraman, Subbu Venkatraman · 2020 · Progress in Biomedical Engineering

Abstract Ever since the term ‘Magic Bullet’ was coined by Nobel laureate Paul Ehrlich to denote selective activity of a therapeutic medicine against a particular target tissue or organism, researchers have been attempting to develop the…

View details →DOI: 10.1088/2516-1091/abb008Cited by 9
Negative / Null Result Report

Strategy war games: how business can outperform the competition

Jason West, Maiko Chu, Lincoln Crooks et al. · 2018 · Journal of Business Strategy

Purpose Business wargames represent an alternative approach to challenge organisations to uncover internal capabilities through competitive actions designed to counteract external threats and address strategic mismatches. Internal…

View details →DOI: 10.1108/jbs-11-2017-0154Cited by 9
Negative / Null Result Report

Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies

Jack W. O’Sullivan, John P. A. Ioannidis · 2021 · Scientific Reports

Abstract With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether…

View details →DOI: 10.1038/s41598-021-97896-yCited by 9
Negative / Null Result Report

Significant effect of information placebo on exercise test results in children with normal weight, overweight and obesity

Shira Fanti‐Oren, Daphna Birenbaum‐Carmeli, Dan Nemet et al. · 2019 · Acta Paediatrica

Abstract Aim The aim of the study was to examine the effect of information placebo on fitness test results in normal weight, overweight and obese children. Methods Twenty‐four pre‐pubertal children with overweight or obesity and 24 age and…

View details →DOI: 10.1111/apa.14959Cited by 9
Negative / Null Result Report

Steroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Rats

Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International

Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…

View details →DOI: 10.1155/2015/207534Cited by 9
Negative / Null Result Report

Biologically relevant small variations of intra-cellular pH can have significant effect on stability of protein–DNA complexes, including the nucleosome

Alexey V. Onufriev · 2023 · Frontiers in Molecular Biosciences

Stability of a protein-ligand complex may be sensitive to pH of its environment. Here we explore, computationally, stability of a set of protein-nucleic acid complexes using fundamental thermodynamic linkage relationship. The nucleosome,…

View details →DOI: 10.3389/fmolb.2023.1067787Cited by 8
Negative / Null Result Report

Effect of Significant Postoperative Complications on Decision Regret After Laparoscopic Sleeve Gastrectomy: a Case–Control Study

Katarzyna Bartosiak, Michał R. Janik, Maciej Walędziak et al. · 2022 · Obesity Surgery

Abstract Background Thus far, no data are available on decision regret about sleeve gastrectomy (SG), particularly in patients who experienced perioperative complications. This study aimed to assess whether patients with postoperative…

View details →DOI: 10.1007/s11695-022-06113-wCited by 8
Negative / Null Result Report

Inflation in 2022 did not affect congressional voting, but abortion did

Diana C. Mutz, Edward D. Mansfield · 2024 · Proceedings of the National Academy of Sciences

This study examines voting in the 2022 United States congressional elections, contests that were widely expected to produce a sizable defeat for Democratic candidates for largely economic reasons. Based on a representative national…

View details →DOI: 10.1073/pnas.2319512121Cited by 8
Negative / Null Result Report

Phytoplankton settling quality has a subtle but significant effect on sediment microeukaryotic and bacterial communities

Séréna Albert, Per Hedberg, Nisha H. Motwani et al. · 2021 · Scientific Reports

Abstract In coastal aphotic sediments, organic matter (OM) input from phytoplankton is the primary food resource for benthic organisms. Current observations from temperate ecosystems like the Baltic Sea report a decline in spring bloom…

View details →DOI: 10.1038/s41598-021-03303-xCited by 8
Negative / Null Result Report

Clinical Decision Support System with Renal Dose Adjustment Did Not Improve Subsequent Renal and Hepatic Function among Inpatients: The Japan Adverse Drug Event Study

Ryuhei Wada, Jiro Takeuchi, Tsukasa Nakamura et al. · 2020 · Applied Clinical Informatics

Abstract Background Medication dose adjustment is crucial for patients with renal dysfunction (RD). The assessment of renal function is generally mandatory; however, the renal function may change during the hospital stay and the manual…

View details →DOI: 10.1055/s-0040-1721056Cited by 8
Negative / Null Result Report

Significant Prognostic Factors Influencing the Survival Difference of Oral Tongue Squamous Cell Carcinoma

Sarinya Boonpoapichart, Pattama Punyavong, Kamonwan Jenwitheesuk et al. · 2021 · Plastic and Reconstructive Surgery - Global Open

Background: Oral tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Overall survival varies across many countries, and poor prognosis is prevalent in developing countries, including Thailand. Our study aimed…

View details →DOI: 10.1097/gox.0000000000003889Cited by 8
Negative / Null Result Report

Evolutionary opportunity and the limits of community similarity in replicate radiations of island lizards

Luke Owen Frishkoff, Gavia Lertzman‐Lepofsky, D. Luke Mahler · 2022 · Ecology Letters

Abstract Ecological community structure ultimately depends on the production of community members by speciation. To understand how macroevolution shapes communities, we surveyed Anolis lizard assemblages across elevations on Jamaica and…

View details →DOI: 10.1111/ele.14098Cited by 8
Negative / Null Result Report

Combining a transosseous cerclage wire after patellar tendon reattachment to treat patella distal pole fracture did not improve functional outcome

Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports

Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…

View details →DOI: 10.1038/s41598-022-13641-zCited by 8
Negative / Null Result Report

Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso et al. · 2015 · Revista da Associação Médica Brasileira

Summary Objective: Objective: to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. Methods: retrospective study analyzing records…

View details →DOI: 10.1590/1806-9282.61.03.215Cited by 8
Negative / Null Result Report

Does Linguistic Analysis Confirm the Validity of Facilitated Communication?

Timo Saloviita · 2016 · Focus on Autism and Other Developmental Disabilities

Facilitated communication (FC) has been interpreted as an ideomotor phenomenon, in which one person physically supports another person’s hand and unconsciously affects the content of the writing. Despite the strong experimental evidence…

View details →DOI: 10.1177/1088357616646075Cited by 8
Negative / Null Result Report

Diagnostic Accuracy Of Global Longitudinal Strain For Detecting Significant Coronary Artery Disease In Diabetic Patients Without Regional Wall Motion Abnormality

Oumaima Alaika, Souad Jamai, Nawal Doghmi et al. · 2020 · Journal of the Saudi Heart Association

Objectives: Speckle-tracking imaging is a novel method for assessing left ventricular (LV) function and ischemic changes. The aim of this prospective study was to assess the diagnostic accuracy of global longitudinal strain (GLS) and…

View details →DOI: 10.37616/2212-5043.1096Cited by 8
Negative / Null Result Report

Content Analysis of YouTube Videos That Demonstrate Periapical Radiography

Marlene Grillon, Andy Wai Kan Yeung · 2022 · Applied Sciences

No prior study has evaluated the content of YouTube videos that demonstrated how to take periapical radiographs, one of the commonest radiographic examinations in dentistry. This study provided a content analysis on these YouTube videos.…

View details →DOI: 10.3390/app12199602Cited by 8
Negative / Null Result Report

Glyceryl Trinitrate Ointment Did Not Reduce Pain After Stapled Hemorrhoidectomy: A Randomized Controlled Trial

Trent Cross, Lynne Bartlett, Chrispen Mushaya et al. · 2012 · International Surgery

Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with…

View details →DOI: 10.9738/cc92.1Cited by 8
Negative / Null Result Report

Together We can Figure It out: Groups Find Hospitality Robots Easier to Use and Interact With Them More than Individuals

Harrison Preusse, Rebecca Skulsky, Marlena R. Fraune et al. · 2021 · Frontiers in Robotics and AI

As robots are becoming more prevalent and entering hospitality settings, understanding how different configurations of individuals and groups interact with them becomes increasingly important for catering to various people. This is…

View details →DOI: 10.3389/frobt.2021.730399Cited by 8