Negative / Null Result ReportOpen accessEngineering
Yuzhou Tang, Judith S. Ford, Tim T. Cockerill · 2026 · Biochar
Abstract The agricultural sector urgently requires scalable solutions to reduce greenhouse gas (GHG) emissions from residue management. Biochar offers a promising carbon removal pathway, but its adoption is limited by technical, regulatory, and economic barriers. A key constraint is the lack of system designs that can accommodate multiple feedstocks while complying with land application regulations. This study designs and evaluates an integrated biochar production system that enables the separate processing of straw and manure through parallel pyrolysis lines, while optimising internal energy
View details →DOI: 10.1007/s42773-025-00527-2Cited by 10 Replication FailureOpen accessMedicine
Daniel Chin, Tamara Hernández-Beeftink, Lauren J. Donoghue et al. · 2026 · European Respiratory Journal
ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease that might represent potential new drug targets, and it has been shown that drug targets with support from genetic studies are more likely to be successful in clinical development. Previous genome-wide association studies (GWAS) of IPF susceptibility have identified more than 20 signals implicating genes involved in multiple mechanisms, including telome
View details →DOI: 10.1183/13993003.00506-2026Cited by 10 Negative / Null Result ReportOpen accessMedicine
Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs et al. · 2026 · JAMA
Importance: Digitalis glycosides may be used as additional therapy in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or HF with reduced EF (HFrEF). Objective: To assess the effect of digitalis glycosides on…
View details →DOI: 10.1001/jama.2026.7886Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Iveny Makore, Chisinga Ngonidzashe Chikutuma · 2025 · Journal of risk and financial management
Zimbabwe’s economy has experienced extreme exchange rate fluctuations over the past decades, driven by persistent macroeconomic instability and episodes of hyperinflation. The instability in exchange rates can significantly impact trade balances, inflation rates, and overall economic resilience. Understanding the impact of exchange rate volatility (ERV) on international trade is crucial in such a context. This study investigates the impact of exchange rate volatility (ERV) on international trade in Zimbabwe, addressing a literature gap related to its unique economic challenges and hyperinflati
View details →DOI: 10.3390/jrfm18070376Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Alexandra Moroianu, Shivani Bhandari, Maria R. Drout et al. · 2025 · The Astrophysical Journal Letters
Abstract We report the milliarcsecond localization of a high (∼1379 pc cm −3 ) dispersion measure (DM) repeating fast radio burst (FRB), FRB 20190417A. Combining European VLBI Network detections of five repeat bursts, we confirm the FRB’s host to be a low-metallicity, star-forming dwarf galaxy at z = 0.12817, similar to the hosts of FRB 20121102A, FRB 20190520B, and FRB 20240114A. We also confirm that it is associated with a previously reported persistent radio source (PRS), which is compact on milliarcsecond scales. Visibility-domain model fitting constrains the transverse physical size of th
View details →DOI: 10.3847/2041-8213/ae28c7Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
P. Abratenko, D. Andrade Aldana, Luciano Arellano et al. · 2025 · Nature
Abstract The existence of three distinct neutrino flavours, ν e , ν μ and ν τ , is a central tenet of the Standard Model of particle physics 1,2 . Quantum-mechanical interference can allow a neutrino of one initial flavour to be detected sometime later as a different flavour, a process called neutrino oscillation. Several anomalous observations inconsistent with this three-flavour picture have motivated the hypothesis that an additional neutrino state exists, which does not interact directly with matter, termed as ‘sterile’ neutrino, ν s (refs. 3–9 ). This includes anomalous observations from
View details →DOI: 10.1038/s41586-025-09757-7Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Tjaša Mlinarič, Arne Van Den Kerchove, Zoe I. Barinaga et al. · 2026 · Scientific Reports
Abstract Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are two major causes of dementia, with overlapping clinical and pathophysiological characteristics. We investigated whether resting-state EEG functional connectivity could distinguish AD, FTD, and healthy controls (HC) using a stacked ensemble learning approach. A publicly available dataset (openneuro.org/datasets/ds004504) was used to extract multiple connectivity metrics across frequency bands. Base classifiers were trained using the Fisher’s Geodesic Minimum Distance to Mean (FgMDM) approach with Euclidean or Riemannian dis
View details →DOI: 10.1038/s41598-026-35316-9Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Shrish Singh, V.K. Jain, Hemraj Verma et al. · 2025 · Discover Food
Food consumption depletes natural resources, pollutes ecosystems, and generates waste, significantly impacting sustainability and the environment. Traditional agriculture, reliant on synthetic fertilizers, pesticides, and excessive water…
View details →DOI: 10.1007/s44187-025-00559-4Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Carlos Alberto de Sousa Rodrigues-Filho, Flávia R. C. Costa, Juliana Schietti et al. · 2024 · Global Change Biology
Tropical biodiversity is undergoing unprecedented changes due to the hydrological cycle intensification, characterized by more intense droughts and wet seasons. This raises concerns about the resilience of animal and plant communities to…
View details →DOI: 10.1111/gcb.17598Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jimmy Chun Yu Louie · 2026 · Critical Reviews in Food Science and Nutrition
The Nova food classification system has become highly influential in nutritional epidemiology, linking negative health outcomes to "ultra-processed foods" based on industrial formulation. It assumes that products made with substances and…
View details →DOI: 10.1080/10408398.2026.2656719Cited by 10 Replication FailureOpen accessMedicine
Min Gao, Megan Kirk, Heather Knight et al. · 2026 · JAMA Psychiatry
Importance: Preclinical evidence and case reports suggest potential therapeutic benefits of ketogenic diets (KDs) in the treatment of depression, but evidence from well-controlled randomized clinical trials (RCTs) is lacking. Objective: To assess the efficacy of a KD compared with a control diet in adults with treatment-resistant depression (TRD). Design, Setting, and Participants: This RCT was conducted between February 22 and June 15, 2024. Participants aged 18 to 65 years with TRD and a score of 15 or greater on the 9-item Patient Health Questionnaire (PHQ-9) from across the UK were include
View details →DOI: 10.1001/jamapsychiatry.2025.4431Cited by 10 Replication FailureOpen accessMedicine
Pallav L. Shah, Dirk‐Jan Slebos, Richard Sue et al. · 2025 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale AIRFLOW-3 was a 1:1 randomized, double-blind, sham-controlled trial of the D’Nerva targeted lung denervation (TLD) system in patients with chronic obstructive pulmonary disease (COPD). Objective To evaluate the impact of…
View details →DOI: 10.1164/rccm.202502-0404ocCited by 10 Negative / Null Result ReportOpen accessHealth Professions
Andrew Hughes, Daniel J. Taylor, P D Morris et al. · 2026 · European Heart Journal
Wearable devices are transforming cardiovascular medicine by enabling continuous monitoring of physiologic and behavioural measures outside of traditional clinical settings. Smartwatches and activity trackers, the most widely used wearables, employ motion and biometric sensors to measure physical activity, sleep quality, heart rate, and rhythm. By converting health goals into objective, quantifiable measures, wearable devices empower patients to assume a more active role in their health while providing clinicians with novel opportunities for longitudinal, real-world assessment. Clinical applic
View details →DOI: 10.1093/eurheartj/ehag189Cited by 10 Negative / Null Result ReportOpen accessImmunology and Microbiology
Ioannis Tsomidis, A. Tsakou, Argyro Voumvouraki et al. · 2026 · Biomedicines
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a continuum of hepatic pathological manifestations of the metabolic syndrome. Pathogenesis is not clearly understood despite recent progress, but Kupffer cells and bone marrow-derived macrophages (BMDMs) have a fundamental role. In this review, the multiple pathophysiological aspects of MASLD are presented, including genetics, insulin resistance, lipotoxicity, and inflammation. The participation of innate and adaptive immunity, as well as the implications of the recently described trained immunity, is presented. The interplay
View details →DOI: 10.3390/biomedicines14010151Cited by 10 Negative / Null Result ReportOpen accessEngineering
Prabhu Gurunathappa Sheelavantar, Poornachandra Pandit, Shreelaxmi Prashant · 2026 · Scientific Reports
Abstract The need for sustainable, practical alternatives to Portland cement and two-part alkali-activated systems has led to the development of one-part alkali-activated concrete (OPAAC), which efficiently reuses industrial by-products like fly ash and ground granulated blast furnace slag (GGBS). This study evaluates the fresh (workability) and hardened properties (compressive, tensile, and flexural strengths) of FA-GGBS-based OPAAC, along with durability indicators including sorptivity and chloride ion permeability. A performance-based multi-response optimization using a Taguchi L 9 array an
View details →DOI: 10.1038/s41598-025-34746-1Cited by 10 Negative / Null Result ReportOpen accessEngineering
Anass Moukhliss, Abdellatif Rahmouni, Rhali Benamar · 2025 · Scientific Reports
This paper proposes a discrete physical model (DPM) for the transverse free vibrations of non-uniform bi-directional functionally graded (2D-FGM) beams. The material properties vary in both the axial and thickness directions according to exponential laws, and the beam rest on a spatially variable elastic foundation and satisfy general support conditions. In the proposed formulation, the continuous beam is replaced by a multi-degree-of-freedom chain of lumped masses connected by bars and linear rotational and vertical springs. An adaptive discretization strategy is employed to construct consist
View details →DOI: 10.1038/s41598-025-32206-4Cited by 10 Negative / Null Result ReportOpen accessMedicine
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia et al. · 2026 · Proceedings of the National Academy of Sciences
Phosphorylated-tau 217 (pTau217) is currently the most promising blood-based biomarker for accurately detecting Alzheimer’s disease (AD) pathology. However, interference from peripheral tau species in the kidneys or peripheral nerves can…
View details →DOI: 10.1073/pnas.2536792123Cited by 10 Abandoned HypothesisOpen accessMedicine
Limin Liu, Qing-Qing Yu, Yulu Zhang et al. · 2026 · Cellular and Molecular Life Sciences
Renal fibrosis is a common pathological endpoint in progressive chronic kidney disease (CKD). Clinical evidence indicates that a decline in renal function is more closely associated with tubulointerstitial fibrosis (TIF) than with…
View details →DOI: 10.1007/s00018-026-06176-3Cited by 10 Replication FailureOpen accessPsychology
David Erritzøe, Tommaso Barba, Tiffanie Benway et al. · 2026 · Nature Medicine
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet many patients have inadequate responses to current treatments. Dimethyltryptamine (DMT), a serotonergic psychedelic with rapid onset and short duration, shows promise as a potential antidepressant (AD), although clinical evidence in MDD remains limited. We conducted a phase IIa, double-blind, placebo-controlled, randomized clinical trial to evaluate the efficacy and safety of intravenous DMT (SPL026; DMT fumarate) in adults with moderate-to-severe MDD. Participants received a single 21.5-mg dose of DMT or placebo i
View details →DOI: 10.1038/s41591-025-04154-zCited by 10 Negative / Null Result ReportOpen accessComputer Science
Joshua D Wenger, C. Daryl Cameron, Michael Inzlicht · 2026 · Communications Psychology
Recent advances in AI have enabled large language models to produce expressions that seem empathetic to human users, raising scientific and ethical questions about how people perceive and choose between human and AI sources of emotional support. Although an increasing number of studies have examined how people rate empathy generated by AI, little to no work has examined whether people would choose to receive empathy from AI. We conducted four studies investigating whether people prefer to receive empathetic expressions from humans or AI, and how they evaluate these expressions. Across diverse
View details →DOI: 10.1038/s44271-025-00387-3Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Jingjuan Wu, Qi Li, Qi Li et al. · 2026 · Energies
Carbon dioxide replacement represents a promising hydrate development strategy that effectively balances production efficiency and environmental considerations. However, its production efficiency is lower than that of the depressurization strategy. This limitation can be effectively alleviated by coupling carbon dioxide replacement with inhibitor injection. The design and optimization of the temperature–pressure operating window constrain its effective implementation. In the present work, the phase equilibrium conditions of carbon dioxide hydrate and methane hydrate were experimentally investi
View details →DOI: 10.3390/en19153536Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Asifa Ashraf, M. Yousaf, Chengxun Yuan et al. · 2026 · The European Physical Journal C
Abstract In this draft, we investigate constant redshift function Morris–Thorne-like traversable wormhole (WH) models which described as a relativistic static fluid distribution in Schwarzschild-type coordinates with a topological global monopole charge under the influence of D -dimensional Einstein gravity. In this scenario we consider three distinct shape functions, while matter sector is supported by anisotropic fluid configuration. We show some basic criteria for the viability of all three shape function models, the radial null energy condition is generally violated while tangential compon
View details →DOI: 10.1140/epjc/s10052-026-15351-6Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ke Shi, Qing Zheng, Baorong Wang et al. · 2026 · Nature Communications
Abstract Extracellular polymeric substances (EPS) are key microbial residues that contribute to soil organic carbon (SOC) and promote soil aggregation. Yet, their abundance and large-scale controls have only begun to be investigated. We conduct extensive soil sampling across a European transect spanning diverse climates, bedrocks, and land uses. Average soil EPS content is 956 ± 55 µg g -1 soil ( n = 92 sites), with EPS-carbon (EPS-C) contributing 1.6 ± 0.1% to SOC. Bedrock influences EPS content, EPS-C contribution to SOC, and the EPS-C/microbial biomass carbon (MBC) ratio, whereas land use m
View details →DOI: 10.1038/s41467-026-70068-0Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jiahui Lin, Zhongping Mao, Fei Yan · 2026 · Biosensors
Developing an ultrasensitive electrochemiluminescence (ECL) detection platform remains challenging due to the limited enrichment efficiency of ECL emitters and co-reactants at the electrode interface, as well as the insufficient catalytic enhancement of co-reactant conversion. Moreover, simultaneous in situ analyte enrichment and efficient anti-interference capability are often difficult to achieve in a single sensing interface. Herein, a new ECL platform was developed based on nanocatalyst-supported nanochannel-confined surfactant micelle (SM) system, which integrates an enhanced luminol-diss
View details →DOI: 10.3390/bios16050236Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Goran Lalić, Dragana Trifunović · 2026 · Social Sciences
This paper examines income convergence in Europe by jointly analyzing European Union member states and Western Balkan economies over the period 2004–2023. While classical growth theory predicts that poorer economies should grow faster than richer ones, empirical evidence for Europe remains mixed, particularly when institutional and structural heterogeneity is taken into account. Using panel data techniques, the study tests for absolute and conditional β-convergence and complements this analysis with an assessment of σ-convergence. The results provide strong evidence of absolute income converge
View details →DOI: 10.3390/socsci15030180Cited by 9 Negative / Null Result ReportOpen accessEngineering
Yufan Zhu, Huifan Liu, Zhiqiang Yang et al. · 2026 · Theranostics
Background: Excessive inflammation and exacerbated oxidative stress are significant hallmarks of the diabetic bone microenvironment, which give rise to dysregulated immune reactions and impaired bone homeostasis, thereby hindering bone defect healing and increasing the incidence of bone nonunion.Methods: A biodegradable photothermal hybrid (SC/MTZ) was developed through the in situ self-assembly of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles on tannic acid (TA)-functionalized Ti3C2Tx MXene nanosheets, which were then integrated into a methacrylated silk fibroin/carboxymethyl chitosa
View details →DOI: 10.7150/thno.130240Cited by 9 Negative / Null Result ReportPsychology
Gorn Huvanandana, Peerayuth Charoensukmongkol · 2026 · International Journal of Workplace Health Management
Purpose Grounded in conservation of resources theory, this study investigates how digital leadership influences AI-related job insecurity, AI use anxiety, technostress, and emotional exhaustion. Innovative climate is proposed as the work…
View details →DOI: 10.1108/ijwhm-09-2025-0252Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuko Shimizu‐Motohashi · 2025 · Brain and Development
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by variants of the DMD that leads to progressive muscle degeneration. Recent advances in gene therapy have opened new therapeutic avenues, particularly through the use of adeno-associated virus (AAV)-mediated micro-dystrophin delivery. Delandistrogene moxeparvovec, the first FDA-approved gene therapy for DMD, has demonstrated transgene expression and potential functional improvement in early phase trials, although its long-term efficacy, durability, and safety remain unconfirmed. Immune-mediated toxicities including
View details →DOI: 10.1016/j.braindev.2025.104424Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Mohammad Hadra, Karleen Cambridge, Mostefa Mesbah · 2026 · International Journal for Educational Integrity
The rapid adoption of generative AI (GenAI) in higher education has intensified concerns about academic integrity, particularly for institutions serving English as a Foreign Language (EFL) learners. AI content detectors such as Turnitin…
View details →DOI: 10.1007/s40979-026-00213-1Cited by 9 Negative / Null Result ReportOpen accessMaterials Science
Vinicius Firmino dos Santos, Eduardo R. Almeida, Lucas Miguel Pereira Souza et al. · 2025 · Macromolecules
High Resolution Image Download MS PowerPoint Slide Polymer brushes exhibit unique structural and dynamic properties compared to free polymers due to their confined and tethered nature. While coarse-grained (CG) models for free polymers are well-established in the literature, their direct application to polymer brushes is limited. This is because brushes demonstrate distinct conformational behaviors, scaling laws, and responses to environmental stimuli that may not be accurately captured by models developed for free polymers. We have systematically evaluated chemically specific CG parameters wi
View details →DOI: 10.1021/acs.macromol.5c00273Cited by 9 