The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease
Ioannis Tsomidis; A. Tsakou; Argyro Voumvouraki; E Kouroumalis · 2026 · Biomedicines
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a continuum of hepatic pathological manifestations of the metabolic syndrome. Pathogenesis is not clearly understood despite recent progress, but Kupffer cells and bone marrow-derived macrophages (BMDMs) have a fundamental role. In this review, the multiple pathophysiological aspects of MASLD are presented, including genetics, insulin resistance, lipotoxicity, and inflammation. The participation of innate and adaptive immunity, as well as the implications of the recently described trained immunity, is presented. The interplay
Abstract by Ioannis Tsomidis; A. Tsakou; Argyro Voumvouraki; E Kouroumalis, Biomedicines (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/biomedicines14010151