Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sk. Kayum Alam, Li Wang, Zhu Zhu et al. · 2023 · npj Precision Oncology
Non-small cell lung cancer (NSCLC) accounts for 80-85% cases of lung cancer cases. Diagnosis at advanced stages is common, after which therapy-refractory disease progression frequently occurs. Therefore, a better understanding of the molecular mechanisms that control NSCLC progression is necessary to develop new therapies. Overexpression of IκB kinase α (IKKα) in NSCLC correlates with poor patient survival. IKKα is an NF-κB-activating kinase that is important in cell survival and differentiation, but its regulation of oncogenic signaling is not well understood. We recently demonstrated that IK
View details →DOI: 10.1038/s41698-023-00370-3Cited by 9 Negative / Null Result ReportMedicine
Leah Amundson, Brandon Boelts, Vivek Kataria et al. · 2021 · Infectious Diseases in Clinical Practice
To the Editor: Coronavirus disease 2019 (COVID-19) has resulted in a widespread pandemic in which various therapeutics have been studied. Targeted therapies focus on either the viral or the inflammatory phase to ultimately reduce disease…
View details →DOI: 10.1097/ipc.0000000000001035Cited by 9 Negative / Null Result Report
H. R. Spaulding, T. Quindry, J. C. Quindry et al. · 2020 · Experimental Physiology
New Findings What is the central question of this study? We previously demonstrated that quercetin transiently preserved respiratory function in dystrophin‐deficient mice. To gain lasting therapeutic benefits, we tested quercetin in…
View details →DOI: 10.1113/ep087887Cited by 9 Negative / Null Result ReportOpen accessMedicine
Vasileios Angelis, Alicia Okines · 2023 · Cancers
Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase in
View details →DOI: 10.3390/cancers16010023Cited by 9 Negative / Null Result ReportOpen accessMedicine
S. Lot Aronson, Bram Thijssen, Marta López‐Yurda et al. · 2025 · Nature Communications
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in high-grade serous ovarian cancer (HGSOC) remains limited. Some patients, however, achieve lasting responses, emphasizing the need to…
View details →DOI: 10.1038/s41467-025-58440-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology
PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…
View details →DOI: 10.1200/jco-25-01569Cited by 9 Negative / Null Result ReportMedicine
Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research
AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…
View details →DOI: 10.1111/j.1447-0756.2010.01271.xCited by 9 Negative / Null Result ReportOpen accessMedicine
Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open
STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…
View details →DOI: 10.1002/emp2.12229Cited by 9 Negative / Null Result Report
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
View details →DOI: 10.1152/japplphysiol.00162.2019Cited by 9 Negative / Null Result Report
Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research
The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…
View details →DOI: 10.1103/physrevresearch.6.013154Cited by 9 Negative / Null Result ReportOpen accessMedicine
Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…
View details →DOI: 10.1186/s12933-025-02871-wCited by 9 Negative / Null Result ReportOpen accessMedicine
Sha Sha, Lina Ren, Xiaona Xing et al. · 2025 · Neural Regeneration Research
Alzheimer's disease, a devastating neurodegenerative disorder, is characterized by progressive cognitive decline, primarily due to amyloid-beta protein deposition and tau protein phosphorylation. Effectively reducing the cytotoxicity of…
View details →DOI: 10.4103/nrr.nrr-d-24-00846Cited by 9 Negative / Null Result ReportOpen accessMedicine
Lucy Plumb, Anna Casula, Manish D. Sinha et al. · 2023 · Clinical Kidney Journal
ABSTRACT Background Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study…
View details →DOI: 10.1093/ckj/sfad070Cited by 9 Negative / Null Result ReportOpen accessMedicine
Jwa Hoon Kim, Jae Ho Jeong, Baek‐Yeol Ryoo et al. · 2020 · Cancer Research and Treatment
PURPOSE: This study evaluated the efficacy of adjuvant chemotherapy (AC) in patients with resected ampulla of Vater (AoV) carcinoma. MATERIALS AND METHODS: Data from 646 patients who underwent surgical resection at Asan Medical Center…
View details →DOI: 10.4143/crt.2020.953Cited by 9 Negative / Null Result ReportOpen accessMedicine
Lujun Shen, Fei Cao, Ying Liu et al. · 2025 · BMC Medicine
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) stage C…
View details →DOI: 10.1186/s12916-025-04110-1Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science
We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…
View details →DOI: 10.1016/j.jacbts.2024.05.014Cited by 9 Null DatasetOpen accessMedicine
Peter Beckwith, Mpho Tlali, Salome Charalambous et al. · 2021 · American Journal of Tropical Medicine and Hygiene
Tuberculosis (TB) remains the leading cause of hospitalization and in-hospital mortality in HIV-positive adults. Using data from hospital and clinic files, research databases, and autopsy, we describe causes and outcomes of admissions, and…
View details →DOI: 10.4269/ajtmh.21-0133Cited by 9 Negative / Null Result ReportOpen accessMedicine
Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences
Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention
View details →DOI: 10.3389/fresc.2023.1114537Cited by 9 Negative / Null Result ReportOpen accessMedicine
Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research
BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi
View details →DOI: 10.2196/46934Cited by 9 Negative / Null Result ReportOpen accessMedicine
Iván Chérrez-Ojeda, Marcus Maurer, Miguel Félix et al. · 2021 · World Allergy Organization Journal
BackgroundFew studies have explored the association between obstructive sleep apnea (OSA) and chronic urticaria (CU). Our study aims to fill this gap by determining the frequency of the risk categories for OSA and how they might correlate…
View details →DOI: 10.1016/j.waojou.2021.100577Cited by 9 Negative / Null Result ReportOpen accessMedicine
LI-HSIOU CHEN, Kuo-Liang Chiu, Te‐Chun Hsia et al. · 2020 · In Vivo
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among…
View details →DOI: 10.21873/invivo.12153Cited by 9 Negative / Null Result ReportMedicine
Maryam Karimi, Mazaher Khodabandehloo, Bahram Nikkhoo et al. · 2016 · PubMed
Background and Objective: Any role of human papillomavirus (HPV) in the development of breast cancer is conjectural. The aim of this study was to investigate possible links between HPV and breast cancer in women, Sanandaj, Iran. Methods:…
View details →DOI: 10.22034/apjcp.2016.17.10.4741Cited by 9 Negative / Null Result ReportPsychology
Federico de Gregorio, Kasey Windels · 2020 · Journal of Advertising
This exploratory research tests two competing general predictions: the expert-performance literature predicting creatives will demonstrate greater creativity than others while the process-performance paradox literature predicting they will…
View details →DOI: 10.1080/00913367.2020.1799268Cited by 9 Negative / Null Result ReportOpen accessMedicine
J. Robert McCorkle, Rebecca Ahn, Connie D. Cao et al. · 2024 · Cancers
) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate efficacy in ovarian cancer cells. Artesunate and navitoclax both demonstrated antiproliferative effects on 2D and 3D ovarian cancer cell models as single
View details →DOI: 10.3390/cancers16071321Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Surya Prakash, Aritra Das, Sidrat Tasawoor Kanth et al. · 2021 · Cerebral Cortex
Local field potentials (LFPs) in visual cortex are reliably modulated when the subject's focus of attention is cued into versus out of the receptive field of the recorded sites, similar to modulation of spikes. However, human psychophysics…
View details →DOI: 10.1093/cercor/bhab088Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Matthew S W Rassette, Elizabeth I. Pierpont, Tina Wahl et al. · 2011 · PubMed
Treatment of Northern fowl mite (Ornithonyssus sylviarum) infestation on poultry in research facilities can be challenging. The mite has a rapid reproductive cycle (egg to adult in 5 to 7 d), and chemical treatments can be toxic to birds,…
Negative / Null Result ReportOpen accessComputer Science
Eisha Hassan, Fazila‐Tun‐Nesa Malik, Qazi Waqas Khan et al. · 2025 · IEEE Access
Document Clustering has attracted the interest of many researchers who have created several solutions to this problem by combining different techniques, models, and algorithms. While famous for its simplicity, the most commonly used algorithm, K-Means, suffers from issues such as finding the optimal value for k and random initialization of the centroids. In this paper, we propose a hybrid methodology combining K-Means++ with the metaheuristic algorithm PSO to overcome the challenges of both these algorithms. K-Means++ is a smart initialization technique that selects clusters based on probabili
View details →DOI: 10.1109/access.2025.3535226Cited by 9 Negative / Null Result ReportOpen accessMedicine
Urszula Smyczyńska, Szymon Grabia, Zuzanna Nowicka et al. · 2021 · Cancers
State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was development of radiomic NTCP model for radiation-induced hypothyroidism (RIHT) using imaging biomarkers (radiomics). We gathered CT images and clinical data from 98 patients, who underwent intensity-modulated radiation therapy (IMRT) for head and neck cancers with a planned total dose of 70.0 Gy (33–35 fractions). During the 28-month (median) follow-up 27 pat
View details →DOI: 10.3390/cancers13215584Cited by 9 Negative / Null Result ReportOpen accessMedicine
Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ
Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)
View details →DOI: 10.7717/peerj.15969Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science
In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al
View details →DOI: 10.3389/fpls.2023.1221750Cited by 9 