A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 157 of 724
Jean‐Christophe Rozé, Gilles Cambonie, Cyril Flamant et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Controversies persist about management of the ductus arteriosus by nonsteroidal anti-inflammatory drugs in extremely preterm infants. Acetaminophen (paracetamol) appears to be a promising alternative with possibly fewer adverse…
Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
Matthew Bourke, Claudia I. Maddren, Franziska Sippel et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Understanding the within-person association between daily screen use and sleep can help clarify whether this association reflects potentially causal effects or confounding factors. Objective: To synthesize evidence on the…
Chengjiao Yang, Ruici Yang, Binbin Zheng et al. · 2026 · Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pathways (AARS1/2, KATs, HDACs) and non-enzymatic mechanisms (MGO/LGSH), alongside their critical structural underpinnings. Furthermore, we delineate how lactylation signals are interpreted by specific readers (e.g., TRIM33), directly reprogram non-histone protein function through s
Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…
Qiuhan Zhu, Xiangnan Li, Yiang Dong et al. · 2026 · Frontiers in Psychology
Generative AI tools such as ChatGPT now perform core cognitive operations—reasoning, synthesis, evaluation, and creative generation—on users' behalf, raising urgent questions for educational psychology about how AI use relates to cognitive development. Yet research on cognitive offloading has largely treated AI use as a unidimensional phenomenon, obscuring a theoretically consequential distinction: whether AI substitutes for the user's own thinking or scaffolds it. Drawing on the autonomous–dependent help typology and self-determination theory, the present study introduces and examines a disti
Koen H.M. Prange, Gemma Bel-Bordes, MAC Depuydt et al. · 2026 · European Heart Journal
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot
Richard Stiskalek, Harry Desmond, Julien Devriendt et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT The peculiar velocity field of the local Universe provides direct insights into its matter distribution and the underlying theory of gravity, and is essential in cosmological analyses for modelling deviations from the Hubble flow. Numerous methods have been developed to reconstruct the density and velocity fields at $z \lesssim 0.05$, typically constrained by redshift-space galaxy positions or by direct distance tracers such as the Tully–Fisher relation, the Fundamental Plane, or Type Ia supernovae. We introduce a validation framework to evaluate the accuracy of these reconstructions
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology
Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b
Isaac Davor, Francis Ohene Boateng, Franco Osei-Wusu et al. · 2026 · Cogent Education
This study examines the mediating and moderating role of metacognitive awareness in the relationship between self-regulated learning and mathematics achievement of university students in Ghana. Although self-regulated learning has attracted attention as a predictor of academic performance, few studies have examined how metacognitive awareness interacts with self-regulated learning to influence mathematics achievement in the Ghanaian context. A quantitative cross-sectional design was employed. Data were collected from 315 university students, representing a population of 3,240, using a structur
Ashley Rich, Ziqi Li, Alessandro De Simone et al. · 2026 · Nature Physics
Amputated salamander limbs or fish fins precisely regenerate to their pre-injury size, providing a paradigm for positional memory. Although this phenomenon has been appreciated for centuries, how position-dependent cues control tissue…
Teevrat Garg, Ryan Hanna, Jeff Myers et al. · 2026 · Journal of Environmental Economics and Management
Aligning electric vehicle (EV) charging with periods of abundant clean energy is essential for decarbonizing transportation. In solar-dominated grids, this requires shifting charging to midday hours – when vehicles are typically parked at workplaces. Yet workplace charging networks operate under institutional constraints such as shared infrastructure, bundled parking and charging services, and limited willingness to require drivers to move vehicles, making time-of-day pricing and active management difficult to implement. In a natural field experiment (n = 629 drivers) across a large workplace
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
Ali Raza, Fareeha Hanif, Heba Abdelgader Mohammed · 2026 · Scientific Reports
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and accurate early diagnosis plays a critical role in improving patient survival. In this study, a comparative analysis of multiple lightweight Convolutional Neural Network (CNN) variants is presented for multi-class lung cancer classification using histopathological images. Four CNN architectures were designed to systematically explore the trade-off between model complexity and classification performance. Each variant was trained and evaluated within a unified experimental framework incorporating data augment
Tahrim Ramzan, Muhammad Shahbaz, Farooq Ahmad et al. · 2026 · New Zealand Journal of Crop and Horticultural Science
Salinity stress is a major abiotic factor that inhibits plant growth and yield. This study's objective was to evaluate how foliar applications of melatonin and ascorbic acid affected canola varieties under salt stress. The treatments of…
Guowu Gan, Ruonan Chen, Peining Zheng et al. · 2026 · Frontiers in Cellular and Infection Microbiology
The oral-gut axis represents a critical bidirectional pathway linking oral microbiota to systemic health. Dysbiosis of the oral microbiome, driven by pathogens like Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus species, and Helicobacter pylori, disrupts gut ecology via direct translocation, metabolite signaling (e.g., TMAO, SCFAs), and immune crosstalk (e.g., Th17). This leads to gut barrier dysfunction, systemic inflammation, and metabolic disturbances, contributing to diverse diseases beyond the oral cavity. Evidence supports causal links with conditions including rheumato
Lei Li, Hongchao Huang, Yin He et al. · 2025 · Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high. Emerging evidence indicates that cell-free DNA (cfDNA), as a novel biomarker and molecular therapeutic target, holds promise for improving the clinical management of sepsis. cfDNA refers to DNA fragments present in body fluids, including naked DNA, membrane-coated DNA, nucleosomes, and neutrophil extracellular traps (NETs). cfDNA is released from host cells o
Giuseppe Russo, Manoel Horta Ribeiro, Tim R. Davidson et al. · 2025 · Proceedings of the ACM on Human-Computer Interaction
Journals and conferences worry that peer reviews assisted by artificial intelligence (AI), in particular, large language models (LLMs), may negatively influence the validity and fairness of the peer-review system, a cornerstone of modern…
Jessica Coria, Jūratė Jaraitė · 2025 · Research Policy
This paper examines whether the EU Emissions Trading Scheme (EU ETS) and innovation subsidies interact to enhance green innovation at the firm level. Using staggered difference-in-differences and matched samples, we find no evidence of synergetic effects: firms subject to both the EU ETS and innovation subsidies do not outperform those subject only to subsidies in terms of green patenting outcomes. By contrast, subsidies alone have a clear positive impact on green innovation. Firms receiving subsidies generate more green patents, receive more citations, and develop technologies with greater te
Sad Abu alim, Marwan Mansour · 2026 · Sustainability
FinTech adoption is increasingly viewed as a catalyst for sustainable finance, yet empirical evidence on how and under what conditions it enhances environmental, social, and governance (ESG) performance remains mixed, particularly in emerging economies. This study examines the relationship between FinTech adoption and ESG performance in MENA banks, explicitly modeling corruption risk as an internal governance transmission channel. Using a panel of 152 listed banks across 11 MENA countries over the period 2013–2023 and a novel bank-level FinTech Adoption Index constructed through textual analys
Sevgi Kundu, Senem Akkoç, Yalçın Erzurumlu et al. · 2026 · Molecular and Cellular Biochemistry
Abstract Within the scope of this investigation, two novel compounds ( 3a and 3b ) were designed and synthesized in two steps. Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines. It was determined that compound 3b exhibited high levels of cytotoxic activity against both liver and breast cancer cell lines, with IC 50 values of 10.83 and 11.55 µM, respectively. Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD ,
Ke Shi, Qing Zheng, Baorong Wang et al. · 2026 · Nature Communications
Abstract Extracellular polymeric substances (EPS) are key microbial residues that contribute to soil organic carbon (SOC) and promote soil aggregation. Yet, their abundance and large-scale controls have only begun to be investigated. We conduct extensive soil sampling across a European transect spanning diverse climates, bedrocks, and land uses. Average soil EPS content is 956 ± 55 µg g -1 soil ( n = 92 sites), with EPS-carbon (EPS-C) contributing 1.6 ± 0.1% to SOC. Bedrock influences EPS content, EPS-C contribution to SOC, and the EPS-C/microbial biomass carbon (MBC) ratio, whereas land use m
Asifa Ashraf, M. Yousaf, Chengxun Yuan et al. · 2026 · The European Physical Journal C
Abstract In this draft, we investigate constant redshift function Morris–Thorne-like traversable wormhole (WH) models which described as a relativistic static fluid distribution in Schwarzschild-type coordinates with a topological global monopole charge under the influence of D -dimensional Einstein gravity. In this scenario we consider three distinct shape functions, while matter sector is supported by anisotropic fluid configuration. We show some basic criteria for the viability of all three shape function models, the radial null energy condition is generally violated while tangential compon
Jiahui Lin, Zhongping Mao, Fei Yan · 2026 · Biosensors
Developing an ultrasensitive electrochemiluminescence (ECL) detection platform remains challenging due to the limited enrichment efficiency of ECL emitters and co-reactants at the electrode interface, as well as the insufficient catalytic enhancement of co-reactant conversion. Moreover, simultaneous in situ analyte enrichment and efficient anti-interference capability are often difficult to achieve in a single sensing interface. Herein, a new ECL platform was developed based on nanocatalyst-supported nanochannel-confined surfactant micelle (SM) system, which integrates an enhanced luminol-diss
Yiting Lei, Yuwei Zhang, Liangbin Zhou et al. · 2025 · Journal of Orthopaedic Translation
models of orthopaedic conditions have yielded valuable insights into disease mechanisms and drug efficacy, only a few discoveries have been successfully translated to clinical practice. Organoids and organs-on-chips (OoCs) are transforming…
Jingjuan Wu, Qi Li, Qi Li et al. · 2026 · Energies
Carbon dioxide replacement represents a promising hydrate development strategy that effectively balances production efficiency and environmental considerations. However, its production efficiency is lower than that of the depressurization strategy. This limitation can be effectively alleviated by coupling carbon dioxide replacement with inhibitor injection. The design and optimization of the temperature–pressure operating window constrain its effective implementation. In the present work, the phase equilibrium conditions of carbon dioxide hydrate and methane hydrate were experimentally investi