Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
View details →DOI: 10.1080/03650340.2025.2603669Cited by 10 Negative / Null Result ReportOpen accessMedicine
Athina Trachalaki, Anna Lindahl, Simone Petrarulo et al. · 2025 · Breathe
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow disease progression, IPF remains a disease with poor survival. Promising therapeutic…
View details →DOI: 10.1183/20734735.0260-2024Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Zhendong Zhao, Huiwang Dai, Tiantian Nie et al. · 2025 · Nature Communications
High-valent iron-oxo species (FeIV=O) have garnered increasing attention for water purification, while the selective generation of FeIV = O in Fenton-like reactions still lacks an effective control protocol at the atomic level. Here, we…
View details →DOI: 10.1038/s41467-025-66177-xCited by 10 Negative / Null Result ReportOpen accessMedicine
Pinar Sargin, Mark F. Roethle, Shuang Jia et al. · 2022 · Gut Microbes
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day
View details →DOI: 10.1080/19490976.2022.2136467Cited by 10 Negative / Null Result ReportOpen accessImmunology and Microbiology
Yadong Yang, Lei Xu, Yongdong Li et al. · 2025 · Journal of Extracellular Vesicles
ABSTRACT Bacterial outer membrane vesicles (OMVs) are emerging as promising platforms for drug delivery and immunotherapy. However, bacteria only secrete a small amount of OMVs during the growth process, which seriously restricts their…
View details →DOI: 10.1002/jev2.70194Cited by 10 Negative / Null Result ReportOpen accessMedicine
Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →DOI: 10.2196/64028Cited by 10 Negative / Null Result ReportOpen accessMedicine
Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →DOI: 10.1002/pul2.12430Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →DOI: 10.1007/s40122-024-00631-4Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →DOI: 10.3390/brainsci14050516Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Giacomo Mutti, Eduard Ocaña‐Pallarès, Toni Gabaldón · 2025 · Molecular Biology and Evolution
Recent developments in protein structure prediction have allowed the use of this previously limited source of information at genome-wide scales. It has been proposed that the use of structural information may offer advantages over…
View details →DOI: 10.1093/molbev/msaf149Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Jinbiao Huo, Ziyuan Gu, Zhiyuan Liu et al. · 2025 · Transportation Science
This study focuses on simulation-based optimization (SBO) in transportation systems considering the pervasive and influential heteroscedastic noise. Existing studies rarely consider the effects of such heteroscedasticity on the solution…
View details →DOI: 10.1287/trsc.2024.0840Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Dhyani Mehta · 2024 · Carbon Research
Abstract The current research investigates the impact of financial development, digitalization, green trade, manufacturing, and national income on carbon dioxide (CO 2 ) emissions of six Mediterranean countries (MEDIT-6). The study uses a nonlinear panel quantile regression model with panel data of MEDIT-6 countries from 1994 to 2022. The study asserts that higher financial development will reduce CO 2 emissions for MEDIT-6 countries, as it provides more financing options to invest in green energy and potentially curb excessive energy consumption which in turn reduces CO 2 emissions. The study
View details →DOI: 10.1007/s44246-024-00161-wCited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jayeshkumar Kanani · 2025 · The Egyptian Journal of Neurosurgery : the official publication of the Egyptian Society of Neurological Surgeons/Egyptian journal of neurosurgery
Abstract Background Hemangioblastomas are rare, slow-growing benign neoplasms predominantly affecting the central nervous system (CNS). Despite their benign nature, they pose diagnostic challenges due to their diverse clinical manifestations and radiological features. Case presentation. A 40-year-old male presented with chronic headaches and diplopia persisting for 8 years. Initial MRI revealed two cystic lesions in the cerebellum, causing compression and herniation. Surgical removal of one cyst yielded inconclusive results. Follow-up MRIs showed cyst growth and syrinx development. The patient
View details →DOI: 10.1186/s41984-025-00461-2Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jong Won Shin, Minh Nguyen Thien, Sun Ha Jee · 2025 · Healthcare
Background: Bilirubin is a potent endogenous antioxidant that plays a key role in regulating oxidative stress and inflammation, both closely linked to lung carcinogenesis. This study reinterprets the ALBI (Albumin–Bilirubin) and PALBI (Platelet–Albumin–Bilirubin) indices as composite markers of antioxidant and inflammatory status and evaluates their associations with lung cancer risk by sex, including stratified analyses by major lifestyle factors such as smoking and alcohol use. Methods: This study utilized data from the Korean Cancer Prevention Study-II (KCPS-II) cohort, which included 133,6
View details →DOI: 10.3390/healthcare13111321Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jing Zeng, Ali Punjwani · 2025 · Sustainability
Achieving environmental sustainability remains a critical challenge for governments worldwide, particularly within the G20 bloc, due to rapid urbanization, resource-intensive industrial activities, and the environmental pressures associated with globalization. Despite various efforts, ecological degradation continues to escalate, necessitating a deeper understanding of the factors influencing environmental sustainability. This study investigates the role of technological innovation (TLI), education (EDU), human capital (HMC), and natural resources (NTS) in shaping ecological sustainability, wh
View details →DOI: 10.3390/su17073130Cited by 10 Negative / Null Result ReportOpen accessMedicine
Bilal A. Siddiqui, Sumit K. Subudhi, Padmanee Sharma · 2022 · Cell Reports Medicine
The addition of atezolizumab (anti-PD-L1) to enzalutamide (androgen receptor antagonist) did not prolong survival in metastatic prostate cancer.1Powles T. Yuen K.C. Gillessen S. Kadel 3rd, E.E. Rathkopf D. Matsubara N. Drake C.G. Fizazi K.…
View details →DOI: 10.1016/j.xcrm.2022.100613Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Abdulalem Mohammed, Abdullah Kaid Al‐Swidi, Mohammed A. Al-Hakimi et al. · 2025 · Discover Sustainability
The relationship between Corporate Social Responsibility (CSR) and competitive advantage (CA) has become more critical than ever for firms, particularly in the hospitality and other service industries, during times of crisis. This study…
View details →DOI: 10.1007/s43621-025-00824-7Cited by 10 Replication FailureOpen accessMedicine
Julien Vionnet, Jorge P. Torres-Yaguana, Rosa Miquel et al. · 2024 · American Journal of Transplantation
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver
View details →DOI: 10.1016/j.ajt.2024.12.002Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthias Klein, J. J. Mohr, C. T. Davies · 2024 · Astronomy and Astrophysics
Galaxy clusters are useful cosmological probes and interesting astrophysical laboratories. As the cluster samples continue to grow in size, a deeper understanding of the sample characteristics and improved control of systematics becomes more crucial. For this analysis we created a new and larger ACT-DR5-based thermal Sunyaev–Zel’dovich Effect- (tSZE-) selected galaxy cluster catalog with improved control over sample purity and completeness. We employed the red sequence based cluster redshift and confirmation tool MCMF together with optical imaging data from the Legacy Survey DR-10 and infrared
View details →DOI: 10.1051/0004-6361/202451203Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Faisal AlReshaid, Alper Ertürk, Razan Alkhayyat et al. · 2025 · Frontiers in Psychology
Introduction: Leaders' self-awareness is essential to leadership effectiveness. Cognitive styles-how individuals perceive and process information-are key factors in fostering self-awareness. Drawing on Social Identity Theory (SIT), this study explores whether cognitive style congruence between supervisors and subordinates enhances supervisors' self-awareness, and whether Leader-Member Exchange (LMX) mediates this relationship. Methods: We used a time-lagged dyadic design and multilevel polynomial regression to analyze data from 189 subordinates and 36 supervisors. Cognitive styles were measure
View details →DOI: 10.3389/fpsyg.2025.1583837Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Muhammad Asif, Long Yun-rong, Muhammad Azam Zia et al. · 2025 · Energy & Environment
Climate change, caused by the burning of fossil fuels, has emerged as an acute world problem, especially in the Group of Twenty (G20), where CO 2 emissions and other greenhouse gases are accumulating. This research examines how energy…
View details →DOI: 10.1177/0958305x251319367Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Muhammad Haziq Saharuddin, M. Khalid M. Nasir, Muhammad Sofwan Mahmud · 2025 · International Journal of Learning Teaching and Educational Research
Technological pedagogical content knowledge (TPACK) is a theory that describes the knowledge and skills required by a teacher to integrate technology into their teaching. This study aimed to identify the level of TPACK among primary school…
View details →DOI: 10.26803/ijlter.24.1.7Cited by 10 Negative / Null Result ReportOpen accessMedicine
Chiara Livolsi, R. Conti, Tommaso Ciapetti et al. · 2025 · Scientific Reports
Millions of individuals surviving a stroke have lifelong gait impairments that reduce their personal independence and quality of life. Reduced walking speed is one of the major problems limiting community mobility and reintegration. Previous studies have shown positive effect of robot-assisted gait training utilizing hip exoskeletons for individuals with gait impairments due to a stroke, leading to increased walking speed in post-treatment compared to pre-treatment assessments. However, no evidence emerged of a significant increasing in walking speed attributable to device usage compared to wa
View details →DOI: 10.1038/s41598-025-86343-xCited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Chris J. Willott, Yoshihisa Asada, Kartheik G. Iyer et al. · 2025 · The Astrophysical Journal
Abstract We present JWST observations of a gravitationally lensed, extremely metal-poor galaxy at redshift z = 8.203 ± 0.001 from the CANUCS survey. Based on the low oxygen to Balmer line ratios, we infer a gas-phase metallicity of 12 + log(O/H) = 6.85 (1.4% solar), making CANUCS-A370-z8-LAE one of the most metal-poor galaxies known at z > 7. The galaxy has a high H β equivalent width of 225 ± 50 Å, small half-light radius of only r hl = 3 8 − 19 + 3 pc, and high star formation rate density of 50–100 M ⊙ yr −1 kpc −2 . The galaxy shows high-equivalent-width Ly α emission with an i
View details →DOI: 10.3847/1538-4357/addf49Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
T. Zhang, Chuan Qin, Zhaoying Lu · 2025 · International Review of Economics & Finance
This study investigates the relationship between firm-level market competitiveness and corporate environmental, social, and governance (ESG) performance, with a particular focus on the underlying mechanisms and moderating factors…
View details →DOI: 10.1016/j.iref.2025.104201Cited by 10 Negative / Null Result ReportOpen accessMaterials Science
Sonakshi Gupta, Akhlak Mahmood, Shivank Shukla et al. · 2025 · Macromolecular Rapid Communications
ABSTRACT Machine learning and artificial intelligence have revolutionized polymer science by enhancing the ability to rapidly predict key polymer properties and enabling generative design. The utilization of large language models (LLMs) in polymer informatics may offers additional opportunities for advancement. Unlike traditional methods that depend on large labeled datasets, hand‐crafted representations of the materials, and complex feature engineering, LLM‐based methods utilize natural language inputs via a transfer learning process and eliminate the need for complex representation and finge
View details →DOI: 10.1002/marc.202500388Cited by 10 Negative / Null Result ReportOpen accessMedicine
Şafak Kılıç · 2025 · PLoS ONE
BACKGROUND AND OBJECTIVE: Male fertility assessment through sperm morphology analysis remains a critical component of reproductive health evaluation, as abnormal sperm morphology is strongly correlated with reduced fertility rates and poor assisted reproductive technology outcomes. Traditional manual analysis performed by embryologists is time-intensive, subjective, and prone to significant inter-observer variability, with studies reporting up to 40% disagreement between expert evaluators. This research presents a novel deep learning framework combining Convolutional Block Attention Module (CB
View details →DOI: 10.1371/journal.pone.0330914Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Borbála Turcsán, Dorottya Júlia Ujfalussy, Andrea Kerepesi et al. · 2025 · Scientific Reports
Most dog owners in Western countries regard their dogs as companions or family members, prompting extensive research on the human-animal bond. However, many studies rely on broad categories or single dimensions, such as satisfaction or attachment, which can oversimplify the complexity of these relationships. In contrast, our study employed a multifaceted approach, examining the dog-owner bond across 13 relationship scales and comparing these scales to four different types of human relationships to reveal the human-like roles of dogs within a family. Participants (N = 717) characterized their r
View details →DOI: 10.1038/s41598-025-95515-8Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →DOI: 10.1038/s41591-026-04284-yCited by 10 Negative / Null Result ReportOpen accessMedicine
Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren et al. · 2026 · Nature
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
View details →DOI: 10.1038/s41586-025-10020-2Cited by 10 