Negative / Null Result ReportOpen accessEnvironmental Science
Paul Behrens, Catherine M. Champagne, Jason C. G. Halford et al. · 2025 · Frontiers in Science
The global obesity crisis involves an unprecedented and rapid change to the human phenotype. Conferring vast levels of avoidable morbidity and mortality at enormous cost, it has proved refractory to previous policy-led action. This article reviews recent developments in our understanding of obesity and its links to the climate co-crisis, aiming to inform evidence-based, societal-level actions to address both. Recent therapeutic developments now offer transformative interventions for millions of people living with obesity. However, treating all affected adults and children with major bariatric
View details →DOI: 10.3389/fsci.2025.1613595Cited by 9 Negative / Null Result ReportOpen accessEngineering
J. Jithish, Nagarajan Mahalingam, Bo Wang et al. · 2025 · Cybersecurity
Abstract The forthcoming 6G technology offers significant potential for the advancement of the smart grid domain. 6G promises ultra-low latency, higher data transfer rates, native Artificial Intelligence (AI) support, enhanced connectivity, and improved security for smart grids. Smart grids are vulnerable to cyberattacks, such as Distributed Denial-of-Service (DDoS) attacks, posing a significant threat to grid functionality. To address security concerns, smart grids implement intrusion detection systems (IDS), but detecting novel attacks such as subtle multi-domain DDoS attacks through traditi
View details →DOI: 10.1186/s42400-024-00350-5Cited by 9 Negative / Null Result ReportOpen accessEngineering
Lina Maria Ellegård, Gustav Kjellsson, Linn Mattisson · 2026 · The Economic Journal
Abstract The emergence of markets for on-demand online physician consultations —direct-to-consumer telemedicine (DCT) — is currently transforming many healthcare settings. DCT may be a cost-effective substitute for in-person consultations, but the convenience of seeking DCT may increase the demand for the service and consequently also the costs for health insurers. To causally assess the degree to which DCT consultations substitute for in-person primary care consultations, we exploit exogenous changes in patient fees in a fuzzy difference-in-discontinuities analysis of young adults in Sweden.
View details →DOI: 10.1093/ej/ueag016Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
A. J. Nayana, R. Margutti, Eli Wiston et al. · 2025 · The Astrophysical Journal Letters
Abstract We present X-ray (0.3–79 keV) and radio (0.25–203 GHz) observations of the most luminous fast blue optical transient (LFBOT) AT 2024wpp at z = 0.0868, spanning 2–280 days after first light. AT 2024wpp shows luminous ( L X ≈ 1.5 × 10 43 erg s −1 ), variable X-ray emission with a Compton hump peaking at δt ≈ 50 days. The X-ray spectrum evolves from a soft ( F ν ∝ ν −0.6 ) to an extremely hard state ( F ν ∝ ν 1.26 ) accompanied by a rebrightening at δt ≈ 50 days. The X-ray emission properties favor an embedded high-energy source shining through asymmetric expanding ejecta. We detect radi
View details →DOI: 10.3847/2041-8213/ae0b4dCited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →DOI: 10.1086/737989Cited by 9 Negative / Null Result ReportOpen accessEngineering
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
View details →DOI: 10.1039/d5lc00890eCited by 9 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →DOI: 10.3390/economies13040111Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
View details →DOI: 10.1016/j.jconrel.2025.114509Cited by 9 Replication FailureOpen accessMedicine
Mihir A Kelshiker, Patrik Bächtiger, Camille F Petri et al. · 2026 · The Lancet
BACKGROUND: Early detection of cardiovascular disease is a global public health priority. Artificial intelligence (AI)-enabled stethoscopes offer robust performance characteristics in point-of-care detection of heart failure, atrial fibrillation, and valvular heart disease (VHD). We conducted a pragmatic, cluster-randomised controlled implementation trial to determine the real-world effect and implementation challenges of AI-stethoscopes. METHODS: UK primary care practices were cluster randomised 1:1 to intervention (training and implementation in use of AI-stethoscopes in routine care) or con
View details →DOI: 10.1016/s0140-6736(25)02156-7Cited by 9 Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →DOI: 10.3390/ijms27010485Cited by 9 Negative / Null Result ReportOpen accessMedicine
Florian Missey, Emma Acerbo, Adam S. Dickey et al. · 2025 · Brain stimulation
INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated the potential of non-invasive temporal interference (TI) electrical stimulation in reducing epileptic biomarkers in patients with mesiotemporal epilepsy (MTLE) MATERIAL AND METHOD: Thirteen patients implanted with stereoelectroencephalography (sEEG) de
View details →DOI: 10.1016/j.brs.2025.11.008Cited by 9 Negative / Null Result ReportOpen accessDentistry
Rafael Scaf de Molon, João Paulo Steffens, Érica Dorigatti de Ávila et al. · 2026 · Journal of Periodontal Research
Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology
View details →DOI: 10.1111/jre.70060Cited by 9 Negative / Null Result ReportOpen accessMedicine
Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye et al. · 2025 · Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings. However, the performance of RDTs can…
View details →DOI: 10.1038/s41598-025-97259-xCited by 9 Replication FailureOpen accessMedicine
Noor Wortelboer, Annemiek van Ommen-Nijhof, Inge R. Konings et al. · 2026 · JAMA Oncology
Importance: Cyclin-dependent kinase (CDK) 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy are widely used in hormone receptor (HR)-positive, ERBB2-negative advanced breast cancer (ABC). The SONIA trial evaluates the optimal…
View details →DOI: 10.1001/jamaoncol.2025.6585Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna Barton, Maciej Jaśkiewicz, Anna Więch -Walów et al. · 2025 · Cell Communication and Signaling
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
View details →DOI: 10.1186/s12964-025-02459-7Cited by 9 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →DOI: 10.1177/08944865251315791Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Paul A. Djupe, Amanda Friesen, Andrew R. Lewis et al. · 2025 · Political Behavior
Abstract A proliferation of religion variables presents opportunities for those studying religion and politics in the U.S. However, many studies in this growing subfield demonstrate the pitfalls of reporting the “independent” effects of variables without qualification. This is especially evident in work on Christian nationalism where researchers often make the claim that worship attendance promotes more pro-social or liberal outcomes, while Christian nationalism promotes more conservative and less pro-social outcomes. We demonstrate that this finding—and others like it—represents a new version
View details →DOI: 10.1007/s11109-025-10057-zCited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Katsiaryna Salavei Bardos, Dev R. Mishra, Hyacinthe Somé · 2025 · Journal of Corporate Finance
In a sample of U.S. firms, we find strong evidence that firms' implied cost of equity is decreasing in a novel proxy of firm-level climate change sentiments of earnings call participants, supporting prior literature that shows investors demand higher returns from their investments in brown firms and lower returns from that in green firms. This effect, however, is particularly pronounced for the firm-years headquartered in the states experiencing higher than median per-capita energy related CO2 emissions, those headquartered in climate related disaster intensive counties and those headquartered
View details →DOI: 10.1016/j.jcorpfin.2025.102846Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →DOI: 10.1038/s41598-025-99000-0Cited by 9 Replication FailureMedicine
Jason Smith, Rebecca Cardigan, Emily Sanderson et al. · 2026 · New England Journal of Medicine
BACKGROUND: Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. METHODS: We conducted a pragmatic,…
View details →DOI: 10.1056/nejmoa2516043Cited by 9 Negative / Null Result ReportMedicine
Manav Raj, Justin M. Berg, Rob Seamans · 2026 · Journal of Experimental Psychology General
= 27,491), we examine how evaluations of creative writing are affected by whether participants believe the content is produced with an AI model. We find consistent evidence of an AI disclosure penalty: Participant evaluations of creative…
View details →DOI: 10.1037/xge0001889Cited by 9 Replication FailureOpen accessMedicine
Mette Kruse Klausen, Signe Justesen, Julie Niemann Pedersen et al. · 2026 · The Lancet
BACKGROUND: Alcohol use disorder accounts for 5% of deaths worldwide annually, and there is an urgent need for new therapeutic interventions. Preclinical and initial human studies indicate that the GLP-1 receptor agonist semaglutide might reduce alcohol drinking. This study evaluated the efficacy of semaglutide once-weekly in treatment-seeking patients with alcohol use disorder and comorbid obesity. METHODS: In a 26-week, single-centre, randomised, double-blinded, placebo-controlled trial, treatment-seeking participants with moderate to severe alcohol use disorder and comorbid obesity were ass
View details →DOI: 10.1016/s0140-6736(26)00305-3Cited by 9 Negative / Null Result ReportOpen accessEngineering
Rafael Cabral, Ricardo Santos, José A.F.O. Correia et al. · 2025 · Sensors
The automated inspection of civil infrastructure with Unmanned Aerial Vehicles (UAVs) is hampered by the challenge of accurately segmenting multi-damage in high-resolution imagery. While foundational models like the Segment Anything Model (SAM) offer data-efficient segmentation, their effectiveness is constrained by prompting strategies, especially for geometrically complex defects. This paper presents a comprehensive comparative analysis of deep learning strategies to identify an optimal deep learning pipeline for segmenting cracks, efflorescences, and exposed rebars. It systematically evalua
View details →DOI: 10.3390/s25216568Cited by 9 Replication FailureOpen accessMedicine
Robert W. Lentz, Tyler J. Friedrich, Patrick J. Blatchford et al. · 2024 · Clinical Cancer Research
PURPOSE: In this single-institution phase II investigator-initiated study, we assessed the ability of MAPK and VEGF pathway blockade to overcome resistance to immunotherapy in microsatellite-stable metastatic colorectal cancer (MSS mCRC).…
View details →DOI: 10.1158/1078-0432.ccr-24-0090Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
S. H. Suyu, Ana Acebrón, C. Grillo et al. · 2026 · Astronomy and Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs, including parametric and free-form approaches. By conducting a blind analysis where all the mass-modeling teams constructed their models independently without exchanging results, we quantified uncertainties arising from modeling software and assumptions. MACS J0138−2155 is unique as the only cluster found to strongly lens two supernovae (SNe), R
View details →DOI: 10.1051/0004-6361/202557235Cited by 9 Negative / Null Result ReportOpen accessMedicine
Joanna M Porter, Cici Jin, Michael Churchman et al. · 2025 · European Journal of Cancer
BACKGROUND: Antibody-drug conjugates (ADCs) are emerging anti-cancer agents. The folate receptor alpha (FOLRα)-directed ADC mirvetuximab soravtansine recently demonstrated clinical activity in platinum-resistant ovarian cancer, with other ADCs currently in development. The relative expression of FOLRα and other ADC targets is largely unknown across ovarian cancer histotypes. METHODS: Expression levels of the ADC targets FOLRα, TROP2 and B7-H4 were assessed by immunohistochemistry in patient cohorts using tumour tissue microarrays of the major ovarian cancer histotypes: high grade serous (HGSOC
View details →DOI: 10.1016/j.ejca.2025.115522Cited by 9 Negative / Null Result ReportOpen accessPsychology
Yohsuke Ohtsubo, Miyu Higuchi · 2022 · Letters on Evolutionary Behavioral Science
This study aimed at replicating a previously reported pattern: costly apologies are perceived as more sincere than non-costly apologies even when the transgression was unintentional, while costly apologies do not foster forgiveness more than non-costly apologies when the transgression was unintentional. We conducted a vignette study with a 2 (apology cost: costly vs. non-costly) × 3 (intention: no vs. ambiguous vs. malicious intention) between-participants factorial design. We failed to replicate the aforementioned pattern. Instead, we found that costly apologies promote not only perceived sin
View details →DOI: 10.5178/lebs.2022.95Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Junyao Li, Ming-Yang Zhuang, Yue Shen et al. · 2025 · The Astrophysical Journal
Abstract Kiloparsec-scale dual and offset active galactic nuclei (AGNs) are signposts of accreting supermassive black holes (SMBHs) triggered during late-stage galaxy mergers, offering crucial insights into the coevolution of SMBHs and galaxies. However, robustly confirmed systems at high redshift (e.g., z > 1) are scarce and biased toward the most luminous and unobscured systems. In this study, we systematically search for kiloparsec-scale (projected separation <15 kpc) dual and offset AGNs around 571 moderate-luminosity, X-ray-selected AGNs, including the obscured population, utilizing
View details →DOI: 10.3847/1538-4357/adbae2Cited by 9 Replication FailureOpen accessPhysics and Astronomy
D. W. P. Amaral, Dennis G. Uitenbroek, Tjerk H. Oosterkamp et al. · 2025 · Physical Review Letters
We perform the first search for ultralight dark matter using a magnetically levitated particle. A submillimeter permanent magnet is levitated in a superconducting trap with a measured force sensitivity of 0.2 fN/sqrt[Hz]. We find no evidence of a signal and derive limits on dark matter coupled to the difference between baryon and lepton number, B-L, in the mass range (1.10360-1.10485)×10^{-13} eV/c^{2}. Our most stringent limit on the coupling strength is g_{B-L}≲2.98×10^{-21}. We propose the POLONAISE (Probing Oscillations using Levitated Objects for Novel Accelerometry In Searches of Exotic
View details →DOI: 10.1103/physrevlett.134.251001Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})&gt;9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →DOI: 10.1093/mnras/staf2023Cited by 9 