A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Jenny Bouchard, Nicola Gasparre, Thomas Netticadan et al. · 2025 · Journal of Functional Foods
The integration of resveratrol, a naturally occurring, health promoting polyphenolic stilbene, into food systems poses a challenge due to its low water solubility, chemical instability, poor bioavailability, and bitter taste. To address…
Tatsuya Mimura, Hidetaka Noma · 2025 · Antioxidants
Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the elderly, and oxidative stress, primarily mediated by reactive oxygen species (ROS), is widely recognized as a central driver of its onset and progression. The retina is highly susceptible to oxidative damage due to its elevated oxygen consumption, abundant polyunsaturated fatty acids, and continuous exposure to light. Recent studies have elucidated molecular mechanisms in which mitochondrial dysfunction, disruption of redox homeostasis, inflammation, and complement activation interact to promote
Xinyu Li, Tao Huang · 2025 · Breast Cancer
Hormone receptor-positive (HR +) and HER2-positive (HER2+) breast cancers represent a biologically unique subset of breast malignancies characterized by the co-expression of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2). These cancers exhibit distinct molecular features, often leading to aggressive growth and higher recurrence rates. HR+/HER2+ breast cancer cells can utilize estrogen and HER2-driven signaling pathways to promote proliferation, survival, and metastatic potential, presenting unique challenges and opportunities for treat
Shun He, Tianchang Xia, Zhihou Guo et al. · 2025 · Nature Communications
Kidney fibrosis is a key pathological feature of chronic kidney disease (CKD), characterized by the activation and accumulation of αSMA-positive myofibroblasts. The cellular origin of myofibroblasts in kidney fibrosis has been a subject of…
Erlei Zhi, Haowei Bai, Chuan Ren et al. · 2025 · Nature Communications
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we…
Wolfgang Wüster · 2025 · Vertebrate Zoology
The advent of molecular methods has revolutionised the field of species delimitation and description, one of the key tasks of systematic biology. In animal taxonomy, one marker, the mitochondrial DNA (mtDNA) molecule, has acquired and retained disproportionate influence. This is despite its uniparental, clonal mode of inheritance, as a result of which the entire molecule acts as a single locus, and that precludes its use as a test for admixture between putative lineages, a key consideration in species delimitation. To establish the extent to which the limitations of mtDNA affect present-day ta
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
S. H. Suyu, Ana Acebrón, C. Grillo et al. · 2026 · Astronomy and Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs, including parametric and free-form approaches. By conducting a blind analysis where all the mass-modeling teams constructed their models independently without exchanging results, we quantified uncertainties arising from modeling software and assumptions. MACS J0138−2155 is unique as the only cluster found to strongly lens two supernovae (SNe), R
Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
Mette Kruse Klausen, Signe Justesen, Julie Niemann Pedersen et al. · 2026 · The Lancet
BACKGROUND: Alcohol use disorder accounts for 5% of deaths worldwide annually, and there is an urgent need for new therapeutic interventions. Preclinical and initial human studies indicate that the GLP-1 receptor agonist semaglutide might reduce alcohol drinking. This study evaluated the efficacy of semaglutide once-weekly in treatment-seeking patients with alcohol use disorder and comorbid obesity. METHODS: In a 26-week, single-centre, randomised, double-blinded, placebo-controlled trial, treatment-seeking participants with moderate to severe alcohol use disorder and comorbid obesity were ass
Reo Van Eynde, Kevin J. Dillman, Jefim Vogel et al. · 2026 · Ecological Economics
Post-growth has emerged as an umbrella concept for various sustainability visions that prioritise the pursuit of environmental sustainability, social equity, and human wellbeing, while questioning the pursuit of economic growth. Although there are increasing calls to include post-growth scenarios in high-level assessments, there is no coherent framework that specifies what is required to model post-growth. This article addresses this gap by: (1) identifying the minimum requirements for post-growth models, and (2) establishing a set of model elements for representing post-growth policy themes.
Nevin Sanlier, Elif Yildiz Kaya, Ikbal Irem Yucel · 2026 · Food Science & Nutrition
Honey, bee pollen, propolis, bee bread, royal jelly, bee venom, beeswax, and apilarnil are among the bee-derived products that may serve health-related purposes, as they exhibit various biological activities such as antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, antitumor, vasodilatory, and blood pressure-lowering effects. In this review, the possible health effects and action mechanisms of bee products frequently used in apitherapy were examined. The therapeutic potential of bee-derived products is attributed to their content of amino acids, fatty acids, carbohydrates,
Valdemar Brimnes Ingemann Johansen, Anna Katrina Jógvansdóttir Gradel, Stephanie Kjærulff Holm et al. · 2025 · Cell Reports Medicine
Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…
Florian Missey, Emma Acerbo, Adam S. Dickey et al. · 2025 · Brain stimulation
INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated the potential of non-invasive temporal interference (TI) electrical stimulation in reducing epileptic biomarkers in patients with mesiotemporal epilepsy (MTLE) MATERIAL AND METHOD: Thirteen patients implanted with stereoelectroencephalography (sEEG) de
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
Guangxiang Liu, Md Kamal Hossain · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background Amid Bangladesh's national efforts to enhance digital inclusion, rural university students continue to face persistent infrastructural and educational inequalities that limit their access to quality English learning…
Jo Pearson, Itiel E. Dror, Emma Jayes et al. · 2026 · Scientific Reports
The use of Artificial Intelligence (AI) to effectively support human decision making depends on whether humans are willing to trust in, and thus rely on, AI. Understanding human reliance on AI is critical given controversial reports of AI inaccuracy and bias. Furthermore, the erroneous belief that using technology removes biases may lead to overreliance on AI. To examine humans’ reliance on AI, human participants (N = 295, Mage = 33.79) judged the authenticity of 80 faces (40 real, 40 AI-synthesized) presented alongside guidance supposedly from humans or from AI. This guidance was correct only
Alfonz Kedves, Máté Balogh, Jamsheed Abbas Dar et al. · 2026 · Bioresource Technology
The increasing occurrence of microplastics and antibiotics in wastewater poses emerging challenges for biological treatment processes. Microalgal-bacterial granular sludge (MBGS) has emerged as an efficient algae-based biotechnology for wastewater treatment; however, its response to simultaneous exposure to these contaminants remains largely unexplored. Here, the effects of degradable polycaprolactone microplastics (PCL MPs) and sulfamethoxazole (SMX) were evaluated at 1 mg/L during granulation and long-term operation. PCL alone caused only minor changes, whereas SMX impaired granule stability
Domenica Lorusso, Laurence Gladieff, David M O'Malley et al. · 2026 · The Lancet
BACKGROUND: Relacorilant is a selective glucocorticoid receptor antagonist that increases the sensitivity of many cancer cell types to chemotherapy. The efficacy and safety of relacorilant plus nab-paclitaxel were assessed in the phase 3 ROSELLA (GOG-3073, ENGOT-ov72, APGOT-Ov10, and LACOG-0223) trial; the combination showed significant improvement in progression-free survival among patients with platinum-resistant ovarian cancer compared with nab-paclitaxel monotherapy. Results of the final overall survival analysis are reported here. METHODS: intravenously on the aforementioned schedule). Pa
Sami Saeed Binyamin · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
Learning management systems (LMS), which allow education at the student’s choice of place and time, have been widely adopted in higher education worldwide. In the case of Saudi Arabia, LMS have been recently introduced in Saudi…
Weiye Chen, Yige Zeng, Jinxin Zheng et al. · 2026 · Nature Medicine
Antimicrobial resistance (AMR) poses a major global health threat, yet the effectiveness of national action plans (NAPs) remains uncertain. Here we developed a multidimensional One Health governance index through a structured Delphi expert…
Muhammad Dawood, Kim Branson, Sabine Tejpar et al. · 2026 · Nature Biomedical Engineering
Deep learning models that infer clinically relevant biomarker status from tissue images are being explored as rapid and low-cost alternatives to molecular testing. Here we show, through statistical analysis across multiple cancer types, datasets and modelling approaches, that the datasets used to train these models contain strong dependencies between biomarkers and clinicopathological features, which prevent models from isolating the effect of a single biomarker and lead them to learn confounded signals. Consequently, their prediction accuracy varies substantially with the status of codependen
Toni K. Choueiri, R Motzer, Jose A. Karam et al. · 2026 · Journal of Clinical Oncology
LBA418 Background: Adjuvant pembrolizumab is a standard of care for patients with ccRCC at increased risk of recurrence following nephrectomy based on the phase 3 KEYNOTE-564 study (N Engl J Med 385:683; N Engl J Med 390:1359). Combination…
Najabat Ali, Md Reza Sultanuzzaman · 2026 · Energies
This study investigates the determinants of green energy penetration in the Next Eleven (N-11) economies over the period 2000–2022, with a particular focus on the roles of foreign direct investment (FDI), green transition, governance quality, industrial growth, and urbanization. The primary objective of the study is to assess how investment flows, structural transformation, and institutional capacity jointly shape the adoption of renewable energy in fast-growing emerging economies. To achieve this goal, the study employs a second-generation panel econometric and machine-learning framework that
Floyd Khoza · 2025 · Journal of risk and financial management
Understanding the role of liquidity and leverage is crucial in assessing financial performance, particularly in the consumer goods sector. This study examined the impact of liquidity and leverage on financial performance, using a sample of 13 consumer goods firms listed on the Johannesburg Stock Exchange (JSE) from 2014 to 2024. Despite the present literature on this association, few traceable studies have investigated this phenomenon, and there is a dearth of literature in this sector. The dependent variable for this study was financial performance, and the return on assets (ROA) was employed
Michael Vaccaro, Mikayla Friday, Arash E. Zaghi · 2025 · Applied Sciences
Multi-agent large language models promise flexible, modular architectures for delivering personalized educational content. Drawing on a pilot randomized controlled trial with middle school students (n = 23), we introduce a two-agent GPT-4 framework in which a Profiler agent infers learner-specific preferences and a Rewrite agent dynamically adapts science passages via an explicit message-passing protocol. We implement structured system and user prompts as inter-agent communication schemas to enable real-time content adaptation. The results of an ordinal logistic regression analysis hinted that
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
S Jakubowski, Paweł Kawalec, Przemysław Holko et al. · 2024 · Frontiers in Pharmacology
Objectives: The aim of this study was to characterize the reimbursement policy for orphan drugs (ODs) in Central and Eastern European (CEE) countries in relation to the availability and impact of clinical evidence, health technology assessment (HTA) procedure, selected economic indicators, and the drug type according to indications. Materials and methods: A list of authorized medicines with orphan designation and information about active substance, Anatomical Therapeutic Chemical (ATC) classification, and therapeutic area was extracted from the web-based register of the European Medicines Agen
W. V. Jacobson-Galán, Luc Dessart, Kyle W. Davis et al. · 2025 · The Astrophysical Journal
Abstract We present analysis of the plateau and late-time phase properties of a sample of 39 Type II supernovae (SNe II) that show narrow, transient, high-ionization emission lines (i.e., “IIn-like”) in their early-time spectra from interaction with confined, dense circumstellar material (CSM). Originally presented by W. V. Jacobson-Galán et al., this sample also includes multicolor light curves and spectra extending to late-time phases of 35 SNe with no evidence for IIn-like features at <2 days after first light. We measure photospheric phase light-curve properties for the distance-correct
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat