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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19815 results in Negative / Null Result Report · page 151 of 661

Negative / Null Result ReportOpen accessMedicine

Anti-inflammatory agents for the management of COPD - Quo Vadis?

Agamemnon Bakakos, Zoi Sotiropoulou, Nektarios Anagnostopoulos et al. · 2025 · Respiratory Medicine

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by chronic inflammation. Despite the use of maximum bronchodilation and in selected patients inhaled corticosteroids (ICS), current therapies neither halt disease progression nor prevent exacerbations and loss of lung function. Recent research has focused on developing novel anti-inflammatory agents targeting specific pathways implicated in COPD pathogenesis, ai

View details →DOI: 10.1016/j.rmed.2025.108396Cited by 9
Negative / Null Result ReportOpen accessEngineering

Vascularizing organoids-on-chip for perfused and personalized models

Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip

models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…

View details →DOI: 10.1039/d5lc00890eCited by 9
Negative / Null Result ReportOpen accessEnvironmental Science

Granulation and stability of microalgal–bacterial granular sludge under single and combined exposure to polycaprolactone microplastics and sulfamethoxazole

Alfonz Kedves, Máté Balogh, Jamsheed Abbas Dar et al. · 2026 · Bioresource Technology

The increasing occurrence of microplastics and antibiotics in wastewater poses emerging challenges for biological treatment processes. Microalgal-bacterial granular sludge (MBGS) has emerged as an efficient algae-based biotechnology for wastewater treatment; however, its response to simultaneous exposure to these contaminants remains largely unexplored. Here, the effects of degradable polycaprolactone microplastics (PCL MPs) and sulfamethoxazole (SMX) were evaluated at 1 mg/L during granulation and long-term operation. PCL alone caused only minor changes, whereas SMX impaired granule stability

View details →DOI: 10.1016/j.biortech.2026.134820Cited by 9
Negative / Null Result ReportOpen accessEngineering

Review on Thermal Stimulation in Deep Geothermal Reservoirs: Thermo-Mechanical Mechanisms and Fracture Evolution

Kaituo Li, Lin Zhu, Fei Xiong et al. · 2026 · Processes

Enhanced geothermal systems (EGS) are a key technology for developing deep geothermal resources, yet they face significant challenges in constructing efficient thermal reservoirs within high-stress, high-strength, and low-permeability crystalline rock formations. Traditional hydraulic fracturing (HF) techniques encounter deep challenges in these environments, including excessively high fracturing pressures, limited fracture network patterns, and the risk of induced seismicity. This paper reviews the multi-scale thermal-mechanical mechanisms, fracture evolution patterns, and control strategies

View details →DOI: 10.3390/pr14081199Cited by 9
Negative / Null Result ReportOpen accessEngineering

D-π-A sensitized carbon dots as long-lived type-I/Ⅱ photosensitizers for NIR-excited hypoxia-regulated photodynamic therapy

Zhenlin Zhang, Lang Yan, Weiwei Li et al. · 2026 · Nature Communications

In the development of clinically translatable triplet photosensitizers for hypoxia regulated photodynamic therapy (PDT), there is an unmet need for engineering sensitizers as near-infrared (NIR)-responsive, type I/type Ⅱ dual…

View details →DOI: 10.1038/s41467-026-71476-yCited by 9
Negative / Null Result Report

Content Analysis of YouTube Videos That Demonstrate Periapical Radiography

Marlene Grillon, Andy Wai Kan Yeung · 2022 · Applied Sciences

No prior study has evaluated the content of YouTube videos that demonstrated how to take periapical radiographs, one of the commonest radiographic examinations in dentistry. This study provided a content analysis on these YouTube videos.…

View details →DOI: 10.3390/app12199602Cited by 8
Negative / Null Result Report

Did Expanded Dental Insurance Reduce Out-of-Pocket Expenditures on Dental Care among Older Adults in Korea? Interrupted Time-Series Analysis

Nam-Hee Kim, Se-Hwan Jung, Ichiro Kawachi · 2021 · International Journal of Environmental Research and Public Health

The Korean National Health Insurance extended its coverage to reduce the economic burden of receiving dentures and implants for older adults in 2012 and 2014, respectively. We examined whether the new policy resulted in reduced…

View details →DOI: 10.3390/ijerph18063003Cited by 8
Negative / Null Result Report

Together We can Figure It out: Groups Find Hospitality Robots Easier to Use and Interact With Them More than Individuals

Harrison Preusse, Rebecca Skulsky, Marlena R. Fraune et al. · 2021 · Frontiers in Robotics and AI

As robots are becoming more prevalent and entering hospitality settings, understanding how different configurations of individuals and groups interact with them becomes increasingly important for catering to various people. This is…

View details →DOI: 10.3389/frobt.2021.730399Cited by 8
Negative / Null Result Report

How can we better use Twitter to find a person who got lost due to dementia?

Kelvin K. F. Tsoi, Nicholas B. Chan, Felix C. H. Chan et al. · 2018 · npj Digital Medicine

Abstract Twitter is a social media platform for online message sharing. The aim of this study is to evaluate the effectiveness of using Twitter to search for people who got lost due to dementia. The online messages on Twitter, i.e.,…

View details →DOI: 10.1038/s41746-018-0017-5Cited by 8
Negative / Null Result Report

Glyceryl Trinitrate Ointment Did Not Reduce Pain After Stapled Hemorrhoidectomy: A Randomized Controlled Trial

Trent Cross, Lynne Bartlett, Chrispen Mushaya et al. · 2012 · International Surgery

Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with…

View details →DOI: 10.9738/cc92.1Cited by 8
Negative / Null Result Report

Effect of Significant Postoperative Complications on Decision Regret After Laparoscopic Sleeve Gastrectomy: a Case–Control Study

Katarzyna Bartosiak, Michał R. Janik, Maciej Walędziak et al. · 2022 · Obesity Surgery

Abstract Background Thus far, no data are available on decision regret about sleeve gastrectomy (SG), particularly in patients who experienced perioperative complications. This study aimed to assess whether patients with postoperative…

View details →DOI: 10.1007/s11695-022-06113-wCited by 8
Negative / Null Result Report

Combining a transosseous cerclage wire after patellar tendon reattachment to treat patella distal pole fracture did not improve functional outcome

Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports

Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…

View details →DOI: 10.1038/s41598-022-13641-zCited by 8
Negative / Null Result Report

Significant Prognostic Factors Influencing the Survival Difference of Oral Tongue Squamous Cell Carcinoma

Sarinya Boonpoapichart, Pattama Punyavong, Kamonwan Jenwitheesuk et al. · 2021 · Plastic and Reconstructive Surgery - Global Open

Background: Oral tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Overall survival varies across many countries, and poor prognosis is prevalent in developing countries, including Thailand. Our study aimed…

View details →DOI: 10.1097/gox.0000000000003889Cited by 8
Negative / Null Result Report

Does the Establishment of National New Areas Improve Urban Ecological Efficiency? Empirical Evidence Based on Staggered DID Model

Jingbin Wang, Huiling Qiao, Jing Liu et al. · 2022 · International Journal of Environmental Research and Public Health

The environmental effects of national new areas have been an important topic but received little attention in academia. This study conducts a quasi-natural experiment using panel data of China’s 282 prefecture-level cities from 2006 to…

View details →DOI: 10.3390/ijerph192013623Cited by 8
Negative / Null Result Report

Biologically relevant small variations of intra-cellular pH can have significant effect on stability of protein–DNA complexes, including the nucleosome

Alexey V. Onufriev · 2023 · Frontiers in Molecular Biosciences

Stability of a protein-ligand complex may be sensitive to pH of its environment. Here we explore, computationally, stability of a set of protein-nucleic acid complexes using fundamental thermodynamic linkage relationship. The nucleosome,…

View details →DOI: 10.3389/fmolb.2023.1067787Cited by 8
Negative / Null Result Report

Significant sex difference in the association between C‐reactive protein concentration and anthropometry among 13‐ to 19‐year olds, but not 6‐ to 12‐year olds in Nepal

Shoko Konishi, Rajendra Prasad Parajuli, Erica Takane et al. · 2014 · American Journal of Physical Anthropology

ABSTRACT Life history theory predicts a trade‐off between immunostimulation and growth. Using a cross‐sectional study design, this study aims to test the hypothesis that C‐reactive protein (CRP) is negatively associated with height‐for‐age…

View details →DOI: 10.1002/ajpa.22470Cited by 8
Negative / Null Result Report

NUMBER OF RUNS VARIATIONS ON AUTODOCK 4 DO NOT HAVE A SIGNIFICANT EFFECT ON RMSD FROM DOCKING RESULTS

M.R.F. Pratama, S. Siswandono · 2021 · Pharmacy & Pharmacology

The aim . The number of runs in the docking process with AutoDock 4 is known to play an important role in the validity of the results obtained. The greater the number of runs it is often associated with the more valid docking results.…

View details →DOI: 10.19163/2307-9266-2020-8-6-476-480Cited by 8
Negative / Null Result Report

Evolutionary opportunity and the limits of community similarity in replicate radiations of island lizards

Luke Owen Frishkoff, Gavia Lertzman‐Lepofsky, D. Luke Mahler · 2022 · Ecology Letters

Abstract Ecological community structure ultimately depends on the production of community members by speciation. To understand how macroevolution shapes communities, we surveyed Anolis lizard assemblages across elevations on Jamaica and…

View details →DOI: 10.1111/ele.14098Cited by 8
Negative / Null Result Report

DID FOREIGN OWNERSHIP OF KOREAN CREDIT RATING AGENCIES IMPROVE THEIR RATINGS?

Denis Yongmin Joe, Frederick Dongchuhl Oh · 2016 · Contemporary Economic Policy

In this study, we investigate whether foreign equity participation fostered the growth of Korea's credit rating industry during the 2002–2013 period. We find that the rating quality deteriorated steadily even though the foreign ownership…

View details →DOI: 10.1111/coep.12176Cited by 8
Negative / Null Result Report

Inflation in 2022 did not affect congressional voting, but abortion did

Diana C. Mutz, Edward D. Mansfield · 2024 · Proceedings of the National Academy of Sciences

This study examines voting in the 2022 United States congressional elections, contests that were widely expected to produce a sizable defeat for Democratic candidates for largely economic reasons. Based on a representative national…

View details →DOI: 10.1073/pnas.2319512121Cited by 8
Negative / Null Result Report

Phytoplankton settling quality has a subtle but significant effect on sediment microeukaryotic and bacterial communities

Séréna Albert, Per Hedberg, Nisha H. Motwani et al. · 2021 · Scientific Reports

Abstract In coastal aphotic sediments, organic matter (OM) input from phytoplankton is the primary food resource for benthic organisms. Current observations from temperate ecosystems like the Baltic Sea report a decline in spring bloom…

View details →DOI: 10.1038/s41598-021-03303-xCited by 8
Negative / Null Result Report

The Relationship between Obsessive Compulsive Personality and Obsessive Compulsive Disorder Treatment Outcomes: Predictive Utility and Clinically Significant Change

Shalane K. Sadri, Peter M. McEvoy, Sarah J. Egan et al. · 2017 · Behavioural and Cognitive Psychotherapy

Background: The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is…

View details →DOI: 10.1017/s1352465817000194Cited by 8
Negative / Null Result Report

Evening Caffeine Did Not Improve 100-m Swimming Time Trials Performed 60 Min Post-Ingestion or the Next Morning After Sleep

Josh W. Newbury, Bryan Saunders, Lewis A. Gough · 2022 · International Journal of Sport Nutrition and Exercise Metabolism

The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has…

View details →DOI: 10.1123/ijsnem.2022-0042Cited by 8
Negative / Null Result Report

Subclinical Systemic Sclerosis Primary Heart Involvement by Cardiovascular Magnetic Resonance Shows No Significant Interval Change

Raluca B. Dumitru, Lesley‐Anne Bissell, Bara Erhayiem et al. · 2023 · ACR Open Rheumatology

Objective Subclinical systemic sclerosis (SSc) primary heart involvement is commonly described. Whether these findings progress over time is not clear. The study aimed to investigate cardiovascular magnetic resonance (CMR) interval change…

View details →DOI: 10.1002/acr2.11515Cited by 8
Negative / Null Result Report

CURING HEPATITIS C WITH THE NEW DIRECT ACTING ANTIVIRALS DID NOT IMPROVE INSULIN RESISTANCE AFTER ONE YEAR

Lohanna STRAUHS-NITSCH, Marcela Ferro CAMPIOLO, Daphne Benatti Gonçalves MORSOLETTO et al. · 2020 · Arquivos de Gastroenterologia

ABSTRACT BACKGROUND: Chronic hepatitis C still figures as an important cause of morbidity among the Brazilian population, and is closely associated with metabolic disturbances, including insulin resistance (IR), which can be evaluated by…

View details →DOI: 10.1590/s0004-2803.202000000-50Cited by 8
Negative / Null Result Report

Para‐aortic lymphadenectomy did not improve overall survival among women with type I endometrial cancer

Lin Li, Mingming Tang, Dan Nie et al. · 2020 · International Journal of Gynecology & Obstetrics

Abstract Objective To compare outcomes and prognosis among women with type I endometrial cancer undergoing hysterectomy and bilateral salpingo‐oophorectomy (H‐BSO) with or without systematic pelvic lymphadenectomy (PLD) or para‐aortic…

View details →DOI: 10.1002/ijgo.13228Cited by 8