Negative / Null Result ReportOpen accessPsychology
Hae Won Kim, Jee In Kang, Eunhee Hwang et al. · 2018 · PLoS ONE
Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphis
View details →DOI: 10.1371/journal.pone.0190593Cited by 10 Negative / Null Result ReportOpen accessMedicine
Athina Trachalaki, Anna Lindahl, Simone Petrarulo et al. · 2025 · Breathe
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow disease progression, IPF remains a disease with poor survival. Promising therapeutic…
View details →DOI: 10.1183/20734735.0260-2024Cited by 10 Negative / Null Result ReportOpen accessMedicine
Chiara Livolsi, R. Conti, Tommaso Ciapetti et al. · 2025 · Scientific Reports
Millions of individuals surviving a stroke have lifelong gait impairments that reduce their personal independence and quality of life. Reduced walking speed is one of the major problems limiting community mobility and reintegration. Previous studies have shown positive effect of robot-assisted gait training utilizing hip exoskeletons for individuals with gait impairments due to a stroke, leading to increased walking speed in post-treatment compared to pre-treatment assessments. However, no evidence emerged of a significant increasing in walking speed attributable to device usage compared to wa
View details →DOI: 10.1038/s41598-025-86343-xCited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
View details →DOI: 10.1080/03650340.2025.2603669Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Chris J. Willott, Yoshihisa Asada, Kartheik G. Iyer et al. · 2025 · The Astrophysical Journal
Abstract We present JWST observations of a gravitationally lensed, extremely metal-poor galaxy at redshift z = 8.203 ± 0.001 from the CANUCS survey. Based on the low oxygen to Balmer line ratios, we infer a gas-phase metallicity of 12 + log(O/H) = 6.85 (1.4% solar), making CANUCS-A370-z8-LAE one of the most metal-poor galaxies known at z > 7. The galaxy has a high H β equivalent width of 225 ± 50 Å, small half-light radius of only r hl = 3 8 − 19 + 3 pc, and high star formation rate density of 50–100 M ⊙ yr −1 kpc −2 . The galaxy shows high-equivalent-width Ly α emission with an i
View details →DOI: 10.3847/1538-4357/addf49Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →DOI: 10.1007/s40122-024-00631-4Cited by 10 Negative / Null Result ReportOpen accessMedicine
Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →DOI: 10.1002/pul2.12430Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →DOI: 10.3390/brainsci14050516Cited by 10 Negative / Null Result ReportOpen accessMedicine
Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →DOI: 10.2196/64028Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Paul A. Djupe, Amanda Friesen, Andrew R. Lewis et al. · 2025 · Political Behavior
Abstract A proliferation of religion variables presents opportunities for those studying religion and politics in the U.S. However, many studies in this growing subfield demonstrate the pitfalls of reporting the “independent” effects of variables without qualification. This is especially evident in work on Christian nationalism where researchers often make the claim that worship attendance promotes more pro-social or liberal outcomes, while Christian nationalism promotes more conservative and less pro-social outcomes. We demonstrate that this finding—and others like it—represents a new version
View details →DOI: 10.1007/s11109-025-10057-zCited by 9 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →DOI: 10.3390/economies13040111Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Katsiaryna Salavei Bardos, Dev R. Mishra, Hyacinthe Somé · 2025 · Journal of Corporate Finance
In a sample of U.S. firms, we find strong evidence that firms' implied cost of equity is decreasing in a novel proxy of firm-level climate change sentiments of earnings call participants, supporting prior literature that shows investors demand higher returns from their investments in brown firms and lower returns from that in green firms. This effect, however, is particularly pronounced for the firm-years headquartered in the states experiencing higher than median per-capita energy related CO2 emissions, those headquartered in climate related disaster intensive counties and those headquartered
View details →DOI: 10.1016/j.jcorpfin.2025.102846Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eva S. M. van der Heijden, Karin Näsvall, Fernando Seixas et al. · 2025 · Proceedings of the National Academy of Sciences
A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions. Here, we study the drivers of continental radiations of Melinaea and Mechanitis butterflies (Nymphalidae: Ithomiini), which have rapidly radiated in the continental Ne
View details →DOI: 10.1073/pnas.2410939122Cited by 9 Negative / Null Result ReportOpen accessMedicine
Bekir Enes Koca, Sümeyye Sarıtaş, Mikhaël Bechelany et al. · 2025 · International Journal of Molecular Sciences
Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. Thi
View details →DOI: 10.3390/ijms262211074Cited by 9 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →DOI: 10.1177/08944865251315791Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →DOI: 10.1086/737989Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Valdemar Brimnes Ingemann Johansen, Anna Katrina Jógvansdóttir Gradel, Stephanie Kjærulff Holm et al. · 2025 · Cell Reports Medicine
Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…
View details →DOI: 10.1016/j.xcrm.2025.101996Cited by 9 Negative / Null Result ReportOpen accessPsychology
Yohsuke Ohtsubo, Miyu Higuchi · 2022 · Letters on Evolutionary Behavioral Science
This study aimed at replicating a previously reported pattern: costly apologies are perceived as more sincere than non-costly apologies even when the transgression was unintentional, while costly apologies do not foster forgiveness more than non-costly apologies when the transgression was unintentional. We conducted a vignette study with a 2 (apology cost: costly vs. non-costly) × 3 (intention: no vs. ambiguous vs. malicious intention) between-participants factorial design. We failed to replicate the aforementioned pattern. Instead, we found that costly apologies promote not only perceived sin
View details →DOI: 10.5178/lebs.2022.95Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →DOI: 10.1177/13678779241307032Cited by 9 Negative / Null Result ReportMedicine
Maximilian Stahl, Amer M. Zeidan · 2025 · Blood
ABSTRACT: Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →DOI: 10.1182/blood.2025029727Cited by 9 Negative / Null Result ReportOpen accessMedicine
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →DOI: 10.1021/mp500460gCited by 9 Negative / Null Result ReportOpen accessChemistry
Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →DOI: 10.3390/microorganisms9040701Cited by 9 Negative / Null Result ReportOpen accessEngineering
H. Fu, Xiong Zhou, Pengfei Xu et al. · 2025 · Materials
Predicting the compressive strength of concrete is essential for engineering design and quality assurance. Traditional empirical formulas often fall short in capturing complex multi-factor interactions and nonlinear relationships. This study employs an interpretable machine learning framework using Gradient Boosting Trees, Random Forest, and Backpropagation Neural Networks to predict concrete compressive strength. Bayesian optimization was employed for hyperparameter tuning, and SHAP analysis was used to quantify feature contributions. Based on 223 sets of compression test data, this study sys
View details →DOI: 10.3390/ma18215009Cited by 9 Negative / Null Result ReportOpen accessEngineering
Takahiro Ogawa, Rune Shibata, Keiji Komatsu et al. · 2025 · International Journal of Implant Dentistry
PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m
View details →DOI: 10.1186/s40729-025-00656-0Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
S Jakubowski, Paweł Kawalec, Przemysław Holko et al. · 2024 · Frontiers in Pharmacology
Objectives: The aim of this study was to characterize the reimbursement policy for orphan drugs (ODs) in Central and Eastern European (CEE) countries in relation to the availability and impact of clinical evidence, health technology assessment (HTA) procedure, selected economic indicators, and the drug type according to indications. Materials and methods: A list of authorized medicines with orphan designation and information about active substance, Anatomical Therapeutic Chemical (ATC) classification, and therapeutic area was extracted from the web-based register of the European Medicines Agen
View details →DOI: 10.3389/fphar.2024.1369178Cited by 9 Negative / Null Result ReportOpen accessDecision Sciences
Pablo Ruiz‐Palomino, Juliana Toro‐Arias, María del Pilar Rodríguez‐Córdoba et al. · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT A supportive ethical culture (EC) can encourage moral behavior among employees and help them avoid wrongdoing. One option for fostering EC is ethics training; its longer‐term effectiveness, however, has rarely been examined,…
View details →DOI: 10.1111/beer.70000Cited by 9 Negative / Null Result ReportMedicine
Manav Raj, Justin M. Berg, Rob Seamans · 2026 · Journal of Experimental Psychology General
= 27,491), we examine how evaluations of creative writing are affected by whether participants believe the content is produced with an AI model. We find consistent evidence of an AI disclosure penalty: Participant evaluations of creative…
View details →DOI: 10.1037/xge0001889Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →DOI: 10.1093/mnras/staf2023Cited by 9 Negative / Null Result ReportOpen accessEnergy
Haisheng Zhang, Jiawei Li, Haijing Yan et al. · 2025 · Advanced Materials
Proton exchange membrane water electrolysis (PEMWE) is a promising blueprint for the industrial production of green hydrogen in the short term, but its large-scale deployment is extremely constrained by the high cost and low storage of…
View details →DOI: 10.1002/adma.202516207Cited by 9 Negative / Null Result ReportOpen accessEngineering
Fengxiang Liu, Shipeng Ning, Xia Wang et al. · 2025 · Science Advances
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)-mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosom
View details →DOI: 10.1126/sciadv.adr8001Cited by 9 