Bridging the missing middle in osseointegration: meso-scale topography between macro design and microroughness
Takahiro Ogawa; Rune Shibata; Keiji Komatsu; Takanori Matsuura; Denny Chao; Won‐Hee Park; Makoto Hirota · 2025 · International Journal of Implant Dentistry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m
Abstract by Takahiro Ogawa; Rune Shibata; Keiji Komatsu; Takanori Matsuura; Denny Chao; Won‐Hee Park; Makoto Hirota, International Journal of Implant Dentistry (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s40729-025-00656-0