A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
444 results in Replication Failure · page 15 of 15
Dong B, Xian Z · 2026 · Journal of visualized experiments : JoVE
Adolescent bipolar disorder is a severe psychiatric condition frequently complicated by school refusal behavior, a debilitating functional impairment that often persists even after the pharmacological stabilization of mood symptoms. While…
Van Brussel L, Geurden T · 2026 · Ticks and tick-borne diseases
Background Rapid and high efficacy against ticks after attachment has the potential to aid in the prevention of tick-borne pathogen transmission. The objective of the study was to assess the speed-of-kill of Simparica Trio® against Ixodes…
Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges
Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…
Yang L, Zhuang H, Yang Z et al. · 2026 · Medical ultrasonography
Aims To evaluate the applicability of transluminal dual-plane shear wave elastography (SWE) for measuring the anal sphincter in healthy adult women. Material and methods This prospective study recruited 140 healthy women between January…
Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science
This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…
Sumińska S, Rynkiewicz A, Szulczewski M · 2026 · Scientific reports
Heart rate variability biofeedback (HRVB) is increasingly examined as an adjunctive method for reducing psychological symptoms. Standard protocols involve identifying each participant's resonance frequency (RF); however, it remains unclear…
Tsutsumi T, Okuma H, Kazama F et al. · 2026 · Andrology
Background Obesity and low testosterone levels are closely interconnected, with the FTO gene being the most robust genetic determinant of body mass index (BMI). However, whether this primary genetic driver of obesity directly influences…
Ugege CO, F OM, Caleb AA et al. · 2025 · Preprint
Abstract Background: Diabetes mellitus is characterized by impaired glucose metabolism and a resultant effect of persistent hyperglycaemia. Type 2 diabetes also known as adult-onset diabetes is majorly caused by insulin resistance. The…
Ciećwież SM, Lewandowska K, Boroń A et al. · 2026 · Scientific reports
Reports suggest increased urinary excretion of Brain-Derived Neurotrophic Factor in patients with Overactive Bladder (OAB). The rs6265 (c.196G > A, p.Val66Met) polymorphism in the BDNF gene was previously associated with impaired secretion…
Schmidt C, Scheubeck G, Jurinovic V et al. · 2025 · Haematologica
Immunochemotherapy induces long-term responses in patients with follicular lymphoma. However, the toxicity of chemotherapy remains a relevant challenge. The Bruton tyrosine kinase inhibitor ibrutinib has shown significant activity in…
Sonnick MA, Laothamatas K, Furfaro D et al. · 2024 · Transplantation proceedings
Background In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is…
Pradhan A, Bhandari M, Vishwakarma P et al. · 2024 · European review for medical and pharmacological sciences
Heart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the…
Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal
Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…
Feng J, Yang C, Xie L et al. · 2026 · The Lancet. Neurology
Background Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear. We aimed to…
Nabid A, Carrier N, Vigneault É et al. · 2026 · International journal of radiation oncology, biology, physics
Purpose The impact of persistent hypogonadism post-androgen deprivation therapy (ADT) on overall survival (OS) of patients with prostate cancer (PCa) is poorly documented. We compared OS between patients who recovered testosterone and…
Bi W, Li J, Xiong M et al. · 2024 · Genetic testing and molecular biomarkers
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) ( EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of…
Zhao Q, Nie W, Dong J et al. · 2024 · Preprint
Aim: Disorders of mineral metabolism, including elevated levels of serum calcium, phosphate, 25-hydroxyvitamin D (25OH-VitD), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), have been reported in patients with calcific…
Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance
Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…
McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…
Rehe D, Subashchandran V, Zhang Y et al. · 2025 · Journal of clinical anesthesia
Study objective To determine whether preoperative LDL-C concentration affects the risk of perioperative major adverse cardiovascular or cerebrovascular events (MACCE) after noncardiac surgery. Design Single center retrospective cohort…
Hoffman LJ, Foley JM, Tanrıverdi B et al. · 2025 · Memory & cognition
Memories are pliable and can be biased by post-encoding information. In targeted memory reactivation (TMR) studies, participants encode information then sleep, during which time sounds or scents that were previously associated with the…
Belmaker RH · 2025 · Pharmaceuticals (Basel, Switzerland)
Lithium was the first discovered mood stabilizer for bipolar disorder. However, several antiepileptics such as valproate and carbamazepine have also proven to be mood stabilizers in all phases of bipolar disorder with profiles barely…
August D, Marsh N, Hall S et al. · 2026 · The Journal of perinatal & neonatal nursing
Purpose Implement and evaluate near-infrared (NIR) huddles for neonatal peripheral intravenous catheter (PIVC) insertion. Methods An implementation project investigated PIVC insertion attempts, site, inserter designation, dwell, and…
Xu K, Zhang R, Yuan Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Aims Gallbladder carcinoma (GBC) has a poor prognosis, with lymph node metastasis (LNM) being a key prognostic factor. Controversies remain regarding lymph node dissection (LND) utility and prognostic differences of direct (DGBC) vs.…