A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19814 results in Negative / Null Result Report · page 145 of 661
Peter N. Chalmers · 2019 · Arthroscopy
Abstract The optimal surgical technique for arthroscopic rotator cuff repair remains controversial, with advantages and disadvantages to each of the most commonly used methods. The pattern as well as number of suture anchors relative to…
Shira Fanti‐Oren, Daphna Birenbaum‐Carmeli, Dan Nemet et al. · 2019 · Acta Paediatrica
Abstract Aim The aim of the study was to examine the effect of information placebo on fitness test results in normal weight, overweight and obese children. Methods Twenty‐four pre‐pubertal children with overweight or obesity and 24 age and…
Natsu Sasaki, Reiko Kuroda, Kanami Tsuno et al. · 2022 · Neuropsychopharmacology Reports
Abstract Objectives This study aimed to examine the effectiveness of vaccination to improve mental health among employees in Japan based on a prospective study. Methods The data were retrieved from the Employee Cohort Study conducted…
Janet Quint, Pei Zhu, Rekha Balu et al. · 2015 · SSRN Electronic Journal
Success for All (SFA) combines a challenging elementary reading program, whole-school reform elements, and an emphasis on continuous improvement. In 2010, the Success for All Foundation (SFAF) received a scale-up grant under the U.S.…
Diane Pecher, Heleen van Mierlo, Rouwen Cañal‐Bruland et al. · 2015 · Journal of Experimental Psychology General
Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that…
Nikoletta Symeonidou, Beatrice G. Kuhlmann · 2021 · Cognition & Emotion
Emotion-enhanced memory (EEM) describes the robust memory advantage of emotional over non-emotional stimuli. While extensively investigated with emotional items, it is unclear whether the EEM effect extends to source memory for a neutral…
Bahru M. Gebeyehu, Asie k. Jabir, Getachew Tegegne et al. · 2023 · Remote Sensing
Quantification of hydrologic model prediction uncertainty for various flow quantiles is of great importance for water resource planning and management. Thus, this study is designed to assess the effect of subbasin spatial scale on the hydrological model prediction uncertainty for different flow quantiles. The Soil Water Assessment Tool (SWAT), a geographic information system (GIS) interfaced hydrological model, was used in this study. Here, the spatial variations within the sub-basins of the Omo Gibe River basin in Ethiopia’s Abelti, Wabi, and Gecha watersheds from 1989 to 2020 were examined.
Emanuela S. Gritti, Gregory J. Meyer, Robert F. Bornstein et al. · 2020 · Journal of Personality Assessment
We used self-reported narcissistic grandiosity and vulnerability and a component derived from 11 potential grandiosity and narcissism variables (GNVs) coded from Rorschach behavior to predict fluctuations in self-esteem and their links to…
Joao Gabriel Ostrowski, József Menyhárt · 2020 · Acta Polytechnica Hungarica
Based particularly on data technologies, information is rapidly evolving in engineering. In mechanical engineering, maintenance is benefiting the most from data innovations, the reduction of maintenance costs, and the improvement of system…
Magdalena Sabat, Bartosz Haładus, Michał Klincewicz et al. · 2022 · Scientific Reports
The perceived duration of an interval depends on numerous aspects of the passed event both endogenous, including physiological arousal, level of wakefulness, attention, and surprise, as well as exogenous such as valence, salience, or context in the environment. There is some evidence that "time-giving" cues from the environment (zeitgebers) are coupled with time perception. The movement of the sun on the horizon was demonstrated to affect interval perception in a study conducted by Schatzschneider et al. (2016) claiming that the sun's motion is a zeitgeber that influences time perception. In t
Pooja Advani, Kathryn J. Ruddy, Joerg Herrmann et al. · 2023 · Frontiers in Oncology
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum
Chunyuan Zhang, Xu Wu, Yanfang Xian et al. · 2019 · Evidence-Based Complementary and Alternative Medicine
Isorhynchophylline (IRN) and rhynchophylline (RN), a pair of stereoisomers, are tetracyclic oxindole alkaloids isolated from Uncaria rhynchophylla , a commonly used Chinese medicinal herb. These two compounds have drawn extensive attention…
Kawthar Al-Salmi, Farook S Wali, Ahmed Sameer Nadeem et al. · 2019 · Journal of Neurology & Stroke
Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and…
Yi-Lun Ge, Pu-Zhi Wang, Jia-Hui Yan et al. · 2022 · Advanced Neurology
Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists
Andreea Geambașu, Sybren Spit, Daan van Renswoude et al. · 2022 · Developmental Science
We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has
Mattias Ekre, Jakob Tytor, Mogens Bove et al. · 2020 · Diseases of the Esophagus
Summary Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with eosinophilic infiltration of the esophageal mucosa. The most prominent symptom is dysphagia, which may result in esophageal bolus impaction in need of surgical…
Simon Holmbacka, Robert Müller · 2017
Current benchmark suites for evaluating energy efficiency of modern computer systems fail to replicate real-world streaming applications accurately enough because of indeterministic load pattern which depends heavily on the input data of…
Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A
Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…
Mariela E. Jaffé, Rainer Greifeneder · 2019 · Journal of Language and Social Psychology
This article investigates the negativity bias in truth judgments, which holds that negatively (vs. positively) framed statements are more likely to be judged true. Throughout four studies we find that expectations moderate the negativity…
Peter Doshi · 2024 · BMJ
A top selling antiplatelet drug has never quite shaken off doubts about its advantage over cheaper rivals. With generic versions of ticagrelor about to launch, Peter Doshi takes a fresh look at the evidence
Aliea M. Jalali, Brent M. Peterson, Thushara Galbadage · 2020 · Frontiers in Public Health
The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude and rigor of their initial public health response was unprecedented. As a response, the entire nation shutdown at the state-level for the duration of a ~1-3 months. These public health interventions, however, were not arbitrarily decided, but rather, implemented as a result of evidence-based practices. These practices were a result of lessons learned during the 1918 influenza pandemic and the ci
Mohammad R. Jahan‐Parvar, Filip Žikeš · 2023 · Review of Financial Studies
Abstract We present evidence that several popular low-frequency measures of effective spread suffer from a volatility-induced bias and that volatility is the primary driver of the variation of these liquidity proxies. Using data for U.S. equities and major foreign exchange rates, we show that the bias arises when the effective spread is small relative to volatility. We document that the bias has become more acute over time and show that volatility-biased measures fail to replicate some well-known results in empirical finance. We conclude by providing guidance on the choice of low-frequency mea
Zengyou He, Hao Liang, Zheng Chen et al. · 2020 · IEEE Transactions on Knowledge and Data Engineering
Community detection is a key data analysis problem across different fields. During the past decades, numerous algorithms have been proposed to address this issue. However, most work on community detection does not address the issue of…
Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma et al. · 2023 · npj Vaccines
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl
Elizabeth Bartlett, Ashley Yttredahl, Maura Boldrini et al. · 2023 · European Psychiatry
Abstract Background Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT 1A R) binding potential, especially…
Sherry Towers, Anuj Mubayi, Carlos Castillo‐Chávez · 2018 · PLoS ONE
BACKGROUND: When attempting to statistically distinguish between a null and an alternative hypothesis, many researchers in the life and social sciences turn to binned statistical analysis methods, or methods that are simply based on the moments of a distribution (such as the mean, and variance). These methods have the advantage of simplicity of implementation, and simplicity of explanation. However, when null and alternative hypotheses manifest themselves in subtle differences in patterns in the data, binned analysis methods may be insensitive to these differences, and researchers may erroneou
Gautam Das, Malayendu Saha, Abhijit Kundu · 2016 · Vision The Journal of Business Perspective
The anomalies in respect to initial public offering (IPO) performance in literature have stimulated multitude of research works in explaining critical issues, such as under-pricing during short-run and underperformance phenomena in the…
Zerrin Önder, İbrahim Çanak, Ümit Totur · 2017 · Open Mathematics
Abstract In this paper, we prove that a bounded double sequence of fuzzy numbers which is statistically convergent is also statistically ( C , 1, 1) summable to the same number. We construct an example that the converse of this statement…
Amanda Zieselman, Jonathan Fisher, Ting Hu et al. · 2014 · BioData Mining
BACKGROUND: Alzheimer's disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the genetic analysis of grey matter density as an endophenotype for late onset Alzheimer's disease. Our approach combines machine learning analysis of gene-gene interactions with large-scale functional genomics data for assessing biological relationships. RESULTS: We found a statistically significant synergistic interaction among t
Mojun Zhu, Brian A. Costello, Jun Yin et al. · 2021 · Pancreas
OBJECTIVES: Systemic therapies for pancreatic neuroendocrine tumors (PNETs) are limited. The combination of bevacizumab and temsirolimus showed significant antitumor activity, but the single-agent activity of bevacizumab was unknown. We…