Negative / Null Result Report
Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong et al. · 2020 · BMC Pulmonary Medicine
Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia…
View details →DOI: 10.1186/s12890-020-1056-7Cited by 10 Negative / Null Result ReportOpen accessEngineering
Prabhu Gurunathappa Sheelavantar, Poornachandra Pandit, Shreelaxmi Prashant · 2026 · Scientific Reports
Abstract The need for sustainable, practical alternatives to Portland cement and two-part alkali-activated systems has led to the development of one-part alkali-activated concrete (OPAAC), which efficiently reuses industrial by-products like fly ash and ground granulated blast furnace slag (GGBS). This study evaluates the fresh (workability) and hardened properties (compressive, tensile, and flexural strengths) of FA-GGBS-based OPAAC, along with durability indicators including sorptivity and chloride ion permeability. A performance-based multi-response optimization using a Taguchi L 9 array an
View details →DOI: 10.1038/s41598-025-34746-1Cited by 10 Negative / Null Result ReportOpen accessMedicine
Francesco Nonino, Silvia Minozzi, L. Sambati et al. · 2026 · Cochrane Database of Systematic Reviews
RATIONALE: Alzheimer's disease is a neurodegenerative disorder and the most common cause of dementia. Aggregated amyloid-beta protein deposits are implicated in its pathogenesis. Amyloid-beta-targeting monoclonal antibodies (sometimes represented as Aβ-mAbs) are potentially disease-modifying for Alzheimer's disease: through the clearance of amyloid in the brain, they may slow cognitive and functional decline. OBJECTIVES: To assess the clinical benefits and harms of amyloid-beta-targeting monoclonal antibodies aducanumab, bapineuzumab, crenezumab, donanemab, gantenerumab, lecanemab, ponezumab,
View details →DOI: 10.1002/14651858.cd016297Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Ali Derakhshan, Gurpinder Singh Lalli, Yujong Park · 2026 · Language Testing in Asia
While Artificial Intelligence (AI) has significantly transformed L2 testing and assessment, empirical research into how EFL practitioners perceive the specific opportunities and challenges of these tools remains limited. To address this…
View details →DOI: 10.1186/s40468-026-00445-5Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Shaofeng Wang, Hao Zhang · 2026 · International Journal of Educational Technology in Higher Education
Abstract The rapid integration of generative artificial intelligence (GenAI) into higher education has precipitated a critical tension between the pursuit of efficiency and the imperative for deep, transformative learning. While GenAI offers unprecedented speed in knowledge processing, it raises concerns that efficiency-driven motivations may erode the cognitive struggle essential for intellectual growth. This study investigates how Human-GenAI pedagogical partnerships influence transformative learning through the dual cognitive pathways of vigilance and offloading, moderated by efficiency ori
View details →DOI: 10.1186/s41239-026-00585-xCited by 10 Negative / Null Result ReportOpen accessEngineering
Jieling Qin, Zhenqi Jiang · 2026 · International Journal of Molecular Sciences
Metastatic breast cancer remains a significant therapeutic challenge due to its high invasiveness and resistance to conventional treatments. In this study, an ultrasound-responsive copper-calcium phosphate (Ca19Cu2(PO4)14) nanomaterial is developed for synergistic ion-mediated tumor therapy. The Ca19Cu2(PO4)14 nanomaterials exhibit a uniform morphology and crystalline structure, as well as good colloidal stability. Upon ultrasound irradiation, the release of Cu2+ and Ca2+ is spatiotemporally controlled via mechanical and cavitation effects. In vitro studies using highly metastatic 4T1 cells de
View details →DOI: 10.3390/ijms27042016Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Jacob A. Westerberg, Pieter R. Roelfsema · 2025 · Trends in Cognitive Sciences
Perceptual experience depends on recurrent interactions between lower and higher cortices. One theory, predictive coding, posits that feedback from higher to lower brain regions decreases neuronal activity predicted by higher-level representations. Despite the widespread adoption of predictive coding in neuroscience, the correspondence to neurophysiological findings in sensory cortices remains elusive. Here, we review how the canonical patterns of intra- and inter-cortical interactions that occur during perception and shifts of attention deviate from those predicted by predictive coding. We ar
View details →DOI: 10.1016/j.tics.2025.09.018Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang et al. · 2025 · Agronomy
Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advances in chromosome-scale genome assemblies, pan-genomics, and haplotype-resolved resequencing have greatly enhanced the capacity to identify causal variants and recover non-reference alleles linked to fibre development and environmental adaptation. Parallel progress in functional genomics and precision genome editing, particularly CRISPR/Cas
View details →DOI: 10.3390/agronomy15102393Cited by 10 Negative / Null Result ReportOpen accessEngineering
Rui Zhao, Qiushi Feng, Yangyang Xia et al. · 2025 · Pharmaceuticals
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses and advancing precision oncology, with established correlations to clinical outcomes in patient-derived models. These systems have transformed preclinical drug screening by bridging the gap between conventional two-dimensional (2D) cultures and in vivo models, preserving tumor histopathology, cellular heterogeneity, and patient-specific molecular
View details →DOI: 10.3390/ph18101540Cited by 10 Negative / Null Result ReportOpen accessEngineering
Yawen Zhu, Wanqi Yang, Zhong‐Xia Wang et al. · 2025 · Journal of Nanobiotechnology
Liver regeneration is a sophisticated biological process influenced by a complex microenvironment that becomes profoundly altered in various pathological conditions. Current therapeutic approaches, including liver transplantation and…
View details →DOI: 10.1186/s12951-025-03729-9Cited by 10 Negative / Null Result ReportOpen accessEngineering
Cao Zhengzheng, Xie Mengqi, Rong Tao et al. · 2026 · Scientific Reports
With the development of underground engineering and oil and gas exploitation, the problem of fluid-solid interaction in fractured rock mass has become increasingly prominent, and its complex coupling mechanism has a profound impact on the…
View details →DOI: 10.1038/s41598-025-25823-6Cited by 10 Negative / Null Result ReportOpen accessPsychology
Muhammad Kamal Uddin, Md Tarikul Islam, Muhammad Asaduzzaman · 2026 · Zenodo (CERN European Organization for Nuclear Research)
A large body of research has documented that smoking behavior is associated with a number of psychological variables. Weiss, Mouttapa, Cen, Johnson, and Unger (2011) studied a culturally diverse sample of 1,771 adolescents who reported that the risk of smoking initiation was significantly higher among students who scored higher on hostility and depressive symptoms, and were bully-victims. Mykletun, Overland, Aaro, Liabo, and Stewart (2008) carried out a population-based health survey on 60,814 adults aged between 20 to 89 years and reported that anxiety and depression were the most common in c
View details →DOI: 10.5281/zenodo.20354465Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Sieun Kim · 2025 · Scientific Reports
This study investigated the neurophysiological and affective responses elicited by nature-inspired indoor design elements, including curvilinear forms (CL), nature views (N), and wooden interiors (W), in a virtual environment, and their…
View details →DOI: 10.1038/s41598-025-18629-zCited by 10 Negative / Null Result ReportOpen accessMedicine
Tara L. Alvarez, Mitchell Scheiman, Farzin Hajebrahimi et al. · 2025 · British Journal of Sports Medicine
OBJECTIVE: The CONCUSS randomised clinical trial compared the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed therapy for the treatment of concussion-related convergence insufficiency…
View details →DOI: 10.1136/bjsports-2025-109807Cited by 10 Negative / Null Result ReportOpen accessMedicine
Yu Jun Wong, Laurent Lam, Pierre‐Antoine Soret et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis (PBC). However, the frequency and clinical relevance of discordant biochemical and LSM changes remain unclear. We aim to determine the performance of the most recent or current LSM (LSMc) in predicting first hepatic decompensation (HD) in the setting of discordant biochemical and LSM responses. METHODS: In this international, multicenter study, we included patients with at least two reliable LSM performed at least 6 months apart. Patients
View details →DOI: 10.1016/j.jhep.2025.09.024Cited by 10 Negative / Null Result ReportOpen accessMedicine
Janine Kutzsche, Nicoleta Carmen Cosma, Gunther Kauselmann et al. · 2025 · Nature Communications
Self-replicating amyloid beta (Aβ) oligomers are considered as one of the major drivers for disrupted synaptic function and plasticity, leading to impaired neuronal viability and progression of Alzheimer's disease (AD). Here, we investigated the safety, tolerability and pharmacokinetics of the anti-oligomeric peptide PRI-002, which was developed to disassemble toxic Aβ oligomers into non-toxic monomers. In a randomized, double-blind, single-center phase 1b trial, 20 patients aged between 50 and 80 years, with mild neurocognitive impairment (MCI) or mild dementia due to AD were recruited. Eligi
View details →DOI: 10.1038/s41467-025-59295-zCited by 10 Negative / Null Result ReportOpen accessComputer Science
Ramteja Sajja, Yusuf Sermet, Brian Fodale et al. · 2026 · Scientific Reports
As generative AI becomes increasingly integrated into higher education, understanding how students engage with these technologies is essential for responsible adoption. This study evaluates the Educational AI Hub, an AI-powered learning…
View details →DOI: 10.1038/s41598-026-39237-5Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jack W. O’Sullivan, Anil Palepu, Khaled Saab et al. · 2026 · Nature Medicine
The scarcity of subspecialist medical expertise poses a considerable challenge for healthcare delivery. This issue is particularly acute in cardiology, where timely, accurate management determines outcomes. We explored the potential of Articulate Medical Intelligence Explorer (AMIE), a large language model-based experimental medical artificial intelligence system, to augment clinical decision-making in this challenging context. We conducted a randomized controlled trial comparing large language model-assisted care with the usual care of complex patients suspected of having a genetic cardiomyop
View details →DOI: 10.1038/s41591-025-04190-9Cited by 10 Negative / Null Result ReportOpen accessHealth Professions
Shanti Prasad Khanal, Chitra Bahadur Budhathoki, Orkan Okan · 2025 · BMC Public Health
BACKGROUND: There is a gap in theory-based interventions targeting adolescent health literacy. This study evaluated the impact of a school-based health literacy intervention on self-efficacy, health literacy awareness, situation, and…
View details →DOI: 10.1186/s12889-025-24827-1Cited by 10 Negative / Null Result ReportOpen accessMedicine
Fatemeh Mohammadyari, Amirreza Aflak, Mahta ZareDini et al. · 2025 · Frontiers in Medicine
Background: Gastrointestinal bleeding (GIB), which includes both upper GIB (variceal and non-variceal) and lower GIB, represents a significant cause of emergency department referrals. Main body: Given the potential risks of blood transfusion, re-bleeding, and mortality in these patients, it is essential to establish a system for prioritizing critical patients. Several risk stratification scoring systems have been developed based on patients' clinical characteristics and/or endoscopic findings. However, the optimal scoring system for each clinical scenario remains uncertain. Conclusion: In this
View details →DOI: 10.3389/fmed.2025.1564015Cited by 10 Negative / Null Result ReportOpen accessMedicine
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe
View details →DOI: 10.3390/nu17121964Cited by 10 Negative / Null Result ReportOpen accessMedicine
Calvin Trieu, Argonde C. van Harten, Mardou S. S. A. van Leeuwenstijn et al. · 2025 · JAMA Network Open
Importance: Blood-based biomarkers identify Alzheimer disease and hold promise for monitoring disease progression, even in the preclinical disease stages. Objective: To investigate longitudinal trajectories of blood-based biomarkers and association with cognitive decline and risk of progression in individuals with subjective cognitive decline (SCD). Design, Setting, and Participants: This prospective cohort study (Subjective Cognitive Impairment Cohort) of individuals with SCD evaluated at a memory clinic underwent biennial biomarker collection and annual cognitive assessment and diagnostic ev
View details →DOI: 10.1001/jamanetworkopen.2025.45862Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sami Alobaidi · 2025 · Frontiers in Medicine
Chronic kidney disease (CKD) remains a major global health issue, affecting millions and presenting persistent diagnostic and therapeutic challenges. Conventional biomarkers such as serum creatinine and estimated glomerular filtration rate have well-recognized limitations, underscoring the need for novel diagnostic tools and interventions. Emerging evidence highlights the gut-kidney axis as a central contributor to CKD pathogenesis, shaped by microbial dysbiosis and altered metabolite production. Harmful metabolites such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide promote
View details →DOI: 10.3389/fmed.2025.1675458Cited by 10 Negative / Null Result ReportOpen accessPsychology
Sylwia Sumińska, Andrzej Rynkiewicz · 2025 · PLoS ONE
INTRODUCTION: Mindfulness-Based Stress Reduction (MBSR) helps counteract the negative consequences of stress. An essential aspect of mind-body therapies is learning to be mindful of emotional reactions and bodily sensations, a process defined as interoceptive awareness. This awareness can also be enhanced by providing physiological feedback from a smartwatch. However, the impact of using smartwatch-generated physiological signals during mindfulness training has not been studied yet. The study aims at verifying, whether physiological signals from a smartwatch would support the MBSR. METHODS: We
View details →DOI: 10.1371/journal.pone.0322413Cited by 10 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Hartmut Jaeschke, Anup Ramachandran · 2025 · Exploration of Digestive Diseases
Acetaminophen (APAP)-induced liver injury and acute liver failure is a significant clinical problem worldwide; in addition, APAP overdoses in animals or in cell culture are used as popular models to study drug-induced liver injury mechanisms and test therapeutic interventions. Early assumptions that APAP toxicity is caused by a single mechanism resulting in a defined mode of cell death in hepatocytes had to be questioned when over the years many different mechanisms and modes of cell death were reported. Although many of the contradictory results and conclusions reported over the years can be
View details →DOI: 10.37349/edd.2025.100569Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Jung Ho Choi, Brandon Gipper, Shawn Shi · 2025 · Review of Accounting Studies
Early empirical evidence showed a lack of relative performance evaluation (RPE) for executive pay, a surprise given its theoretical appeal. We hypothesize that executive pay transparency can enhance the monitoring of pay practices and…
View details →DOI: 10.1007/s11142-025-09880-wCited by 10 Negative / Null Result ReportOpen accessMedicine
Van Nguyen, Sreenidhi Iyengar, Haroon Rasheed et al. · 2025 · Ophthalmology Science
Purpose Develop and test a deep learning (DL) algorithm for detecting referable glaucoma. Design Retrospective cohort study. Participants A total of 6116 patients from the Los Angeles County (LAC) Department of Health Services (DHS) were…
View details →DOI: 10.1016/j.xops.2025.100751Cited by 10 Negative / Null Result ReportOpen accessMedicine
Francesco Fortunato, Francesco D’Amico, Anny Votano et al. · 2025 · Epilepsia
OBJECTIVE: To estimate the proportion of individuals with focal epilepsy treated with at least one among carbamazepine (CBZ), oxcarbazepine (OXC), or eslicarbazepine (ESL), who were hospitalized due to hyponatremia-related symptoms in 2024, and to test the hypothesis that there is an association with climatic variables. METHODS: We undertook a prospective study in which people with focal epilepsy treated with at least one of the target drugs and at least one attendance in 2024 formed the study cohort. Individuals who were admitted or seen as outpatients for hyponatremia in 2024 were considered
View details →DOI: 10.1111/epi.18584Cited by 10 Negative / Null Result ReportOpen accessMedicine
Marwah Karim, Manjari Mishra, Chieh‐Wen Lo et al. · 2025 · Nature Communications
In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of…
View details →DOI: 10.1038/s41467-025-61759-1Cited by 10 Negative / Null Result ReportOpen accessPsychology
Raeanna Kilby, Kristin D. Mickelson · 2025 · Frontiers in Psychiatry
Social media movements centered on body positivity and body neutrality both encourage healthy attitudes toward the physical body; however, these movements are conceptually distinct and may have unique influences on body image. This study examined how brief exposure to different types of body acceptance and weight-stigmatizing content affects body image and mood. Participants consisted of women and gender-diverse individuals (N = 326) who completed an online survey and were randomly assigned to view one of four TikTok video compilations: body neutrality, body positivity, weight-stigmatizing, or
View details →DOI: 10.3389/fpsyt.2025.1577063Cited by 10 