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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21697 results · page 140 of 724

Negative / Null Result ReportOpen accessDecision Sciences

Influence of Strategic Planning to Firm Performance in Agricultural Research Based Institutions of Kenya

Yusuf Wanjala Musi, Elegwa Mukulu, Margaret Oloko · 2018 · Journal of Management and Sustainability

Strategic planning is a very crucial phenomenon in all organisations. It is the tool that determines the destiny of the firm. The objective of this study was to investigate the influence of financial resource strategic planning on firm performance, to determine influence of human capital strategic planning on firm performance, to analyze the influence of material resource strategic planning on firm performance and to determine influence of information resource strategic planning on firm performance in agriculture research based institutions of Kenya. Although there had been previous internatio

View details →DOI: 10.5539/jms.v8n4p83Cited by 12
Negative / Null Result ReportOpen accessNursing

The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation

Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients

Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.

View details →DOI: 10.3390/nu14204395Cited by 12
Negative / Null Result ReportOpen accessMedicine

A cross-sectional study to assess response generated by ChatGPT and ChatSonic to patient queries about Epilepsy

Aditya Kumar Gudimella Tirumala, Shubham Mishra, Nritya Trivedi et al. · 2023 · Telematics and Informatics Reports

This article presents a study comparing the responses of two AI chatbots, ChatGPT and ChatSonic, regarding inquiries about epilepsy. Overall, ChatGPT and ChatSonic are very similar in terms of their capabilities and limitations and they…

View details →DOI: 10.1016/j.teler.2023.100110Cited by 12
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gαqprotein-induced cardiomyopathy

Valeriy Timofeyev, C. A. Porter, Dipika Tuteja et al. · 2010 · American Journal of Physiology-Heart and Circulatory Physiology

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy…

View details →DOI: 10.1152/ajpheart.01208.2009Cited by 12
Negative / Null Result Report

OXIDIZED LIPIDS DID NOT REDUCE LIFESPAN IN THE FRUIT FLY, Drosophila melanogaster

Oleh V. Lushchak, Dmytro V. Gospodaryov, Ihor S. Yurkevych et al. · 2015 · Archives of Insect Biochemistry and Physiology

Aging is often associated with accumulation of oxidative damage in proteins and lipids. However, some studies do not support this view, raising the question of whether high levels of oxidative damage are associated with lifespan. In the…

View details →DOI: 10.1002/arch.21308Cited by 12
Negative / Null Result ReportOpen accessPsychology

Testing the Magnitude of Correlations Across Experimental Conditions

Simone Di Plinio · 2022 · Frontiers in Psychology

Correlation coefficients are often compared to investigate data across multiple research fields, as they allow investigators to determine different degrees of correlation to independent variables. Even with adequate sample size, such differences may be minor but still scientifically relevant. To date, although much effort has gone into developing methods for estimating differences across correlation coefficients, adequate tools for variable sample sizes and correlational strengths have yet to be tested. The present study evaluated four different methods for detecting the difference between two

View details →DOI: 10.3389/fpsyg.2022.860213Cited by 12
Negative / Null Result ReportOpen accessMaterials Science

Significant effect on annealing temperature and enhancement on structural, optical and electrical properties of zinc oxide nanowires

Suriati Paiman, T. Hui Ling, M. Husham et al. · 2020 · Results in Physics

This paper focused on the growth of zinc oxide nanowires on unannealed and annealed indium tin oxide-coated-coated glass substrates on the structural, optical, and electrical properties towards surface acoustic wave (SAW) piezoelectric…

View details →DOI: 10.1016/j.rinp.2020.103185Cited by 12
Negative / Null Result ReportOpen accessImmunology and Microbiology

Mast cells selectively produce inflammatory mediators and impact the early response to Chlamydia reproductive tract infection

Animamalar Mayavannan, Emily Shantz, Ian D. Haidl et al. · 2023 · Frontiers in Immunology

Introduction Chlamydia trachomatis ( C. trachomatis ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells, which are common at mucosal barriers, may contribute to responses to Chlamydia infection and aimed to define human mast cell responses to C. trachomatis . Methods Human cord blood-derived mast cells (CBMCs) were exposed to C. trachomatis to assess bacterial uptake, mast cell degranulation, gene expression, and production of inflammatory mediato

View details →DOI: 10.3389/fimmu.2023.1166068Cited by 12
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Functional implications of residues of the B′ motif of geminivirus replication initiator protein in its helicase activity

Rajrani Ruhel, Mohit Mazumder, Prabu Gnanasekaran et al. · 2021 · FEBS Journal

Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuclease, ligase, ATPase, and helicase. B'…

View details →DOI: 10.1111/febs.16053Cited by 12
Negative / Null Result ReportOpen accessPsychology

A network analysis of female sexual function: comparing symptom networks in women with decreased, increased, and stable sexual desire

Annika Gunst, Marlene Werner, Lourens Waldorp et al. · 2018 · Scientific Reports

Problems related to low sexual desire in women are common clinical complaints, and the aetiology is poorly understood. We investigated predictors of change in levels of sexual desire using a novel network approach, which assumes that mental disorders arise from direct interactions between symptoms. Using population-based data from 1,449 Finnish women, we compared between-subject networks of women whose sexual desire decreased, increased, or remained stable over time. Networks were estimated and analyzed at T1 (2006) and replicated at T2 (2013) using R. Domains included were, among others, sexu

View details →DOI: 10.1038/s41598-018-34138-8Cited by 12
Negative / Null Result ReportSocial Sciences

Side-by-Side Sports Reporters: A Between-Subjects Experiment of the Effect of Gender in Reporting on the NFL

Gayle Jansen Brisbane, Patrick Ferrucci, Edson C. Tandoc · 2021 · Communication & Sport

Women are more visible than ever in sports media. Yet, extant research has shown that females have endured an array of issues exclusive to their gender. Consistent research updates on gender in sports media is necessary in order to…

View details →DOI: 10.1177/2167479521995462Cited by 12
Negative / Null Result ReportOpen accessMedicine

Rodent Models of Alzheimer’s Disease: Past Misconceptions and Future Prospects

Helen M Collins, Susan A. Greenfield · 2024 · International Journal of Molecular Sciences

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau. Yet transgenic rodent models poorly replicate the neuropatho

View details →DOI: 10.3390/ijms25116222Cited by 12
Negative / Null Result ReportOpen accessNeuroscience

Comparing fear and anxiety chemosignals: Do they modulate facial muscle activity and facilitate identifying facial expressions?

Nuno Gomes, Bettina M. Pause, Monique A. M. Smeets et al. · 2023 · Chemical Senses

Fear and anxiety are the most frequently studied emotional states in chemosignal research. Despite differences between these two emotional states, findings from research using fear and anxiety body odors (BOs) are often treated as part of…

View details →DOI: 10.1093/chemse/bjad016Cited by 12
Negative / Null Result ReportOpen accessComputer Science

Augmenting Immersive Telepresence Experience with a Virtual Body

Nikunj Arora, Markku Suomalainen, Matti Pouke et al. · 2022 · IEEE Transactions on Visualization and Computer Graphics

We propose augmenting immersive telepresence by adding a virtual body, representing the user's own arm motions, as realized through a head-mounted display and a 360-degree camera. Previous research has shown the effectiveness of having a virtual body in simulated environments; however, research on whether seeing one's own virtual arms increases presence or preference for the user in an immersive telepresence setup is limited. We conducted a study where a host introduced a research lab while participants wore a head-mounted display which allowed them to be telepresent at the host's physical loc

View details →DOI: 10.1109/tvcg.2022.3150473Cited by 12
Negative / Null Result ReportOpen accessEngineering

Functional evaluation of a real-time EMG controlled prosthetic hand

Amlan Jyoti Kalita, Maibam Pooya Chanu, Nayan M. Kakoty et al. · 2025 · Wearable Technologies

Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand ca

View details →DOI: 10.1017/wtc.2025.7Cited by 12
Negative / Null Result ReportPsychology

Evaluating the Factor Structure of the Posttraumatic Cognitions Inventory

Sarah E. Whiteman, Lindsay B. Kramer, Madison W. Silverstein et al. · 2020 · Assessment

The Posttraumatic Cognitions Inventory (PTCI) is one of the most widely used measure of posttraumatic cognitions. The original factor analysis of the PTCI provided evidence for a three-factor model of negative cognitions about self, world,…

View details →DOI: 10.1177/1073191120954915Cited by 12
Negative / Null Result ReportMedicine

Biomimetic Human Lung Alveolar Interstitium Chip with Extended Longevity

Kun Man, Jiafeng Liu, Cindy Liang et al. · 2023 · ACS Applied Materials & Interfaces

Determining the mechanistic causes of lung diseases, developing new treatments thereof, and assessing toxicity whether from chemical exposures or engineered nanomaterials would benefit significantly from a preclinical human lung alveolar…

View details →DOI: 10.1021/acsami.3c04091Cited by 12
Negative / Null Result ReportOpen accessDentistry

BLOOD LIPID LEVELS RELATED TO ALLERGIC RHINITIS: A SIGNIFICANT ASSOCIATION?

Ignazio La Mantia, Claudio Andaloro, Pasquale Gianluca Albanese et al. · 2026 · EuroMediterranean Biomedical Journal

Allergic rhinitis is a common problem increasing greatly over the past three decades. Several studies have found a possible link between dyslipidem ia and allergic disease but the relating causal mechanisms remain elusive. The aim of this…

View details →DOI: 10.3269/1970-5492.2017.12.30Cited by 12
Negative / Null Result ReportOpen accessNeuroscience

Predicting ‘Brainage’ in late childhood to adolescence (6-17yrs) using structural MRI, morphometric similarity, and machine learning

Daniel Griffiths-King, Amanda Wood, Jan Novák · 2023 · Scientific Reports

Brain development is regularly studied using structural MRI. Recently, studies have used a combination of statistical learning and large-scale imaging databases of healthy children to predict an individual's age from structural MRI. This data-driven, predicted 'Brainage' typically differs from the subjects chronological age, with this difference a potential measure of individual difference. Few studies have leveraged higher-order or connectomic representations of structural MRI data for this Brainage approach. We leveraged morphometric similarity as a network-level approach to structural MRI t

View details →DOI: 10.1038/s41598-023-42414-5Cited by 12
Negative / Null Result ReportOpen accessNeuroscience

Target Size Manipulations Affect Error-Processing Duration and Success Perceptions but not Behavioural Indices of Learning

Nicole T. Ong, Jamie Hawke, Nicola J. Hodges · 2019 · Brain Sciences

We evaluated if and how success perceptions, through target size manipulations, impact processes related to motor learning. This work was based on recent literature suggesting that expectations and self-efficacy exert a direct impact on learning. We measured arousal, kinematics, learner expectancies, motivation, and outcomes in a dart-throwing task. Novices (n = 29) were assigned to either a “Large-target” (horizontal target, 10-cm high) or “Small-target” (2-cm high) group for practice (t = 90), and both groups completed 24-h retention tests. The Small-target group took longer to plan and proc

View details →DOI: 10.3390/brainsci9050119Cited by 12
Negative / Null Result ReportOpen accessEnvironmental Science

Metagenomic comparison of effects of mesophilic and thermophilic manure anaerobic digestion on antimicrobial resistance genes and mobile genetic elements

Daniel Flores-Orozco, David B. Levin, Ayush Kumar et al. · 2023 · Environmental Advances

This study evaluated the long-term effects of mesophilic (MAD) and thermophilic (TAD) anaerobic digestion on the fate and evolution of antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs) in cattle manure following a…

View details →DOI: 10.1016/j.envadv.2023.100472Cited by 12
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Implications of root morphology and anatomy for water deficit tolerance and recovery of grapevine rootstocks

David García Alonso, Ignacio Buesa, Luis Flor et al. · 2025 · Frontiers in Plant Science

The intensification of drought conditions due to climate change poses a major challenge to sustainable grape production. Rootstocks are essential in supporting grapevine water uptake and drought resilience; however, their physiological responses to water stress are not fully understood. Under the hypothesis that root morphology and anatomy may be key traits in grapevine tolerance to water deficit, this study aimed to investigate these traits across diverse rootstocks under progressive water deficit and recovery phases. Thirteen genotypes, including commercial rootstocks and recently bred RG-se

View details →DOI: 10.3389/fpls.2025.1541523Cited by 12
Negative / Null Result Report

Significant difference in femoral torsion between coronal plane alignment of the knee type 1 and 4

Jonas Ziegenhorn, Julia Kirschberg, Markus Heinecke et al. · 2024 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to find out whether the torsions of the femur and tibia are dependent on the coronal plane alignment of the knee (CPAK) type. Methods Five hundred patients (1000 legs) were included, who…

View details →DOI: 10.1002/ksa.12149Cited by 12
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection

Marlee R. Labroo, Jessica Rutkoski · 2022 · BMC Genomics

BACKGROUND: Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain. Usually, generations are discrete in recurrent selection, which means that breeding candidates are evaluated and considered for selection for only one cycle. Alternately, generations can overlap, with breeding candidates considered for selection as parents for multiple cycles. With recurrent genomic selection but not phenotypic selection, candidates can be re-evaluated by using genomic estimated breeding v

View details →DOI: 10.1186/s12864-022-08929-3Cited by 12
Negative / Null Result Report

Significant effects on neonatal morbidity and mortality after regional change in management of post‐term pregnancy

CHARLOTTA GRUNEWALD, STELLAN HÅKANSSON, SISSEL SALTVEDT et al. · 2010 · Acta Obstetricia et Gynecologica Scandinavica

Abstract Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post‐term pregnancy from 43 +0 to 42 +0 gestational weeks (GWs). Design and setting. Nationwide retrospective register study…

View details →DOI: 10.1111/j.1600-0412.2010.01019.xCited by 12
Negative / Null Result ReportOpen accessComputer Science

Prediction of breast cancer survivability using ensemble algorithms

Vincent Adegoke, Daqing Chen, Ebad Banissi et al. · 2017

In this paper, several ensemble cancer survivability predictive models are presented and tested based on three variants of AdaBoost algorithm. In the models we used Random Forest, Radial Basis Function Network and Neural Network algorithms…

View details →DOI: 10.1109/sst.2017.8188699Cited by 12
Negative / Null Result Report

Large‐Scale Industrial Cloud Perturbations Confirm Bidirectional Cloud Water Responses to Anthropogenic Aerosols

Heido Trofimov, Nicolas Bellouin, Velle Toll · 2020 · Journal of Geophysical Research: Atmospheres

Abstract Aerosols offset a poorly quantified fraction of anthropogenic greenhouse gas warming, and the aerosol impact on clouds is the most uncertain mechanism of anthropogenic climate forcing. Here observations of a relatively weak…

View details →DOI: 10.1029/2020jd032575Cited by 12
Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of combination behavioral activation for smoking cessation and varenicline for treating tobacco dependence among individuals with current or past major depressive disorder: A 2 × 2 factorial, randomized, placebo‐controlled trial

Brian Hitsman, George D. Papandonatos, Jackie K. Gollan et al. · 2023 · Addiction

BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12…

View details →DOI: 10.1111/add.16209Cited by 12
Negative / Null Result Report

ADJUSTMENT OF CORPORATE REAL ESTATE DURING A PERIOD OF SIGNIFICANT BUSINESS CHANGE

Howard Cooke, Rianne Appel-Meulenbroek, Theo Arentze · 2019 · International Journal of Strategic Property Management

This paper seeks to understand whether the alignment process between business strategy and Corporate Real Estate (CRE) between 2007 and 2014 was dynamic. It investigated the financial data of 230 UK companies by means of a distributed time…

View details →DOI: 10.3846/ijspm.2019.7954Cited by 12