Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
View details →DOI: 10.1371/journal.pone.0093743Cited by 11 Negative / Null Result ReportOpen accessMedicine
Luís Alberto de Pádua Covas Lage, Rita Novello de Vita, Lucas Bassolli de Oliveira Alves et al. · 2024 · Cancers
Background: Diffuse large B-cell lymphoma (DLBCL) especially affects the older population. Old (≥60 years) and very old age (≥80 years) DLBCL patients often present high-risk molecular alterations, lower tolerability to conventional immunochemotherapy, and poor clinical outcomes. In this scenario, attenuated therapeutic strategies, such as the R-MiniCHOP and R-MiniCHOP of the elderly regimens, have emerged for this particularly fragile population. However, the responses, clinical outcomes, and toxicities of these regimens currently remain poorly understood, mainly because these individuals are
View details →DOI: 10.3390/cancers16081459Cited by 11 Negative / Null Result ReportOpen accessMedicine
Allyson L. Anding, Sofia Kinton, Kaitlyn Baranowski et al. · 2023 · Journal of Pharmacology and Experimental Therapeutics
Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidase, which leads to muscle weakness, cardiac and respiratory failure, and early mortality. Alglucosidase alfa, a recombinant…
View details →DOI: 10.1124/jpet.123.001593Cited by 11 Negative / Null Result Report
Bianca Bonato, Qiuran Wang, Silvia Guerra et al. · 2023 · AoB PLANTS
Abstract In life, it is common for almost every kind of organism to interact with one another. In the human realm, such interactions are at the basis of joint actions, when two or more agents syntonize their actions to achieve a common…
View details →DOI: 10.1093/aobpla/plad088Cited by 11 Negative / Null Result ReportMedicine
Xu Yang, Lina Zhao, Anhui Shi et al. · 2023 · The American Journal of Gastroenterology
INTRODUCTION: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This…
View details →DOI: 10.14309/ajg.0000000000002257Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hiroki Isono, Taiju Miyagami, Kohta Katayama et al. · 2016 · Internal Medicine
Tetanus is a potentially fatal infection. Approximately 100 cases are reported in Japan each year; however, little is known about its clinical course and outcomes in the current era of treatment. We herein report three cases of tetanus in…
View details →DOI: 10.2169/internalmedicine.55.7131Cited by 11 Negative / Null Result ReportOpen accessMedicine
Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono et al. · 2017 · Acute Medicine & Surgery
Aim Our aim was to evaluate the effect of ulinastatin on 28‐day mortality in patients who developed multiple organ failure ( MOF ) related to their acute illness and were admitted to the intensive care unit ( ICU ). Methods We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28‐day all‐cause mortality. Secondary outcomes were ventilator‐free days, ICU ‐free days, and vasopressor‐free days at day 28. We investigated the association between ulinastatin treatment and ou
View details →DOI: 10.1002/ams2.304Cited by 11 Negative / Null Result Report
JOHN LOOMIS, CATHERINE KESKE · 2011 · Contemporary Economic Policy
Outdoor recreation is a large industry that can diversify public land‐based economies that have traditionally relied upon resource extraction. However, what happens to nature‐based recreation visitor spending and benefits during times of…
View details →DOI: 10.1111/j.1465-7287.2011.00277.xCited by 11 Negative / Null Result ReportMedicine
Shahid Habib, Nehali Patel, Sandeep Yarlagadda et al. · 2018 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: Infection is a leading precipitant of acute-on-chronic liver failure. This study aims to determine the safety and efficacy of antibiotics within acute-on-chronic liver failure. METHODS: Retrospective study of 457…
View details →DOI: 10.1111/jgh.14267Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ali Nouri · 2022 · Scientific Reports
Abstract The study was conducted to consider the anticoccidial and immunogenic effectivities of encapsulated organic acids and anticoccidial drugs in broilers reared on a reused litter infected with Eimeria spp. for simulating in-field exposure to avian coccidiosis. 525 mixed -sex one-day-old broiler chicks (Ross 308) were used in a 2 × 3 factorial experiment as a completely randomized design with seven experimental groups and five replicates of 15 chicks. The seven experimental groups were included: negative (uninfected; T 1 ) and positive (infected; T 2 ) control groups fed a diet without ad
View details →DOI: 10.1038/s41598-022-20990-2Cited by 11 Negative / Null Result ReportOpen accessMedicine
Arthur R. H. van Zanten, Y. G. Van Der Meer, Willem A. Venhuizen et al. · 2015 · Journal of Parenteral and Enteral Nutrition
Neurologic adverse reactions, including extrapyramidal disorders, dyskinesia, dystonia, convulsions, hypertonia, and tremors.4 The reported occurrence of tardive dyskinesia ranges from <0.01%–23%.5 High occurrence is attributed to chronic…
View details →DOI: 10.1177/0148607114567711Cited by 11 Negative / Null Result ReportOpen accessMedicine
Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…
View details →DOI: 10.1016/j.bneo.2024.100009Cited by 11 Negative / Null Result ReportOpen accessMedicine
Mathilde Ruggiu, Bruno Cassinat, Jean‐Jacques Kiladjian et al. · 2020 · Biology of Blood and Marrow Transplantation
BCR-ABL-negative myeloproliferative neoplasms (MPNs) in transformation have a dismal prognosis, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the sole curative therapeutic option. We retrospectively…
View details →DOI: 10.1016/j.bbmt.2020.02.019Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kristin Köppen, Diana Fatykhova, Gudrun Holland et al. · 2023 · Frontiers in Cellular and Infection Microbiology
Introduction Tularemia is mainly caused by Francisella tularensis ( Ft ) subsp. tularensis ( Ftt ) and Ft subsp. holarctica ( Ftt ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment. So far, only 2D cell culture and animal models are used to study Francisella virulence , but the gained results are transferable to human infections only to a certain extent. Method In this study, we firstly established an ex
View details →DOI: 10.3389/fcimb.2023.1224356Cited by 11 Negative / Null Result ReportOpen accessMedicine
Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers et al. · 2012 · Journal of Applied Biomechanics
Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our…
View details →DOI: 10.1123/jab.28.2.184Cited by 11 Negative / Null Result ReportPsychology
Casey LaDuke, Benjamin Locklair, Kirk Heilbrun · 2018 · Journal of Forensic Psychology Research and Practice
Neuroscientific evidence is assuming an increasingly prominent role in criminal law, where it has considerable potential for affecting legal decision making. Our understanding of this effect is currently limited. Research initially…
View details →DOI: 10.1080/24732850.2018.1439142Cited by 11 Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Taylor, Kelsey C. Hewitt, Robert A. Reeves et al. · 2013 · Procedia Technology
Previously, in the field to solve complex problems, we had found that majority rule (MR) decision-making out-performed consensus rule (CR) by making decisions that were quicker, more practical, and of better quality. This is an important…
View details →DOI: 10.1016/j.protcy.2013.12.055Cited by 11 Negative / Null Result ReportOpen accessImmunology and Microbiology
Natalia Ristic, Mario P. S. Chin · 2010 · Retrovirology
BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate in human T cell lines. The replication restriction phenotype in the SL1 deletion mutant appears to be multifactorial, with defects in viral RNA dimerization and packaging in producer cells as well as in reverse transcription of the viral RNA in infected cells. In this study, we sought to characterize SL
View details →DOI: 10.1186/1742-4690-7-73Cited by 11 Negative / Null Result ReportOpen accessMedicine
Ross D. Pollock, Caroline J. Jolley, N. Abid et al. · 2021 · Aerospace Medicine and Human Performance
Abstract BACKGROUND: Members of the public will soon be taking commercial suborbital spaceflights with significant G x (chest-to-back) acceleration potentially reaching up to 6 G x . Pulmonary physiology is gravity-dependent and is likely…
View details →DOI: 10.3357/amhp.5790.2021Cited by 11 Negative / Null Result Report
Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi et al. · 2015 · F1000Research
Background : We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study…
View details →DOI: 10.12688/f1000research.6312.1Cited by 11 Negative / Null Result Report
Rui Perdigão · 2018 · Entropy
The information shared among observables representing processes of interest is traditionally evaluated in terms of macroscale measures characterizing aggregate properties of the underlying processes and their interactions. Traditional…
View details →DOI: 10.3390/e20010026Cited by 11 Negative / Null Result Report
Samuel Kyle Jones, Jodie Davies-Thompson, Jeremy Tree · 2021 · Frontiers in Human Neuroscience
Bilingualism has been identified as a potential cognitive factor linked to delayed onset of dementia as well as boosting executive functions in healthy individuals. However, more recently, this claim has been called into question following…
View details →DOI: 10.3389/fnhum.2021.621772Cited by 11 Failed Experiment Report
Ching-Yi Lai, Kai-Min Chung · 2018 · Quantum Information and Computation
Homomorphic encryption is an encryption scheme that allows computations to be evaluated on encrypted inputs without knowledge of their raw messages. Recently Ouyang et al. constructed a quantum homomorphic encryption (QHE) scheme for…
View details →DOI: 10.26421/qic18.9-10-4Cited by 11 Negative / Null Result ReportMedicine
Leonardo Calza, Isabella Bon, Marco Borderi et al. · 2020 · JAIDS Journal of Acquired Immune Deficiency Syndromes
Calza, Leonardo MD; Bon, Isabella PhD; Borderi, Marco MD; Colangeli, Vincenzo MD; Viale, Pierluigi MD Author Information
View details →DOI: 10.1097/qai.0000000000002427Cited by 11 Negative / Null Result Report
Uraiwan Buatoom, Muhammad Usman Jamil · 2023 · Applied Sciences
In image classification, various techniques have been developed to enhance the performance of principal component analysis (PCA) dimension reduction techniques with guiding weighting features to remove redundant and irrelevant features.…
View details →DOI: 10.3390/app13032005Cited by 11 Negative / Null Result ReportNeuroscience
Nathan Leggett, Nicole A. Thomas, Michael E. R. Nicholls · 2015 · Cognition & Emotion
Approach motivation leads to greater left hemisphere activation, whereas an avoidant motivational state activates the right hemisphere. Recent research, which served as the basis for the current experiment, suggests line bisection provides…
View details →DOI: 10.1080/02699931.2015.1053842Cited by 11 Negative / Null Result ReportNeuroscience
Katherine A. Rawson, Kathryn T. Wissman, Kalif E. Vaughn · 2015 · Journal of Experimental Psychology Learning Memory and Cognition
Recent research on testing effects (i.e., practice tests are more effective than restudy for enhancing subsequent memory) has focused on explaining when and why testing enhances memory. Of particular interest for present purposes, Zaromb…
View details →DOI: 10.1037/xlm0000127Cited by 11 Negative / Null Result ReportOpen accessMedicine
Enzo M. Scutigliani, Edwin R. Scholl, Anita E. Grootemaat et al. · 2018 · Frontiers in Microbiology
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multi-drug resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of Mycobacterium tuberculosis. We demonstrate that the DNA of M. tuberculosis can condense under stressful conditions such as starvation and antibiotic trea
View details →DOI: 10.3389/fmicb.2018.02034Cited by 11 Negative / Null Result ReportNeuroscience
Anne Gast, Jasmin Richter, Borys Ruszpel · 2019 · Cognition & Emotion
In three experiments we investigated whether memory-independent evaluative conditioning (EC) and other memory-independent contingency learning (CL) effects occur in the valence contingency task (VCT). In the VCT, participants respond to…
View details →DOI: 10.1080/02699931.2019.1652147Cited by 11 Negative / Null Result ReportOpen accessMedicine
Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple
View details →DOI: 10.3389/fpsyg.2020.01820Cited by 11 