Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Buhari Doğan, Mohammad Razib Hossain, Rabeh Khalfaoui et al. · 2026 · Financial Innovation
Abstract Drawing from the recent COP28, which espouses a boom in clean energy transition through technological forwardness, and the framework of the SDG, we address critical questions related to green investment, energy investment, and environmental sustainability. We scrutinize whether green technology genuinely leads to green investment and energy investment in China and whether the causal nexus between these variables holds amid an EKC postulation. We use Chinese provincial data from 1998 to 2020 and deploy the quantile moment-based non-parametric regression technique and the newly develope
View details →DOI: 10.1186/s40854-025-00894-6Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dingya Sun, Jialu Wang, Xin Li et al. · 2026 · Antioxidants
Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metab
View details →DOI: 10.3390/antiox15010109Cited by 11 Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →DOI: 10.1001/jamacardio.2026.0101Cited by 11 Replication FailureOpen accessMedicine
S Bangalore, Santosh Kumar Sinha, Rakendra Singh et al. · 2026 · JAMA Cardiology
Importance: The optimal dual antiplatelet therapy after percutaneous coronary intervention (PCI) in patients with diabetes is not clearly defined. Although both ticagrelor and prasugrel are potent inhibitors of P2Y purinergic receptor 12…
View details →DOI: 10.1001/jamacardio.2025.5057Cited by 11 Negative / Null Result ReportOpen accessEngineering
Naman Gupta, Rantong Gong, Y. Wu et al. · 2025 · Nature Communications
The discovery of superconductivity in La3Ni2O7 under pressure has motivated the investigation of a parent spin density wave (SDW) state, which could provide the underlying pairing interaction. Here, we employ resonant soft x-ray scattering…
View details →DOI: 10.1038/s41467-025-61653-wCited by 11 Negative / Null Result ReportOpen accessNeuroscience
James Downar, James Downar, Julie Lapenskie et al. · 2024 · Palliative Medicine
Background: Psychological and existential suffering affects many people with advanced illness, and current therapeutic options have limited effectiveness. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy…
View details →DOI: 10.1177/02692163241234799Cited by 11 Negative / Null Result ReportOpen accessNeuroscience
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta et al. · 2024 · Cell Reports
The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects…
View details →DOI: 10.1016/j.celrep.2024.113991Cited by 11 Negative / Null Result ReportOpen accessMedicine
Igor Strahovnik, Andrej Strahovnik, Samo K. Fokter · 2025 · Bioengineering
Whole-leg radiographs (WLRs) are widely used to assess coronal alignment before total knee arthroplasty (TKA), but may be inaccurate in patients with atypical morphotypes or malrotation. This study evaluated the discrepancy between WLR and 3D computed tomography (CT) scans across coronal plane alignment of the knee (CPAK) morphotypes and introduced a novel projection index—the femoral notch projection ratio (FNPR). In CPAK III knees, 19% of cases exceeded a clinically relevant threshold (>3° difference), prompting investigation of underlying projection factors. In 187 knees, coronal angles—
View details →DOI: 10.3390/bioengineering12080794Cited by 11 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Suelen Gauna Trindade, Fernando Bonin Okasaki, Ashley P. Williams et al. · 2025 · Journal of Colloid and Interface Science
The self-assembly of glycyrrhizic acid (GA) in aqueous solutions has significant implications for soft matter science and material design. Here, we describe the self-assembly of GA under well-defined conditions, focusing on measurements of the critical aggregation concentration (CAC) - when GA dimers start stacking into nanofibrils, and of the critical gel concentration (CGC) - when nanofibrils entangle into a viscoelastic network. We examine in detail the structure at low concentrations and its evolution into a viscoelastic hydrogel, addressing the kinetic pathway. We highlight the dependence
View details →DOI: 10.1016/j.jcis.2025.138280Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhuoxu Gu, Zhonghao Wang, Xianquan Zhang et al. · 2025 · Frontiers in Pharmacology
As a modern dosage form of traditional Chinese medicine, Traditional Chinese Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as a critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential of TCMFG in treating complex diseases, such as inflammation, tumors, metabolic disorders, fibrosis, and orthopedic conditions like osteoarthritis and osteoporosis, by modulati
View details →DOI: 10.3389/fphar.2025.1609211Cited by 11 Negative / Null Result ReportOpen accessMedicine
Xinyi Chen, Mu Yang, Yongbiao Huang et al. · 2025 · Therapeutic Advances in Medical Oncology
Abscopal immunity—the regression of distant, non-irradiated lesions after localized radiotherapy (RT)—signals conversion of focal DNA damage into systemic antitumor immunity. This review advances a unifying three-stage…
View details →DOI: 10.1177/17588359251387534Cited by 11 Negative / Null Result ReportOpen accessImmunology and Microbiology
Marcello Candelli, Marta Sacco Fernandez, Gloria Rozzi et al. · 2025 · Diagnostics
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
View details →DOI: 10.3390/diagnostics15222927Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sarah L. Addison, Zhenzhen Yan, Thomas F. Carlin et al. · 2025 · Global Change Biology
Increased aridity is emerging as a key impact of climate change in terrestrial ecosystems globally. Forest biomes are particularly vulnerable to the impacts of changing environmental conditions due to their long-lived and sessile nature.…
View details →DOI: 10.1111/gcb.70165Cited by 11 Negative / Null Result ReportOpen accessEnvironmental Science
Yuchen Suo, Tong Li, Christian von Sperber et al. · 2025 · Biogeochemistry
Abstract The stability of carbon (C) stocks in peatlands is intricately linked to phosphorus (P) bioavailability. Given that organic P compounds (P o ) can make up to 89% of total soil P in these ecosystems, it is vital to understand their role in regulating plant productivity and organic matter decomposition. Despite this significance, the mechanisms controlling P bioavailability remain poorly understood. Plants and soil microorganisms primarily regulate the release of soil P via low-molecular-weight organic acids (LMWOAs) and modulate the hydrolysis of P o through phosphatase enzymes, partic
View details →DOI: 10.1007/s10533-025-01210-1Cited by 11 Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
View details →DOI: 10.1093/eurheartj/ehaf1082Cited by 11 Negative / Null Result ReportOpen accessNeuroscience
Astrid Feiten, Kilian Dahm, Kai Schlepckow et al. · 2026 · Nature Communications
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met
View details →DOI: 10.1038/s41467-026-68706-8Cited by 11 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Stevo Pavićević, Thomas Keil · 2024 · Strategic Management Journal
Abstract Research Summary Why do some boards of directors dismiss the CEO when a firm performs poorly, while others do not? We argue that military directors—outside directors with military backgrounds—on the board increase the likelihood…
View details →DOI: 10.1002/smj.3675Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fanzhuo Xu, Yu Xie, Weiwei Yu et al. · 2026 · Frontiers in Microbiology
Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systematically analyses antimicrobial strategies targeting the outer membrane of Gram-negative bacteria, mainly including: (1) directly disrupting the outer membrane structure and enhancing drug permeability; (2) inhibiting the biosynthesis or transport pathways of key outer membrane com
View details →DOI: 10.3389/fmicb.2026.1734749Cited by 11 Negative / Null Result ReportOpen accessSocial Sciences
Amy Nivette, Christof Nägel, Emily Gilbert · 2023 · Police Practice and Research
High-profile incidents of police misconduct can have serious consequences for public trust in the police. A recent study in the British Journal of Political Science found that Eric Garner’s death in NYC lead to more negative attitudes towards the police in London among Black residents compared to White and Asian residents. The current study aimed to replicate this transnational effect by assessing the impact of George Floyd’s death on Londoners’ perceptions of police. Using the same data and methodological approach, we did not replicate the immediate effect on Black Londoners’ attitudes. We di
View details →DOI: 10.1080/15614263.2023.2185241Cited by 11 Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
View details →DOI: 10.1128/aac.02205-18Cited by 11 Negative / Null Result ReportOpen accessSocial Sciences
Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology
BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su
View details →DOI: 10.1186/s40359-020-00414-4Cited by 11 Failed Experiment ReportOpen accessNeuroscience
Min Li, Min Li, Shuang Chen et al. · 2025 · Signal Transduction and Targeted Therapy
Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preceding β-amyloid accumulation and driving disease progression. However, therapeutic autophagy modulation is severely restricted by the blood-brain barrier (BBB). To overcome this, we developed Microglia-Liposome Fusion Extrusion (MiLi-FE), a method to engineer microglia-derived nanovesicles (AR@ENV) for the codelivery of AR7 (a CMA inducer) and rapamycin (a mac
View details →DOI: 10.1038/s41392-025-02453-yCited by 11 Failed Experiment ReportOpen accessPhysics and Astronomy
Steven McNamara, S. Abouelazayem, А. И. Алиева et al. · 2026 · Nuclear Fusion
Abstract As part of the U.S. Department of Energy’s Milestone-Based Fusion Energy Development Program, Tokamak Energy has completed the pre-concept design of the ST–E1 fusion power plant. ST–E1 is envisaged to operate in two phases: a pilot plant phase, targeting sustained net power production of 300 − 500 MWe for a duration > 1 hr , followed by a commercial power plant phase targeting steady-state operations and a normalised overnight capital cost of ⩽ 12 000 $ / kWe . The design process adopted was highly iterative, integrating all major plant systems and progressing i
View details →DOI: 10.1088/1741-4326/ae5f33Cited by 11 Negative / Null Result ReportOpen accessMedicine
Faith Hartley, Martin A. Ebert, Alistair Cook · 2025 · Clinical & Translational Immunology
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warranting research into combined treatment strategies for improving outcomes. The use of radiotherapy for this purpose has garnered much interest. Preclinical study has established that radiotherapy activates various immune mechanisms to improve T-cell activation, localisation and function within tumors, which improves response to immune checkpoint inhibitors.
View details →DOI: 10.1002/cti2.70030Cited by 11 Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →DOI: 10.2143/acb.67.4.2062666Cited by 11 Replication FailureOpen accessNeuroscience
Ralf Reilmann, Andrew Feigin, Anne Rosser et al. · 2025 · Nature Medicine
Huntington's disease (HD) is a rare, neurodegenerative disorder for which only symptomatic treatments are available. The PROOF-HD study was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the efficacy and safety of pridopidine, a selective Sigma-1 receptor agonist, in HD. The primary and key secondary endpoints, change in total functional capacity (TFC) and composite Unified Huntington's Disease Rating Scale (cUHDRS) score at week 65, were not met in the overall population. The TFC least-squares mean difference between pridopidine and placebo was -0.18 (95% confidence i
View details →DOI: 10.1038/s41591-025-03920-3Cited by 11 Replication FailureOpen accessChemistry
Farhan Sheth, Ishika Chatter, Manvendra Jasra et al. · 2025 · Plant Methods
Herbs have historically been central to medicinal practices, representing one of the earliest forms of therapeutic intervention. While synthetic drugs are often highly effective in treating acute conditions, their use is frequently…
View details →DOI: 10.1186/s13007-025-01421-5Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lorenzo Fant, Iuri Macocco, Jacopo Grilli · 2026 · PLoS Computational Biology
Microbial communities are taxonomically diverse and variable: species presence and abundances widely fluctuate over time, space, and even across biological replicates under controlled experimental conditions. However, environmental conditions exert strong selection on the traits of community members and their functions. Similar environmental conditions are expected to produce functionally similar communities. This environmental selection, combined with taxonomic variability, leads to the influential concept of functional redundancy - the idea that many species can perform the same function, al
View details →DOI: 10.1371/journal.pcbi.1014437Cited by 11 Negative / Null Result ReportOpen accessSocial Sciences
Syed Imran Ali, Morgan C. MacDonald, J. Jincy et al. · 2011 · Journal of Water Sanitation and Hygiene for Development
This study investigated the efficacy of a POU water treatment system featuring sari-cloth filtration and/or Moringa oleifera coagulation as pre-treatments for solar disinfection (SODIS). Surface water from a peri-urban slum in Chennai,…
View details →DOI: 10.2166/washdev.2011.043Cited by 11 Negative / Null Result ReportOpen accessMedicine
Jing Cheng, Carl Gao, Reeta Ala‐Jaakkola et al. · 2024 · JAMA Network Open
Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking. Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation,…
View details →DOI: 10.1001/jamanetworkopen.2024.36888Cited by 11 