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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21247 results · page 137 of 709

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gαqprotein-induced cardiomyopathy

Valeriy Timofeyev, C. A. Porter, Dipika Tuteja et al. · 2010 · American Journal of Physiology-Heart and Circulatory Physiology

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy…

View details →DOI: 10.1152/ajpheart.01208.2009Cited by 12
Negative / Null Result Report

ADJUSTMENT OF CORPORATE REAL ESTATE DURING A PERIOD OF SIGNIFICANT BUSINESS CHANGE

Howard Cooke, Rianne Appel-Meulenbroek, Theo Arentze · 2019 · International Journal of Strategic Property Management

This paper seeks to understand whether the alignment process between business strategy and Corporate Real Estate (CRE) between 2007 and 2014 was dynamic. It investigated the financial data of 230 UK companies by means of a distributed time…

View details →DOI: 10.3846/ijspm.2019.7954Cited by 12
Negative / Null Result Report

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection

Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ

Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…

View details →DOI: 10.7717/peerj.10295Cited by 12
Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of combination behavioral activation for smoking cessation and varenicline for treating tobacco dependence among individuals with current or past major depressive disorder: A 2 × 2 factorial, randomized, placebo‐controlled trial

Brian Hitsman, George D. Papandonatos, Jackie K. Gollan et al. · 2023 · Addiction

BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12…

View details →DOI: 10.1111/add.16209Cited by 12
Negative / Null Result Report

Significant effects on neonatal morbidity and mortality after regional change in management of post‐term pregnancy

CHARLOTTA GRUNEWALD, STELLAN HÅKANSSON, SISSEL SALTVEDT et al. · 2010 · Acta Obstetricia et Gynecologica Scandinavica

Abstract Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post‐term pregnancy from 43 +0 to 42 +0 gestational weeks (GWs). Design and setting. Nationwide retrospective register study…

View details →DOI: 10.1111/j.1600-0412.2010.01019.xCited by 12
Negative / Null Result Report

Significant difference in femoral torsion between coronal plane alignment of the knee type 1 and 4

Jonas Ziegenhorn, Julia Kirschberg, Markus Heinecke et al. · 2024 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to find out whether the torsions of the femur and tibia are dependent on the coronal plane alignment of the knee (CPAK) type. Methods Five hundred patients (1000 legs) were included, who…

View details →DOI: 10.1002/ksa.12149Cited by 12
Negative / Null Result Report

No significant difference in the prognostic value of the 5th and 7th editions of AJCC staging for differentiated thyroid cancer

Alexis Vrachimis, Joachim Gerss, Maren Stoyke et al. · 2014 · Clinical Endocrinology

Summary Objective The seventh edition of the American Joint Committee on Cancer ( AJCC ) has more detailed staging categories for differentiated thyroid cancer ( DTC ) than the fifth edition. The aim was to compare potential alterations in…

View details →DOI: 10.1111/cen.12405Cited by 12
Negative / Null Result ReportOpen accessComputer Science

Prediction of breast cancer survivability using ensemble algorithms

Vincent Adegoke, Daqing Chen, Ebad Banissi et al. · 2017

In this paper, several ensemble cancer survivability predictive models are presented and tested based on three variants of AdaBoost algorithm. In the models we used Random Forest, Radial Basis Function Network and Neural Network algorithms…

View details →DOI: 10.1109/sst.2017.8188699Cited by 12
Negative / Null Result Report

RNAi Targeting Putative Genes in Phosphatidylcholine Turnover Results in Significant Change in Fatty Acid Composition in Crambe abyssinica Seed Oil

Rui Guan, Xueyuan Li, Per Hofvander et al. · 2015 · Lipids

Abstract The aim of this study was to evaluate the importance of three enzymes, LPCAT, PDCT and PDAT, involved in acyl turnover in phosphatidylcholine in order to explore the possibility of further increasing erucic acid (22:1) content in…

View details →DOI: 10.1007/s11745-015-4004-1Cited by 12
Negative / Null Result Report

The addition of chemotherapy to radiotherapy did not reduce the rate of distant metastases in low‐risk HPV‐related oropharyngeal cancer in a real‐world setting

Stephen F. Hall, Rebecca J. Griffiths, Brian O'Sullivan et al. · 2019 · Head & Neck

Abstract Background Distant metastases (DM) are a leading cause of death for patients with oropharyngeal cancer (OPSCC). The objective of this study was to compare the rates of DM after chemoradiotherapy (CRT) and radiotherapy alone (RT)…

View details →DOI: 10.1002/hed.25679Cited by 12
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection

Marlee R. Labroo, Jessica Rutkoski · 2022 · BMC Genomics

BACKGROUND: Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain. Usually, generations are discrete in recurrent selection, which means that breeding candidates are evaluated and considered for selection for only one cycle. Alternately, generations can overlap, with breeding candidates considered for selection as parents for multiple cycles. With recurrent genomic selection but not phenotypic selection, candidates can be re-evaluated by using genomic estimated breeding v

View details →DOI: 10.1186/s12864-022-08929-3Cited by 12
Negative / Null Result ReportOpen accessMedicine

Combining Structural and Vascular Parameters to Discriminate Among Glaucoma Patients, Glaucoma Suspects, and Healthy Subjects

Alessandro Rabiolo, Federico Fantaguzzi, Riccardo Sacconi et al. · 2021 · Translational Vision Science & Technology

Purpose: Compare the ability of peripapillary and macular structural parameters, vascular parameters, and their integration to discriminate among glaucoma, suspected glaucoma (GS), and healthy controls (HCs). Methods: In this study, 196…

View details →DOI: 10.1167/tvst.10.14.20Cited by 12
Negative / Null Result ReportOpen accessDecision Sciences

Predicting future citation counts of scientific manuscripts submitted for publication: a cohort study in transplantology

Michael Kossmeier, Georg Heinze · 2018 · Transplant International

Citations are widely used for measuring scientific impact. The goal of the present study was to predict citation counts of manuscripts submitted to Transplant International (TI) in the two calendar years following publication. We…

View details →DOI: 10.1111/tri.13292Cited by 12
Negative / Null Result Report

Routine Diagnostics Confirm Novel Neurodevelopmental Disorders

Robin-Tobias Jauss, Sophia Schließke, Rami Abou Jamra · 2022 · Genes

Routine diagnostics is biased towards genes and variants with satisfactory evidence, but rare disorders with only little confirmation of their pathogenicity might be missed. Many of these genes can, however, be considered relevant,…

View details →DOI: 10.3390/genes13122305Cited by 12
Negative / Null Result Report

Large‐Scale Industrial Cloud Perturbations Confirm Bidirectional Cloud Water Responses to Anthropogenic Aerosols

Heido Trofimov, Nicolas Bellouin, Velle Toll · 2020 · Journal of Geophysical Research: Atmospheres

Abstract Aerosols offset a poorly quantified fraction of anthropogenic greenhouse gas warming, and the aerosol impact on clouds is the most uncertain mechanism of anthropogenic climate forcing. Here observations of a relatively weak…

View details →DOI: 10.1029/2020jd032575Cited by 12
Negative / Null Result ReportEarth and Planetary Sciences

Tornadic Supercell Environments Analyzed Using Surface and Reanalysis Data: A Spatiotemporal Relational Data-Mining Approach

David John Gagne, Amy McGovern, Jeffrey B. Basara et al. · 2012 · Journal of Applied Meteorology and Climatology

Abstract Oklahoma Mesonet surface data and North American Regional Reanalysis data were integrated with the tracks of over 900 tornadic and nontornadic supercell thunderstorms in Oklahoma from 1994 to 2003 to observe the evolution of…

View details →DOI: 10.1175/jamc-d-11-060.1Cited by 12
Negative / Null Result ReportOpen accessDentistry

BLOOD LIPID LEVELS RELATED TO ALLERGIC RHINITIS: A SIGNIFICANT ASSOCIATION?

Ignazio La Mantia, Claudio Andaloro, Pasquale Gianluca Albanese et al. · 2026 · EuroMediterranean Biomedical Journal

Allergic rhinitis is a common problem increasing greatly over the past three decades. Several studies have found a possible link between dyslipidem ia and allergic disease but the relating causal mechanisms remain elusive. The aim of this…

View details →DOI: 10.3269/1970-5492.2017.12.30Cited by 12
Negative / Null Result Report

When do neural networks outperform kernel methods?*

Behrooz Ghorbani, Song Mei, Theodor Misiakiewicz et al. · 2021 · Journal of Statistical Mechanics: Theory and Experiment

Abstract For a certain scaling of the initialization of stochastic gradient descent (SGD), wide neural networks (NN) have been shown to be well approximated by reproducing kernel Hilbert space (RKHS) methods. Recent empirical work showed…

View details →DOI: 10.1088/1742-5468/ac3a81Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

Women’s environmental quality of life is key to their overall quality of life and health: Global evidence from the WHOQOL-100

Suzanne M. Skevington, Kara Schick‐Makaroff, Christine Rowland et al. · 2024 · PLoS ONE

Gender inequalities in health-related quality of life (QoL) are generally few and small, even in large surveys. Many generic measures limit assessment to QoL overall and its physical and psychological dimensions, while overlooking internationally important environmental, social, and spiritual QoL domains. Unique cross-cultural legacy data was collected using four WHOQOL-100 surveys of adults living in 43 cultures world-wide (17,608 adults; ages 15-101). It was first used to examined gender profiles of its five QoL international domains, and their component facets. Few significant gender differ

View details →DOI: 10.1371/journal.pone.0310445Cited by 12
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Mitochondrial Dysfunction in Cardiomyopathy and Heart Failure: From Energetic Collapse to Therapeutic Opportunity

Nikola Pavlović, Petar Todorović, Mirko Maglica et al. · 2025 · Biomolecules

The heart’s relentless contractile activity depends critically on mitochondrial function to meet its extraordinary bioenergetic demands. Mitochondria, through oxidative phosphorylation, not only supply ATP but also regulate metabolism, calcium homeostasis, and apoptotic signaling, ensuring cardiomyocyte viability and cardiac function. Mitochondrial dysfunction is a hallmark of cardiomyopathies and heart failure, characterized by impaired oxidative phosphorylation, excessive production of reactive oxygen species (ROS), dysregulated calcium handling, and disturbances in mitochondrial dynamics an

View details →DOI: 10.3390/biom15111572Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

The (alleged) consequences of affective polarization: A survey experiment in nine democracies

Eelco Harteveld, Lars Erik Berntzen, Andrej Kokkonen et al. · 2026 · European Journal of Political Research

Abstract Affective polarization (or antipathy between supporters of opposing political camps) is considered a threat to societal cohesion and democratic stability worldwide. However, causal evidence of its impact remains scarce, especially outside the United States. Our study examines the individual-level consequences of affective polarization by manipulating it in a survey experiment in nine countries (Brazil, France, Germany, Italy, Poland, Spain, Sweden, the United Kingdom, and the United States; N ≈ 18,000) and subsequently assessing the downstream consequences for social avoidance and dis

View details →DOI: 10.1017/s1475676526101273Cited by 12
Negative / Null Result ReportOpen accessMedicine

Genetic predictors of GLP1 receptor agonist weight loss and side effects

Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature

The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…

View details →DOI: 10.1038/s41586-026-10330-zCited by 12
Negative / Null Result ReportOpen accessNeuroscience

Higher visual areas act like domain-general filters with strong selectivity and functional specialization

Meenakshi Khosla, Leila Wehbe · 2026 · Nature Communications

Neuroscientific studies rely heavily on a-priori hypotheses, which can bias results toward existing theories. Here, we use a hypothesis-neutral approach to study category selectivity in higher visual cortex. Using only stimulus images and their associated fMRI activity, we constrain randomly initialized neural networks to predict voxel activity. Despite no category-level supervision, units in the trained networks act as detectors for semantic concepts like 'faces' or 'words', providing solid empirical support for categorical selectivity. Importantly, this selectivity is mostly maintained when

View details →DOI: 10.1038/s41467-026-73938-9Cited by 12
Negative / Null Result ReportOpen accessMedicine

Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy

Akram I. Ahmad, Samita Garg, Jeffrey Jacobs et al. · 2026 · JAMA Internal Medicine

Importance: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known to increase the risk of retained gastric contents. High-quality data are lacking to guide periprocedure management of GLP-1 and GIP agonists. Objective: To compare the risk of clinically significant residual gastric volume (RGV) in patients who continue vs hold 1 dose of weekly or daily GLP-1 and GIP agonists prior to sedation. Design, Setting, and Participants: This randomized, single-masked clinical trial conducted at 2 large tertiary referral centers in the US included patients under

View details →DOI: 10.1001/jamainternmed.2026.0027Cited by 12
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Diversity of adapted tobacco microbial community and its application in improving tobacco quality

Jing Mai, Ying Ning, Zhonglong Lin et al. · 2025 · Industrial Crops and Products

Many bacteria such as Bacillus , Pseudomonas , and Lactobacillus are widely present in flue-cured tobacco leaves during the aging process, indicating they play important roles in improving tobacco quality. In this study, we aimed to screen…

View details →DOI: 10.1016/j.indcrop.2025.121580Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

Sustaining Exposure to Fact-Checks: Misinformation Discernment, Media Consumption, and Its Political Implications

Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review

Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon

View details →DOI: 10.1017/s0003055424001394Cited by 12
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Artificial Intelligence Adoption and Role of Energy Structure, Infrastructure, Financial Inclusions, and Carbon Emissions: Quantile Analysis of E-7 Nations

Shanwen Gu, Adil Javed · 2025 · Sustainability

The E-7 nations face significant challenges in harmonizing artificial intelligence (AI) adoption with sustainable economic and environmental goals. While AI holds transformative potential to revolutionize energy structures, modernize infrastructure, broaden financial inclusion, and reduce carbon emissions, its effective integration is frequently hindered by policy inertia, economic limitations, and long-standing institutional barriers. Using the multi-level perspective (MLP), this study employs the method of moments quantile regression (MMQREG) on panel data from 2004 to 2024 to investigate th

View details →DOI: 10.3390/su17135920Cited by 12
Negative / Null Result ReportOpen accessPhysics and Astronomy

Very Bright, Very Blue, and Very Red: JWST CAPERS Analysis of Highly Luminous Galaxies with Extreme Ultraviolet Slopes at z = 10

Callum T. Donnan, Mark Dickinson, Anthony J. Taylor et al. · 2025 · The Astrophysical Journal

Abstract We present JWST/NIRSpec PRISM observations of three luminous ( M UV < −20) galaxies at z ∼ 10 observed with the CANDELS-Area Prism Epoch of Reionization Survey (CAPERS) Cycle 3 program. These galaxies exhibit extreme UV slopes compared to typical galaxies at z = 10. Of the three sources, two of them are a close pair (0 . ″ 22) of blue galaxies at z = 9.800 ± 0.003 and z = 9.808 ± 0.002 with UV slopes of β = −2.87 ± 0.15 and β = −2.46 ± 0.10, respectively, selected from PRIMER COSMOS NIRCam imaging. We perform spectrophotometric modeling of the galaxies, which suggests extre

View details →DOI: 10.3847/1538-4357/ae0a1fCited by 12
Negative / Null Result ReportOpen accessNeuroscience

Music and Language Processing Share Behavioral and Cerebral Features

Clara E. James · 2012 · Frontiers in Psychology

A commentary on Musical expertise and statistical learning of musical and linguistic structures by Schön, D., and François, C. (2011). Front. Psychology 2:167. doi: 10.3389/ fpsyg.2011.00167 Both language and music consist of discrete elements organized in embedded hierarchical structures. Schön and François nicely expose in this review that musical expertise facilitates learning of both linguistic and musical structures. At the behavioral level, the musicians did not outperform the nonmusicians. However, ERP analyses showed that acquisition of boundary perception (segmentation) between units

View details →DOI: 10.3389/fpsyg.2012.00052Cited by 12