A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
444 results in Replication Failure · page 13 of 15
Haoyu Lian, Siyuan Zhou, Huanyang He et al. · 2026 · Frontiers in Oncology
Objective The purpose of this study was to reveal the genetic correlation of RANKL polymorphisms with bone metastasis in breast cancer patients. Methods In this study, 139 bone metastasis patients and 152 no metastasis were included as the…
Robert H. Biggerstaff · 1973
The study of the Carabelli trait among 199 monozygotic and dizygotic twin pairs failed to demonstrate a high degree of heritability. Analyses of antimere differences in individuals indicated a lack of mirroring and no sexual dimorphism.…
John H. Strickler · 2018
Abstract Summary: Anti-EGFR therapies have failed to improve survival for unselected patients with metastatic gastroesophageal cancer, but in a subset of patients, EGFR amplification may predict treatment benefit. Maron and colleagues…
Arenas Hoyos J, Dalela D, Schlomer BJ et al. · 2026 · Journal of pediatric urology
Background There is insufficient evidence to support the effectiveness of preoperative antibiotic prophylaxis in reducing surgical site infections (SSI) during urgent testicular torsion (TT) surgeries. Objective The primary objective was…
Wang J, Du L, Wang Y et al. · 2026 · Cellular oncology (Dordrecht, Netherlands)
Purpose Combinations of anti-PD-1/PD-L1 immunotherapy (IO) and anti-VEGF tyrosine kinase inhibitor (TKI) are recommended as first-line therapy for metastatic renal cell carcinoma (RCC). We aimed to evaluate the predictive value of tissue…
Lin MC, Jiang X, Qiu ZC et al. · 2026 · Head & neck
Background Management of the clinically node-negative (cN0) neck in intermediate-grade mucoepidermoid carcinoma (MEC) of the head and neck remains controversial. Methods We retrospectively reviewed patients with cN0 intermediate-grade MEC…
Baxi SM, Igbinosa II, Main EK et al. · 2026 · AJOG global reports
Background Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent that has been shown to reduce hemorrhage-related mortality in trauma, is used…
Wang C, Li S, Lu H et al. · 2026 · BMC gastroenterology
Background While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of…
Vukšić J, Kustić D · 2026 · Rheumatology international
To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…
Can V, Polat F, Kaya AF et al. · 2026 · Journal of cardiovascular pharmacology
Abstract Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean…
Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology
Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…
Amuji DN, Iweala EEJ · 2026 · BMC cancer
BACKGROUND: Breast cancer (BC) is a major cause of cancer-related mortality among women worldwide. Genetic polymorphisms, such as those in the Mesenchymal Epithelial Transition factor (MET) proto-oncogene, may influence cancer risk and…
Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition
Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…
Şakir Doğan TUNCER, Behiç COŞKUN, Rıfat CANTORAY et al. · Eurasian Journal of Veterinary Sciences
This experiment was carried out to investigate the effects of Na -lasalocid that was added into concentrate mixtures in 25, 50 and 75 g per ton on growth performance and against the possible coccidia infection of lambs. In the experiment, 40 Akkaraman male lambs with 3.5 - 4 months old were used. The research works were conducted as 4 groups for the period of 84 days. The ratian of the control group did not contain any Na-lasalocid. The average of final weights of lambs in the groups were 47.41; 48.91; 49.98 and 49.96 kg respectively, (P>0.05). Average daily weight gain was found to be 260 g i
Kraemer Rachel, Claas Steven A, Devereux Richard B et al. · 2009 · BMC Medical Genetics
Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a
Ramphul R, McCurdy SA, Lee J et al. · 2026 · Drug and alcohol dependence
Background In 2023, an estimated 39.6 million adults aged ≥ 18 years had a substance use disorder (SUD) and 94.7 % did not seek treatment. Recovery residences provide essential support for individuals recovering from SUD, yet their…
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
Glynatsis MN, Economou M, Papadopoulou K et al. · 2024 · Cureus
This report presents a rare case of a central retinal artery occlusion in an eight-year-old girl attributed to an undiagnosed patent ductus arteriosus (PDA). Despite intensive treatment, the patient's eyesight failed to improve. Cases of…
Novik AV, Protsenko SA, Baldueva IA et al. · 2021 · The oncologist
Lessons learned Melatonin did not increase the efficacy of systemic chemotherapy in melanoma. Metformin did not increase the efficacy of systemic chemotherapy in melanoma. Background Current data support the possibility of antitumor…
Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist
Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…
Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…
Sheng YC, Chen X, Zhang YF et al. · 2026 · Huan jing ke xue= Huanjing kexue
Achieving ecological protection and high-quality development is the fundamental goal of sustainable development in the Yellow River Basin， and it is also an inevitable choice for the practice of the concept of Chinese-style modernization.…
Frank Meier, Hans Walliser · 1996 · arXiv
We present a procedure to calculate 1-loop graphs in the soliton sector of chiral Lagrangians and use it to calculate quantum corrections to certain baryon observables in Skyrme-type models. Results generally show an improvement over the values obtained in tree approximation except for the case of the axial coupling g_A.
N. V. Dmitrieva, M. V. Eidelshtein, V. V. Aginova et al. · 2019 · Сибирский онкологический журнал
The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resi
Webster E, Ng L, Prendergast K et al. · 2026 · Journal of insect physiology
Climate change and urbanisation are major drivers of global insect pollinator decline. However, the combined effects of these stressors remain poorly understood, particularly in relation to pollinator behaviour. Understanding how these…
van der Linden C, Trapp P, Dembek TA et al. · 2026 · Preprint
Background Deep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/PSA) in Essential Tremor (ET) and the subthalamic nucleus (STN) in Parkinson’s disease (PD) are established treatment for…
Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports
The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…
J. Ming, M. A. Papa, H.-B. Eggenstein et al. · 2024 · The Astrophysical Journal
We perform a search for continuous nearly monochromatic gravitational waves from the central compact objects associated with the supernova remnants Vela Jr. and G347.3. Over 10 ^18 different waveforms are considered, covering signal frequencies between 20 and 1300 Hz (20 and 400 Hz) for G347.3-0.5 (Vela Jr.) and a very broad range of frequency derivatives. The data set used for this first search is from the second observing run of LIGO (O2). Thousands of volunteers donating compute cycles through the computing project Einstein@Home have made this endeavor possible. Following the Einstein@Home
Eroğlu AS, Demirtaş OK · 2026 · Acta neurochirurgica
Objectives This study aims to retrospectively analyze the factors affecting implant failure in patients who underwent anterior cervical plating (ACP) following anterior cervical discectomy and fusion (ACDF). Methods Data from 332 patients…
Florens N, Demiselle J · 2026 · Kidney360
Iodinated contrast media have long been feared for causing contrast-induced AKI (CI-AKI), a concern rooted in early reports with high-osmolar agents. Experimental data suggest potential nephrotoxic mechanisms, yet clinical evidence from…