A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
750 results in Failed Experiment Report · page 13 of 25
Wilson KF, Fox AE · 2024 · Appetite
A high-fat diet has negative effects on physical, neurological, and behavioral outcomes. One consistent finding is that a diet high in fat increases impulsive choice behavior-behavior that is linked to a wide range of other negative health…
Shatsnimitkul E, Laopeamthong I, Tansawet A et al. · 2024 · BJS open
Background Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are rare, and post-ERCP pancreatitis is a serious adverse event. This study aimed to determine the role of aggressive intravenous hydration with lactated…
Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…
Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2024 · Preprint
The degree to which mitochondrial-linked cell death pathways contribute to skeletal muscle atrophy during cancer remain unknown. Here, we combined a novel and robust mouse model of metastatic ovarian cancer with chronic administration of…
Carroll I, Schievink W · 2024 · Headache
Spontaneous intracranial hypotension (SIH) commonly results from ventral spinal cerebrospinal fluid (CSF) leaks and epidural patches are advocated as first-line treatment. Complications such as superficial siderosis can arise but have…
Medina E, Sanchez-Sandoval AL, Barrón-Palma EV et al. · 2024 · Preprint
Background Coronavirus disease 2019 (COVID-19) has created the need to evaluate drugs such as favipiravir (FPV), an antiviral inhibitor of RNA-dependent RNA-polymerase (RdRp), and Maraviroc (MVC), an antiretroviral that antagonizes the…
Ahmed Eltayeb S, Dressler JM, Schlatt L et al. · 2024 · Archives of toxicology
Oxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral neurotoxicity, OIPN), diminishing survivor quality of life. Organic cation transporter 2 (OCT2) is a key OHP uptake…
Martindale DM, Haraschak JL, Thiel AJ et al. · 2024 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Objective To describe the presentation, management, and postmortem examination findings in a dog with confirmed lisdexamfetamine dimesylate (LDX) toxicosis. Case summary A 3-year-old female neutered mixed breed dog initially presented with…
Nasir S, Mehfooz S, Basu S et al. · 2025 · Taiwan journal of ophthalmology
Purpose Rhegmatogenous retinal detachments (RRD) are the most common and sight-threatening complication of acute retinal necrosis (ARN). This study aims to analyze the clinical characteristics, treatment outcomes, and factors influencing…
Yin J, Wu D, Cooledge EC et al. · 2026 · Global change biology
Extreme heat events have increased markedly over recent decades globally, with potentially severe impacts on soil carbon (C) cycling. Here, we conducted a mechanistic study to assess the impact of a single 3-day extreme heat event (30°C,…
Harazin A, Reinert LS, Alam P et al. · 2026 · Cell biochemistry and function
Double-stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS-STING signaling pathway comprising the cyclic GMP-AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors.…
Mwenechanya M, Tembo AM, Chomba E et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective To evaluate if the effect of low-dose aspirin (LDA) commenced between 6 and 13 weeks of gestational age (GA) on preterm delivery (PTD) is modified by total exposure. Design Post hoc analysis of a randomized controlled trial.…
Barbaro K, Candida E, Biavati FS et al. · 2026 · Orthodontics & craniofacial research
Objective Traditional biocompatibility assessments primarily address cytotoxicity and bulk material properties but often overlook molecular responses that occur below toxicity thresholds. Detecting these subtle effects is crucial for…
Serttas MF, Kochai A, Eryilmaz BH et al. · 2025 · Medicine
Background This study compares the change in cervical sagittal alignment (CSA) after surgery in Lenke 5 patients who underwent selective and nonselective fusion and to evaluate the effect of this situation on functional results. Methods A…
Zampino S, Hosler R, Brown K et al. · 2026 · The Journal of cardiovascular nursing
Background Reiki plus manual therapy are utilized to improve relaxation, sleep, emotional state, and pain. Evidence within hospital settings was limited, and previous studies had weak designs. Objective The purpose of this study was to…
Randall MM, Uchimura RN, Steinmann JC et al. · 2026 · Injury
Introduction Vertebral compression fractures are common and incur significant healthcare costs. Orthotic bracing is a frequently used treatment; however, studies have shown uncertainty regarding its effectiveness. Upright radiographs after…
Pukalski Y, Auroi J, Yanev P et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society
BACKGROUND: Diaphyseal fractures of both forearm bones (both-bone forearm fractures) are common pediatric injuries. When surgical treatment is indicated, elastic stable intramedullary nailing is widely used due to its minimally invasive…
Lee JH · 2026 · Preprint
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and irritable bowel syndrome (IBS) frequently co-occur following infection, yet shared genetic architecture at the locus level has not been systematically…
· 2025 · International wound journal
Retraction C.-S. Li, X.-F. Li, X.-Y. Huang, and F.-F. Chen, "Evaluating the Effectiveness of Echocardiographic Guidance in Diminishing Postoperative Wound Complications for Left Atrial Appendage Closure: A Clinical Retrospective Study,"…
Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research
While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…
Martin E, Conway CJ · 2026 · Ecology and evolution
Aggregation is common across taxa and typically confers clear benefits to group members (e.g., allo-parenting, group defense, thermoregulation, access to resources). But aggregation can also be costly. The mechanisms that underpin…
Huchegowda R, Harbishettar V, Sinha P et al. · 2025 · Preprint
Background Cognitive impairment in the older adult population has been linked to low Vitamin B12 levels and elevated Homocysteine levels, but evidence is not clear. This study examines the relationship between serum Vitamin B12 (B12)…
Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist
Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…
Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science
Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…
Martinez G, Tolentino K, Sukheja P et al. · 2025 · Bioorganic & medicinal chemistry letters
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and…
Coello K, Stanislaus S, Forman JL et al. · 2025 · Free radical biology & medicine
Aims Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD…
Mo X, Wen Q, Jiang C et al. · 2024 · Preprint
Abstract It was commonly accepted that adverse-risk acute myeloid leukemia patients should receive allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). In this multicenter study, we aimed to…
Ball JGC, Jaffer S, Laybros A et al. · 2026 · Preprint
A bstract Airborne imaging spectroscopy enables species-level classification in hyperdiverse tropical forests, but accuracy varies enormously among species. We asked which ecological and evolutionary attributes make a tropical tree species…
Strandberg E, Vikmoen O, Svindland KV et al. · 2026 · European journal of sport science
To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy- and heat-shock-related proteins in women with breast cancer. Exploratory analyses assessed associations between changes…
Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…