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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21245 results · page 126 of 709

Negative / Null Result ReportOpen accessMedicine

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi‐institutional randomized controlled trial

Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer

Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…

View details →DOI: 10.1002/ijc.33316Cited by 15
Negative / Null Result ReportOpen accessMedicine

Phase II clinical trial of sequential treatment with systemic chemotherapy and intraperitoneal paclitaxel for gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial

Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer

BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo

View details →DOI: 10.1186/s12885-023-10680-1Cited by 15
Negative / Null Result ReportOpen accessMedicine

Comparing Biomechanical Properties, Repair Times, and Value of Common Core Flexor Tendon Repairs

Aakash Chauhan, Patrick J. Schimoler, Mark Carl Miller et al. · 2017 · Hand

BACKGROUND: The aim of the study was to compare biomechanical strength, repair times, and repair values for zone II core flexor tendon repairs. METHODS: A total of 75 fresh-frozen human cadaveric flexor tendons were harvested from the…

View details →DOI: 10.1177/1558944717701238Cited by 15
Negative / Null Result ReportPsychology

Impact of a Student Success Course on Undergraduate Academic Outcomes

Leah D. Hoops, Shirley L. Yu, Andrea Burridge et al. · 2015 · Journal of College Reading and Learning

Both community colleges and four-year institutions offer Student Success Courses (SSCs) to promote student engagement (self-regulated learning, SRL) and performance (grades, retention, and graduation). However, little work has been done to…

View details →DOI: 10.1080/10790195.2015.1032041Cited by 15
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Automated Analysis of Aggregated Datasets to Identify Climatic Predictors of Botrytis Bunch Rot in Wine Grapes

G.N. Hill, R.M. Beresford, KJ Evans · 2018 · Phytopathology

Botrytis bunch rot (BBR), caused by Botrytis cinerea, results in serious losses to wine-grape production in some seasons during the preharvest period. In order to predict seasons that are at risk from BBR, datasets consisting of 25…

View details →DOI: 10.1094/phyto-10-17-0357-rCited by 15
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Guadalupe Nibeyro, Verónica M. Baronetto, Juan I. Folco et al. · 2023 · Frontiers in Immunology

Introduction: Identification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases. Methods: Here, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I present

View details →DOI: 10.3389/fimmu.2023.1094236Cited by 15
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Skill-relatedness and employment growth of firms in times of prosperity and crisis in an oil-dependent region

John-Erik Rørheim, Ron Boschma · 2021 · Environment and Planning A Economy and Space

Many studies have shed light on the positive side of relatedness, but little attention has yet been devoted to possible downsides of relatedness for firm performance in regions. We found in a case study of the oil-dependent Stavanger region in Norway that plants in industries that are skill-related to the dominant oil and gas industry showed lower employment growth than plants in other industries. This was the case both in the boom and the crisis periods, even when controlling for supply linkages to the oil and gas sector. However, we also found that plants skill-related to the oil and gas ind

View details →DOI: 10.1177/0308518x211066102Cited by 15
Negative / Null Result ReportOpen accessComputer Science

Solutions for loss of information in high‐beta‐diversity community data

Robert J. Smith · 2016 · Methods in Ecology and Evolution

Summary Dissimilarity measures, which gauge compositional resemblance between sample units, tend to lose information with increasing distance along ecological gradients. This undesirable property is especially common in high‐beta‐diversity…

View details →DOI: 10.1111/2041-210x.12652Cited by 15
Negative / Null Result Report

Annual and spatial variation in composition and activity of terrestrial mammals on two replicate plots in lowland forest of eastern Ecuador

John G. Blake, Bette A. Loiselle · 2018 · PeerJ

Terrestrial mammals are important components of lowland forests in Amazonia (as seed dispersal agents, herbivores, predators) but there are relatively few detailed studies from areas that have not been affected by human activities (e.g.,…

View details →DOI: 10.7717/peerj.4241Cited by 15
Negative / Null Result ReportOpen accessMedicine

Evaluating deep learning methods in detecting and segmenting different sizes of brain metastases on 3D post-contrast T1-weighted images

Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging

Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…

View details →DOI: 10.1117/1.jmi.8.3.037001Cited by 15
Negative / Null Result ReportOpen accessImmunology and Microbiology

Significant association of CD4+CD25+Foxp3+ regulatory T cells with clinical findings in patients with systemic lupus erythematosus

Xiaofan Yang, Weiwen Wang, Juan Xu et al. · 2019 · Annals of Translational Medicine

Background: Regulatory T (Treg) cells are one of the important mechanisms in maintaining self-tolerance and immune homeostasis. CD4+CD25+Foxp3+Treg is considered to have a role in the pathogenesis of systemic lupus erythematosus (SLE).…

View details →DOI: 10.21037/atm.2019.01.38Cited by 15
Negative / Null Result ReportOpen accessPsychology

A Bayesian Reanalysis of a Trial of Psilocybin Versus Escitalopram for Depression

Sandeep M. Nayak, Bilal A. Bari, David B. Yaden et al. · 2022 · Psychedelic Medicine

Objectives: To perform a Bayesian reanalysis of a recent trial of psilocybin (COMP360) versus escitalopram for Major Depressive Disorder (MDD) in order to provide a more informative interpretation of the indeterminate outcome of a previous…

View details →DOI: 10.1089/psymed.2022.0002Cited by 15
Negative / Null Result ReportAgricultural and Biological Sciences

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

Allegra Niggeler, Jens Tetens, Anna Stäuble et al. · 2017 · Animal Genetics

Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on…

View details →DOI: 10.1111/age.12614Cited by 15
Negative / Null Result ReportMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes

Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…

View details →DOI: 10.1097/qai.0000000000002911Cited by 15
Negative / Null Result ReportAgricultural and Biological Sciences

Stay cool, travel far: cold‐acclimated oriental fruit moth females have enhanced flight performance but lay fewer eggs

Aurélie Ferrer, Dominique Mazzi, Silvia Dorn · 2014 · Entomologia Experimentalis et Applicata

Abstract Acclimation to a particular environment may provide organisms with advantages in that environment. In species with multiple generations per year, acclimation may cause life‐history traits to vary with season and between…

View details →DOI: 10.1111/eea.12163Cited by 15
Negative / Null Result Report

Saline versus Saline with Blood as a Contrast Agent for Right‐to‐left Shunt Diagnosis by Transcranial Doppler: Is There a Significant Difference?

Marcos Christiano Lange, Viviane Flumignan Zétola, Élcio J Piovesan et al. · 2010 · Journal of Neuroimaging

ABSTRACT BACKGROUND AND PURPOSE Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right‐to‐left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and…

View details →DOI: 10.1111/j.1552-6569.2010.00521.xCited by 15
Negative / Null Result Report

Home-based intervention for non-Hispanic black families finds no significant difference in infant size or growth: results from the Mothers & Others randomized controlled trial

Heather M. Wasser, Amanda L. Thompson, Chirayath M. Suchindran et al. · 2020 · BMC Pediatrics

Abstract Background Non-Hispanic black (NHB) infants are twice as likely as non-Hispanic white infants to experience rapid weight gain in the first 6 months, yet few trials have targeted this population. The current study tests the…

View details →DOI: 10.1186/s12887-020-02273-9Cited by 15
Negative / Null Result Report

Mid‐term results show no significant difference in postoperative clinical outcome, pain and range of motion between a well‐established total knee arthroplasty design and its successor: a prospective, randomized, controlled trial

Georg Hauer, Nina Hörlesberger, Sebastian Klim et al. · 2020 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to compare the clinical and functional outcome scores following total knee arthroplasty (TKA) with two different systems. The hypothesis was that there is a difference between patients…

View details →DOI: 10.1007/s00167-020-06027-zCited by 15
Negative / Null Result Report

Writing as a Tool to Demonstrate Mathematical Understanding

Christie Lynn Martin · 2015 · School Science and Mathematics

In this study, I examine how using a writers' workshop model in mathematics creates a space for students to write about their mathematical thinking and problem solving and how their writing impacts instruction. This case study of one…

View details →DOI: 10.1111/ssm.12131Cited by 15
Negative / Null Result ReportOpen accessMedicine

Facial skin complaints and work at visual display units. Epidemiological, clinical and histopathological studies

M Berg · 2026 · Acta Dermato Venereologica

Only in Sweden is skin disease reputedly caused by working at visual display units (VDUs) a considerable problem. In the present work facial skin complaints in VDU-exposed persons have been studied by means of epidemiological, clinical and…

View details →DOI: 10.2340/000155551989150140Cited by 15
Negative / Null Result ReportOpen accessEngineering

Mathematical Modeling of Operational Reliability of Mine Lifting Equipment Based on Censored Data

Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics

In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull

View details →DOI: 10.3390/math14040716Cited by 15
Negative / Null Result ReportOpen accessNursing

Limited evidence for anatomical contacts between intestinal GLP-1 cells and vagal neurons in male mice

Newton Cao, Warda Merchant, Laurent Gautron · 2024 · Scientific Reports

The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering the availability of anti-obesity and anti-diabetic approaches targeting GLP-1…

View details →DOI: 10.1038/s41598-024-74000-8Cited by 15
Negative / Null Result ReportOpen accessMedicine

Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials

Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology

OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…

View details →DOI: 10.1002/acr2.70001Cited by 15
Negative / Null Result ReportOpen accessNeuroscience

Phosphatidylinositol 4,5-bisphosphate drives the formation of EGFR and EphA2 complexes

Pradeep Kumar Singh, Jennifer A. Rybak, Ryan J Schuck et al. · 2024 · Science Advances

Receptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes.…

View details →DOI: 10.1126/sciadv.adl0649Cited by 15
Negative / Null Result ReportOpen accessMedicine

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial

Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open

•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…

View details →DOI: 10.1016/j.esmoop.2024.103604Cited by 15
Negative / Null Result ReportOpen accessMedicine

Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study

Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage

• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…

View details →DOI: 10.1016/j.neuroimage.2024.120869Cited by 15