Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society
The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…
View details →DOI: 10.12681/jhvms.22967Cited by 15 Negative / Null Result ReportOpen accessMedicine
Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal
Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…
View details →DOI: 10.1016/j.csbj.2025.05.025Cited by 15 Negative / Null Result ReportOpen accessMedicine
Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology
<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…
View details →DOI: 10.1159/000439448Cited by 15 Negative / Null Result ReportOpen accessMedicine
Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease
BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers
View details →DOI: 10.3233/jpd-191860Cited by 15 Negative / Null Result ReportComputer Science
Jundong Li, Osmar R. Zaı̈ane · 2017 · Intelligent Data Analysis
Established associative classification algorithms have shown to be very effective in handling categorical data such as text data. The learned model is a set of rules that are easy to understand and can be edited. However, they still suffer…
View details →DOI: 10.3233/ida-163141Cited by 15 Negative / Null Result ReportOpen accessSocial Sciences
Selina Banda, Florence Phiri, Jack Kaale et al. · 2023
Bloom’s Taxonomy is crucial in any teaching and learning environment because it determines direction for a course of study. This study assessed application of Bloom’s Taxonomy in courses of study offered in colleges in Lusaka District. Objectives were: Assess the application of Bloom’s Taxonomy in setting learning outcomes for the courses; Assess reflection of Bloom’s Taxonomy in activities set for course participants; Ascertain significance attached to Bloom’s Taxonomy in courses of study designed for participants. The study employed a mixed methodology, in particular employing a descriptive
View details →DOI: 10.7176/jep/14-4-02Cited by 15 Negative / Null Result ReportMedicine
Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine
BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…
View details →DOI: 10.1016/j.jsxm.2018.09.019Cited by 15 Negative / Null Result Report
Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGARCH Computer Architecture News
Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…
View details →DOI: 10.1145/2490301.2451141Cited by 15 Failed Experiment ReportOpen accessMedicine
Miguel Oliveira Santos, Mamede de Carvalho · 2024 · Expert Review of Neurotherapeutics
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive motor neuron disorder with a fatal outcome 3-5 years after disease onset due to respiratory complications. Superoxide dismutase 1 (SOD1) mutations are found in…
View details →DOI: 10.1080/14737175.2024.2355983Cited by 15 Negative / Null Result ReportAgricultural and Biological Sciences
Carlos M. Herrera · 2021 · Ecology
Pollinators can mediate facilitative or competitive relationships between plant species, but the relative importance of these two conflicting phenomena in shaping community-wide pollinator resource use remains unexplored. This article…
View details →DOI: 10.1002/ecy.3327Cited by 15 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
George Gitonga Inoti · 2014 · Journal of Finance and Accounting
This study sought to determine whether acquisitions enhance corporate financial performance. The general objective of the study was to assess the effects of acquisitions on the financial performance of the acquiring companies in Kenya. The…
View details →DOI: 10.11648/j.jfa.20140205.12Cited by 15 Negative / Null Result ReportOpen accessSocial Sciences
Evan A. Valdes, James H. Liu, Matt N Williams · 2022 · Asian Journal Of Social Psychology
The status‐legitimacy hypothesis proposes that those who are most disadvantaged by unequal social systems are even more likely than members of more advantaged groups to provide ideological support for the very social system that is responsible for their disadvantages. Li, Yang, Wu, and Kou (2020, Personality and Social Psychology Bulletin ) sought to expand the generalizability of this hypothesis by testing it in China, addressing inconsistencies surrounding the empirical support for this hypothesis by postulating that the construct of status should be separated into an objective and subjectiv
View details →DOI: 10.1111/ajsp.12555Cited by 15 Negative / Null Result ReportMedicine
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry
BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…
View details →DOI: 10.1111/jcpp.13682Cited by 15 Negative / Null Result ReportOpen accessMedicine
Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus
Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret
View details →DOI: 10.7759/cureus.2515Cited by 15 Negative / Null Result ReportOpen accessMedicine
Markus Karlsson, Tino Kurz · 2016 · Acta Ophthalmologica
PURPOSE: Oxidative stress-related damage to retinal pigment epithelial (RPE) cells is an important feature in the development of age-related macular degeneration. Iron-catalysed intralysosomal production of hydroxyl radicals is considered…
View details →DOI: 10.1111/aos.13076Cited by 15 Negative / Null Result ReportOpen accessMedicine
В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
View details →DOI: 10.1007/s40801-021-00250-xCited by 15 Negative / Null Result Report
Bjoern Zante, Katja Erne, Marie-Madlen Jeitziner · 2022 · Scientific Reports
Abstract To help reduce the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, ICU visits were banned or restricted. Therefore, family-centered care as usually practiced was not feasible Video calls were recommended to meet…
View details →DOI: 10.1038/s41598-022-18616-8Cited by 15 Negative / Null Result ReportOpen accessMedicine
Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology
BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…
View details →DOI: 10.1093/neuonc/noab263Cited by 15 Negative / Null Result ReportOpen accessMedicine
James M. Heun, Axel Grothey, Megan E. Branda et al. · 2011 · The Oncologist
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the difference in survival prediction between response criteria (WHO) when used as a two-level variable (CR/PR vs. other) and as a three-level…
View details →DOI: 10.1634/theoncologist.2011-0064Cited by 15 Negative / Null Result ReportOpen accessMedicine
Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure
AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…
View details →DOI: 10.1002/ehf2.13189Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy
ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%
View details →DOI: 10.1128/aac.00346-23Cited by 15 Failed Experiment ReportOpen accessMedicine
Fiona Carty, Hazel Dunbar, Ian J. Hawthorne et al. · 2021 · Stem Cells Translational Medicine
Cell-based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry-sponsored…
View details →DOI: 10.1002/sctm.21-0008Cited by 15 Negative / Null Result ReportEnvironmental Science
Christopher J. Kotalik, William H. Clements · 2019 · Environmental Science & Technology
Evaluations of aquatic insect responses to contaminants typically use larval life stages to characterize taxa sensitivity, but the effects of contaminants to emerging terrestrial adults have received less attention. We present the results…
View details →DOI: 10.1021/acs.est.9b00883Cited by 15 Negative / Null Result Report
Kumi Orita, Yukihide Minoda, Ryo Sugama et al. · 2020 · The Bone & Joint Journal
Aims Vitamin E-infused highly cross-linked polyethylene (E1) has recently been introduced in total knee arthroplasty (TKA). An in vitro wear simulator study showed that E1 reduced polyethylene wear. However there is no published…
View details →DOI: 10.1302/0301-620x.102b11.bjj-2020-0413.r1Cited by 15 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Stephen J. Tomasetti, Jeffrey R. Kraemer, Christopher J. Gobler · 2021 · Frontiers in Marine Science
Many shallow coastal systems experience diel fluctuations in dissolved oxygen (DO) and pH that can intensify throughout the summer season and expose estuarine organisms to repeated episodes of coastal hypoxia and acidification. In temperate regions, larval release of the economically important blue crab Callinectes sapidus occurs in the summer, and while the earliest stage (zoea I) larvae are susceptible to persistent low DO and low pH conditions, their sensitivity to diel fluctuations is unknown. Here, a series of short-term (≤96 h) experiments were conducted to investigate the survival of C.
View details →DOI: 10.3389/fmars.2021.720175Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xuan Xu, Penghao Zhen, Fuchao Yu et al. · 2022 · Frontiers in Cardiovascular Medicine
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H
View details →DOI: 10.3389/fcvm.2022.974345Cited by 15 Negative / Null Result ReportOpen accessMedicine
Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports
Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON
View details →DOI: 10.14814/phy2.12456Cited by 15 Negative / Null Result ReportOpen accessMedicine
Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina
Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy
View details →DOI: 10.3390/medicina57040374Cited by 15 Negative / Null Result ReportOpen accessMedicine
Michelli Marcela Dadam, Aline Braz Pereira, Mariane R. Cardoso et al. · 2024 · Respiratory Care
BACKGROUND: Re-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of…
View details →DOI: 10.4187/respcare.11077Cited by 15 Negative / Null Result Report
Anna Larsson, Johanna Berg, Mikael Gellerfors et al. · 2021 · BMC Medical Informatics and Decision Making
Abstract Background Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage…
View details →DOI: 10.1186/s12911-021-01558-yCited by 15 