A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 125 of 724
Luca Testa, J M De La Torre Hernandez, Giovanni Luigi De Maria et al. · 2026 · New England Journal of Medicine
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used for revascularization of unprotected left main coronary artery disease. Whether intravascular ultrasonographic (IVUS) guidance during PCI results in better clinical…
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
Luísa Sório Flor, Cory N Spencer, Jack Cagney et al. · 2025 · The Lancet
BACKGROUND: Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both nat
Takahiro Ezaki, Kazumichi Ohtsuka, Mohcine Chraibi et al. · 2026 · Qucosa (Saxon State and University Library Dresden)
To better design safe and comfortable urban spaces, understanding the nature of human crowd movement is important. However, precise interactions among pedestrians are difficult to measure in the presence of their complex decision-making processes and many related factors. While extensive studies on pedestrian flow through bottlenecks and corridors have been conducted, the dominant mode of interaction in these scenarios may not be relevant in different scenarios. Here, we attempt to decipher the factors that affect human reactions to other individuals from a different perspective. We conducted
Sanaa R. Elsegeny, Fatima S. Radwan, Yomna M. Elshamy et al. · 2025 · Annals of Microbiology
Abstract Background Aquaculture is an essential sector for global food security, providing protein-rich food, reducing pressure on wild stocks, creating jobs, and contributing to national economies. However, it faces major sustainability challenges, including disease outbreaks, inefficient feed utilization, and environmental impact. Main body The significance of probiotics in mitigating these issues is highlighted in this review. The current review underscores and highlights important considerations while developing or using probiotics in the aquaculture field: how strains are selected as cand
Yuqi Ren, Miao Cheng, Hongbin He et al. · 2025 · Nature Communications
CO2-to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O2 partial pressures and sluggish C2-product formation. Herein, Ru0.6Cu1(Cu0–Cu1+)/CeO2 catalysts with adaptive O2 tolerance are…
Aliasghar Azma, Yakun Liu, Eden Tatek Alemu · 2026 · Scientific Reports
The aim of this study was to evaluate groundwater quality the Marvdasht aquifer using the Groundwater Quality Index (GWQI), which was determined using a conventional method and also predicted using three machine learning algorithms:…
Kevin J. Mitchell, Darren Dahly, Dorothy Bishop · 2025 · Neuron
The idea that the gut microbiome causally contributes to autism has gained currency in the scientific literature and popular press. Support for this hypothesis comes from three lines of evidence: human observational studies, preclinical experiments in mice, and human clinical trials. We critically assessed this literature and found that it is beset by conceptual and methodological flaws and limitations that undermine claims that the gut microbiome is causally involved in the etiology or pathophysiology of autism.
Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
Andrew T. Rajczewski, J. Alfredo Blakeley‐Ruiz, Annaliese Meyer et al. · 2025 · PROTEOMICS
Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being data-dependent acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in…
Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA
Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…
Clare Balboni, Robin Burgess, Benjamin Olken · 2025 · The Review of Economic Studies
Abstract Environmental externalities—uncompensated damages imposed on others—lie at the root of climate change, pollution, deforestation and biodiversity loss. Empirical evidence is limited, however, as to how externalities drive private decision making. We study one such behaviour, illegal tropical forest fires, using 15 years of daily satellite data covering over 107,000 fires across Indonesia. Weather-induced variation in fire spread risk and variation in who owns surrounding land allow us to identify how far externalities influence the decision to use fire. Relative to when all spread risk
Nicholas Forelli, Trace Thome, Deborah Eaton et al. · 2026 · Science
Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i…
Gabriel Jiménez, DMITRY KUVSHINOV, José‐Luis Peydró et al. · 2026 · The Journal of Finance
ABSTRACT We show that a U‐shaped monetary rate path increases banking crisis risk, via credit and asset price cycles, analyzing 17 countries over 150 years. Rate hikes (raw or instrumented) increase crisis risk, but only if preceded by prolonged cuts. These patterns are unique to banking crises, unlike noncrisis recessions. Regarding the mechanism, prolonged cuts raise the likelihood of large credit and asset price booms, consistent with higher credit supply and risk‐taking. Subsequent hikes strongly reduce credit and asset prices, and increase banks' realized credit risk, rather than interest
Claudia Monaco, Coleen A. McNamara, Bram Slütter et al. · 2025 · Physiological Reviews
Cardiovascular disease is the global number one cause of mortality and morbidity. The majority of cardiovascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The…
Roohi Chaudhary, Ralf Weiskirchen, Marcelo Ehrlich et al. · 2025 · Frontiers in Pharmacology
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
Tingting Bai, Dong Xu, Muhammad Ali Nasir · 2026 · Technological Forecasting and Social Change
With the accelerating growth of the digital economy, digital technology—as a type of general-purpose technology—creates a more inclusive and open environment for innovation, thereby facilitating the shift toward a low-carbon economy by promoting green innovation. However, we know little about whether there are differences in the roles of various types of green innovation. Therefore, this study evaluates the impact of DE on low-carbon development (LCD) through heterogeneous green innovation. The results show that DE has a significant nonlinear effect on LCD, with an initial suppressing effect t
Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi et al. · 2026 · PubMed
Regular exercise has recognized health benefits, partly because it reportedly lowers the levels of the oxidation products of proteins and DNA at rest, in contrast with the effect of acute exercise. However, when we compared oxidative…
Ashish Sriram Mishra, Bhavna Ghosh, Sivakumar Ponnurengam Malliappan et al. · 2026 · RSC Advances
The development of colon-targeted drug delivery systems (CDDS) has gained increasing attention due to their potential to improve therapeutic outcomes for diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and other colonic disorders. Targeted delivery to the colon offers the advantages of site-specific action, reduced systemic side effects, and improved patient compliance. However, several physiological barriers, such as variable pH, microbial metabolism, enzymatic degradation, and transit time, pose significant formulation challenges. This re
Amélie Cabirol, Andrew Quinn, Julie Schafer et al. · 2026 · Proceedings of the National Academy of Sciences
Abstract The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bees’
Federica Canfora · 2025 · Journal of Oral & Facial Pain and Headache
Burning Mouth Syndrome (BMS) is a complex, chronic neuropathic orofacial pain disorder characterized by a persistent burning or dysesthetic sensation in the oral cavity without an identifiable organic cause. Accurate diagnosis and…
Jonne Kotta, Helen Orav‐Kotta, Kristjan Herkül et al. · 2024 · Työväentutkimus Vuosikirja
Following the establishment of the invasive gammarid amphipod Gammarus tigrinus the native gammarids almost disappeared from some habitats of the northeastern Baltic Sea.The aims of the current work were to experimentally study whether the habitat choice of G. tigrinus and G. salinus was similar and whether G. tigrinus modified the habitat selection of G. salinus, providing thus evidence that competition for space between the two species might explain the disappearance of the native gammarids from the study area.In general, the gammarid amphipods had a significant overlap in habitat selection.
Xinchi Luan, Xuezhe Wang, Ying Shi et al. · 2025 · Frontiers in Psychiatry
Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeu
Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang et al. · 2026 · Nature Neuroscience
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder,…
Rishi Chanderraj, Brian Bartek, Kathleen A. Stringer et al. · 2026 · Journal of Clinical Investigation
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host response. Here, we investigate the potential influence of the causative pathogen on sepsis heterogeneity and pathobiology.METHODSWe performed a retrospective observational analysis of
Yimao Wu, Kaiyu Zhang, 夏新亚 et al. · 2026 · BMC Medicine
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women worldwide, and its marked heterogeneity together with the complexity of the tumor microenvironment contributes to substantial variability in therapeutic…
Isabel O. Gallegos, Chen Shani, Weiyan Shi et al. · 2026 · PNAS Nexus
Abstract As generative AI enables the creation and dissemination of information at massive scale and speed, it is increasingly important to understand how people perceive AI-generated content. One prominent policy proposal requires explicitly labeling AI-generated content to increase transparency and encourage critical thinking about the information, but prior research has not yet tested the effects of such labels. To address this gap, we conducted a survey experiment (N=1,601) on a diverse sample of Americans, presenting participants with an AI-generated message about several public policies
Mukhlis Mukhlis, Ahmad Nabriz, Muhammad Eissawy Abu El Yazid et al. · 2026 · Integrated Education Journal
This study aims to comparatively analyze the perspectives, policies, implementation, and challenges of multicultural education in developed and developing countries. A qualitative approach was employed using library research, drawing on scholarly journal articles, academic books, educational policy documents, and relevant previous studies. Data were analyzed through comparative content analysis to identify patterns of similarities, differences, challenges, and implementation strategies across the two contexts. The findings indicate that developed countries generally demonstrate more systematic
Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…
Pradeep Kumar Singh, Jennifer A. Rybak, Ryan J Schuck et al. · 2024 · Science Advances
Receptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes.…