A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 125 of 674
John E. Kiat, Ai Rene Ong, Asha Ganesan · 2017 · Educational Psychology
Multiple-choice questions (MCQs) play a key role in standardised testing and in-class assessment. Research into the influence of within-item response order on MCQ characteristics has been mixed. While some researchers have shown…
Md Sahabul Alam, Fabrice Labeau, Georges Kaddoum · 2016 · IEEE Transactions on Communications
In this paper, we consider the performance analysis of a decode-and-forward (DF) cooperative relaying (CR) scheme over channels impaired by bursty impulsive noise. Although the Middleton class-A model and the Bernoulli-Gaussian model give…
Cécile Hérate, Clarisse Vigne, Carolin A. Guenzel et al. · 2016 · Retrovirology
BACKGROUND: Through incorporation into virus particles, the HIV-1 Vpr protein participates in the early steps of the virus life cycle by influencing the reverse transcription process. We previously showed that this positive impact on reverse transcription was related to Vpr binding to the uracil DNA glycosylase 2 enzyme (UNG2), leading to enhancement of virus infectivity in established CD4-positive cell lines via a nonenzymatic mechanism. RESULTS: We report here that Vpr can form a trimolecular complex with UNG2 and the p32 subunit (RPA32) of the replication protein A (RPA) complex and we expl
Christopher J. Ferguson · 2018 · Annual Review of Law and Social Science
During the early 2000s, several states and municipalities sought to regulate minors’ access to violent video games owing to perceived harms to minors. The resultant case law, culminating in the US Supreme Court case Brown v. EMA (2011),…
Suzanna Forwood, Amy L. Ahern, Gareth J Hollands et al. · 2013 · PLoS ONE
OBJECTIVE: Previous studies have shown that estimations of the calorie content of an unhealthy main meal food tend to be lower when the food is shown alongside a healthy item (e.g. fruit or vegetables) than when shown alone. This effect has been called the negative calorie illusion and has been attributed to averaging the unhealthy (vice) and healthy (virtue) foods leading to increased perceived healthiness and reduced calorie estimates. The current study aimed to replicate and extend these findings to test the hypothesized mediating effect of ratings of healthiness of foods on calorie estimat
Christoph Rochlitz, Roger von Moos, Martin Bigler et al. · 2014 · Journal of Clinical Oncology
518 Background: Bevacizumab combined with chemotherapy has been shown to improve response rate and PFS in metastatic breast cancer. The aim of our study was to demonstrate decreased toxicity of metronomic chemotherapy/bevacizumab when…
Larissa Bomfim, Isabela Ramos · 2020 · The FASEB Journal
In insects, synthesis and deposition of the chorion (eggshell) are performed by the professional secretory follicle cells (FCs) that surround the oocytes in the course of oogenesis. Here, we found that ULK1/ATG1, an autophagy-related…
X. J. Li, Desheng Zhao, Desheng Jiang et al. · 2014 · Journal of Applied Physics
The significant effect of the thickness of Ni film on the performance of the Ohmic contact of Ni/Au to p-GaN is studied. The Ni/Au metal films with thickness of 15/50 nm on p-GaN led to better electrical characteristics, showing a lower…
Yvette A. Girard, Christine K. Johnson, Heather Fritz et al. · 2015 · International Journal for Parasitology Parasites and Wildlife
Tissue-cyst forming coccidia in the family Sarcocystidae are etiologic agents of protozoal encephalitis in marine mammals including the federally listed Southern sea otter (Enhydra lutris). California sea lions (Zalophus californianus),…
Müge Özbek, Annette Bohn, Dorthe Berntsen · 2020 · Applied Cognitive Psychology
Summary We have limited knowledge as to whether the phenomenological differences between episodic memories, counterfactuals, and future projections show the same pattern across age groups and diverse samples. Here we compared the…
Noor Azlinna Azizan, Bahari Mohamed · 2013 · Asian journal of social sciences & humanities
This study focuses on the effects of perceived service quality on patient satisfaction in a public hospital. Data was collected from 109 respondents that experienced the hospital service. Using a PLS-SEM tool, the hypothesized effects…
Meghan Roche, Andrea Carr, In Heok Lee et al. · 2016 · Journal of Career Assessment
This study explored the measurement equivalence of the Career Indecision Profile (CIP) in a Chinese sample with both U.S. and South Korean samples. Past measurement invariance research on the CIP in four international samples (Icelandic…
Waylon J. Hastings, Laura Etzel, Christine M. Heim et al. · 2022 · Aging
Various approaches exist to assess population differences in biological aging. Telomere length (TL) is one such measure, and is associated with disease, disability and early mortality. Yet, issues surrounding precision and reproducibility are a concern for TL measurement. An alternative method to estimate TL using DNA methylation (DNAmTL) was recently developed. Although DNAmTL has been characterized in adult and elderly cohorts, its utility in pediatric populations remains unknown. We examined the comparability of leukocyte TL measurements generated using qPCR (absolute TL; aTL) to those esti
Jon P. Beckmann, Sarah H. Olson, Renee G. Seidler et al. · 2016 · Global Ecology and Conservation
To meet societal demands for energy, ∼50,000 gas sites are developed annually in North America, among which many are in western less-developed and wildlife rich areas. To evaluate effects of increasing energy infrastructure requires…
Alberto Zanchetti · 2016 · Journal of Hypertension
The articles published in the current issue of the Journal of Hypertension focus on risk factors for the development of hypertension and on the relationship of hypertension with cardiovascular disease. Two articles illustrate the role of…
John Hitz, Elaine J. Francis · 2016 · Linguistics
Abstract Gibson and Fedorenko (2013, The need for quantitative methods in syntax and semantics research, Language and Cognitive Processes 28(2), 88–124) have argued against the continued use of informally collected acceptability judgments…
Jaroslava Durdiaková, Varun Warrier, Simon Baron‐Cohen et al. · 2014 · Molecular Autism
BACKGROUND: Autism Spectrum Conditions (ASC) are a group of developmental conditions which affect communication, social interactions and behaviour. Mitochondrial oxidative dysfunction has been suggested as a mechanism of autism based on the results of multiple genetic association and expression studies. SLC25A12 is a gene encoding a calcium-binding carrier protein that localizes to the mitochondria and is involved in the exchange of aspartate for glutamate in the inner membrane of the mitochondria regulating the cytosolic redox state. rs2056202 SNP in this gene has previously been associated w
Aarish Manzar, Aleksandar Sič, Crystal E. Banh et al. · 2025 · Cells
Calcium channel blockers (CCBs), originally developed for cardiovascular indications, have gained attention for their therapeutic potential in neuropsychiatric, endocrine, and pain-related disorders. In neuropsychiatry, nimodipine and isradipine, both L-type CCBs, show mood-stabilizing and neuroprotective effects, with possible benefits in depression, bipolar disorder, and schizophrenia. In endocrinology, verapamil, a non-dihydropyridine L-type blocker, has been associated with the preservation of pancreatic β-cell function and reduced insulin dependence in diabetes. CCBs may also aid in manag
Margareth C. Ozelo, Jane Mason, Amy L. Dunn et al. · 2025 · Journal of Thrombosis and Haemostasis
BACKGROUND: Valoctocogene roxaparvovec, an adeno-associated virus vector that transfers a human factor (F)VIII (FVIII) coding sequence to hepatocytes, provides bleeding protection for people with severe hemophilia A. OBJECTIVES: Determine…
T.C. Bruinjé, S.J. LeBlanc · 2025 · Animals
In the early postpartum period, dairy cows undergo significant adaptations in Ca and lipid metabolism, immune function, and inflammatory processes. Concurrent exposure to endotoxins from the uterus, gastrointestinal tract, or mammary gland increases the risk of disease and reproductive problems. Metabolic and inflammatory imbalances during this phase can have both immediate and long-term effects on reproductive health. Associations between metabolic disorders and reproductive outcomes are often confounded by immune activation and systemic inflammation. However, optimal markers, thresholds, and
Jeremy McGale, Harrison J. Howell, Arnaud Beddok et al. · 2024 · Pharmaceuticals
The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the potential for this alliance to advance pharmaceutical innovation by accelerating the development and deployment of novel therapeutics. We previously performed a scoping review of three databases (Embase, MEDLINE, and CENTRAL), identifying 87 studies published between 2018 and 2022 relevant to medical imaging (e.g., CT, PET, MRI), immunotherapy, arti
Astrid Marinoni, John L. Voorheis · 2026 · Research Policy
The question of who gains from high-quality entrepreneurship is crucial to understanding whether investments in innovative startup firms produce socially beneficial outcomes. Although entrepreneurship is widely viewed as a central driver…
Yuldoshboy Sobirov, Beruniy Artikov, Elbek Khodjaniyazov et al. · 2025 · Sustainability
This study examines the long-run relationship between carbon dioxide (CO2) emissions and key macroeconomic and sectoral drivers in ten ASEAN economies from 1995 to 2023. Employing Driscoll–Kraay standard errors, Prais–Winsten regression, heteroskedastic panel-corrected standard errors, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS), and Canonical Cointegrating Regression (CCR) estimators, the analysis accounts for cross-sectional dependence, slope heterogeneity, and endogeneity. Results indicate that GDP exerts a more-than-unitary positive effect on emissi
Alì Soltani, Parviz Azizi, Aliasghar Rahimioun et al. · 2025 · Journal of Urban Management
The escalating complexities of rapid urbanization necessitate a paradigm shift in urban form evaluation, moving beyond traditional horizontal analyses to incorporate the crucial dimension of vertical growth. This study pioneers a volumetric approach, integrating 3D and 2D spatial analyses, to dissect compactness, sprawl, and their underlying drivers across two contrasting metropolitan regions: the Tehran Metropolitan Region (TMR) and the Greater Sydney Region (GSR) over a 40-year period (1980s–2020s). Our findings reveal a striking dichotomy: TMR exhibits pronounced ‘vertical sprawl,’ characte
Imre Fertő, Gábor Harangozó · 2025 · Scientific Reports
This study investigates the complex relationships between globalization, economic growth, urbanization, and ecological footprint in the context of advancing the United Nations Sustainable Development Goals (SDGs). Employing a club convergence framework, we evaluate global SDG Index from 2000 to 2023 for 149 countries with 3212 observations, identifying five converging clubs and one non-converging group. Our analysis demonstrates that higher GDP per capita and various dimensions of globalization positively impact SDG outcomes, whereas rapid urbanization and expansive ecological footprints exert
Yayaati Chachan, Jonathan J. Fortney, Kazumasa Ohno et al. · 2025 · The Astrophysical Journal
Abstract The rate at which giant planets accumulate solids and gas is a critical component of planet formation models, yet it is extremely challenging to predict from first principles. Characterizing the heavy element (everything other than hydrogen and helium) content of giant planets provides important clues about their provenance. Using thermal evolution models with an updated H–He equation of state and atmospheric boundary conditions that vary with envelope metallicity, we quantify the bulk heavy element content of 147 warm (<1000 K) giant planets with well-measured masses and radii, mo
Miya Williams Fayne, Stephanie Edgerly · 2025 · Mass Communication & Society
This study examines three forms of news avoidance (repertoire, self-identified, and topical) among Black Americans and the overlap between the different forms. We center African Americans, who are often ignored or stereotyped by mainstream…
Yuan Ma, Wenchao Zhang, Chengxiang Ma et al. · 2025 · International Review of Economics & Finance
In an era defined by digital transformation, artificial intelligence (AI) has emerged as a critical driver of corporate competitiveness, yet the mechanisms through which it enhances innovation remain a key area of inquiry. This study…
Fengqiu Adam Dong, Kaitlyn Shin, Casey Law et al. · 2025 · The Astrophysical Journal Letters
Abstract We report the discovery of CHIME J1634+44, a long-period radio transient (LPT) unique for two aspects: it is the first known LPT to emit fully circularly polarized radio bursts, and it is the first LPT with a significant spin-up. Given that high circular polarization (>90%) has been observed in FRB 20201124A and in some giant pulses of PSR B1937+21, we discuss the implications of the high circular polarization of CHIME J1634+44 and conclude its emission mechanism is likely to be “pulsar-like.” While CHIME J1634+44 has a pulse period of 841 s, its burst arrival patterns are indicati
Mina Kian, Mingyu Zong, Katrin Fischer et al. · 2026 · Frontiers in Robotics and AI
Mental health is a significant healthcare challenge, and cognitive behavioral therapy (CBT) is a widely used therapeutic method for treating anxiety and depression. However, traditional CBT often requires access to trained clinicians and can be cost-prohibitive or logistically difficult for many individuals. To address these barriers, we developed a low-cost socially assistive robot (SAR) that uses a large language model (LLM) to guide the user through interactive at-home CBT exercises. In this exploratory study, 38 university students completed CBT exercises across a 15-day period using one o