Negative / Null Result ReportMedicine
Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering
Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…
View details →DOI: 10.1080/10255842.2012.742075Cited by 15 Negative / Null Result ReportOpen accessMedicine
Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease
BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers
View details →DOI: 10.3233/jpd-191860Cited by 15 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience
OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:
View details →DOI: 10.5713/ajas.19.0828Cited by 15 Negative / Null Result ReportOpen accessMedicine
Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal
Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…
View details →DOI: 10.1016/j.csbj.2025.05.025Cited by 15 Negative / Null Result ReportOpen accessMedicine
Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety
Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…
View details →DOI: 10.1007/s40264-017-0506-5Cited by 15 Negative / Null Result ReportAgricultural and Biological Sciences
Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…
View details →DOI: 10.1089/scd.2017.0106Cited by 15 Negative / Null Result ReportOpen accessMedicine
Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →DOI: 10.3389/fneur.2019.00884Cited by 15 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Abby E. Davis, Kaitlin R. Deutsch, Alondra M. Torres et al. · 2021 · Scientific Reports
Flowers can be transmission platforms for parasites that impact bee health, yet bees share floral resources with other pollinator taxa, such as flies, that may be hosts or non-host vectors (i.e., mechanical vectors) of parasites. Here, we assessed whether the fecal-orally transmitted gut parasite of bees, Crithidia bombi, can infect Eristalis tenax flower flies. We also investigated the potential for two confirmed solitary bee hosts of C. bombi, Osmia lignaria and Megachile rotundata, as well as two flower fly species, Eristalis arbustorum and E. tenax, to transmit the parasite at flowers. We
View details →DOI: 10.1038/s41598-021-95323-wCited by 15 Negative / Null Result Report
Charles M. Reigeluth, Peter Honebein · 2020 · Revista de Educación a Distancia (RED)
La mayoría de los investigadores que diseñan experiencias innovadoras de aprendizaje digital y luego realizan investigaciones que investigan la utilidad de esas experiencias de aprendizaje, no aplican completamente la teoría de la…
View details →DOI: 10.6018/red.405871Cited by 15 Negative / Null Result ReportOpen accessComputer Science
Wilhelmiina Hämäläinen · 2010 · Työväentutkimus Vuosikirja
Analyzing statistical dependencies is a fundamental problem in all empirical science. Dependencies help us understand causes and effects, create new scientific theories, and invent cures to problems. Nowadays, large amounts of data is…
Negative / Null Result ReportPsychology
Karen R. Gouze, John V. Lavigne, Joyce Hopkins et al. · 2012 · Infant Mental Health Journal
Temperamental negative affectivity (NA) and effortful control (EC) have long been of interest to psychologists, but sensory regulation (SR) has received less attention. Using confirmatory factor analysis, the present study reexamined the…
View details →DOI: 10.1002/imhj.21363Cited by 15 Negative / Null Result ReportOpen accessMedicine
Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure
AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…
View details →DOI: 10.1002/ehf2.13189Cited by 15 Negative / Null Result ReportOpen accessMedicine
Lionel Perrier, Frédéric Balusson, Magali Morelle et al. · 2024 · Radiotherapy and Oncology
BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore…
View details →DOI: 10.1016/j.radonc.2024.110116Cited by 15 Negative / Null Result ReportOpen accessMedicine
Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports
Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON
View details →DOI: 10.14814/phy2.12456Cited by 15 Negative / Null Result ReportOpen accessMedicine
В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
View details →DOI: 10.1007/s40801-021-00250-xCited by 15 Negative / Null Result ReportOpen accessMedicine
James M. Heun, Axel Grothey, Megan E. Branda et al. · 2011 · The Oncologist
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the difference in survival prediction between response criteria (WHO) when used as a two-level variable (CR/PR vs. other) and as a three-level…
View details →DOI: 10.1634/theoncologist.2011-0064Cited by 15 Negative / Null Result ReportOpen accessMedicine
Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer
BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo
View details →DOI: 10.1186/s12885-023-10680-1Cited by 15 Negative / Null Result ReportOpen accessMedicine
Michelli Marcela Dadam, Aline Braz Pereira, Mariane R. Cardoso et al. · 2024 · Respiratory Care
BACKGROUND: Re-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of…
View details →DOI: 10.4187/respcare.11077Cited by 15 Negative / Null Result Report
Bjoern Zante, Katja Erne, Marie-Madlen Jeitziner · 2022 · Scientific Reports
Abstract To help reduce the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, ICU visits were banned or restricted. Therefore, family-centered care as usually practiced was not feasible Video calls were recommended to meet…
View details →DOI: 10.1038/s41598-022-18616-8Cited by 15 Negative / Null Result Report
Kumi Orita, Yukihide Minoda, Ryo Sugama et al. · 2020 · The Bone & Joint Journal
Aims Vitamin E-infused highly cross-linked polyethylene (E1) has recently been introduced in total knee arthroplasty (TKA). An in vitro wear simulator study showed that E1 reduced polyethylene wear. However there is no published…
View details →DOI: 10.1302/0301-620x.102b11.bjj-2020-0413.r1Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy
ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%
View details →DOI: 10.1128/aac.00346-23Cited by 15 Negative / Null Result ReportOpen accessMedicine
Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology
BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…
View details →DOI: 10.1093/neuonc/noab263Cited by 15 Negative / Null Result Report
Anna Larsson, Johanna Berg, Mikael Gellerfors et al. · 2021 · BMC Medical Informatics and Decision Making
Abstract Background Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage…
View details →DOI: 10.1186/s12911-021-01558-yCited by 15 Negative / Null Result ReportOpen accessMedicine
Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…
View details →DOI: 10.1002/ijc.33316Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xuan Xu, Penghao Zhen, Fuchao Yu et al. · 2022 · Frontiers in Cardiovascular Medicine
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H
View details →DOI: 10.3389/fcvm.2022.974345Cited by 15 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Stephen J. Tomasetti, Jeffrey R. Kraemer, Christopher J. Gobler · 2021 · Frontiers in Marine Science
Many shallow coastal systems experience diel fluctuations in dissolved oxygen (DO) and pH that can intensify throughout the summer season and expose estuarine organisms to repeated episodes of coastal hypoxia and acidification. In temperate regions, larval release of the economically important blue crab Callinectes sapidus occurs in the summer, and while the earliest stage (zoea I) larvae are susceptible to persistent low DO and low pH conditions, their sensitivity to diel fluctuations is unknown. Here, a series of short-term (≤96 h) experiments were conducted to investigate the survival of C.
View details →DOI: 10.3389/fmars.2021.720175Cited by 15 Negative / Null Result ReportOpen accessMedicine
Vanja Vaccaro · 2013 · World Journal of Gastroenterology
AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase…
View details →DOI: 10.3748/wjg.v19.i28.4511Cited by 15 Negative / Null Result ReportOpen accessMedicine
Markus Karlsson, Tino Kurz · 2016 · Acta Ophthalmologica
PURPOSE: Oxidative stress-related damage to retinal pigment epithelial (RPE) cells is an important feature in the development of age-related macular degeneration. Iron-catalysed intralysosomal production of hydroxyl radicals is considered…
View details →DOI: 10.1111/aos.13076Cited by 15 Negative / Null Result ReportOpen accessMedicine
Jittawadee Murphy, Walter R. Weiss, David J. Fryauff et al. · 2014 · Malaria Journal
BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability
View details →DOI: 10.1186/1475-2875-13-215Cited by 15 Negative / Null Result ReportOpen accessMedicine
Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina
Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy
View details →DOI: 10.3390/medicina57040374Cited by 15 