Negative / Null Result ReportOpen accessMedicine
В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
View details →DOI: 10.1007/s40801-021-00250-xCited by 15 Negative / Null Result ReportOpen accessMedicine
James M. Heun, Axel Grothey, Megan E. Branda et al. · 2011 · The Oncologist
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the difference in survival prediction between response criteria (WHO) when used as a two-level variable (CR/PR vs. other) and as a three-level…
View details →DOI: 10.1634/theoncologist.2011-0064Cited by 15 Negative / Null Result ReportOpen accessMedicine
Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer
BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo
View details →DOI: 10.1186/s12885-023-10680-1Cited by 15 Negative / Null Result ReportOpen accessMedicine
Michelli Marcela Dadam, Aline Braz Pereira, Mariane R. Cardoso et al. · 2024 · Respiratory Care
BACKGROUND: Re-intubation is necessary in 2% to 30% of cases of patients receiving a planned extubation. This procedure is associated with prolonged mechanical ventilation, a greater need for tracheostomy, a higher incidence of…
View details →DOI: 10.4187/respcare.11077Cited by 15 Negative / Null Result Report
Bjoern Zante, Katja Erne, Marie-Madlen Jeitziner · 2022 · Scientific Reports
Abstract To help reduce the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, ICU visits were banned or restricted. Therefore, family-centered care as usually practiced was not feasible Video calls were recommended to meet…
View details →DOI: 10.1038/s41598-022-18616-8Cited by 15 Negative / Null Result Report
Kumi Orita, Yukihide Minoda, Ryo Sugama et al. · 2020 · The Bone & Joint Journal
Aims Vitamin E-infused highly cross-linked polyethylene (E1) has recently been introduced in total knee arthroplasty (TKA). An in vitro wear simulator study showed that E1 reduced polyethylene wear. However there is no published…
View details →DOI: 10.1302/0301-620x.102b11.bjj-2020-0413.r1Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy
ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%
View details →DOI: 10.1128/aac.00346-23Cited by 15 Negative / Null Result ReportOpen accessMedicine
Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology
BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…
View details →DOI: 10.1093/neuonc/noab263Cited by 15 Negative / Null Result Report
Anna Larsson, Johanna Berg, Mikael Gellerfors et al. · 2021 · BMC Medical Informatics and Decision Making
Abstract Background Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage…
View details →DOI: 10.1186/s12911-021-01558-yCited by 15 Negative / Null Result ReportOpen accessMedicine
Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…
View details →DOI: 10.1002/ijc.33316Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xuan Xu, Penghao Zhen, Fuchao Yu et al. · 2022 · Frontiers in Cardiovascular Medicine
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H
View details →DOI: 10.3389/fcvm.2022.974345Cited by 15 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Stephen J. Tomasetti, Jeffrey R. Kraemer, Christopher J. Gobler · 2021 · Frontiers in Marine Science
Many shallow coastal systems experience diel fluctuations in dissolved oxygen (DO) and pH that can intensify throughout the summer season and expose estuarine organisms to repeated episodes of coastal hypoxia and acidification. In temperate regions, larval release of the economically important blue crab Callinectes sapidus occurs in the summer, and while the earliest stage (zoea I) larvae are susceptible to persistent low DO and low pH conditions, their sensitivity to diel fluctuations is unknown. Here, a series of short-term (≤96 h) experiments were conducted to investigate the survival of C.
View details →DOI: 10.3389/fmars.2021.720175Cited by 15 Negative / Null Result ReportOpen accessMedicine
Vanja Vaccaro · 2013 · World Journal of Gastroenterology
AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase…
View details →DOI: 10.3748/wjg.v19.i28.4511Cited by 15 Negative / Null Result ReportOpen accessMedicine
Markus Karlsson, Tino Kurz · 2016 · Acta Ophthalmologica
PURPOSE: Oxidative stress-related damage to retinal pigment epithelial (RPE) cells is an important feature in the development of age-related macular degeneration. Iron-catalysed intralysosomal production of hydroxyl radicals is considered…
View details →DOI: 10.1111/aos.13076Cited by 15 Negative / Null Result ReportOpen accessMedicine
Jittawadee Murphy, Walter R. Weiss, David J. Fryauff et al. · 2014 · Malaria Journal
BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability
View details →DOI: 10.1186/1475-2875-13-215Cited by 15 Negative / Null Result ReportOpen accessMedicine
Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina
Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy
View details →DOI: 10.3390/medicina57040374Cited by 15 Negative / Null Result ReportEnvironmental Science
Christopher J. Kotalik, William H. Clements · 2019 · Environmental Science & Technology
Evaluations of aquatic insect responses to contaminants typically use larval life stages to characterize taxa sensitivity, but the effects of contaminants to emerging terrestrial adults have received less attention. We present the results…
View details →DOI: 10.1021/acs.est.9b00883Cited by 15 Negative / Null Result ReportOpen accessMedicine
Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus
Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret
View details →DOI: 10.7759/cureus.2515Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohamad Saad, Ayman El‐Menyar, Khalid Kunji et al. · 2022 · Circulation Genomic and Precision Medicine
Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry…
View details →DOI: 10.1161/circgen.122.003712Cited by 15 Negative / Null Result ReportMedicine
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry
BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…
View details →DOI: 10.1111/jcpp.13682Cited by 15 Negative / Null Result ReportComputer Science
Jundong Li, Osmar R. Zaı̈ane · 2017 · Intelligent Data Analysis
Established associative classification algorithms have shown to be very effective in handling categorical data such as text data. The learned model is a set of rules that are easy to understand and can be edited. However, they still suffer…
View details →DOI: 10.3233/ida-163141Cited by 15 Negative / Null Result ReportOpen accessMedicine
Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology
<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…
View details →DOI: 10.1159/000439448Cited by 15 Negative / Null Result ReportAgricultural and Biological Sciences
Carlos M. Herrera · 2021 · Ecology
Pollinators can mediate facilitative or competitive relationships between plant species, but the relative importance of these two conflicting phenomena in shaping community-wide pollinator resource use remains unexplored. This article…
View details →DOI: 10.1002/ecy.3327Cited by 15 Negative / Null Result ReportOpen accessSocial Sciences
Melissa Chapple, Philip Davis, Josie Billington et al. · 2022 · Frontiers in Psychology
Dominant theoretical models of autism and resultant research enquiries have long centered upon an assumed autism-specific empathy deficit. Associated empirical research has largely relied upon cognitive tests that lack ecological validity and associate empathic skill with heuristic-based judgments from limited snapshots of social information. This artificial separation of thought and feeling fails to replicate the complexity of real-world empathy, and places socially tentative individuals at a relative disadvantage. The present study aimed to qualitatively explore how serious literary fiction,
View details →DOI: 10.3389/fpsyg.2022.828603Cited by 15 Negative / Null Result ReportMedicine
Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine
BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…
View details →DOI: 10.1016/j.jsxm.2018.09.019Cited by 15 Negative / Null Result ReportOpen accessMedicine
Adam Stevens, Philip Murray, Jérôme Wojcik et al. · 2016 · European Journal of Endocrinology
OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou
View details →DOI: 10.1530/eje-16-0357Cited by 15 Negative / Null Result ReportOpen accessSocial Sciences
Jonathan E. Ramsay, Eddie M. W. Tong, Joyce S. Pang et al. · 2016 · PLoS ONE
Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words "religion", "God" and a neutral contro
View details →DOI: 10.1371/journal.pone.0147178Cited by 15 Negative / Null Result Report
Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGARCH Computer Architecture News
Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…
View details →DOI: 10.1145/2490301.2451141Cited by 15 Negative / Null Result ReportOpen accessSocial Sciences
Evan A. Valdes, James H. Liu, Matt N Williams · 2022 · Asian Journal Of Social Psychology
The status‐legitimacy hypothesis proposes that those who are most disadvantaged by unequal social systems are even more likely than members of more advantaged groups to provide ideological support for the very social system that is responsible for their disadvantages. Li, Yang, Wu, and Kou (2020, Personality and Social Psychology Bulletin ) sought to expand the generalizability of this hypothesis by testing it in China, addressing inconsistencies surrounding the empirical support for this hypothesis by postulating that the construct of status should be separated into an objective and subjectiv
View details →DOI: 10.1111/ajsp.12555Cited by 15 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jacqueline Ramı́rez, Tae Won Kim, Wanqing Liu et al. · 2013 · Pharmacogenetics and Genomics
XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly by aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in…
View details →DOI: 10.1097/fpc.0000000000000023Cited by 15 