Negative / Null Result ReportOpen accessMedicine· cited by 15

Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies

Jittawadee Murphy; Walter R. Weiss; David J. Fryauff; Megan Dowler; Tatyana Savransky; Cristina Stoyanov; Olga Muratova; Lynn Lambert · 2014 · Malaria Journal

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability

Abstract by Jittawadee Murphy; Walter R. Weiss; David J. Fryauff; Megan Dowler; Tatyana Savransky; Cristina Stoyanov; Olga Muratova; Lynn Lambert, Malaria Journal (2014) — licensed CC BY 4.0.

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