Chronic intermittent hypoxia accelerates cardiac dysfunction and cardiac remodeling during cardiac pressure overload in mice and can be alleviated by PHD3 overexpression
Xuan Xu; Penghao Zhen; Fuchao Yu; Tao Wang; Shengnan Li; Wei Qin; Jiayi Tong · 2022 · Frontiers in Cardiovascular Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H
Abstract by Xuan Xu; Penghao Zhen; Fuchao Yu; Tao Wang; Shengnan Li; Wei Qin; Jiayi Tong, Frontiers in Cardiovascular Medicine (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcvm.2022.974345