A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Lukas Koedijk, Ana Oprescu · 2022
The EU Green Deal mirrors the societal concern regarding climate change. In the software industry this means reducing the energy consumption of a program. This can be done by looking both at the hardware and the software used. We take a…
Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica
Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…
Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics
BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…
Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…
Aerlyn G. Dawn, Naomi Lawrence · 2013 · Dermatologic Surgery
BACKGROUND: Squamous cell carcinomas (SCCs) generally have been reported to be more prevalent on the lips than basal cell carcinomas (BCCs), but in our experience, BCCs of the lips are common, particularly in women. OBJECTIVES: To…
Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology
Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the
Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing
Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…
Moonkyoo Kong, Yu Jin Lim, Youngkyong Kim · 2018 · PubMed
Background: We conducted this study to contribute to resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were included in this…
Beryn A. Otieno, Helen F. Nahrung, Martin J. Steinbauer · 2019 · Forests
Research Highlights: We present the first attempts to model the distributions of the two cryptic and globally invasive species of Leptocybe invasa sensu lato (Fisher & LaSalle) (Hymenoptera: Eulophidae) in its purported country of origin,…
Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine
Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…
Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology
Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…
Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development
The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…
Olga Stavrova, Lena Haarmann · 2019 · Motivation and Emotion
Abstract Although perceptions of subjective well-being (SWB) in unacquainted others have been shown to play a major role in impression formation, little is known about how accurate such perceptions are. In two original studies and one pre-registered replication, we explored the accuracy of life satisfaction and happiness judgments from texts and its underlying mechanisms (use of linguistic cues). Participants filled in life satisfaction and happiness measures and completed a brief writing task. Another sample of participants judged the targets’ life satisfaction and happiness from the obtained
Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed
We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…
Cécile Barbet, Guillaume Thierry · 2016 · Frontiers in Psychology
In sentence verification tasks involving under-informative statements such as Some elephants are mammals, some adults appear more tolerant to pragmatic violations than others. The underlying causes of such inter-individual variability remain however essentially unknown. Here, we investigated inter-individual variation in adults deriving the scalar inference "not all" triggered by the quantifier some. We first assessed the individual intolerance to pragmatic violations in adult participants presented with under-informative some-statements (e.g., Some infants are young). We then recorded event-r
Sakae Konishi, Shingo Hatakeyama, Atsushi Imai et al. · 2020 · LUTS Lower Urinary Tract Symptoms
OBJECTIVES: To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older. METHODS: We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in…
Rebecca Hun Ping Cheung, Magdalena Mo Ching Mok · 2018 · Creativity Research Journal
Previous studies have suggested that teacher’s personality traits and pedagogy are the important areas of investigation in creativity research; however, little is known about the relationship between teachers’ personality traits and…
Hieab H.H. Adams, Vincentius J.A. Verlinden, Michele L. Callisaya et al. · 2015 · The Journals of Gerontology Series A
Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam…
Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications
Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or
Christopher A. Wolters, Marcia A. Barnes, Paulina A. Kulesz et al. · 2016 · The Journal of Educational Research
The authors' purpose was to examine adolescents' reading motivation in relation to standardized assessments of reading comprehension and fluency. After a reading pretest, 60 ninth-grade students (M age = 14.9 years) were randomly assigned…
Chen Xing, Fei Liu, Bin Wang et al. · 2019 · Journal of Climate
Abstract We analyzed global surface air temperature (SAT) responses to five major tropical volcanic eruptions from 1870 to 2005 using outputs from 97 historical and 58 Atmospheric Model Intercomparison Project (AMIP) runs that participated…
Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology
OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…
Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma
Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…
Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology
The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…
Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences
BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as
Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre
Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…
Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE
BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do
Liang He, Janne Pitkäniemi, Kauko Heikkilä et al. · 2016 · Brain and Behavior
BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o
Pengcheng Niu, Wenya Li, Z. Zhang et al. · 2016 · Science and Technology of Welding & Joining
A 30–40 μm thick oxide layer was prefabricated on the top, butt or bottom surfaces of AA2024 sheets by micro-arc oxidation, which were then friction stir welded. Sheets without oxide layer were also welded with blowing oxygen along the…
Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo et al. · 2018 · Molecular Genetics & Genomic Medicine
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in TGFβ/BMP9 pathway genes and characterized by vascular malformations (VM) including arteriovenous malformations (AVM) in lung, liver, and brain, which lead to severe complications including intracranial hemorrhage (ICH) from brain VM. The clinical heterogeneity of HHT suggests a role for genetic modifier effects. Common variants in loci that modify phenotype severity in Tgfb knockout mice were previously reported as associated with lung AVM in HHT. Common variants in candidate genes were reported as associated wit