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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21691 results · page 119 of 724

Negative / Null Result Report

Fresh‐frozen plasma transfusion did not reduce 30‐day mortality in patients undergoing cardiopulmonary bypass cardiac surgery with excessive bleeding: the PLASMACARD multicenter cohort study

Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion

Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…

View details →DOI: 10.1111/trf.12422Cited by 18
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genetic polymorphisms of the adrenergic system and implantable cardioverter-defibrillator therapies in patients with heart failure

Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace

AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…

View details →DOI: 10.1093/europace/euq040Cited by 18
Negative / Null Result ReportOpen accessImmunology and Microbiology

Significant Differences in RNA Structure Destabilization by HIV-1 Gag∆p6 and NCp7 Proteins

Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses

Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d

View details →DOI: 10.3390/v12050484Cited by 18
Negative / Null Result ReportOpen accessMedicine

Cocultures of Mesenchymal Stem Cells and Endothelial Cells As Organotypic Models of Prostate Cancer Metastasis

Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics

In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…

View details →DOI: 10.1021/mp500141bCited by 18
Negative / Null Result ReportOpen accessNeuroscience

Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors

Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer

BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…

View details →DOI: 10.1002/cncr.34512Cited by 18
Negative / Null Result ReportOpen accessMedicine

Design and baseline characteristics of the LANDMARK study

Etsuro Ogata, Masafumi Fukagawa, Hideki Hirakata et al. · 2016 · Clinical and Experimental Nephrology

BACKGROUND: Calcium (Ca)-based phosphate (P) binders, compared to non-Ca-based P binders, contribute to vascular calcification, which is associated with cardiovascular events. METHODS: The LANDMARK study is a multicenter, randomized, open-label, parallel comparative study of lanthanum carbonate (LC) and calcium carbonate (CC) in hemodialysis patients. Stable hemodialysis patients with intact parathyroid hormone ≤240 pg/mL meeting ≥1 of the following criteria (age >65 years, postmenopause, diabetes mellitus) were randomized into the LC and CC groups. LC group patients initially received LC 750

View details →DOI: 10.1007/s10157-016-1310-8Cited by 18
Negative / Null Result ReportOpen accessMedicine

Blood Pressure Trajectories Prior to Death in Patients With Diabetes

Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care

OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…

View details →DOI: 10.2337/dc11-0441Cited by 18
Negative / Null Result Report

Climate Change Can Drive a Significant Loss of Suitable Habitat for Polylepis quadrijuga, a Treeline Species in the Sky Islands of the Northern Andes

Lina Caballero-Villalobos, Francisco Fajardo-Gutiérrez, Mariasole Calbi et al. · 2021 · Frontiers in Ecology and Evolution

It is predicted that climate change will strongly affect plant distributions in high elevation “sky islands” of tropical Andes. Polylepis forests are a dominant element of the treeline throughout the Andes Cordillera in South America.…

View details →DOI: 10.3389/fevo.2021.661550Cited by 18
Negative / Null Result Report

Using Bibliometrics to Demonstrate the Value of Library Journal Collections

Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries

Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…

View details →DOI: 10.5860/crl.77.4.410Cited by 18
Negative / Null Result Report

Benthic invertebrates in Svalbard fjords—when metabarcoding does not outperform traditional biodiversity assessment

Endre Willassen, Jon-Ivar Westgaard, Jon Anders Kongsrud et al. · 2022 · PeerJ

To protect and restore ecosystems and biodiversity is one of the 10 challenges identified by the United Nations’s Decade of the Ocean Science. In this study we used eDNA from sediments collected in two fjords of the Svalbard archipelago…

View details →DOI: 10.7717/peerj.14321Cited by 17
Negative / Null Result Report

Single‐family room design in the neonatal intensive care unit did not improve growth

Bente Silnes Tandberg, Kathrine Frey Frøslie, Trond Markestad et al. · 2019 · Acta Paediatrica

Abstract Aim The aim was to compare growth in very premature infants cared for in a single‐family room (SFR) and an open‐bay (OB) unit. We recorded duration of parental presence and skin‐to‐skin contact as proxies for parental involvement…

View details →DOI: 10.1111/apa.14746Cited by 17
Negative / Null Result ReportOpen accessPsychology

How to tell a happy person: Accuracy of subjective well-being perception from texts

Olga Stavrova, Lena Haarmann · 2019 · Motivation and Emotion

Abstract Although perceptions of subjective well-being (SWB) in unacquainted others have been shown to play a major role in impression formation, little is known about how accurate such perceptions are. In two original studies and one pre-registered replication, we explored the accuracy of life satisfaction and happiness judgments from texts and its underlying mechanisms (use of linguistic cues). Participants filled in life satisfaction and happiness measures and completed a brief writing task. Another sample of participants judged the targets’ life satisfaction and happiness from the obtained

View details →DOI: 10.1007/s11031-019-09815-4Cited by 17
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer's disease (AD).

Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed

We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…

View details →Cited by 17
Negative / Null Result ReportOpen accessPsychology

Some Alternatives? Event-Related Potential Investigation of Literal and Pragmatic Interpretations of Some Presented in Isolation

Cécile Barbet, Guillaume Thierry · 2016 · Frontiers in Psychology

In sentence verification tasks involving under-informative statements such as Some elephants are mammals, some adults appear more tolerant to pragmatic violations than others. The underlying causes of such inter-individual variability remain however essentially unknown. Here, we investigated inter-individual variation in adults deriving the scalar inference "not all" triggered by the quantifier some. We first assessed the individual intolerance to pragmatic violations in adult participants presented with under-informative some-statements (e.g., Some infants are young). We then recorded event-r

View details →DOI: 10.3389/fpsyg.2016.01479Cited by 17
Negative / Null Result ReportOpen accessMedicine

Overactive bladder and sleep disturbance have a significant effect on indoor falls: Results from the community health survey in Japan

Sakae Konishi, Shingo Hatakeyama, Atsushi Imai et al. · 2020 · LUTS Lower Urinary Tract Symptoms

OBJECTIVES: To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older. METHODS: We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in…

View details →DOI: 10.1111/luts.12326Cited by 17
Negative / Null Result ReportPsychology

Early Childhood Teachers’ Perception of Creative Personality as a Predictor of Their Support of pedagogy important for fostering Creativity: A Chinese Perspective

Rebecca Hun Ping Cheung, Magdalena Mo Ching Mok · 2018 · Creativity Research Journal

Previous studies have suggested that teacher’s personality traits and pedagogy are the important areas of investigation in creativity research; however, little is known about the relationship between teachers’ personality traits and…

View details →DOI: 10.1080/10400419.2018.1488345Cited by 17
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants

Hieab H.H. Adams, Vincentius J.A. Verlinden, Michele L. Callisaya et al. · 2015 · The Journals of Gerontology Series A

Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam…

View details →DOI: 10.1093/gerona/glv081Cited by 17
Negative / Null Result ReportOpen accessSocial Sciences

Examining the replicability of backfire effects after standalone corrections

Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications

Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or

View details →DOI: 10.1186/s41235-023-00492-zCited by 17
Negative / Null Result ReportPsychology

Examining a motivational treatment and its impact on adolescents' reading comprehension and fluency

Christopher A. Wolters, Marcia A. Barnes, Paulina A. Kulesz et al. · 2016 · The Journal of Educational Research

The authors' purpose was to examine adolescents' reading motivation in relation to standardized assessments of reading comprehension and fluency. After a reading pretest, 60 ninth-grade students (M age = 14.9 years) were randomly assigned…

View details →DOI: 10.1080/00220671.2015.1048503Cited by 17
Negative / Null Result ReportEnvironmental Science

Boreal Winter Surface Air Temperature Responses to Large Tropical Volcanic Eruptions in CMIP5 Models

Chen Xing, Fei Liu, Bin Wang et al. · 2019 · Journal of Climate

Abstract We analyzed global surface air temperature (SAT) responses to five major tropical volcanic eruptions from 1870 to 2005 using outputs from 97 historical and 58 Atmospheric Model Intercomparison Project (AMIP) runs that participated…

View details →DOI: 10.1175/jcli-d-19-0186.1Cited by 17
Negative / Null Result ReportOpen accessArts and Humanities

Evaluation of the auricular surface method for subadult sex estimation on Italian modern (19th to 20th century) identified skeletal collections

Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology

OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…

View details →DOI: 10.1002/ajpa.24146Cited by 17
Negative / Null Result ReportNeuroscience

Dissociated Predegenerated Peripheral Nerve Transplants for Spinal Cord Injury Repair: A Comprehensive Assessment of Their Effects on Regeneration and Functional Recovery Compared to Schwann Cell Transplants

Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma

Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…

View details →DOI: 10.1089/neu.2012.2377Cited by 17
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

ASSA: Fast identification of statistically significant interactions between long RNAs

Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…

View details →DOI: 10.1142/s0219720018400012Cited by 17
Negative / Null Result ReportOpen accessMedicine

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice

Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences

BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as

View details →DOI: 10.1186/s13293-015-0026-xCited by 17
Negative / Null Result ReportMedicine

Studies on protein content, protease activity, antioxidants potential, melanin composition, glucosinolate and pectin constitution with brief statisticalanalysis in some medicinally significant fruit peels

Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre

Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…

View details →Cited by 17